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The map label for this gene is hhoB [H]

Identifier: 37520904

GI number: 37520904

Start: 1428011

End: 1429330

Strand: Reverse

Name: hhoB [H]

Synonym: gll1335

Alternate gene names: 37520904

Gene position: 1429330-1428011 (Counterclockwise)

Preceding gene: 37520905

Following gene: 37520903

Centisome position: 30.68

GC content: 63.03

Gene sequence:

>1320_bases
GTGCGAGCGGCCCCCGGGCGCGGTGCTAGGATAGCCGTTGAGCGATTTGTCCGCGAACTTACGAGGATTGCTGGAAGTAT
GCTGAGCCATTGGAAAAAAAGACTTGTACAGCTTGCTGTTGTCGGAGCGGTGGCGGGCGGCAGCTTTTCACTGGGTACCT
TTGCGGTGCGCCAGGTTGCGGGTGTTCCCCTGGCGGCGGCTCCGGCCCCGCAGGCGAGCCTGACCAGCAGCGATTCGGTG
CCGCTTCCGGCTCTATCGAGTGCCGAAGGTCCGCAGCGGGCCTCCGCGGCCACGACTTTCTTGGGTCCCAACTTCATCGC
CGATGCGGCCGAAAAGGCTTCTCCAGCCGTGGTACGCATCAACACCGAGCGGGTGCGCGAGGTGGGTGGCCGCACGCCGC
TGGAGCAATTTTTTCCTGAATTCACACCGCGCCGGGGCGGCATGCCCCGCCTGGAGCAGGGGGCGGGTTCAGGCTTTATC
CTGAGCGGTGACGGCACCGTGGTCACCAACGCCCATGTCGTCGAAAAGGCCGACAAAGTCTACGTCACCCTGGGCGACGG
CCGCAAAACCACCGGCAAGGTGATCGGCGCCGACCCGCTCACCGACATTGCCGTAATCAAAATCGACGCGGGCATTGACT
TGCCGACCGCCCCGTTGGGCGACTCGGACAGGTTGCGCGCCGGTGAATGGGTGATTGCCGTGGGTAATCCGCTGGGCCTC
GATCACACCGTCACCGCCGGCATCATCAGTGCCCTCAAGCGCTCCAGCAACGAAGTCGGTGTGCGCGAGGACCGGCGGCT
CGACTTTATCCAGACCGACGCCGCCATCAATCCGGGCAATTCCGGCGGCCCGCTGGTCAACATCTACGGTCAGGTGGTGG
GCATCAACACGGCCATTCGCGCCGACGGCCAGGGTATCGGCTTTGCCATCCCGATCAACAAAGTCAAAGAGATCACGGCG
AGTTTATTGAGGGACGGCCGGGTGATTCGCCCCTACATCGGCATCTCGATGGTGAGCATTACCCCCGAACTGCTGCGCGA
ACTCAAAGAGAACCCCGACGTCGCCAAGCTGCCCCAGGCCGAAAAAGGCGTCTGGATCCGCGAGGTGATCAAAGGCTCCC
CCGCCGCCACAGCCGGGTTGCGCGCCGACGACATTATTGTCGAAGTCGACGGCAAAGCGGTTTCTGAGGCCAGGCAGGTG
CAGGAACTGATTGGAGCGCGCAAGGTGGGCGACACCGTCTCGGTCAGTGTCCAACGCAACAGCAAGCTCTCGACTTTTGA
AGTGCGCACGGTGGAATTGAGCCAGACACCGCTCAGCTAA

Upstream 100 bases:

>100_bases
CACAGACACCGCCGTCCGCTTCATCAACGGCGTCCTGCGGCGGGTGGTGCAGCATCTGCAGCTGGAACAGCGCCCGCGCC
GTTGACGTCTAGAATTGCGA

Downstream 100 bases:

>100_bases
GTCGTTTACGCCGTCAGGACAACTCCACCGCTGCGCGGATGCCTACCGGGCGGTGGAGTCATCAGCTAAAGAAAACGTTA
AACAAACCTGGCGCGGATCC

Product: serine proteinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MRAAPGRGARIAVERFVRELTRIAGSMLSHWKKRLVQLAVVGAVAGGSFSLGTFAVRQVAGVPLAAAPAPQASLTSSDSV
PLPALSSAEGPQRASAATTFLGPNFIADAAEKASPAVVRINTERVREVGGRTPLEQFFPEFTPRRGGMPRLEQGAGSGFI
LSGDGTVVTNAHVVEKADKVYVTLGDGRKTTGKVIGADPLTDIAVIKIDAGIDLPTAPLGDSDRLRAGEWVIAVGNPLGL
DHTVTAGIISALKRSSNEVGVREDRRLDFIQTDAAINPGNSGGPLVNIYGQVVGINTAIRADGQGIGFAIPINKVKEITA
SLLRDGRVIRPYIGISMVSITPELLRELKENPDVAKLPQAEKGVWIREVIKGSPAATAGLRADDIIVEVDGKAVSEARQV
QELIGARKVGDTVSVSVQRNSKLSTFEVRTVELSQTPLS

Sequences:

>Translated_439_residues
MRAAPGRGARIAVERFVRELTRIAGSMLSHWKKRLVQLAVVGAVAGGSFSLGTFAVRQVAGVPLAAAPAPQASLTSSDSV
PLPALSSAEGPQRASAATTFLGPNFIADAAEKASPAVVRINTERVREVGGRTPLEQFFPEFTPRRGGMPRLEQGAGSGFI
LSGDGTVVTNAHVVEKADKVYVTLGDGRKTTGKVIGADPLTDIAVIKIDAGIDLPTAPLGDSDRLRAGEWVIAVGNPLGL
DHTVTAGIISALKRSSNEVGVREDRRLDFIQTDAAINPGNSGGPLVNIYGQVVGINTAIRADGQGIGFAIPINKVKEITA
SLLRDGRVIRPYIGISMVSITPELLRELKENPDVAKLPQAEKGVWIREVIKGSPAATAGLRADDIIVEVDGKAVSEARQV
QELIGARKVGDTVSVSVQRNSKLSTFEVRTVELSQTPLS
>Mature_439_residues
MRAAPGRGARIAVERFVRELTRIAGSMLSHWKKRLVQLAVVGAVAGGSFSLGTFAVRQVAGVPLAAAPAPQASLTSSDSV
PLPALSSAEGPQRASAATTFLGPNFIADAAEKASPAVVRINTERVREVGGRTPLEQFFPEFTPRRGGMPRLEQGAGSGFI
LSGDGTVVTNAHVVEKADKVYVTLGDGRKTTGKVIGADPLTDIAVIKIDAGIDLPTAPLGDSDRLRAGEWVIAVGNPLGL
DHTVTAGIISALKRSSNEVGVREDRRLDFIQTDAAINPGNSGGPLVNIYGQVVGINTAIRADGQGIGFAIPINKVKEITA
SLLRDGRVIRPYIGISMVSITPELLRELKENPDVAKLPQAEKGVWIREVIKGSPAATAGLRADDIIVEVDGKAVSEARQV
QELIGARKVGDTVSVSVQRNSKLSTFEVRTVELSQTPLS

Specific function: A putative protease, its function overlaps that of the related putative proteases HtrA and HhoA [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=325, Percent_Identity=41.8461538461538, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI22129776, Length=315, Percent_Identity=41.5873015873016, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI24308541, Length=322, Percent_Identity=37.5776397515528, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI7019477, Length=335, Percent_Identity=37.0149253731343, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1786356, Length=377, Percent_Identity=38.1962864721485, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1789629, Length=329, Percent_Identity=38.2978723404255, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789630, Length=287, Percent_Identity=40.0696864111498, Blast_Score=180, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24646839, Length=311, Percent_Identity=37.620578778135, Blast_Score=185, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 46111; Mature: 46111

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAPGRGARIAVERFVRELTRIAGSMLSHWKKRLVQLAVVGAVAGGSFSLGTFAVRQVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
GVPLAAAPAPQASLTSSDSVPLPALSSAEGPQRASAATTFLGPNFIADAAEKASPAVVRI
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCEEEEE
NTERVREVGGRTPLEQFFPEFTPRRGGMPRLEQGAGSGFILSGDGTVVTNAHVVEKADKV
CHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHCCCCCEEECCCCEEEECHHHEECCCEE
YVTLGDGRKTTGKVIGADPLTDIAVIKIDAGIDLPTAPLGDSDRLRAGEWVIAVGNPLGL
EEEECCCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCC
DHTVTAGIISALKRSSNEVGVREDRRLDFIQTDAAINPGNSGGPLVNIYGQVVGINTAIR
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEEEEECCEEEE
ADGQGIGFAIPINKVKEITASLLRDGRVIRPYIGISMVSITPELLRELKENPDVAKLPQA
ECCCCCEEEECHHHHHHHHHHHHHCCCEEEHHHCEEEEECCHHHHHHHHCCCCHHCCCCC
EKGVWIREVIKGSPAATAGLRADDIIVEVDGKAVSEARQVQELIGARKVGDTVSVSVQRN
CCCCHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
SKLSTFEVRTVELSQTPLS
CCCEEEEEEEEEECCCCCC
>Mature Secondary Structure
MRAAPGRGARIAVERFVRELTRIAGSMLSHWKKRLVQLAVVGAVAGGSFSLGTFAVRQVA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
GVPLAAAPAPQASLTSSDSVPLPALSSAEGPQRASAATTFLGPNFIADAAEKASPAVVRI
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHCCCEEEEE
NTERVREVGGRTPLEQFFPEFTPRRGGMPRLEQGAGSGFILSGDGTVVTNAHVVEKADKV
CHHHHHHCCCCCCHHHHCCCCCCCCCCCCCHHHCCCCCEEECCCCEEEECHHHEECCCEE
YVTLGDGRKTTGKVIGADPLTDIAVIKIDAGIDLPTAPLGDSDRLRAGEWVIAVGNPLGL
EEEECCCCCCCCCEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCC
DHTVTAGIISALKRSSNEVGVREDRRLDFIQTDAAINPGNSGGPLVNIYGQVVGINTAIR
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEEEEEEEEECCEEEE
ADGQGIGFAIPINKVKEITASLLRDGRVIRPYIGISMVSITPELLRELKENPDVAKLPQA
ECCCCCEEEECHHHHHHHHHHHHHCCCEEEHHHCEEEEECCHHHHHHHHCCCCHHCCCCC
EKGVWIREVIKGSPAATAGLRADDIIVEVDGKAVSEARQVQELIGARKVGDTVSVSVQRN
CCCCHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEECC
SKLSTFEVRTVELSQTPLS
CCCEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]