Click here to switch to the map view.

The map label for this gene is dapA [H]

Identifier: 37520587

GI number: 37520587

Start: 1092757

End: 1093638

Strand: Direct

Name: dapA [H]

Synonym: gvip135

Alternate gene names: 37520587

Gene position: 1092757-1093638 (Clockwise)

Preceding gene: 37520586

Following gene: 37520588

Centisome position: 23.45

GC content: 64.63

Gene sequence:

>882_bases
GTGAGCTTCGGTCGGGTGCTCACGGCGATGATCACACCCTTCGACGGCGAGGGTAATGTCCATTACGCCGAGGCCGAAAA
ACTGGCCGACTATCTGGCGGCCCACGGCAGCGATACCCTGGTCGTCTGCGGCACCACCGGCGAATCGCCGACCTTGAGTT
GGGAAGAAGAGTACGAGTTGTTCGATGTGGTGCGCCGGGCGGTGGCCGGCCGCGCCAAGGTGGTGGCGGGCACCGGCTCC
AACGCCACCCGCGAAGCGGTCGTCGCCACCCGCAAAGCCGCAGCCCTGGGTCTCGACGGCACGCTGCAGGTGTGCCCCTA
CTACAACAAACCTACCCAGGACGGGCTTTTTGAGCACTTTCGCGCCGTCGCCCAGGCGGGCGATCTGCCGGTGATCCTCT
ACAATGTGCCGGGGCGCACCGGCGTGCACCTCGCCCCTGAGACCGTCGCCCGCCTTGCCGAGGTACCGGGAATCGTCGCC
ATCAAAGAAGCGAGTGGTTCCCTAGACCAGGTGAGTGCCGTCCGGGCGCTCACCTGCGAGGATTTTGTGATCTACTGCGG
CGACGACTCGCTGACCTTGCCGATGCTTGCCGTCGGGGCGACGGGTGTGGTCAGCATCGCCTCGCACCTGGTGGGAGAGC
CCATCCAGCAGATGATCCGGGCCTTCGAGAACGGCCACAACGACAAAGCCCGCCGGATTCACCTGCACCTGTTGCCGCTT
TTTCGAGGGCTTTTTTGGGAGACCAATCCGATTCCCGTCAAGCTGGCCCTCGCCCTGCAGGGCTGGGATGTCAACCATCT
GCGCCTGCCGCTCGTCGCCGGGAGCGAGGAACTCGGCTCCCGGCTTGAAAAGCTTTTGCACCAGCTTGAACTGCTGGTCT
GA

Upstream 100 bases:

>100_bases
GTCCGGGGGCTCTGGACCTGTGGCTTTCGGGCGATCAGATCCGCAAGGGAGCGGCCCTCAACGCCGTCCAGATTGCCGAA
CAGTTGGCGGGAGGGAGGCG

Downstream 100 bases:

>100_bases
GCGGTCCGTCCGACCGCATCTTTACCACGACAACACCGCACACAAGGAACCTTATAATATGGCTGAAAGCCCGAACCAGA
CTGTTTCGCCCCTACGCATC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MSFGRVLTAMITPFDGEGNVHYAEAEKLADYLAAHGSDTLVVCGTTGESPTLSWEEEYELFDVVRRAVAGRAKVVAGTGS
NATREAVVATRKAAALGLDGTLQVCPYYNKPTQDGLFEHFRAVAQAGDLPVILYNVPGRTGVHLAPETVARLAEVPGIVA
IKEASGSLDQVSAVRALTCEDFVIYCGDDSLTLPMLAVGATGVVSIASHLVGEPIQQMIRAFENGHNDKARRIHLHLLPL
FRGLFWETNPIPVKLALALQGWDVNHLRLPLVAGSEELGSRLEKLLHQLELLV

Sequences:

>Translated_293_residues
MSFGRVLTAMITPFDGEGNVHYAEAEKLADYLAAHGSDTLVVCGTTGESPTLSWEEEYELFDVVRRAVAGRAKVVAGTGS
NATREAVVATRKAAALGLDGTLQVCPYYNKPTQDGLFEHFRAVAQAGDLPVILYNVPGRTGVHLAPETVARLAEVPGIVA
IKEASGSLDQVSAVRALTCEDFVIYCGDDSLTLPMLAVGATGVVSIASHLVGEPIQQMIRAFENGHNDKARRIHLHLLPL
FRGLFWETNPIPVKLALALQGWDVNHLRLPLVAGSEELGSRLEKLLHQLELLV
>Mature_292_residues
SFGRVLTAMITPFDGEGNVHYAEAEKLADYLAAHGSDTLVVCGTTGESPTLSWEEEYELFDVVRRAVAGRAKVVAGTGSN
ATREAVVATRKAAALGLDGTLQVCPYYNKPTQDGLFEHFRAVAQAGDLPVILYNVPGRTGVHLAPETVARLAEVPGIVAI
KEASGSLDQVSAVRALTCEDFVIYCGDDSLTLPMLAVGATGVVSIASHLVGEPIQQMIRAFENGHNDKARRIHLHLLPLF
RGLFWETNPIPVKLALALQGWDVNHLRLPLVAGSEELGSRLEKLLHQLELLV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=232, Percent_Identity=28.448275862069, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI13540533, Length=305, Percent_Identity=27.8688524590164, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788823, Length=270, Percent_Identity=44.4444444444444, Blast_Score=231, Evalue=3e-62,
Organism=Escherichia coli, GI1789620, Length=230, Percent_Identity=29.1304347826087, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI87082415, Length=294, Percent_Identity=29.9319727891156, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786463, Length=276, Percent_Identity=28.9855072463768, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31539; Mature: 31407

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00666 DHDPS_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFGRVLTAMITPFDGEGNVHYAEAEKLADYLAAHGSDTLVVCGTTGESPTLSWEEEYEL
CCHHHEEHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHH
FDVVRRAVAGRAKVVAGTGSNATREAVVATRKAAALGLDGTLQVCPYYNKPTQDGLFEHF
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHH
RAVAQAGDLPVILYNVPGRTGVHLAPETVARLAEVPGIVAIKEASGSLDQVSAVRALTCE
HHHHHCCCCCEEEEECCCCCCCEECHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHEEEC
DFVIYCGDDSLTLPMLAVGATGVVSIASHLVGEPIQQMIRAFENGHNDKARRIHLHLLPL
CEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEEEHHHH
FRGLFWETNPIPVKLALALQGWDVNHLRLPLVAGSEELGSRLEKLLHQLELLV
HHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFGRVLTAMITPFDGEGNVHYAEAEKLADYLAAHGSDTLVVCGTTGESPTLSWEEEYEL
CHHHEEHHHCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHH
FDVVRRAVAGRAKVVAGTGSNATREAVVATRKAAALGLDGTLQVCPYYNKPTQDGLFEHF
HHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHH
RAVAQAGDLPVILYNVPGRTGVHLAPETVARLAEVPGIVAIKEASGSLDQVSAVRALTCE
HHHHHCCCCCEEEEECCCCCCCEECHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHEEEC
DFVIYCGDDSLTLPMLAVGATGVVSIASHLVGEPIQQMIRAFENGHNDKARRIHLHLLPL
CEEEEECCCCCCHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEEEHHHH
FRGLFWETNPIPVKLALALQGWDVNHLRLPLVAGSEELGSRLEKLLHQLELLV
HHHHCCCCCCCCEEEEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA