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The map label for this gene is hemA

Identifier: 37520787

GI number: 37520787

Start: 1295405

End: 1296697

Strand: Direct

Name: hemA

Synonym: gvip168

Alternate gene names: 37520787

Gene position: 1295405-1296697 (Clockwise)

Preceding gene: 37520780

Following gene: 37520788

Centisome position: 27.8

GC content: 61.64

Gene sequence:

>1293_bases
ATGCAGATCGCGGTCATCGGATTGAGTCACCGAACTGCACCAGTCGAAATTCGCGAACGGGTCAGCATTGCCGAGGGGCA
GGTTCCCGAATACGTGTCTCGGTTGCGAAGCTGCTCACAAGTTGCCGAATGCGCGATTTTGAGCACCTGTAATCGTCTAG
AAATTTATACGGTCCTGCGCGACAGCGAGCACGGTCTGCGCGAGGTGACCCGCTTTCTGGCCGAGAGCAAAGGGGTGCTG
CTGCCGACGCTCCAGCGCCACCTGTTCGTGCTGTTGCACCAGGATGCGGTGATGCATCTGATGCGCGTGGCGGCCGGGCT
CGATTCGATCGTGCTGGGCGAAGGGCAGATTCTTGCCCAGGTGAAGATGACCCAAAGCCTCGCCCAGCAGGGTAAGGGCG
TGGACCGCGTCCTCAACCAGCTGTTCAAGACGGCGATCACCGCCGGCAAGCGGGTGCGCAGCGACACCAACATCGGCACC
GGCGCAGTCTCGGTCTCCTCGGCGGCGGTCGAGATGGCCCTGCGCAAAAAAGGTCCCCTGCACAACCAGCGCTGTCTGGT
GGTGGGGGCGGGCAAGATGGGCGAACTGTTGGTGCGCCATCTGCTCGCCAAGGGGGCGCGCCAGATCATCGTGCTTAACC
GCTCCCTCGAAAAGGCGGCCCAGATGGTCGAGCAGTTCGGGCTGATGCTGCCGGTGGCCACGGTCGACGAGTTGACCAAC
TACGTGCCCTGCTCCGATTTGATCTTCACCTGCACAGGCGCCACCGAACCGCTGCTGACGCTGGAGAAGATGAGCTCCTT
GCGCCGCGACCAGTCGCTGATGATCTTCGACATCGCCGTGCCGCGCAACGTCGCGACCGAGGTGGACGAGTTGCCGAACG
TGCAACTATTCAACGTCGATCACCTCAAGCAGGTGGTCGAGGAGAACCGTGCCTACCGGCAGCTGATGGTCACCCAGTGC
GAGGAGATTCTGCTGGAGCAGCTCGATGAATTTCTCGACTGGTGGCGCGGCCTGGAGGCGGTGCCCACGATCAACCAGTT
GCGCCAAAAAGTCGAAACCATCCGCGAGCAGGAACTCGAAAAAGCCCTCTCGCGCCTGGGAACCGAATTTGCCGAGAAGC
ACCAGGGCATTATCGACTCGCTCACCCGCGCCATTGTCAACAAAATCCTGCACGACCCGATGGTGCAACTGAGAGCCCAG
CGCGACATCGAAGCGCGCCGCCGTGCCCTGCAGACCTTGCAGACGCTCTTCAACCTCGAAGCGCAGAGCAATCCCGAGCC
TCCGACACTTTAG

Upstream 100 bases:

>100_bases
GAAGATTGCATAACCTACCATCTAACACTCTGCGCGGTTGTGCGCAAAGTGCAATGTGCTACAGTATGAGGCGCTACGAA
CGCGCAGTGGGAGAGCGTGG

Downstream 100 bases:

>100_bases
TATCTTTCTCTGAATTTGCTTAATGTATCTATGTCTGCACCCGTTCCACCTGTTCTCACCCCTGAGAACACCCTGGGTGT
TGACGTTGGGTTGCAGGATT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MQIAVIGLSHRTAPVEIRERVSIAEGQVPEYVSRLRSCSQVAECAILSTCNRLEIYTVLRDSEHGLREVTRFLAESKGVL
LPTLQRHLFVLLHQDAVMHLMRVAAGLDSIVLGEGQILAQVKMTQSLAQQGKGVDRVLNQLFKTAITAGKRVRSDTNIGT
GAVSVSSAAVEMALRKKGPLHNQRCLVVGAGKMGELLVRHLLAKGARQIIVLNRSLEKAAQMVEQFGLMLPVATVDELTN
YVPCSDLIFTCTGATEPLLTLEKMSSLRRDQSLMIFDIAVPRNVATEVDELPNVQLFNVDHLKQVVEENRAYRQLMVTQC
EEILLEQLDEFLDWWRGLEAVPTINQLRQKVETIREQELEKALSRLGTEFAEKHQGIIDSLTRAIVNKILHDPMVQLRAQ
RDIEARRRALQTLQTLFNLEAQSNPEPPTL

Sequences:

>Translated_430_residues
MQIAVIGLSHRTAPVEIRERVSIAEGQVPEYVSRLRSCSQVAECAILSTCNRLEIYTVLRDSEHGLREVTRFLAESKGVL
LPTLQRHLFVLLHQDAVMHLMRVAAGLDSIVLGEGQILAQVKMTQSLAQQGKGVDRVLNQLFKTAITAGKRVRSDTNIGT
GAVSVSSAAVEMALRKKGPLHNQRCLVVGAGKMGELLVRHLLAKGARQIIVLNRSLEKAAQMVEQFGLMLPVATVDELTN
YVPCSDLIFTCTGATEPLLTLEKMSSLRRDQSLMIFDIAVPRNVATEVDELPNVQLFNVDHLKQVVEENRAYRQLMVTQC
EEILLEQLDEFLDWWRGLEAVPTINQLRQKVETIREQELEKALSRLGTEFAEKHQGIIDSLTRAIVNKILHDPMVQLRAQ
RDIEARRRALQTLQTLFNLEAQSNPEPPTL
>Mature_430_residues
MQIAVIGLSHRTAPVEIRERVSIAEGQVPEYVSRLRSCSQVAECAILSTCNRLEIYTVLRDSEHGLREVTRFLAESKGVL
LPTLQRHLFVLLHQDAVMHLMRVAAGLDSIVLGEGQILAQVKMTQSLAQQGKGVDRVLNQLFKTAITAGKRVRSDTNIGT
GAVSVSSAAVEMALRKKGPLHNQRCLVVGAGKMGELLVRHLLAKGARQIIVLNRSLEKAAQMVEQFGLMLPVATVDELTN
YVPCSDLIFTCTGATEPLLTLEKMSSLRRDQSLMIFDIAVPRNVATEVDELPNVQLFNVDHLKQVVEENRAYRQLMVTQC
EEILLEQLDEFLDWWRGLEAVPTINQLRQKVETIREQELEKALSRLGTEFAEKHQGIIDSLTRAIVNKILHDPMVQLRAQ
RDIEARRRALQTLQTLFNLEAQSNPEPPTL

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=425, Percent_Identity=33.8823529411765, Blast_Score=218, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_GLOVI (Q7NLA8)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924164.1
- ProteinModelPortal:   Q7NLA8
- SMR:   Q7NLA8
- GeneID:   2598886
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1218
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   GVIO251221:GLR1218-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48137; Mature: 48137

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIAVIGLSHRTAPVEIRERVSIAEGQVPEYVSRLRSCSQVAECAILSTCNRLEIYTVLR
CEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
DSEHGLREVTRFLAESKGVLLPTLQRHLFVLLHQDAVMHLMRVAAGLDSIVLGEGQILAQ
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHH
VKMTQSLAQQGKGVDRVLNQLFKTAITAGKRVRSDTNIGTGAVSVSSAAVEMALRKKGPL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
HNQRCLVVGAGKMGELLVRHLLAKGARQIIVLNRSLEKAAQMVEQFGLMLPVATVDELTN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHC
YVPCSDLIFTCTGATEPLLTLEKMSSLRRDQSLMIFDIAVPRNVATEVDELPNVQLFNVD
CCCCCHHHEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCEEECHH
HLKQVVEENRAYRQLMVTQCEEILLEQLDEFLDWWRGLEAVPTINQLRQKVETIREQELE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KALSRLGTEFAEKHQGIIDSLTRAIVNKILHDPMVQLRAQRDIEARRRALQTLQTLFNLE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHCC
AQSNPEPPTL
CCCCCCCCCC
>Mature Secondary Structure
MQIAVIGLSHRTAPVEIRERVSIAEGQVPEYVSRLRSCSQVAECAILSTCNRLEIYTVLR
CEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
DSEHGLREVTRFLAESKGVLLPTLQRHLFVLLHQDAVMHLMRVAAGLDSIVLGEGQILAQ
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHH
VKMTQSLAQQGKGVDRVLNQLFKTAITAGKRVRSDTNIGTGAVSVSSAAVEMALRKKGPL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
HNQRCLVVGAGKMGELLVRHLLAKGARQIIVLNRSLEKAAQMVEQFGLMLPVATVDELTN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHC
YVPCSDLIFTCTGATEPLLTLEKMSSLRRDQSLMIFDIAVPRNVATEVDELPNVQLFNVD
CCCCCHHHEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCEEECHH
HLKQVVEENRAYRQLMVTQCEEILLEQLDEFLDWWRGLEAVPTINQLRQKVETIREQELE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KALSRLGTEFAEKHQGIIDSLTRAIVNKILHDPMVQLRAQRDIEARRRALQTLQTLFNLE
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHCC
AQSNPEPPTL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292