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The map label for this gene is purL

Identifier: 37521682

GI number: 37521682

Start: 2264593

End: 2266917

Strand: Direct

Name: purL

Synonym: gvip290

Alternate gene names: 37521682

Gene position: 2264593-2266917 (Clockwise)

Preceding gene: 37521681

Following gene: 37521683

Centisome position: 48.61

GC content: 64.47

Gene sequence:

>2325_bases
ATGACCGCGCCGACCGAGTCCTCCCCGTTTAGCCCCGCCGATCTGGCCCGCCACCGCCTGAGCCCCCAGGAGTACCGGCG
CATCACCGAACTGATCGGACGCCACCCCAACCTCAACGAGTTGGGCATGTTCAGCGTGATGTGGTCTGAACACTGCTGCT
ATAAAAATTCCCGGCCGCTGCTTAAAGGATTTCCGACCACCGGCCCGCGGGTGCTGGTGGGACCGGGCGAGAACGCCGGG
GTGATCGATATCGGCGACGGCCTGCGCGTCGCTTTCAAAATTGAATCGCACAACCACCCGAGTGCGGTGGAGCCGTTTCA
AGGGGCAGCCACCGGCGTCGGGGGCATTCTGCGCGACATTTTTACGATGGGAGCGCGGCCCATCGCTTCGCTCAATTCGC
TGCGCTTCGGACCGCTCGAAGACGCCCGCAACCGGGCGCTTTTTCGGGGCGTCGTCCACGGCATCGGTCACTACGGCAAT
TGTGTCGGGGTGCCCACGGTCGGGGGCGAGGTGTACTTCGATCCGACCTATTCCGGCAACCCGCTGGTGAACGCCATGGC
CATCGGCGTGCTCGAAACGCCCGAGATCGTCCGCTCCGGGGCGGCGGGCATCGGCAACCCGGTGCTCTATGTCGGCTCCA
CCACCGGCCGCGACGGCATGGGCGGGGCAAGCTTCGCCTCGGCGGAACTTTCTGACGCGTCGCAAAAGGACCGCCCTGCG
GTACAGGTGGGCGACCCGTTCACCGAAAAATCGCTCATCGAGGCGTGTCTGGAAGCTTTTCGCACCGGGGCGGTGGTCGC
CGCCCAGGACATGGGGGCGGCGGGGCTCACCTGCTCGTCTTCGGAGATGGCCGCCAAGGGTGGGGTCGGTATCGAGATGG
ACCTCGACCTGGTGCCCGTGCGCGAGACGGGCATGGTGCCCTACGAATTTCTGCTTTCTGAGTCGCAGGAGCGTATGCTC
TTCGTGGCCGAAAAGGGCCGCGAAGGCGAACTGATTGCCCTGTTTGAGCGCTGGGGATTGCACGCGGTGGTAGTAGGCCG
GGTGATCGGTGAACCCCTGGTGCGCATTTTTCACAGCGGCAAGGTCGTGGCGGAACTCCCCGCCCGCGCCCTCACCGACG
ATGCCCCGGTCTATCCCCGAGCAGTGCTCCCCGAGCCCCCGGCTGCGATCCTCAAGCTCAGGGCCTTCGACTGGCATTCG
CTCGCTGAACCCACCGACTACGCCGAAGCGCTGCTTACGCTGCTCGACAGTCCGACGATTGGTTCCAAAAGTTGGGTCTA
CCGCCAGTACGACCACCAGGTGCAGAACAACACGGTGATCGTGCCGGGGGCGGCGGACGCTGCTGTCATTCGGGTGCGTC
CGCAGAGTTTTGGCCCCGGCGAAGTCGAAGCGGTGCCGTTTACCGAGCGGGGCATCGCCGCCACAGTTGATTGCAACAGC
CGCTACGTCTATCTCGACCCGTACCGGGGGGCGATGCTCGCCGTGGCCGAGGCGGCCCGCAACTTGAGCTGCGTGGGAGC
CACTCCGCTCGCGGTCACCGACAACCTCAATTTCGGTTCCCCCGAAAAGCCCGAAGGCTACTGGCAGTTGGCGATGGCCT
GCCGGGGGATTGCAGACGCCTGCCTCGAACTGATGACCCCGGTCACCGGCGGCAACGTCTCGCTCTACAACGAGACCCAG
AGCGACGGCAGGACAACAGCCATCTACCCGACTCCCACGATCGGTATGGTCGGGCTGGTGGAAGATATCCACCGCACCTG
CAGCCAGAATTTCAAGTCCCCCGGCGATCTGGTGTATCTGCTGGGGGGCGGCGAACCGACCCTGGGCGGATCCGAGTACC
TGGCTTGTCTGCACGGCGTGGCGGCGGGCGAGCCTCCGGTTCTGGACATGGCCCTTGAAATCCAGGTGCAGTCGGTCTGC
CGCCTGGGTATCGAGCGGGGGTTGTTCAAATCGGCCCACGACGTTGCCGAAGGTGGTCTTGCCGTTGCTCTGGCCGAGTG
CTGCATCACAGGTAACTTGGGGCTCGACGCTGTGCTGGGGGCGAATCACCCGCGCGCCGATGTGGTGTGCTTCGGGGAGA
TGGCTGCCGCCATCATTGTCACCATCGATCCTTGTGATCAGGTCGCCTGCGAACTTTGGCTCGAATGCTCCCTAGCCGAG
CGCTGGAAACTCCTGGGCACAGTCGCCGCGCAAAGTTTCGATCTGCGCGTCGAAAATCGCGATTGCCGCATCTCCACTTC
CTGCGAGCGGCTCAAGACCACCTTCGAACAAGCCATCCCCCGCCGGATGGAGCACATACCTGTCACCGAGGCACCCCAAC
GATGA

Upstream 100 bases:

>100_bases
TGTCGGGCTTTAGTCCAGCCGGCGGGGTGGGTGAAACCAAGAAGCCCTGACGGGAGAGCGAGAGCAAACGTTATAATCGG
CGGGTGAATACTTGGCCGAG

Downstream 100 bases:

>100_bases
CCTACGCTGCACCCTCTGCTCCCGACAAGCCTGAGGAGGCTTGCGGGGTCTTCGGCATCCTGGCGCCGGGCGAAGCCGTC
GCCAAATTGACCTACTTCGG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MTAPTESSPFSPADLARHRLSPQEYRRITELIGRHPNLNELGMFSVMWSEHCCYKNSRPLLKGFPTTGPRVLVGPGENAG
VIDIGDGLRVAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIASLNSLRFGPLEDARNRALFRGVVHGIGHYGN
CVGVPTVGGEVYFDPTYSGNPLVNAMAIGVLETPEIVRSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDASQKDRPA
VQVGDPFTEKSLIEACLEAFRTGAVVAAQDMGAAGLTCSSSEMAAKGGVGIEMDLDLVPVRETGMVPYEFLLSESQERML
FVAEKGREGELIALFERWGLHAVVVGRVIGEPLVRIFHSGKVVAELPARALTDDAPVYPRAVLPEPPAAILKLRAFDWHS
LAEPTDYAEALLTLLDSPTIGSKSWVYRQYDHQVQNNTVIVPGAADAAVIRVRPQSFGPGEVEAVPFTERGIAATVDCNS
RYVYLDPYRGAMLAVAEAARNLSCVGATPLAVTDNLNFGSPEKPEGYWQLAMACRGIADACLELMTPVTGGNVSLYNETQ
SDGRTTAIYPTPTIGMVGLVEDIHRTCSQNFKSPGDLVYLLGGGEPTLGGSEYLACLHGVAAGEPPVLDMALEIQVQSVC
RLGIERGLFKSAHDVAEGGLAVALAECCITGNLGLDAVLGANHPRADVVCFGEMAAAIIVTIDPCDQVACELWLECSLAE
RWKLLGTVAAQSFDLRVENRDCRISTSCERLKTTFEQAIPRRMEHIPVTEAPQR

Sequences:

>Translated_774_residues
MTAPTESSPFSPADLARHRLSPQEYRRITELIGRHPNLNELGMFSVMWSEHCCYKNSRPLLKGFPTTGPRVLVGPGENAG
VIDIGDGLRVAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIASLNSLRFGPLEDARNRALFRGVVHGIGHYGN
CVGVPTVGGEVYFDPTYSGNPLVNAMAIGVLETPEIVRSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDASQKDRPA
VQVGDPFTEKSLIEACLEAFRTGAVVAAQDMGAAGLTCSSSEMAAKGGVGIEMDLDLVPVRETGMVPYEFLLSESQERML
FVAEKGREGELIALFERWGLHAVVVGRVIGEPLVRIFHSGKVVAELPARALTDDAPVYPRAVLPEPPAAILKLRAFDWHS
LAEPTDYAEALLTLLDSPTIGSKSWVYRQYDHQVQNNTVIVPGAADAAVIRVRPQSFGPGEVEAVPFTERGIAATVDCNS
RYVYLDPYRGAMLAVAEAARNLSCVGATPLAVTDNLNFGSPEKPEGYWQLAMACRGIADACLELMTPVTGGNVSLYNETQ
SDGRTTAIYPTPTIGMVGLVEDIHRTCSQNFKSPGDLVYLLGGGEPTLGGSEYLACLHGVAAGEPPVLDMALEIQVQSVC
RLGIERGLFKSAHDVAEGGLAVALAECCITGNLGLDAVLGANHPRADVVCFGEMAAAIIVTIDPCDQVACELWLECSLAE
RWKLLGTVAAQSFDLRVENRDCRISTSCERLKTTFEQAIPRRMEHIPVTEAPQR
>Mature_773_residues
TAPTESSPFSPADLARHRLSPQEYRRITELIGRHPNLNELGMFSVMWSEHCCYKNSRPLLKGFPTTGPRVLVGPGENAGV
IDIGDGLRVAFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIASLNSLRFGPLEDARNRALFRGVVHGIGHYGNC
VGVPTVGGEVYFDPTYSGNPLVNAMAIGVLETPEIVRSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDASQKDRPAV
QVGDPFTEKSLIEACLEAFRTGAVVAAQDMGAAGLTCSSSEMAAKGGVGIEMDLDLVPVRETGMVPYEFLLSESQERMLF
VAEKGREGELIALFERWGLHAVVVGRVIGEPLVRIFHSGKVVAELPARALTDDAPVYPRAVLPEPPAAILKLRAFDWHSL
AEPTDYAEALLTLLDSPTIGSKSWVYRQYDHQVQNNTVIVPGAADAAVIRVRPQSFGPGEVEAVPFTERGIAATVDCNSR
YVYLDPYRGAMLAVAEAARNLSCVGATPLAVTDNLNFGSPEKPEGYWQLAMACRGIADACLELMTPVTGGNVSLYNETQS
DGRTTAIYPTPTIGMVGLVEDIHRTCSQNFKSPGDLVYLLGGGEPTLGGSEYLACLHGVAAGEPPVLDMALEIQVQSVCR
LGIERGLFKSAHDVAEGGLAVALAECCITGNLGLDAVLGANHPRADVVCFGEMAAAIIVTIDPCDQVACELWLECSLAER
WKLLGTVAAQSFDLRVENRDCRISTSCERLKTTFEQAIPRRMEHIPVTEAPQR

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=684, Percent_Identity=26.6081871345029, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI48994899, Length=769, Percent_Identity=25.4876462938882, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17553022, Length=669, Percent_Identity=24.0657698056801, Blast_Score=102, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321498, Length=747, Percent_Identity=23.1593038821954, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24582111, Length=647, Percent_Identity=25.6568778979907, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24582109, Length=647, Percent_Identity=25.6568778979907, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137292, Length=647, Percent_Identity=25.6568778979907, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_GLOVI (Q7NIR9)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_925059.1
- ProteinModelPortal:   Q7NIR9
- SMR:   Q7NIR9
- GeneID:   2600514
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.2113
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   GVIO251221:GLR2113-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 82657; Mature: 82526

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTESSPFSPADLARHRLSPQEYRRITELIGRHPNLNELGMFSVMWSEHCCYKNSRPL
CCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCCCCCCCCH
LKGFPTTGPRVLVGPGENAGVIDIGDGLRVAFKIESHNHPSAVEPFQGAATGVGGILRDI
HCCCCCCCCEEEECCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
FTMGARPIASLNSLRFGPLEDARNRALFRGVVHGIGHYGNCVGVPTVGGEVYFDPTYSGN
HHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCCCCC
PLVNAMAIGVLETPEIVRSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDASQKDRPA
CCCHHEEECCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCC
VQVGDPFTEKSLIEACLEAFRTGAVVAAQDMGAAGLTCSSSEMAAKGGVGIEMDLDLVPV
EEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEECCCCHHHCCCCCEEEECEEEEC
RETGMVPYEFLLSESQERMLFVAEKGREGELIALFERWGLHAVVVGRVIGEPLVRIFHSG
CCCCCCCHHHHHCCCCCEEEEEECCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHCC
KVVAELPARALTDDAPVYPRAVLPEPPAAILKLRAFDWHSLAEPTDYAEALLTLLDSPTI
CEEECCCHHHCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
GSKSWVYRQYDHQVQNNTVIVPGAADAAVIRVRPQSFGPGEVEAVPFTERGIAATVDCNS
CCCCCEEEHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCC
RYVYLDPYRGAMLAVAEAARNLSCVGATPLAVTDNLNFGSPEKPEGYWQLAMACRGIADA
EEEEECCCCCHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
CLELMTPVTGGNVSLYNETQSDGRTTAIYPTPTIGMVGLVEDIHRTCSQNFKSPGDLVYL
HHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
LGGGEPTLGGSEYLACLHGVAAGEPPVLDMALEIQVQSVCRLGIERGLFKSAHDVAEGGL
EECCCCCCCHHHHHHHHHHCCCCCCCEEEHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AVALAECCITGNLGLDAVLGANHPRADVVCFGEMAAAIIVTIDPCDQVACELWLECSLAE
HHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCEEEEEEEECCHHHHHHHHHHHCCHHH
RWKLLGTVAAQSFDLRVENRDCRISTSCERLKTTFEQAIPRRMEHIPVTEAPQR
HHHHHHHHHHCEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAPTESSPFSPADLARHRLSPQEYRRITELIGRHPNLNELGMFSVMWSEHCCYKNSRPL
CCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHCCCCCCCCH
LKGFPTTGPRVLVGPGENAGVIDIGDGLRVAFKIESHNHPSAVEPFQGAATGVGGILRDI
HCCCCCCCCEEEECCCCCCCEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
FTMGARPIASLNSLRFGPLEDARNRALFRGVVHGIGHYGNCVGVPTVGGEVYFDPTYSGN
HHHCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEECCCCCCC
PLVNAMAIGVLETPEIVRSGAAGIGNPVLYVGSTTGRDGMGGASFASAELSDASQKDRPA
CCCHHEEECCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHCCCCCCCCCC
VQVGDPFTEKSLIEACLEAFRTGAVVAAQDMGAAGLTCSSSEMAAKGGVGIEMDLDLVPV
EEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEECCCCHHHCCCCCEEEECEEEEC
RETGMVPYEFLLSESQERMLFVAEKGREGELIALFERWGLHAVVVGRVIGEPLVRIFHSG
CCCCCCCHHHHHCCCCCEEEEEECCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHCC
KVVAELPARALTDDAPVYPRAVLPEPPAAILKLRAFDWHSLAEPTDYAEALLTLLDSPTI
CEEECCCHHHCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
GSKSWVYRQYDHQVQNNTVIVPGAADAAVIRVRPQSFGPGEVEAVPFTERGIAATVDCNS
CCCCCEEEHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCEEEECCCCCCEEEEEECCC
RYVYLDPYRGAMLAVAEAARNLSCVGATPLAVTDNLNFGSPEKPEGYWQLAMACRGIADA
EEEEECCCCCHHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
CLELMTPVTGGNVSLYNETQSDGRTTAIYPTPTIGMVGLVEDIHRTCSQNFKSPGDLVYL
HHHHHCCCCCCCEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEE
LGGGEPTLGGSEYLACLHGVAAGEPPVLDMALEIQVQSVCRLGIERGLFKSAHDVAEGGL
EECCCCCCCHHHHHHHHHHCCCCCCCEEEHEEHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AVALAECCITGNLGLDAVLGANHPRADVVCFGEMAAAIIVTIDPCDQVACELWLECSLAE
HHHHHHHHHCCCCCCEEEECCCCCCCCEEEECCCEEEEEEEECCHHHHHHHHHHHCCHHH
RWKLLGTVAAQSFDLRVENRDCRISTSCERLKTTFEQAIPRRMEHIPVTEAPQR
HHHHHHHHHHCEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292