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The map label for this gene is hisIE

Identifier: 37520780

GI number: 37520780

Start: 1288733

End: 1289389

Strand: Direct

Name: hisIE

Synonym: gvip167

Alternate gene names: 37520780

Gene position: 1288733-1289389 (Clockwise)

Preceding gene: 37520779

Following gene: 37520787

Centisome position: 27.66

GC content: 63.62

Gene sequence:

>657_bases
ATGGCGCCCCACCAGTTCAAGAGTAAGGGAGCACCCACTTTGGTCCACGTACGGGAAGCTGCCCGCTTCGACCGCGACGG
GCTCATCCCCGCCGTTGTGCAGGATGTGCTGGATGGCACGGTGCTGATGGTGGCCTGGATGAACCGCGAGGCGCTTGAAC
GCACGCTCGAAACCGGCGAGAGCTGGTTCTGGAGTCGCTCGCGCCAGGAACTCTGGCACAAAGGCGCCACCTCCGGCCAC
CGGCAAAAAATCAAAGCCCTGCGCTACGACTGCGACAGCGACGTGCTGCTGCTCACCGTCGAGCAGCAGGGCGACATCGC
CTGCCATCTGGGCGAGCGCAGTTGCTTTCACCGCGACGAGGCGGGCGACTACGACCTACCCCCGGCCGACACCCTCTCTC
AGGTCTTCCGCGTCGTAGAGGAGCGCAAAGCCCATCCCCATCCCGATTCTTATACCAGCCGCCTGCTCGAAGCCGGATCC
AACAAGATCCTTAAGAAAATCGGCGAGGAGGCGACCGAGGTGGTGATGGCCGCCAAAGACGGCGAGCGAGTAGCCGAAGA
AGTGGCCGACCTCTGGTACCACACGCTGGTGCTGTTGGCCCACGCCGATGTCGATATCCTCGATGTTTATCGGGCGCTCC
AGCAGCGGCGGCGCTGA

Upstream 100 bases:

>100_bases
CGTGCACTCAATGCCGAACTGGCACTGATAGAAGCTGAACTCGACCGCCGCTACGAAGACAGCCCCATTGGCCAATTCCA
TGCCCGCCGCCGCCGCGGCA

Downstream 100 bases:

>100_bases
GCAGAGGCCCCGCTGCAACCCGCTACCGTTGCTCCTGTCTTACCCGCGCTCCACAGCACCGCTAGAGCAAACGCTATCAG
GGCGGGTGCGGTGTCAATGG

Product: phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MAPHQFKSKGAPTLVHVREAARFDRDGLIPAVVQDVLDGTVLMVAWMNREALERTLETGESWFWSRSRQELWHKGATSGH
RQKIKALRYDCDSDVLLLTVEQQGDIACHLGERSCFHRDEAGDYDLPPADTLSQVFRVVEERKAHPHPDSYTSRLLEAGS
NKILKKIGEEATEVVMAAKDGERVAEEVADLWYHTLVLLAHADVDILDVYRALQQRRR

Sequences:

>Translated_218_residues
MAPHQFKSKGAPTLVHVREAARFDRDGLIPAVVQDVLDGTVLMVAWMNREALERTLETGESWFWSRSRQELWHKGATSGH
RQKIKALRYDCDSDVLLLTVEQQGDIACHLGERSCFHRDEAGDYDLPPADTLSQVFRVVEERKAHPHPDSYTSRLLEAGS
NKILKKIGEEATEVVMAAKDGERVAEEVADLWYHTLVLLAHADVDILDVYRALQQRRR
>Mature_217_residues
APHQFKSKGAPTLVHVREAARFDRDGLIPAVVQDVLDGTVLMVAWMNREALERTLETGESWFWSRSRQELWHKGATSGHR
QKIKALRYDCDSDVLLLTVEQQGDIACHLGERSCFHRDEAGDYDLPPADTLSQVFRVVEERKAHPHPDSYTSRLLEAGSN
KILKKIGEEATEVVMAAKDGERVAEEVADLWYHTLVLLAHADVDILDVYRALQQRRR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=39.4871794871795, Blast_Score=137, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319819, Length=196, Percent_Identity=34.1836734693878, Blast_Score=93, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_GLOVI (Q7NLB5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_924157.1
- ProteinModelPortal:   Q7NLB5
- GeneID:   2598977
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.1211
- HOGENOM:   HBG294308
- OMA:   VMACKDD
- BioCyc:   GVIO251221:GLR1211-MONOMER
- BRENDA:   3.5.4.19
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01019
- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH

EC number: =3.5.4.19; =3.6.1.31

Molecular weight: Translated: 24795; Mature: 24664

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPHQFKSKGAPTLVHVREAARFDRDGLIPAVVQDVLDGTVLMVAWMNREALERTLETGE
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEHHHHHCHHHHHHHHHHHH
SWFWSRSRQELWHKGATSGHRQKIKALRYDCDSDVLLLTVEQQGDIACHLGERSCFHRDE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCHHHHCCCC
AGDYDLPPADTLSQVFRVVEERKAHPHPDSYTSRLLEAGSNKILKKIGEEATEVVMAAKD
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
GERVAEEVADLWYHTLVLLAHADVDILDVYRALQQRRR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
APHQFKSKGAPTLVHVREAARFDRDGLIPAVVQDVLDGTVLMVAWMNREALERTLETGE
CCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEHHHHHCHHHHHHHHHHHH
SWFWSRSRQELWHKGATSGHRQKIKALRYDCDSDVLLLTVEQQGDIACHLGERSCFHRDE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEEEECCCHHHHCCCC
AGDYDLPPADTLSQVFRVVEERKAHPHPDSYTSRLLEAGSNKILKKIGEEATEVVMAAKD
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
GERVAEEVADLWYHTLVLLAHADVDILDVYRALQQRRR
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292