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The map label for this gene is cysM [H]

Identifier: 37520334

GI number: 37520334

Start: 818378

End: 819340

Strand: Reverse

Name: cysM [H]

Synonym: gll0765

Alternate gene names: 37520334

Gene position: 819340-818378 (Counterclockwise)

Preceding gene: 37520335

Following gene: 37520333

Centisome position: 17.59

GC content: 65.52

Gene sequence:

>963_bases
GTGGTGAGCACCGAGATTGGCCCGAGCGCCCTGGGAAGCGTCCAGCCTCCCGCCGAGACGGACCTGCTGCAGTGGGTGGG
CAACACGCCTTTGCTGCGCCTGGAGCGGGTGACGGCGGGGCTTTCCCCGGACGTCGAAGTGTACGGCAAGGCGGAGTGGT
TCAACCCGGGCGGCTCCGTCAAAGATCGCCCGGCGCTCAATATGATTCTCGAAGGCGAGCGCAGCGGCCGGCTGACCCGC
GAGAAAATTATTCTCGATGCCACCTCCGGCAACACCGGCATCGCCTACGCCTGGATCGCCGCGCGCCGGGGCTATCGCGT
CAAACTGGCCCTGCCCCTGAACGCGAGCGAAGAGCGCAAGCGCATCCTCAAGGCCTACGGCGTCGATCTCATCCTCACCG
ATCCGACCCTCGGTTCCGACGGTGCCATCCAGGAGGCACGCCGGCTCTACGCAGCGGATCCCGAACGGTACTTCTATCCC
GACCAGTACAGCAACAACGCCAACTGGCAGGCGCACTATCTGACGACGGGCGTCGAAATCTACCAGCAGACCGGTGGGCG
GGTCACCCATTTTGTGGCGGGGCTCGGCACCTCGGGCACCTGCATGGGGGTGGGACGGCGCCTCAAGGAGTTCGACCCGG
CCGTTCGGGTGATTGCCATGCAGCCCGACTCGCCCTTCCATGGGCTCGAAGGGCTCAAACACATGGAGACGGCGATCGTC
CCGGCGATCTACAACCCTGCTTTGCCCGACCGGCAGGTCGAAGTGTCCACCGAGGAAGCCCAACGCACCGTCAAGCGCCT
CGCCCGTGAGGAGGGCATGCTGGTGGGCATCTCCGCAGGGGGCAACGTGGCGGCGGCTTTACGCCTGGCGCGCGAACTCG
ACCGCGGCGTGGTGGTCACCATTTTGTGCGACAGTGCCGACAAGTACCTTTCGGAGCGCTTCTGGGACGACCCGAATCTA
TAA

Upstream 100 bases:

>100_bases
CAGAATCGCTTACTCCTCAATTCCGACCGGCATGGTTGGGTTTTGCCGAAGCAGCGGCGATAGAATTGGAGAAAGACCGC
CCGTTGCGAGGATCTGTGCC

Downstream 100 bases:

>100_bases
TCCGCCCGAAGCGTTGACCGCCGGCCTCCGAGCGCCGAAGATAAGGGTGCCTATCCTATCCACCGCACCGGGAAGCGACG
GTCCCCGGCGGTCGTGTGGG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MVSTEIGPSALGSVQPPAETDLLQWVGNTPLLRLERVTAGLSPDVEVYGKAEWFNPGGSVKDRPALNMILEGERSGRLTR
EKIILDATSGNTGIAYAWIAARRGYRVKLALPLNASEERKRILKAYGVDLILTDPTLGSDGAIQEARRLYAADPERYFYP
DQYSNNANWQAHYLTTGVEIYQQTGGRVTHFVAGLGTSGTCMGVGRRLKEFDPAVRVIAMQPDSPFHGLEGLKHMETAIV
PAIYNPALPDRQVEVSTEEAQRTVKRLAREEGMLVGISAGGNVAAALRLARELDRGVVVTILCDSADKYLSERFWDDPNL

Sequences:

>Translated_320_residues
MVSTEIGPSALGSVQPPAETDLLQWVGNTPLLRLERVTAGLSPDVEVYGKAEWFNPGGSVKDRPALNMILEGERSGRLTR
EKIILDATSGNTGIAYAWIAARRGYRVKLALPLNASEERKRILKAYGVDLILTDPTLGSDGAIQEARRLYAADPERYFYP
DQYSNNANWQAHYLTTGVEIYQQTGGRVTHFVAGLGTSGTCMGVGRRLKEFDPAVRVIAMQPDSPFHGLEGLKHMETAIV
PAIYNPALPDRQVEVSTEEAQRTVKRLAREEGMLVGISAGGNVAAALRLARELDRGVVVTILCDSADKYLSERFWDDPNL
>Mature_320_residues
MVSTEIGPSALGSVQPPAETDLLQWVGNTPLLRLERVTAGLSPDVEVYGKAEWFNPGGSVKDRPALNMILEGERSGRLTR
EKIILDATSGNTGIAYAWIAARRGYRVKLALPLNASEERKRILKAYGVDLILTDPTLGSDGAIQEARRLYAADPERYFYP
DQYSNNANWQAHYLTTGVEIYQQTGGRVTHFVAGLGTSGTCMGVGRRLKEFDPAVRVIAMQPDSPFHGLEGLKHMETAIV
PAIYNPALPDRQVEVSTEEAQRTVKRLAREEGMLVGISAGGNVAAALRLARELDRGVVVTILCDSADKYLSERFWDDPNL

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=311, Percent_Identity=36.3344051446945, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI295821200, Length=311, Percent_Identity=36.3344051446945, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI4557415, Length=311, Percent_Identity=36.3344051446945, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI2367138, Length=294, Percent_Identity=44.5578231292517, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788754, Length=311, Percent_Identity=39.5498392282958, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=41.8604651162791, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17562970, Length=301, Percent_Identity=39.202657807309, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=40.1360544217687, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=38.6885245901639, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=38.1270903010033, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566672, Length=215, Percent_Identity=36.7441860465116, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25147552, Length=317, Percent_Identity=29.9684542586751, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=31.6614420062696, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321594, Length=331, Percent_Identity=32.3262839879154, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=32.9113924050633, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=32.9113924050633, Blast_Score=144, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35068; Mature: 35068

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSTEIGPSALGSVQPPAETDLLQWVGNTPLLRLERVTAGLSPDVEVYGKAEWFNPGGSV
CCCCCCCCHHCCCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCCCEEEEEEEEEECCCCCC
KDRPALNMILEGERSGRLTREKIILDATSGNTGIAYAWIAARRGYRVKLALPLNASEERK
CCCCCEEEEEECCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCEEEEEEEECCCCHHHH
RILKAYGVDLILTDPTLGSDGAIQEARRLYAADPERYFYPDQYSNNANWQAHYLTTGVEI
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEEHHHHH
YQQTGGRVTHFVAGLGTSGTCMGVGRRLKEFDPAVRVIAMQPDSPFHGLEGLKHMETAIV
HHHCCCEEEEHEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
PAIYNPALPDRQVEVSTEEAQRTVKRLAREEGMLVGISAGGNVAAALRLARELDRGVVVT
HHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCEEEE
ILCDSADKYLSERFWDDPNL
EEECCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVSTEIGPSALGSVQPPAETDLLQWVGNTPLLRLERVTAGLSPDVEVYGKAEWFNPGGSV
CCCCCCCCHHCCCCCCCCHHHHHHHHCCCCCEEEEHHHCCCCCCEEEEEEEEEECCCCCC
KDRPALNMILEGERSGRLTREKIILDATSGNTGIAYAWIAARRGYRVKLALPLNASEERK
CCCCCEEEEEECCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCEEEEEEEECCCCHHHH
RILKAYGVDLILTDPTLGSDGAIQEARRLYAADPERYFYPDQYSNNANWQAHYLTTGVEI
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHCCCCCCEECCCCCCCCCCEEEEEEEHHHHH
YQQTGGRVTHFVAGLGTSGTCMGVGRRLKEFDPAVRVIAMQPDSPFHGLEGLKHMETAIV
HHHCCCEEEEHEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHH
PAIYNPALPDRQVEVSTEEAQRTVKRLAREEGMLVGISAGGNVAAALRLARELDRGVVVT
HHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCEEEE
ILCDSADKYLSERFWDDPNL
EEECCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]