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The map label for this gene is mutT [H]

Identifier: 37520438

GI number: 37520438

Start: 916264

End: 916656

Strand: Direct

Name: mutT [H]

Synonym: gvip114

Alternate gene names: 37520438

Gene position: 916264-916656 (Clockwise)

Preceding gene: 37520437

Following gene: 37520439

Centisome position: 19.67

GC content: 63.61

Gene sequence:

>393_bases
ATGCCCAAAGCAATTGCCATCGGCATCGTGTGCTTCGCAGGCAAAGTGCTCATCGATCGCAGGCCCGTGGACGCGGCGCT
GGGTGGGTTGTGGGAGTTTCCCGGCGGCAAAATCCTCCCCGGAGAGACACCTGAGGCGTGCGTGGCCCGCGAGGTGCTGG
AGGAAGTGGGACTTACCGTAACCGTGGGCGAACTGCTGGCTATTCTGGAGCACGACTACTCCGATTTTTTCGTCCGCATC
CGCGCCTACCTGTGCCACAGTGAGAGCGACGCCGCCCGGGCGATCGCCTGCGATGCCGTCGAGTGGGTGGAGCCGCGGGA
ACTGGATGGCTACACGTTTCCGGTGGCGAACGCCCCGCTTATCCCGCTGATTCAGCAGCGCCTTTGCCCATGA

Upstream 100 bases:

>100_bases
CGGATTTATGGGTATCGGCGGCAAGCGGGTGAGCGAGGCGGAGGCGGTTTATCTGACAGAAATCGACACTGCCCTCGGCG
TGGGGACGCAGGCCGGTTGA

Downstream 100 bases:

>100_bases
CTGCCTCTGTGCCCCTTGCCTTTCCGATCACCGCCGTCGTCGCCCAGGAGGCGATCAAGCTCGCCCTGCTGCTCGCGGTC
ACCGATCCGGGGCTGGGGGG

Product: mutator protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MPKAIAIGIVCFAGKVLIDRRPVDAALGGLWEFPGGKILPGETPEACVAREVLEEVGLTVTVGELLAILEHDYSDFFVRI
RAYLCHSESDAARAIACDAVEWVEPRELDGYTFPVANAPLIPLIQQRLCP

Sequences:

>Translated_130_residues
MPKAIAIGIVCFAGKVLIDRRPVDAALGGLWEFPGGKILPGETPEACVAREVLEEVGLTVTVGELLAILEHDYSDFFVRI
RAYLCHSESDAARAIACDAVEWVEPRELDGYTFPVANAPLIPLIQQRLCP
>Mature_129_residues
PKAIAIGIVCFAGKVLIDRRPVDAALGGLWEFPGGKILPGETPEACVAREVLEEVGLTVTVGELLAILEHDYSDFFVRIR
AYLCHSESDAARAIACDAVEWVEPRELDGYTFPVANAPLIPLIQQRLCP

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=123, Percent_Identity=34.9593495934959, Blast_Score=71, Evalue=3e-14,
Organism=Escherichia coli, GI1788056, Length=117, Percent_Identity=31.6239316239316, Blast_Score=69, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 14147; Mature: 14015

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKAIAIGIVCFAGKVLIDRRPVDAALGGLWEFPGGKILPGETPEACVAREVLEEVGLTV
CCCHHEEHHHHHHCCCEECCCCHHHHHCCCEECCCCEECCCCCHHHHHHHHHHHHCCCEE
TVGELLAILEHDYSDFFVRIRAYLCHSESDAARAIACDAVEWVEPRELDGYTFPVANAPL
EHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCH
IPLIQQRLCP
HHHHHHHCCC
>Mature Secondary Structure 
PKAIAIGIVCFAGKVLIDRRPVDAALGGLWEFPGGKILPGETPEACVAREVLEEVGLTV
CCHHEEHHHHHHCCCEECCCCHHHHHCCCEECCCCEECCCCCHHHHHHHHHHHHCCCEE
TVGELLAILEHDYSDFFVRIRAYLCHSESDAARAIACDAVEWVEPRELDGYTFPVANAPL
EHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCCCCH
IPLIQQRLCP
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]