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The map label for this gene is folE

Identifier: 37521149

GI number: 37521149

Start: 1699078

End: 1699722

Strand: Reverse

Name: folE

Synonym: gvip221

Alternate gene names: 37521149

Gene position: 1699722-1699078 (Counterclockwise)

Preceding gene: 37521150

Following gene: 37521148

Centisome position: 36.48

GC content: 61.09

Gene sequence:

>645_bases
ATGACGATTGCCCACAAGGATTTTCTGCCTTCCGACTGGCACGAAGACGACTCCGCTTCAGAAGCCGCAAGCCGCAACGG
CCTCGACCCGATGATGGACGCGGTCCGCACGCTTTTAGTCGGGGTGGGCGAGGATCCCGAGCGCAATGGCCTGGAGCGCA
CACCCAAGCGAGTGGCGGAGGCGCTGAAGTTTCTCACCAAAGGCTATGGTCAGTCGCTCGAAGAACTGCTCAACGGCGCC
ATCTTCGACCTCGGGCACGACGAGTTGGTGCTGGTGCGCGATATCGATCTATTCAGCATGTGTGAGCACCACATGCTGCC
GTTTATCGGCCGAGCCCACGTCGGTTATATCCCCGACCAGAAGGTGGTGGGCCTGTCAAAACTTGCCCGCATCGTCGAGA
TGTACGCCCGTCGCCTGCAGGTGCAGGAGCGCCTCACCCGCCAGATCGCCGAGGCGCTGCAGGAGGTGTTGCAGCCGCGG
GGTGTGGCGGTGGTGATCGAAGCCTCGCACATGTGCATGGTGATGCGCGGCGTGCAGAAGCCCAATTCCTGGACGGTGAC
CAGTTCGATGGTGGGGGTCTTCAAAGAGAGCCAGTCCACCCGCCAGGAATTTCTGGACCTGATCCACCACAAGGCGACGT
TTTAA

Upstream 100 bases:

>100_bases
TGCTCTACACGGTGAATCTTCCTCCCGACGCTGTGCTCGAAGCAGCGATTTTGATGCCCGGCCGGGGCACTTTCTAAATC
ATTTACAAGGAAACCGAAAC

Downstream 100 bases:

>100_bases
TCGCCCGGTGACATAGAGCGTCCCGCGGGAGATACTGGCAGCGAACAGCGACCCTGGCGGTGGATGAAGCCGGTTTCTCT
ATCAAGTTTGCTTGGCGATC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MTIAHKDFLPSDWHEDDSASEAASRNGLDPMMDAVRTLLVGVGEDPERNGLERTPKRVAEALKFLTKGYGQSLEELLNGA
IFDLGHDELVLVRDIDLFSMCEHHMLPFIGRAHVGYIPDQKVVGLSKLARIVEMYARRLQVQERLTRQIAEALQEVLQPR
GVAVVIEASHMCMVMRGVQKPNSWTVTSSMVGVFKESQSTRQEFLDLIHHKATF

Sequences:

>Translated_214_residues
MTIAHKDFLPSDWHEDDSASEAASRNGLDPMMDAVRTLLVGVGEDPERNGLERTPKRVAEALKFLTKGYGQSLEELLNGA
IFDLGHDELVLVRDIDLFSMCEHHMLPFIGRAHVGYIPDQKVVGLSKLARIVEMYARRLQVQERLTRQIAEALQEVLQPR
GVAVVIEASHMCMVMRGVQKPNSWTVTSSMVGVFKESQSTRQEFLDLIHHKATF
>Mature_213_residues
TIAHKDFLPSDWHEDDSASEAASRNGLDPMMDAVRTLLVGVGEDPERNGLERTPKRVAEALKFLTKGYGQSLEELLNGAI
FDLGHDELVLVRDIDLFSMCEHHMLPFIGRAHVGYIPDQKVVGLSKLARIVEMYARRLQVQERLTRQIAEALQEVLQPRG
VAVVIEASHMCMVMRGVQKPNSWTVTSSMVGVFKESQSTRQEFLDLIHHKATF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=205, Percent_Identity=57.0731707317073, Blast_Score=250, Evalue=6e-67,
Organism=Homo sapiens, GI4503949, Length=205, Percent_Identity=57.0731707317073, Blast_Score=250, Evalue=6e-67,
Organism=Homo sapiens, GI66932970, Length=174, Percent_Identity=51.1494252873563, Blast_Score=192, Evalue=1e-49,
Organism=Homo sapiens, GI66932972, Length=165, Percent_Identity=53.3333333333333, Blast_Score=191, Evalue=4e-49,
Organism=Escherichia coli, GI1788476, Length=124, Percent_Identity=53.2258064516129, Blast_Score=123, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17560486, Length=215, Percent_Identity=57.2093023255814, Blast_Score=253, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6321706, Length=180, Percent_Identity=56.6666666666667, Blast_Score=221, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24656782, Length=189, Percent_Identity=60.3174603174603, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24656791, Length=192, Percent_Identity=59.375, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24656796, Length=189, Percent_Identity=60.3174603174603, Blast_Score=234, Evalue=3e-62,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_GLOVI (Q7NK98)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924526.1
- ProteinModelPortal:   Q7NK98
- SMR:   Q7NK98
- GeneID:   2598546
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1580
- HOGENOM:   HBG370191
- OMA:   ARIVEMF
- ProtClustDB:   PRK09347
- BioCyc:   GVIO251221:GLL1580-MONOMER
- BRENDA:   3.5.4.16
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 24094; Mature: 23963

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIAHKDFLPSDWHEDDSASEAASRNGLDPMMDAVRTLLVGVGEDPERNGLERTPKRVAE
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHH
ALKFLTKGYGQSLEELLNGAIFDLGHDELVLVRDIDLFSMCEHHMLPFIGRAHVGYIPDQ
HHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCH
KVVGLSKLARIVEMYARRLQVQERLTRQIAEALQEVLQPRGVAVVIEASHMCMVMRGVQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCC
PNSWTVTSSMVGVFKESQSTRQEFLDLIHHKATF
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIAHKDFLPSDWHEDDSASEAASRNGLDPMMDAVRTLLVGVGEDPERNGLERTPKRVAE
CCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHHH
ALKFLTKGYGQSLEELLNGAIFDLGHDELVLVRDIDLFSMCEHHMLPFIGRAHVGYIPDQ
HHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCH
KVVGLSKLARIVEMYARRLQVQERLTRQIAEALQEVLQPRGVAVVIEASHMCMVMRGVQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCC
PNSWTVTSSMVGVFKESQSTRQEFLDLIHHKATF
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292