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The map label for this gene is accC [H]

Identifier: 37521581

GI number: 37521581

Start: 2161491

End: 2162840

Strand: Reverse

Name: accC [H]

Synonym: gvip271

Alternate gene names: 37521581

Gene position: 2162840-2161491 (Counterclockwise)

Preceding gene: 37521582

Following gene: 37521578

Centisome position: 46.42

GC content: 64.0

Gene sequence:

>1350_bases
GTGGTCTATTTTCGCAAGATTTTGATTGCCAACCGGGGCGAAGTGGCGCTGCGCATCCTGCGCACCTGCAGCGAACTCGG
TATCGGCACCGTGGCGGTACACTCGACGGCCGACGCCCTCTCGCTGCACGTGCAACTGGCCGACCAGGCGGTGTGCATCG
GCGAACCGATGGCCAGCAAGAGCTATTTGAGCATTCCGAATTTGATCTCGGCGGCCCTGACGCGCGACTGCGACGCCGTC
CACCCGGGCTACGGTTTTTTGTCGGAAAACGAGCGCTTCGCTGAAATCTGCGCCGATCACGGCCTCACTTTTATTGGCCC
TTCGCCCCGGGCGATGGTGCTGATGGGCGACAAATCCACCGCCCGCGACACGATGAAGGCGGCGGGGGTGCCCACCGTAC
CCGGCTCCGAGGGGCTCATCGACAGTGAACAAGAAGCCTACGAGGCGGCCAAAGCGATTGGCTACCCGGTGATGATCAAG
GCGACGGCCGGGGGCGGCGGGCGCGGCATGCGCATTGCGGGCAACGAGCGCGACCTCATCAAAATGGTCCAGACCGCCCA
GCGCGAGGCGGAGGCGGCCTTCGGCAACCGGGGGGTCTACATCGAGAAGTACCTCGAAGAACCCCGGCACATCGAATTTC
AGATTCTCGCCGACCAGCACGGCAACGTCGTGCACCTGGGCGAGCGCGACTGCTCGATCCAAAGGCGCCACCAGAAATTG
CTCGAAGAATCCCCCAGCCCCTTTCTCACCCCCGCGATGCGCGAGCGCATGGGGGAGGCGGCCCTACAGGCGGCGAGGTC
GATCAACTACGTGGGGGCGGGCACCATCGAGTTTCTGGTCGACAAAAAGGGCGACTTTTACTTCATGGAGATGAACACCC
GCATCCAGGTGGAGCACCCGGTCACCGAGATGCGCACGGGTATCGATCTGATCGCCGAGCAGATCCGGATCGCCGCCGGG
GAGCCGTTGGGCTACACCCAGTCCGACATCCGCATGGAAGGCCACGCCATCGAGTGCCGGATCAACTGCGAGGATCCCAA
TAATGACTTTCGGCCCACCCCGGGCACGATCAGCGCCTATCTGGCGCCGGGTGGTCCGGGGGTGCGCATGGATTCTCACC
TGTACCCGGGCTATAAGGTGCCGTCCCACTACGATTCGCTCTTGGGCAAGCTGATCGTCTGGGGCCGCAACCGCGACGAG
GCCATCCGCCGCATGCGCCGGGCGCTCGCCGAGTGTGCGATCACCGGGGTACCGACCACCATTCCCTTTCACCTGCGGGT
GCTCGACAACGCCTGGTTCCTGCGCGGCGACGTCTACACCAACTTTGTCCAGCGACGGATGAGCGAGTGA

Upstream 100 bases:

>100_bases
GCGTCTTTTGACCGGGAGCGCCCCACAGGCCGAGCGCGAAGCGGGCGAAGGGGCGTGATAAGATGAGCGCCGGGATCGGT
CTTTTATAGAAGCAACTATT

Downstream 100 bases:

>100_bases
TCAGCCCTGGGGGGCATCGCCGGTCGTCCCGTGGCATTCGAGGGCGACCTTCGGCGGCGCATCGGCCTGGCCGGATTTGC
CGTTGGTCTTGAAGGGTTCT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MVYFRKILIANRGEVALRILRTCSELGIGTVAVHSTADALSLHVQLADQAVCIGEPMASKSYLSIPNLISAALTRDCDAV
HPGYGFLSENERFAEICADHGLTFIGPSPRAMVLMGDKSTARDTMKAAGVPTVPGSEGLIDSEQEAYEAAKAIGYPVMIK
ATAGGGGRGMRIAGNERDLIKMVQTAQREAEAAFGNRGVYIEKYLEEPRHIEFQILADQHGNVVHLGERDCSIQRRHQKL
LEESPSPFLTPAMRERMGEAALQAARSINYVGAGTIEFLVDKKGDFYFMEMNTRIQVEHPVTEMRTGIDLIAEQIRIAAG
EPLGYTQSDIRMEGHAIECRINCEDPNNDFRPTPGTISAYLAPGGPGVRMDSHLYPGYKVPSHYDSLLGKLIVWGRNRDE
AIRRMRRALAECAITGVPTTIPFHLRVLDNAWFLRGDVYTNFVQRRMSE

Sequences:

>Translated_449_residues
MVYFRKILIANRGEVALRILRTCSELGIGTVAVHSTADALSLHVQLADQAVCIGEPMASKSYLSIPNLISAALTRDCDAV
HPGYGFLSENERFAEICADHGLTFIGPSPRAMVLMGDKSTARDTMKAAGVPTVPGSEGLIDSEQEAYEAAKAIGYPVMIK
ATAGGGGRGMRIAGNERDLIKMVQTAQREAEAAFGNRGVYIEKYLEEPRHIEFQILADQHGNVVHLGERDCSIQRRHQKL
LEESPSPFLTPAMRERMGEAALQAARSINYVGAGTIEFLVDKKGDFYFMEMNTRIQVEHPVTEMRTGIDLIAEQIRIAAG
EPLGYTQSDIRMEGHAIECRINCEDPNNDFRPTPGTISAYLAPGGPGVRMDSHLYPGYKVPSHYDSLLGKLIVWGRNRDE
AIRRMRRALAECAITGVPTTIPFHLRVLDNAWFLRGDVYTNFVQRRMSE
>Mature_449_residues
MVYFRKILIANRGEVALRILRTCSELGIGTVAVHSTADALSLHVQLADQAVCIGEPMASKSYLSIPNLISAALTRDCDAV
HPGYGFLSENERFAEICADHGLTFIGPSPRAMVLMGDKSTARDTMKAAGVPTVPGSEGLIDSEQEAYEAAKAIGYPVMIK
ATAGGGGRGMRIAGNERDLIKMVQTAQREAEAAFGNRGVYIEKYLEEPRHIEFQILADQHGNVVHLGERDCSIQRRHQKL
LEESPSPFLTPAMRERMGEAALQAARSINYVGAGTIEFLVDKKGDFYFMEMNTRIQVEHPVTEMRTGIDLIAEQIRIAAG
EPLGYTQSDIRMEGHAIECRINCEDPNNDFRPTPGTISAYLAPGGPGVRMDSHLYPGYKVPSHYDSLLGKLIVWGRNRDE
AIRRMRRALAECAITGVPTTIPFHLRVLDNAWFLRGDVYTNFVQRRMSE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=48.9749430523918, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=49.7737556561086, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.7737556561086, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.7737556561086, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=47.972972972973, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=47.972972972973, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=47.972972972973, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=32.8767123287671, Blast_Score=271, Evalue=6e-73,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=32.8767123287671, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=32.8767123287671, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=32.8767123287671, Blast_Score=271, Evalue=8e-73,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=32.8767123287671, Blast_Score=271, Evalue=9e-73,
Organism=Homo sapiens, GI134142062, Length=512, Percent_Identity=31.8359375, Blast_Score=253, Evalue=3e-67,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=55.3047404063205, Blast_Score=477, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71987519, Length=446, Percent_Identity=47.7578475336323, Blast_Score=417, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.606334841629, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=46.5324384787472, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=30.6748466257669, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=28.9370078740157, Blast_Score=221, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=28.9370078740157, Blast_Score=220, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.0850111856823, Blast_Score=368, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=41.6107382550336, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=47.6510067114094, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323863, Length=481, Percent_Identity=34.3035343035343, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=31.3229571984436, Blast_Score=236, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=46.9662921348315, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=49.8876404494382, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=45.9657701711491, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI161076409, Length=506, Percent_Identity=31.2252964426877, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161076407, Length=506, Percent_Identity=31.2252964426877, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586460, Length=506, Percent_Identity=31.2252964426877, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24586458, Length=506, Percent_Identity=31.2252964426877, Blast_Score=249, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49580; Mature: 49580

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYFRKILIANRGEVALRILRTCSELGIGTVAVHSTADALSLHVQLADQAVCIGEPMASK
CCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCEEEECCCCCCC
SYLSIPNLISAALTRDCDAVHPGYGFLSENERFAEICADHGLTFIGPSPRAMVLMGDKST
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEEEECCCCH
ARDTMKAAGVPTVPGSEGLIDSEQEAYEAAKAIGYPVMIKATAGGGGRGMRIAGNERDLI
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHH
KMVQTAQREAEAAFGNRGVYIEKYLEEPRHIEFQILADQHGNVVHLGERDCSIQRRHQKL
HHHHHHHHHHHHHHCCCCEEHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHH
LEESPSPFLTPAMRERMGEAALQAARSINYVGAGTIEFLVDKKGDFYFMEMNTRIQVEHP
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECC
VTEMRTGIDLIAEQIRIAAGEPLGYTQSDIRMEGHAIECRINCEDPNNDFRPTPGTISAY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCEEEEEEEECCCCCCCCCCCCCCEEEE
LAPGGPGVRMDSHLYPGYKVPSHYDSLLGKLIVWGRNRDEAIRRMRRALAECAITGVPTT
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCC
IPFHLRVLDNAWFLRGDVYTNFVQRRMSE
CCEEEEEECCCEEEECHHHHHHHHHHHCC
>Mature Secondary Structure
MVYFRKILIANRGEVALRILRTCSELGIGTVAVHSTADALSLHVQLADQAVCIGEPMASK
CCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCEEEECCCCCCC
SYLSIPNLISAALTRDCDAVHPGYGFLSENERFAEICADHGLTFIGPSPRAMVLMGDKST
CCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEEEECCCCH
ARDTMKAAGVPTVPGSEGLIDSEQEAYEAAKAIGYPVMIKATAGGGGRGMRIAGNERDLI
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEECCHHHHH
KMVQTAQREAEAAFGNRGVYIEKYLEEPRHIEFQILADQHGNVVHLGERDCSIQRRHQKL
HHHHHHHHHHHHHHCCCCEEHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHH
LEESPSPFLTPAMRERMGEAALQAARSINYVGAGTIEFLVDKKGDFYFMEMNTRIQVEHP
HHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEEECC
VTEMRTGIDLIAEQIRIAAGEPLGYTQSDIRMEGHAIECRINCEDPNNDFRPTPGTISAY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEECCEEEEEEEECCCCCCCCCCCCCCEEEE
LAPGGPGVRMDSHLYPGYKVPSHYDSLLGKLIVWGRNRDEAIRRMRRALAECAITGVPTT
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCCCC
IPFHLRVLDNAWFLRGDVYTNFVQRRMSE
CCEEEEEECCCEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]