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The map label for this gene is cry [H]

Identifier: 37521318

GI number: 37521318

Start: 1854641

End: 1856113

Strand: Direct

Name: cry [H]

Synonym: glr1749

Alternate gene names: 37521318

Gene position: 1854641-1856113 (Clockwise)

Preceding gene: 37521317

Following gene: 37521322

Centisome position: 39.81

GC content: 62.25

Gene sequence:

>1473_bases
ATGATCCGCTCGCTGGTCTGGTTTCGCAAGGGTTTGCGACTACACGACAATCCGGCATTACTAGATGCAGCCCGGGACGC
TGCGCGGCTCTACCCGCTGTTTATTGTCGATCCGTGGTTTGTGAACCCAGAGCGGGTCGGTGTCAACCGGATGCGCTTTT
TGCTTGAAAGTCTGGGGGAGATTGACGGCAACCTTCGCCGACTTGGCTCGCGCCTGATTGTTCTGCAGGGCAGACCTCAG
GAAGTGCTTGAGCGCGTACTTTCACGTTGGCAAATCGGCAGACTTTGCTTCGAGCGGGACACCGAGCCCTACGCCCGCAG
GCGCGACGAAGCGATCCGCTCGATGGCCGAGCGCGTCGGGGTGCGGGTAATTTCCCCCACCGCCCACACCCTCTACGACC
CCGATGAGCTTATCGAGTTGGGCCGTGGGAAAGTTCCCACCACCTACGGCGCCTTCGGGCGGTTGGCGGCAAAATTGGGC
GAACCGGACGCCCCCGTGGCTTCTCCGTCGCACTTGCCGCCGCCAGGAGAATTGGACGCGGACTATGGCATCCCGACCCT
GGCGGAGTTGGGCTACCCTGATCCCGAGTGCCCGTCCAGGGGGATCATCCCACCGGGAGGTGAAGGAGAAGGGCTGCGGC
GCCTGCACGTCTACCTATCCGACCGGCAGCGATCGGCCGGATTTGCCAAACCCGACACCGACCCCACCGCTTTCGATCCG
CCCTCTACCACCGCCCTGGGAGCGCATCTCAAATTCGGATGCCTCTCAGCCAGAACATTTTATGCCGAGGTCCAGAAAGT
CTACCGGGAGGTGGGCGAGCATACCGAGCCGCCAATGTCTCTCATTGGCCAGATCCTCTGGCGCGAATTTTTCTACACCG
TGGGCTACGCGACCCCGAACTACGACCGCATCGAAGGTAACCCCGTGTGCCGCCAGATTCCCTGGGACGACAATCCCGAA
TACCTGGCCGCCTGGAGCGAGGCGCGCACGGGATTCCCGTGGATCGACGCCGCGATGACCCAGCTGCGCACCGAAGGCTG
GCTGCACCACCTGAGCCGCCACGCGGTTGCCTGCTTTCTCACGCGCGGGGATCTATGGGTGAGTTGGGAAAAAGGCCAGG
CCGTCTTCGAGCGCTTGCTGCTCGATCAAGACTGGAGCCTCAACGCGAGTAACTGGATGTGGCTTTCAGCGAGCGCTTTT
TTTAACGCCTACTACCGGGTCTACAGCCCGATCAGCTTTGCCAAAAAGTACGACCCCGAGGGCCGCTACGTCCGCCGCTA
CCTGCCGAAGCTAGCCCGGGTACCCGCCGAATTTATCTACGAACCCTGGAGGGCGCCCCTGTTGGTCCAGAAGCAGGCGG
GCTGCGTCGTGGGCCGCGACTATCCGGATCCCATCGTCGATCACGAACAGGCCAAGGCCTGCAACCTTGAACGGATGCGA
CTGGCCTACGAGCAGAACGCCAAAGGTGGCTGA

Upstream 100 bases:

>100_bases
GGTCCACTGCGGCTATGAGCAGACTGCCGCCATCGACGCGATGGAAATCGCCAACATCCCGCGGGTGCTTGCCAGCGTCA
TCACCGGCCGCTGACGGTCG

Downstream 100 bases:

>100_bases
GCGCTTAGAGCGGTTTTCGGGTGCTTGCTACACACCTCATCTTCTAAAGCGCTTGCCGGGAGCACGTTTCAAAACGTGGC
TATGTAGTGTCGGGCTGCGA

Product: photolyase

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MIRSLVWFRKGLRLHDNPALLDAARDAARLYPLFIVDPWFVNPERVGVNRMRFLLESLGEIDGNLRRLGSRLIVLQGRPQ
EVLERVLSRWQIGRLCFERDTEPYARRRDEAIRSMAERVGVRVISPTAHTLYDPDELIELGRGKVPTTYGAFGRLAAKLG
EPDAPVASPSHLPPPGELDADYGIPTLAELGYPDPECPSRGIIPPGGEGEGLRRLHVYLSDRQRSAGFAKPDTDPTAFDP
PSTTALGAHLKFGCLSARTFYAEVQKVYREVGEHTEPPMSLIGQILWREFFYTVGYATPNYDRIEGNPVCRQIPWDDNPE
YLAAWSEARTGFPWIDAAMTQLRTEGWLHHLSRHAVACFLTRGDLWVSWEKGQAVFERLLLDQDWSLNASNWMWLSASAF
FNAYYRVYSPISFAKKYDPEGRYVRRYLPKLARVPAEFIYEPWRAPLLVQKQAGCVVGRDYPDPIVDHEQAKACNLERMR
LAYEQNAKGG

Sequences:

>Translated_490_residues
MIRSLVWFRKGLRLHDNPALLDAARDAARLYPLFIVDPWFVNPERVGVNRMRFLLESLGEIDGNLRRLGSRLIVLQGRPQ
EVLERVLSRWQIGRLCFERDTEPYARRRDEAIRSMAERVGVRVISPTAHTLYDPDELIELGRGKVPTTYGAFGRLAAKLG
EPDAPVASPSHLPPPGELDADYGIPTLAELGYPDPECPSRGIIPPGGEGEGLRRLHVYLSDRQRSAGFAKPDTDPTAFDP
PSTTALGAHLKFGCLSARTFYAEVQKVYREVGEHTEPPMSLIGQILWREFFYTVGYATPNYDRIEGNPVCRQIPWDDNPE
YLAAWSEARTGFPWIDAAMTQLRTEGWLHHLSRHAVACFLTRGDLWVSWEKGQAVFERLLLDQDWSLNASNWMWLSASAF
FNAYYRVYSPISFAKKYDPEGRYVRRYLPKLARVPAEFIYEPWRAPLLVQKQAGCVVGRDYPDPIVDHEQAKACNLERMR
LAYEQNAKGG
>Mature_490_residues
MIRSLVWFRKGLRLHDNPALLDAARDAARLYPLFIVDPWFVNPERVGVNRMRFLLESLGEIDGNLRRLGSRLIVLQGRPQ
EVLERVLSRWQIGRLCFERDTEPYARRRDEAIRSMAERVGVRVISPTAHTLYDPDELIELGRGKVPTTYGAFGRLAAKLG
EPDAPVASPSHLPPPGELDADYGIPTLAELGYPDPECPSRGIIPPGGEGEGLRRLHVYLSDRQRSAGFAKPDTDPTAFDP
PSTTALGAHLKFGCLSARTFYAEVQKVYREVGEHTEPPMSLIGQILWREFFYTVGYATPNYDRIEGNPVCRQIPWDDNPE
YLAAWSEARTGFPWIDAAMTQLRTEGWLHHLSRHAVACFLTRGDLWVSWEKGQAVFERLLLDQDWSLNASNWMWLSASAF
FNAYYRVYSPISFAKKYDPEGRYVRRYLPKLARVPAEFIYEPWRAPLLVQKQAGCVVGRDYPDPIVDHEQAKACNLERMR
LAYEQNAKGG

Specific function: May have a photoreceptor function. Binds DNA; probably functions as a transcriptional repressor [H]

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=491, Percent_Identity=49.0835030549898, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI188536100, Length=495, Percent_Identity=50.1010101010101, Blast_Score=510, Evalue=1e-144,
Organism=Homo sapiens, GI188536103, Length=446, Percent_Identity=49.1031390134529, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1786926, Length=517, Percent_Identity=28.6266924564797, Blast_Score=162, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6324962, Length=473, Percent_Identity=22.6215644820296, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137248, Length=496, Percent_Identity=50.6048387096774, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24585455, Length=496, Percent_Identity=50.6048387096774, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24648152, Length=506, Percent_Identity=39.9209486166008, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR014133
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 55775; Mature: 55775

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRSLVWFRKGLRLHDNPALLDAARDAARLYPLFIVDPWFVNPERVGVNRMRFLLESLGE
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
IDGNLRRLGSRLIVLQGRPQEVLERVLSRWQIGRLCFERDTEPYARRRDEAIRSMAERVG
CCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
VRVISPTAHTLYDPDELIELGRGKVPTTYGAFGRLAAKLGEPDAPVASPSHLPPPGELDA
EEEECCCHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
DYGIPTLAELGYPDPECPSRGIIPPGGEGEGLRRLHVYLSDRQRSAGFAKPDTDPTAFDP
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
PSTTALGAHLKFGCLSARTFYAEVQKVYREVGEHTEPPMSLIGQILWREFFYTVGYATPN
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
YDRIEGNPVCRQIPWDDNPEYLAAWSEARTGFPWIDAAMTQLRTEGWLHHLSRHAVACFL
CCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEE
TRGDLWVSWEKGQAVFERLLLDQDWSLNASNWMWLSASAFFNAYYRVYSPISFAKKYDPE
ECCCEEEEECCCHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCHHHHHHCCCC
GRYVRRYLPKLARVPAEFIYEPWRAPLLVQKQAGCVVGRDYPDPIVDHEQAKACNLERMR
HHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCCEEECCCCCCCCCCCCHHHHCCHHHHH
LAYEQNAKGG
HHHHHCCCCC
>Mature Secondary Structure
MIRSLVWFRKGLRLHDNPALLDAARDAARLYPLFIVDPWFVNPERVGVNRMRFLLESLGE
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
IDGNLRRLGSRLIVLQGRPQEVLERVLSRWQIGRLCFERDTEPYARRRDEAIRSMAERVG
CCHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
VRVISPTAHTLYDPDELIELGRGKVPTTYGAFGRLAAKLGEPDAPVASPSHLPPPGELDA
EEEECCCHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
DYGIPTLAELGYPDPECPSRGIIPPGGEGEGLRRLHVYLSDRQRSAGFAKPDTDPTAFDP
CCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCC
PSTTALGAHLKFGCLSARTFYAEVQKVYREVGEHTEPPMSLIGQILWREFFYTVGYATPN
CCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
YDRIEGNPVCRQIPWDDNPEYLAAWSEARTGFPWIDAAMTQLRTEGWLHHLSRHAVACFL
CCCCCCCCCEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEE
TRGDLWVSWEKGQAVFERLLLDQDWSLNASNWMWLSASAFFNAYYRVYSPISFAKKYDPE
ECCCEEEEECCCHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHCCHHHHHHCCCC
GRYVRRYLPKLARVPAEFIYEPWRAPLLVQKQAGCVVGRDYPDPIVDHEQAKACNLERMR
HHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCCEEECCCCCCCCCCCCHHHHCCHHHHH
LAYEQNAKGG
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]