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The map label for this gene is ndhH

Identifier: 37521952

GI number: 37521952

Start: 2540605

End: 2541789

Strand: Reverse

Name: ndhH

Synonym: gvip333

Alternate gene names: 37521952

Gene position: 2541789-2540605 (Counterclockwise)

Preceding gene: 37521953

Following gene: 37521947

Centisome position: 54.56

GC content: 58.9

Gene sequence:

>1185_bases
ATGGTCACCATCGAAACCCGCGCCGACCAGATGGTCCTCAATCTAGGACCGCACCACCCTTCCACCCATGGCGTACTGCG
GCTCATCGTCACCCTCGACGGCGAGAACGTCGTTGATTGCCGGCCGGTGTTGGGTTACTTGCACCGCGGCATGGAGAAAA
TCGGCGAGAACCGCACGATTATCCAGTATTTGCCCTACTGTTCGCGCTGGGATTACGCGGCGGCGATGATGAACGAAGCG
CCCGTGGTCAACGCTCCGGAGGCGATGGCCGGGGTAAAGGTGCCGCGCCGGGCGAGTTATATCCGCGTGATCATGCTCGA
ACTGTCGCGCATCGCCAATCACCTGCTGTGGGTGGGGCCGTTCTTGCTCGACATGGGAGCGCAGTCGCCGTTTTTCTATA
TCCTGCGCGAACGCGAATTGATTCTCGACCTGTTCGAGGCGGCCACCGGGCTGCGCATGGTGGGCAACAATTATTTTCGC
GTCGGCGGGGTAACGGTGGATTTGCCCTACGGCTGGGTCGACAAGGCCCATGACCTTTGCGACGTGATACCGGGAAAGAT
CGACGAGTACGAACGGCTGATCACCAACAACCCGATCTTCCGCCGCCGCATCGAAAACTTAGGCTATATCAGCCGCGAGG
ATGCAATCAACTGGGGGCTATCCGGGCCGATGCTGCGCGCCTCGGGCGTCAAGTGGGATCTTAGAAAAGTCGATCACTAC
GAAATCTACGACGAACTGGACTGGGATATCGCCTGGGACACCGGCGGCGACTGTCTGGCGCGCTACATCGTGCGCATCAA
AGAGATGCGCGAGTCGGTCAAAATTATTCGTCAGGCCCTCGATCAGTTGCCCGGCGGTCCATACGAGCAACTGGAGGCAC
GCCGTCTTGCCGAGGGGCCGAAGTCGGAGTGGAACAGTTTCGACTACCAGTTCATCGGTAAAAAGTCTTCGCCGACCTTC
AAAATTCCTACGGGCGAATATTACGCCCGCTCGGAAGAAGCGAAGGGTGAATTGGGCATCTACGTCGTCGGCCGCGACGA
CACGACGCCCTGGCGCTGGAAGATCCGCACGCCGGATTTTGCCAACCTGGCTATCTTGCCGATGATTTTGCAGGGCACGA
AGGTCGCAGATTTGGTCGTGGTTCTCGGTTCAATCGACATCATCATGGGCTCGGTCGACCGCTGA

Upstream 100 bases:

>100_bases
GCTCGCGGGTCTTTCGCTACCCGCTCAAACTCTGTCTTAGGGTGCATTCCACGGCCTGGGCAATACGACTAGTCTTGTGT
GTACTTCGAGACCCCGCCCG

Downstream 100 bases:

>100_bases
ACCGGACAAGAGGTATCGGGTGGATGCAGGGGTGCGCTTCGTCGCACCCCTTTTTTTTGAGACTCACATCGCCGCAAAAT
CCGGTCGAACGAGGAGTAGC

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H 2; NADH-plastoquinone oxidoreductase subunit H 2; NDH-1 subunit H 2; NDH-H 2

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MVTIETRADQMVLNLGPHHPSTHGVLRLIVTLDGENVVDCRPVLGYLHRGMEKIGENRTIIQYLPYCSRWDYAAAMMNEA
PVVNAPEAMAGVKVPRRASYIRVIMLELSRIANHLLWVGPFLLDMGAQSPFFYILRERELILDLFEAATGLRMVGNNYFR
VGGVTVDLPYGWVDKAHDLCDVIPGKIDEYERLITNNPIFRRRIENLGYISREDAINWGLSGPMLRASGVKWDLRKVDHY
EIYDELDWDIAWDTGGDCLARYIVRIKEMRESVKIIRQALDQLPGGPYEQLEARRLAEGPKSEWNSFDYQFIGKKSSPTF
KIPTGEYYARSEEAKGELGIYVVGRDDTTPWRWKIRTPDFANLAILPMILQGTKVADLVVVLGSIDIIMGSVDR

Sequences:

>Translated_394_residues
MVTIETRADQMVLNLGPHHPSTHGVLRLIVTLDGENVVDCRPVLGYLHRGMEKIGENRTIIQYLPYCSRWDYAAAMMNEA
PVVNAPEAMAGVKVPRRASYIRVIMLELSRIANHLLWVGPFLLDMGAQSPFFYILRERELILDLFEAATGLRMVGNNYFR
VGGVTVDLPYGWVDKAHDLCDVIPGKIDEYERLITNNPIFRRRIENLGYISREDAINWGLSGPMLRASGVKWDLRKVDHY
EIYDELDWDIAWDTGGDCLARYIVRIKEMRESVKIIRQALDQLPGGPYEQLEARRLAEGPKSEWNSFDYQFIGKKSSPTF
KIPTGEYYARSEEAKGELGIYVVGRDDTTPWRWKIRTPDFANLAILPMILQGTKVADLVVVLGSIDIIMGSVDR
>Mature_394_residues
MVTIETRADQMVLNLGPHHPSTHGVLRLIVTLDGENVVDCRPVLGYLHRGMEKIGENRTIIQYLPYCSRWDYAAAMMNEA
PVVNAPEAMAGVKVPRRASYIRVIMLELSRIANHLLWVGPFLLDMGAQSPFFYILRERELILDLFEAATGLRMVGNNYFR
VGGVTVDLPYGWVDKAHDLCDVIPGKIDEYERLITNNPIFRRRIENLGYISREDAINWGLSGPMLRASGVKWDLRKVDHY
EIYDELDWDIAWDTGGDCLARYIVRIKEMRESVKIIRQALDQLPGGPYEQLEARRLAEGPKSEWNSFDYQFIGKKSSPTF
KIPTGEYYARSEEAKGELGIYVVGRDDTTPWRWKIRTPDFANLAILPMILQGTKVADLVVVLGSIDIIMGSVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=394, Percent_Identity=40.6091370558376, Blast_Score=302, Evalue=4e-82,
Organism=Homo sapiens, GI260898743, Length=388, Percent_Identity=39.9484536082474, Blast_Score=291, Evalue=9e-79,
Organism=Escherichia coli, GI145693162, Length=390, Percent_Identity=38.4615384615385, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1789076, Length=387, Percent_Identity=29.4573643410853, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1788832, Length=394, Percent_Identity=27.4111675126904, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=40.6091370558376, Blast_Score=314, Evalue=5e-86,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=40.3553299492386, Blast_Score=313, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24638644, Length=393, Percent_Identity=40.2035623409669, Blast_Score=321, Evalue=5e-88,
Organism=Drosophila melanogaster, GI221459469, Length=390, Percent_Identity=40.2564102564103, Blast_Score=312, Evalue=3e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDHH2_GLOVI (Q7NI01)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925329.1
- HSSP:   Q56220
- ProteinModelPortal:   Q7NI01
- SMR:   Q7NI01
- GeneID:   2600784
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2383
- HOGENOM:   HBG459705
- OMA:   FGPFLAD
- ProtClustDB:   PRK07415
- BioCyc:   GVIO251221:GLL2383-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885

Pfam domain/function: PF00346 Complex1_49kDa

EC number: 1.6.5.3

Molecular weight: Translated: 44893; Mature: 44893

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTIETRADQMVLNLGPHHPSTHGVLRLIVTLDGENVVDCRPVLGYLHRGMEKIGENRTI
CEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEE
IQYLPYCSRWDYAAAMMNEAPVVNAPEAMAGVKVPRRASYIRVIMLELSRIANHLLWVGP
EECCCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLLDMGAQSPFFYILRERELILDLFEAATGLRMVGNNYFRVGGVTVDLPYGWVDKAHDLC
HHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCEECCCCEEEECCEEEECCCCCHHHHHHHH
DVIPGKIDEYERLITNNPIFRRRIENLGYISREDAINWGLSGPMLRASGVKWDLRKVDHY
HHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHCCCCE
EIYDELDWDIAWDTGGDCLARYIVRIKEMRESVKIIRQALDQLPGGPYEQLEARRLAEGP
EHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
KSEWNSFDYQFIGKKSSPTFKIPTGEYYARSEEAKGELGIYVVGRDDTTPWRWKIRTPDF
CCCCCCCCEEEECCCCCCCEECCCCHHHCCCCCCCCCEEEEEEECCCCCCEEEEECCCCC
ANLAILPMILQGTKVADLVVVLGSIDIIMGSVDR
CCHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCC
>Mature Secondary Structure
MVTIETRADQMVLNLGPHHPSTHGVLRLIVTLDGENVVDCRPVLGYLHRGMEKIGENRTI
CEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEE
IQYLPYCSRWDYAAAMMNEAPVVNAPEAMAGVKVPRRASYIRVIMLELSRIANHLLWVGP
EECCCCCCCCHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLLDMGAQSPFFYILRERELILDLFEAATGLRMVGNNYFRVGGVTVDLPYGWVDKAHDLC
HHHHCCCCCCEEEEEHHHHHHHHHHHHHCCCEECCCCEEEECCEEEECCCCCHHHHHHHH
DVIPGKIDEYERLITNNPIFRRRIENLGYISREDAINWGLSGPMLRASGVKWDLRKVDHY
HHCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHCCCCE
EIYDELDWDIAWDTGGDCLARYIVRIKEMRESVKIIRQALDQLPGGPYEQLEARRLAEGP
EHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
KSEWNSFDYQFIGKKSSPTFKIPTGEYYARSEEAKGELGIYVVGRDDTTPWRWKIRTPDF
CCCCCCCCEEEECCCCCCCEECCCCHHHCCCCCCCCCEEEEEEECCCCCCEEEEECCCCC
ANLAILPMILQGTKVADLVVVLGSIDIIMGSVDR
CCHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14621292