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The map label for this gene is 37521232

Identifier: 37521232

GI number: 37521232

Start: 1777752

End: 1778657

Strand: Reverse

Name: 37521232

Synonym: gll1663

Alternate gene names: NA

Gene position: 1778657-1777752 (Counterclockwise)

Preceding gene: 37521235

Following gene: 37521231

Centisome position: 38.18

GC content: 63.47

Gene sequence:

>906_bases
ATGAAACAAACAATGCTGCTGATGGCCGCCCTGGTGGTGTGCTGGAGCGCCCCTGCGCTCGCGGACGAAAAGAAAGGTTT
TACGGTCGGCGGATTCGAGTTCGAATCGCAAGAAGCGTTTATCGATAGCGGTGCGCGGTGCGCGGTGGCGCCCCCGAACC
CGGCGGTGATTAAAGAAGTACAACAGAAGCTCGATCGCTGGACGGCGGCGCGCCGTCGTCCCGACGGCACCCTCGAAGCT
GTCGCCACCAAGACCATCCCGGTGGCTTTTCATGTCATCTACAGCGGCAGCACCGGCAACATCTCGGATACGGCCATCGC
CGATCAAATTCGCGTGCTCAACGACGCCTTCGCCCCTTCGGGCTTTCAATTTCAACTCGCCTCGACCGACCGGACCAACA
ACTCCAGCTGGTTCGGCATGACCCCCGGTTCGAGTGCGGAGCGCTCCGCCAAATCCGCCCTGAGCGTCTCGCCCCAGACA
ACCCTCAACTTCTACTCTGCCAACCCGAGCGGCGGCTTGCTCGGTTGGGCAACTTTCCCCTGGTATCTTGACAACGACCC
CGACAACGACGGGGTGGTGGTGCTTTACTCGTCGCTGCCGGGTGGCAGTGCCTTTCCGTACGACGAGGGCGACACCGGCA
CCCACGAGGTCGGCCACTGGCTGGGTCTCTACCACACCTTCCAGGGCGGCTGCTCCAGCAGCGGCGACTCGGTGAGCGAC
ACGCCCTCCGAAAAATCGGCGGCCTACGGCTGTCCCACCGGCCGGGACAGCTGCCGCCGACAGTCGGGCCTCGATCCGAT
CATCAACTTCATGGACTACACCGACGACGCCTGCATGGTCGAATTCACCGGCGGCCAGGCCACCCGCATGCAGTCGAGCG
TCGCCACCTACCGCCCCGAGTTGTGA

Upstream 100 bases:

>100_bases
ATTGTAGCTTCCGCGAATCGATCGAACGTATCTGGGGACACGACCTGCAGAAAGCGACGATTGTGGTATAGATATTCTGT
CCTCTGTGGGATGACTATCT

Downstream 100 bases:

>100_bases
TCCCCGGCCCGCCACCCCCCCAAAGGCGGGCTGCCTCCATAAAATAAGGGACGGGCGCCCCGACAGCCAGGCAGGATTCG
CCATGCTCCACGATCCCCAA

Product: metalloprotease MEP1-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKQTMLLMAALVVCWSAPALADEKKGFTVGGFEFESQEAFIDSGARCAVAPPNPAVIKEVQQKLDRWTAARRRPDGTLEA
VATKTIPVAFHVIYSGSTGNISDTAIADQIRVLNDAFAPSGFQFQLASTDRTNNSSWFGMTPGSSAERSAKSALSVSPQT
TLNFYSANPSGGLLGWATFPWYLDNDPDNDGVVVLYSSLPGGSAFPYDEGDTGTHEVGHWLGLYHTFQGGCSSSGDSVSD
TPSEKSAAYGCPTGRDSCRRQSGLDPIINFMDYTDDACMVEFTGGQATRMQSSVATYRPEL

Sequences:

>Translated_301_residues
MKQTMLLMAALVVCWSAPALADEKKGFTVGGFEFESQEAFIDSGARCAVAPPNPAVIKEVQQKLDRWTAARRRPDGTLEA
VATKTIPVAFHVIYSGSTGNISDTAIADQIRVLNDAFAPSGFQFQLASTDRTNNSSWFGMTPGSSAERSAKSALSVSPQT
TLNFYSANPSGGLLGWATFPWYLDNDPDNDGVVVLYSSLPGGSAFPYDEGDTGTHEVGHWLGLYHTFQGGCSSSGDSVSD
TPSEKSAAYGCPTGRDSCRRQSGLDPIINFMDYTDDACMVEFTGGQATRMQSSVATYRPEL
>Mature_301_residues
MKQTMLLMAALVVCWSAPALADEKKGFTVGGFEFESQEAFIDSGARCAVAPPNPAVIKEVQQKLDRWTAARRRPDGTLEA
VATKTIPVAFHVIYSGSTGNISDTAIADQIRVLNDAFAPSGFQFQLASTDRTNNSSWFGMTPGSSAERSAKSALSVSPQT
TLNFYSANPSGGLLGWATFPWYLDNDPDNDGVVVLYSSLPGGSAFPYDEGDTGTHEVGHWLGLYHTFQGGCSSSGDSVSD
TPSEKSAAYGCPTGRDSCRRQSGLDPIINFMDYTDDACMVEFTGGQATRMQSSVATYRPEL

Specific function: Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M43B family [H]

Homologues:

Organism=Homo sapiens, GI116174738, Length=166, Percent_Identity=35.5421686746988, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008754 [H]

Pfam domain/function: PF05572 Peptidase_M43 [H]

EC number: NA

Molecular weight: Translated: 32212; Mature: 32212

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTMLLMAALVVCWSAPALADEKKGFTVGGFEFESQEAFIDSGARCAVAPPNPAVIKEV
CCHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCCHHHHCCCCEEEECCCCHHHHHHH
QQKLDRWTAARRRPDGTLEAVATKTIPVAFHVIYSGSTGNISDTAIADQIRVLNDAFAPS
HHHHHHHHHHHCCCCCCHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
GFQFQLASTDRTNNSSWFGMTPGSSAERSAKSALSVSPQTTLNFYSANPSGGLLGWATFP
CEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECC
WYLDNDPDNDGVVVLYSSLPGGSAFPYDEGDTGTHEVGHWLGLYHTFQGGCSSSGDSVSD
EEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
TPSEKSAAYGCPTGRDSCRRQSGLDPIINFMDYTDDACMVEFTGGQATRMQSSVATYRPE
CCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCC
L
C
>Mature Secondary Structure
MKQTMLLMAALVVCWSAPALADEKKGFTVGGFEFESQEAFIDSGARCAVAPPNPAVIKEV
CCHHHHHHHHHHHHHCCCCCCCCCCCCEECCEEECCCHHHHCCCCEEEECCCCHHHHHHH
QQKLDRWTAARRRPDGTLEAVATKTIPVAFHVIYSGSTGNISDTAIADQIRVLNDAFAPS
HHHHHHHHHHHCCCCCCHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
GFQFQLASTDRTNNSSWFGMTPGSSAERSAKSALSVSPQTTLNFYSANPSGGLLGWATFP
CEEEEEECCCCCCCCCEEEECCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEECC
WYLDNDPDNDGVVVLYSSLPGGSAFPYDEGDTGTHEVGHWLGLYHTFQGGCSSSGDSVSD
EEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
TPSEKSAAYGCPTGRDSCRRQSGLDPIINFMDYTDDACMVEFTGGQATRMQSSVATYRPE
CCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]