Click here to switch to the map view.

The map label for this gene is cysS

Identifier: 37520420

GI number: 37520420

Start: 901981

End: 903429

Strand: Direct

Name: cysS

Synonym: gvip106

Alternate gene names: 37520420

Gene position: 901981-903429 (Clockwise)

Preceding gene: 37520419

Following gene: 37520423

Centisome position: 19.36

GC content: 62.94

Gene sequence:

>1449_bases
ATGGCCTTGCAGATCTACAACACGCTCACGCGCCGCAAAGAACCGTTCGTCCCCCTCGAAGCGGGCACAGTCAAAATGTA
CGTCTGCGGCGTCACCGTCTACGATTACTGTCACCTGGGCCACGGGCGCACCTACGTCGTCTGGGACACCGTTCGCCGCT
ACCTGATTTCGCGCGGCTACGCGGTCACGTATGTTCAGAATTTTACGGACGTCGACGACAAGATCCTGCGCCGCGCCCAG
CAGGAAGGCACCACGATGGAGGCGGTTGCCGAAAAGTACATCGCCGCCTACTTCGAGGACATGGACAGACTCAACGTCCT
GCGGGCGGACAGCTACCCGCGCGCCACCCAGACGATGCCCGAGATCGGCGCATTGATCGATCGGCTCACCTCGATCGGGT
ACGCCTATCCGGCGGCGGGGGATGTCTACTACAGCGTCCGGCGCTTTGCCGAGTACGGCAAGCTCTCGGGCAAGCGCCTG
GCCGAACTGGAGGCGGGAGCAAGCGAGCGGCTGCAGGACGAAGAACTGGCGCGCAAGAAAGACCCGTTCGACTTCGCCCT
CTGGAAAGGAGCCAAACCGGGAGAGCCCGCCTGGGATTCACCCTGGGGAGCGGGTCGGCCGGGCTGGCACATCGAGTGCT
CGGCGATGGTGAGAAAAAGTCTGGGAGAAACCATCGACATCCACGCCGGGGGCGAGGATTTGCAATTTCCCCACCACGAA
AACGAAATTGCCCAGTCGGAGGCCGTGACGGGTAAGCCGCTCGCGCGCTACTGGATGCACAACGCTTTTCTCAACGTCGT
GAACTCCTCCGGGGCCGAGGAGAAGATGTCTAAGTCCCTGGGCAACTTCAAGACGCTGCGGGATCTGTTCGAAGTTTTCC
CACCGATGGCCCTGCGGTTATTTTTGCTCAAGACCTCCTACCGCAACCCGATCGCCTTTTCGGCCGAAGCTTTCAAGGGT
TCCGAGCAAAACTGGCGAGAGCTGGAAGAGGTGCTGCAACTGGCGGGCTGGATTGCTGGGCAGGGCCGGCCTGCCACCGA
CGACATCGAGTCCGAACCCTGGGTGCGGCGCTTCAACGAGGCGATGGACGACGATTTTAATACTGCCGCCGCCCTCGCCG
AGGTAATCGCCCTGGGTAAGCAACTGGCCGGCCGCTACCACGCCGCCATCCACGGCACGCCCCTCGCGGACCCGGCGCGA
TTTGCCCGGGAGTGGCGCACATTTGCTCTGCTGTGCGACATCCTGGGCCTGAAGGCCGCTGAGCCCGAGGCGCGCCAATC
GGCCCTTCCCGAGGCTGAGATCGAAGCGCAAATCGCCCTGCGCCGTCAGGCCCGCGAAGAGCGCAACTGGGCGGAGGCCG
ACCGCATCCGCAAGCAACTACTGGATCAGGGCATCGTGCTTATCGACCACAAAGAAAAACCGACCACCTGGCGCCACGCC
GATCCGTGA

Upstream 100 bases:

>100_bases
CAGCCGCCGCCTGCGAGCGCTCCGCCGCCCTCGGCCGCAGCGAAGCGGTGGAAGTTCCGGCACTCCCCATAGGATAGAAA
CAGCACGCCCAGGGTGGTCC

Downstream 100 bases:

>100_bases
GCGTTCACGGCCTGAGGGTGAGAAGCCAGCTAATCAACAGCAACAGCGCAAACAGCAGCGGCACGCTCCAGAAGCGCTTA
CTCACGGGCGTCTGGTACAT

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MALQIYNTLTRRKEPFVPLEAGTVKMYVCGVTVYDYCHLGHGRTYVVWDTVRRYLISRGYAVTYVQNFTDVDDKILRRAQ
QEGTTMEAVAEKYIAAYFEDMDRLNVLRADSYPRATQTMPEIGALIDRLTSIGYAYPAAGDVYYSVRRFAEYGKLSGKRL
AELEAGASERLQDEELARKKDPFDFALWKGAKPGEPAWDSPWGAGRPGWHIECSAMVRKSLGETIDIHAGGEDLQFPHHE
NEIAQSEAVTGKPLARYWMHNAFLNVVNSSGAEEKMSKSLGNFKTLRDLFEVFPPMALRLFLLKTSYRNPIAFSAEAFKG
SEQNWRELEEVLQLAGWIAGQGRPATDDIESEPWVRRFNEAMDDDFNTAAALAEVIALGKQLAGRYHAAIHGTPLADPAR
FAREWRTFALLCDILGLKAAEPEARQSALPEAEIEAQIALRRQAREERNWAEADRIRKQLLDQGIVLIDHKEKPTTWRHA
DP

Sequences:

>Translated_482_residues
MALQIYNTLTRRKEPFVPLEAGTVKMYVCGVTVYDYCHLGHGRTYVVWDTVRRYLISRGYAVTYVQNFTDVDDKILRRAQ
QEGTTMEAVAEKYIAAYFEDMDRLNVLRADSYPRATQTMPEIGALIDRLTSIGYAYPAAGDVYYSVRRFAEYGKLSGKRL
AELEAGASERLQDEELARKKDPFDFALWKGAKPGEPAWDSPWGAGRPGWHIECSAMVRKSLGETIDIHAGGEDLQFPHHE
NEIAQSEAVTGKPLARYWMHNAFLNVVNSSGAEEKMSKSLGNFKTLRDLFEVFPPMALRLFLLKTSYRNPIAFSAEAFKG
SEQNWRELEEVLQLAGWIAGQGRPATDDIESEPWVRRFNEAMDDDFNTAAALAEVIALGKQLAGRYHAAIHGTPLADPAR
FAREWRTFALLCDILGLKAAEPEARQSALPEAEIEAQIALRRQAREERNWAEADRIRKQLLDQGIVLIDHKEKPTTWRHA
DP
>Mature_481_residues
ALQIYNTLTRRKEPFVPLEAGTVKMYVCGVTVYDYCHLGHGRTYVVWDTVRRYLISRGYAVTYVQNFTDVDDKILRRAQQ
EGTTMEAVAEKYIAAYFEDMDRLNVLRADSYPRATQTMPEIGALIDRLTSIGYAYPAAGDVYYSVRRFAEYGKLSGKRLA
ELEAGASERLQDEELARKKDPFDFALWKGAKPGEPAWDSPWGAGRPGWHIECSAMVRKSLGETIDIHAGGEDLQFPHHEN
EIAQSEAVTGKPLARYWMHNAFLNVVNSSGAEEKMSKSLGNFKTLRDLFEVFPPMALRLFLLKTSYRNPIAFSAEAFKGS
EQNWRELEEVLQLAGWIAGQGRPATDDIESEPWVRRFNEAMDDDFNTAAALAEVIALGKQLAGRYHAAIHGTPLADPARF
AREWRTFALLCDILGLKAAEPEARQSALPEAEIEAQIALRRQAREERNWAEADRIRKQLLDQGIVLIDHKEKPTTWRHAD
P

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=521, Percent_Identity=35.5086372360845, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI303304987, Length=246, Percent_Identity=40.2439024390244, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI10835051, Length=246, Percent_Identity=40.2439024390244, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI62240992, Length=246, Percent_Identity=40.2439024390244, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI21269877, Length=246, Percent_Identity=40.2439024390244, Blast_Score=188, Evalue=1e-47,
Organism=Escherichia coli, GI1786737, Length=483, Percent_Identity=44.3064182194617, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17509797, Length=331, Percent_Identity=34.441087613293, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17509795, Length=331, Percent_Identity=34.441087613293, Blast_Score=180, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324082, Length=326, Percent_Identity=34.3558282208589, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19922218, Length=389, Percent_Identity=37.7892030848329, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19922364, Length=268, Percent_Identity=37.3134328358209, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_GLOVI (Q7NMB5)

Other databases:

- EMBL:   BA000045
- RefSeq:   NP_923797.1
- ProteinModelPortal:   Q7NMB5
- GeneID:   2599277
- GenomeReviews:   BA000045_GR
- NMPDR:   fig|251221.1.peg.851
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- BioCyc:   GVIO251221:GLR0851-MONOMER
- BRENDA:   6.1.1.16
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 54563; Mature: 54432

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQIYNTLTRRKEPFVPLEAGTVKMYVCGVTVYDYCHLGHGRTYVVWDTVRRYLISRGY
CEEEHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHCCCCCEEEEHHHHHHHHHHCCC
AVTYVQNFTDVDDKILRRAQQEGTTMEAVAEKYIAAYFEDMDRLNVLRADSYPRATQTMP
EEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
EIGALIDRLTSIGYAYPAAGDVYYSVRRFAEYGKLSGKRLAELEAGASERLQDEELARKK
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHHHHHC
DPFDFALWKGAKPGEPAWDSPWGAGRPGWHIECSAMVRKSLGETIDIHAGGEDLQFPHHE
CCCCEEHCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCH
NEIAQSEAVTGKPLARYWMHNAFLNVVNSSGAEEKMSKSLGNFKTLRDLFEVFPPMALRL
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FLLKTSYRNPIAFSAEAFKGSEQNWRELEEVLQLAGWIAGQGRPATDDIESEPWVRRFNE
HHHHHCCCCCCEECHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
AMDDDFNTAAALAEVIALGKQLAGRYHAAIHGTPLADPARFAREWRTFALLCDILGLKAA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
EPEARQSALPEAEIEAQIALRRQAREERNWAEADRIRKQLLDQGIVLIDHKEKPTTWRHA
CCHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
DP
CC
>Mature Secondary Structure 
ALQIYNTLTRRKEPFVPLEAGTVKMYVCGVTVYDYCHLGHGRTYVVWDTVRRYLISRGY
EEEHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHCCCCCEEEEHHHHHHHHHHCCC
AVTYVQNFTDVDDKILRRAQQEGTTMEAVAEKYIAAYFEDMDRLNVLRADSYPRATQTMP
EEEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
EIGALIDRLTSIGYAYPAAGDVYYSVRRFAEYGKLSGKRLAELEAGASERLQDEELARKK
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHCCHHHHHHHC
DPFDFALWKGAKPGEPAWDSPWGAGRPGWHIECSAMVRKSLGETIDIHAGGEDLQFPHHE
CCCCEEHCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCH
NEIAQSEAVTGKPLARYWMHNAFLNVVNSSGAEEKMSKSLGNFKTLRDLFEVFPPMALRL
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
FLLKTSYRNPIAFSAEAFKGSEQNWRELEEVLQLAGWIAGQGRPATDDIESEPWVRRFNE
HHHHHCCCCCCEECHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
AMDDDFNTAAALAEVIALGKQLAGRYHAAIHGTPLADPARFAREWRTFALLCDILGLKAA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
EPEARQSALPEAEIEAQIALRRQAREERNWAEADRIRKQLLDQGIVLIDHKEKPTTWRHA
CCHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCC
DP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292