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The map label for this gene is kefB [H]

Identifier: 37520912

GI number: 37520912

Start: 1434692

End: 1436596

Strand: Direct

Name: kefB [H]

Synonym: glr1343

Alternate gene names: 37520912

Gene position: 1434692-1436596 (Clockwise)

Preceding gene: 37520911

Following gene: 37520914

Centisome position: 30.79

GC content: 62.2

Gene sequence:

>1905_bases
GTGTCTAACGAAAACTTATTCTTTCAGGCGTTTATTTATCTGGCCGCCGCGGTGGTCTCGGTGCCGATCGCCAAGCGCCT
CGGGCTCGGCTCGGTGTTGGGCTATCTGCTCGCCGGGGTGGCCATCGGCCCGTTCGTGCTGGGCCTCGTCGGCAAAGAAG
GAGAAGACGTCATGCACTTCGCCGAATTTGGCGTCGTCATGATGCTCTTTCTGGTGGGTCTTGAGTTGCAGCCCTCGCTG
CTGTGGCGCCTGCGCGTGCCGATCCTGGGCATGGGCGGGCTGCAGGTGATCGGGACGGCTCTGGTGGCGGGAGCGATTGC
CCTGGTGTTCGGCCTGTCCTGGCAGATGTCCCTGGCGGTCGGCCTCATCCTGGCGATGTCCTCGACGGCCATCGTGCTGC
AGACGCTCAACGAAAAAGGGGTAATGAAGAGCGAGGCCGGACAATCGGCCTTTTCGGTGCTGCTGTTTCAAGACATTGCC
GTGATCCCGATCCTGGCCCTGCTGCCGCTGCTGGCCACCGGCAAGGCTACCGAGGTGAGCCTGCAGGCCGCCGCGGGCGA
TCTTATTTTTGTCGCCGCCGGGGGAGCCTCCGGCCCTACGGCGGCTCTGCCCGCCTGGCAGCAGGCGCTGTTGGTGATTG
CCCTGTTGGGCGGCATCGTGCTGGTGGGTAGATTTTTGATGCAACCGGTTTTTCGCTTCATCGCTTCGACCCGCCTGCGC
GAAATTTTCACCGCCACGGCGCTCCTGCTGGTGGTGGGTGTGGCCCTCGCGGTGCAGGCGGTCGGTCTCTCGCCCGCCCT
CGGTACCTTTGTGGCCGGGGTGGTGCTCGCCGAAAACGAGTACCGCCACGAACTGGAAACCGACATCGAACCATTTAAGG
GTCTACTGCTCGGCCTGTTCTTTATTGCCGTGGGGGCGAGCATCAACTTCAATTTGCTCTTCGAGCAACCGCTGCTGATT
CTTGGTCTAGTGATCGGCCTTGCGGTGGTGAAGTTTTCGGTGCTGCTGGCGCTCGGCCAATTTTTTCGTTTGCAGCTGAG
CCAGAGCTTTTTGTTTGCCTTTGCCCTGGCGCAGGGGGGCGAATTTGCCTTCGTGCTCTTTTCTTTTGCCACCCAAAACC
GGGTGCTCACCCCGGAGGTAGCCGAACCGCTCGTGGCGGTGGTGGCGCTGTCGATGGTGATGACGCCGCTGTTGATGATC
CTGCACGACCGGTTGGTGCAGCCGCGCTTTGTCTTGACGGAGCCCGAGCGTGAACCGGACGCCATCGACGAGAACGAAAA
CCCGGTGATCATCGCCGGTTTCGGCCGCTTCGGACAGATTGTCGGCCGCATGTTGATGGCCAACGGCTGCAAAGTGACCA
TCCTCGAAGTCGATCCCAGCCAGATAGACATGCTGCGCCGCTTCGGCTTCAAGCTCTTTTACGGCGACGCCACCCGCATC
GACCTGCTGCACGCGGCCGGGGCGCAGCAGGCGAAGCTGCTGGTGATCGCCATCGACGATCGCGAAAAATCGCTGGAGAT
GGTCGACCTGGTGCGCAAGCATTTTCCGCACCTGAAGATCCTCGCTCGGGCCATCGACCGCCGCCACGCCTACGAACTCA
TCCGGCGCAAAGTCGATGTGGTCGAACGCGAGACGTTCGGCTCCGCCGTGGAGATGGGCGTGGGGGCTTTGAAATTGTTG
GGCGAGCGCTCCTACCGGGCGCAACGGATCGCGAGCACCTTCAAAGCCAACGACGAAAAGATGCTCTACGAGATGGCCGA
ACTGGAGGAAGAAGAAAGGCTCGTGGCGGTCCGCTCGCGCCGGCAGGCCGAGGAACTGGAGCGGGTGCTGCGGGCGGAGG
ATCGCGAACTGACCCGCGATGTCGAGCGCGCCTGGGATGTGTCGGACTTGCGCAAAGAAGCTTAG

Upstream 100 bases:

>100_bases
GCATTGCGCGACGATGCCGTCGACTGGGAGCGCCTCCGGCAAAGCCGCCACTTCAACCACGACCTCGCCCAGCTGCTCCC
GGCCCAGGAGATCGTCCACC

Downstream 100 bases:

>100_bases
ACCCAGCCGCGGATTTCCGGTTCGCTCAAGGGTTTTTCGAGCTTCGCACACTCGCGGCGGGCTCCTTGGAGCCATAAAGC
TGCAGAAAGTTAAAACTTCC

Product: glutathione-regulated potassium efflux system protein KefC-like protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MSNENLFFQAFIYLAAAVVSVPIAKRLGLGSVLGYLLAGVAIGPFVLGLVGKEGEDVMHFAEFGVVMMLFLVGLELQPSL
LWRLRVPILGMGGLQVIGTALVAGAIALVFGLSWQMSLAVGLILAMSSTAIVLQTLNEKGVMKSEAGQSAFSVLLFQDIA
VIPILALLPLLATGKATEVSLQAAAGDLIFVAAGGASGPTAALPAWQQALLVIALLGGIVLVGRFLMQPVFRFIASTRLR
EIFTATALLLVVGVALAVQAVGLSPALGTFVAGVVLAENEYRHELETDIEPFKGLLLGLFFIAVGASINFNLLFEQPLLI
LGLVIGLAVVKFSVLLALGQFFRLQLSQSFLFAFALAQGGEFAFVLFSFATQNRVLTPEVAEPLVAVVALSMVMTPLLMI
LHDRLVQPRFVLTEPEREPDAIDENENPVIIAGFGRFGQIVGRMLMANGCKVTILEVDPSQIDMLRRFGFKLFYGDATRI
DLLHAAGAQQAKLLVIAIDDREKSLEMVDLVRKHFPHLKILARAIDRRHAYELIRRKVDVVERETFGSAVEMGVGALKLL
GERSYRAQRIASTFKANDEKMLYEMAELEEEERLVAVRSRRQAEELERVLRAEDRELTRDVERAWDVSDLRKEA

Sequences:

>Translated_634_residues
MSNENLFFQAFIYLAAAVVSVPIAKRLGLGSVLGYLLAGVAIGPFVLGLVGKEGEDVMHFAEFGVVMMLFLVGLELQPSL
LWRLRVPILGMGGLQVIGTALVAGAIALVFGLSWQMSLAVGLILAMSSTAIVLQTLNEKGVMKSEAGQSAFSVLLFQDIA
VIPILALLPLLATGKATEVSLQAAAGDLIFVAAGGASGPTAALPAWQQALLVIALLGGIVLVGRFLMQPVFRFIASTRLR
EIFTATALLLVVGVALAVQAVGLSPALGTFVAGVVLAENEYRHELETDIEPFKGLLLGLFFIAVGASINFNLLFEQPLLI
LGLVIGLAVVKFSVLLALGQFFRLQLSQSFLFAFALAQGGEFAFVLFSFATQNRVLTPEVAEPLVAVVALSMVMTPLLMI
LHDRLVQPRFVLTEPEREPDAIDENENPVIIAGFGRFGQIVGRMLMANGCKVTILEVDPSQIDMLRRFGFKLFYGDATRI
DLLHAAGAQQAKLLVIAIDDREKSLEMVDLVRKHFPHLKILARAIDRRHAYELIRRKVDVVERETFGSAVEMGVGALKLL
GERSYRAQRIASTFKANDEKMLYEMAELEEEERLVAVRSRRQAEELERVLRAEDRELTRDVERAWDVSDLRKEA
>Mature_633_residues
SNENLFFQAFIYLAAAVVSVPIAKRLGLGSVLGYLLAGVAIGPFVLGLVGKEGEDVMHFAEFGVVMMLFLVGLELQPSLL
WRLRVPILGMGGLQVIGTALVAGAIALVFGLSWQMSLAVGLILAMSSTAIVLQTLNEKGVMKSEAGQSAFSVLLFQDIAV
IPILALLPLLATGKATEVSLQAAAGDLIFVAAGGASGPTAALPAWQQALLVIALLGGIVLVGRFLMQPVFRFIASTRLRE
IFTATALLLVVGVALAVQAVGLSPALGTFVAGVVLAENEYRHELETDIEPFKGLLLGLFFIAVGASINFNLLFEQPLLIL
GLVIGLAVVKFSVLLALGQFFRLQLSQSFLFAFALAQGGEFAFVLFSFATQNRVLTPEVAEPLVAVVALSMVMTPLLMIL
HDRLVQPRFVLTEPEREPDAIDENENPVIIAGFGRFGQIVGRMLMANGCKVTILEVDPSQIDMLRRFGFKLFYGDATRID
LLHAAGAQQAKLLVIAIDDREKSLEMVDLVRKHFPHLKILARAIDRRHAYELIRRKVDVVERETFGSAVEMGVGALKLLG
ERSYRAQRIASTFKANDEKMLYEMAELEEEERLVAVRSRRQAEELERVLRAEDRELTRDVERAWDVSDLRKEA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=384, Percent_Identity=24.7395833333333, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786232, Length=632, Percent_Identity=46.0443037974684, Blast_Score=522, Evalue=1e-149,
Organism=Escherichia coli, GI1789749, Length=626, Percent_Identity=44.408945686901, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1786685, Length=547, Percent_Identity=31.0786106032907, Blast_Score=168, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 69078; Mature: 68946

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNENLFFQAFIYLAAAVVSVPIAKRLGLGSVLGYLLAGVAIGPFVLGLVGKEGEDVMHF
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AEFGVVMMLFLVGLELQPSLLWRLRVPILGMGGLQVIGTALVAGAIALVFGLSWQMSLAV
HHHHHHHHHHHHCCCCCHHHHHHEECCEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GLILAMSSTAIVLQTLNEKGVMKSEAGQSAFSVLLFQDIAVIPILALLPLLATGKATEVS
HHHHHHCCHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LQAAAGDLIFVAAGGASGPTAALPAWQQALLVIALLGGIVLVGRFLMQPVFRFIASTRLR
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIFTATALLLVVGVALAVQAVGLSPALGTFVAGVVLAENEYRHELETDIEPFKGLLLGLF
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHH
FIAVGASINFNLLFEQPLLILGLVIGLAVVKFSVLLALGQFFRLQLSQSFLFAFALAQGG
HHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EFAFVLFSFATQNRVLTPEVAEPLVAVVALSMVMTPLLMILHDRLVQPRFVLTEPEREPD
CEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
AIDENENPVIIAGFGRFGQIVGRMLMANGCKVTILEVDPSQIDMLRRFGFKLFYGDATRI
CCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEECCCHHH
DLLHAAGAQQAKLLVIAIDDREKSLEMVDLVRKHFPHLKILARAIDRRHAYELIRRKVDV
HHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VERETFGSAVEMGVGALKLLGERSYRAQRIASTFKANDEKMLYEMAELEEEERLVAVRSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHH
RQAEELERVLRAEDRELTRDVERAWDVSDLRKEA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure 
SNENLFFQAFIYLAAAVVSVPIAKRLGLGSVLGYLLAGVAIGPFVLGLVGKEGEDVMHF
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AEFGVVMMLFLVGLELQPSLLWRLRVPILGMGGLQVIGTALVAGAIALVFGLSWQMSLAV
HHHHHHHHHHHHCCCCCHHHHHHEECCEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHH
GLILAMSSTAIVLQTLNEKGVMKSEAGQSAFSVLLFQDIAVIPILALLPLLATGKATEVS
HHHHHHCCHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LQAAAGDLIFVAAGGASGPTAALPAWQQALLVIALLGGIVLVGRFLMQPVFRFIASTRLR
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIFTATALLLVVGVALAVQAVGLSPALGTFVAGVVLAENEYRHELETDIEPFKGLLLGLF
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHH
FIAVGASINFNLLFEQPLLILGLVIGLAVVKFSVLLALGQFFRLQLSQSFLFAFALAQGG
HHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EFAFVLFSFATQNRVLTPEVAEPLVAVVALSMVMTPLLMILHDRLVQPRFVLTEPEREPD
CEEEEEEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
AIDENENPVIIAGFGRFGQIVGRMLMANGCKVTILEVDPSQIDMLRRFGFKLFYGDATRI
CCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEECCCHHH
DLLHAAGAQQAKLLVIAIDDREKSLEMVDLVRKHFPHLKILARAIDRRHAYELIRRKVDV
HHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VERETFGSAVEMGVGALKLLGERSYRAQRIASTFKANDEKMLYEMAELEEEERLVAVRSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHH
RQAEELERVLRAEDRELTRDVERAWDVSDLRKEA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA