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The map label for this gene is folP [H]

Identifier: 37520109

GI number: 37520109

Start: 575748

End: 576554

Strand: Direct

Name: folP [H]

Synonym: gvip058

Alternate gene names: 37520109

Gene position: 575748-576554 (Clockwise)

Preceding gene: 37520108

Following gene: 37520112

Centisome position: 12.36

GC content: 61.96

Gene sequence:

>807_bases
ATGACCCAGATAGTCGGCATCGTCAACATTACTACCGATTCCTTTTCGGACGGAGGCCAGTTTCTCGATGCTGAGCGGGC
CATCGGTCATGCACGGCGGCTGCGCGGTGAGGGCGCCCACTGGATCGACCTGGGTGCAGAATCGAGCAACCCTGACGGTG
AACAGGTTACAGCAGAAATAGAAGCAGAGCGCCTCGCCCCGGTCGTTGCCGCACTGAGCGCGGACGGGGTCTCCGTGGCG
GTCGACACTTGCAAAAGCTCGGTGATGGTTCGTTGTCTGGAACTGGGCGCTCGGATGATCAACGACATCACCGCCCTTGC
AGATCCGCGCAGTGTCGAAGTGCTCAAAACTTTTCGGGTGCCGGTGGTGCTGATGTTTGCGCGCAACCGGCAGGCCCGCG
CCGAGCAGCGGCCCGGGGATTGCGAAACGGTCTGGAATGAAATCGAAGCGTTTTTTTCGGGGCGGATCGACCGGTTGCTG
GGTGCCGGTCTGCAGGAGCGACAGTTGATACTTGACCCCGGCATGGGTTTTTTTTTGGGCAGCAACCCCGAACCGAGTCT
GAGGGTGCTTGCCCACGTTGACCGACTGGGCCGCTTCGGCTTGCCGGTGTACTTGAGTGTTTCGCGCAAGTCGTTTATCG
GCAGCGTACTGGGGGGGCGCCCTGCCGGGGGGCGAGACCACGGTACCCTGGCCGCCGAAATCTGGGCGTATCTGGCCGGT
GTGGATTACCTGCGCACCCACGCAGTCGCTCCGCTCAGCGACGCTATCCGAGTGATTGCAGCAATTCGGGCGCAAGCGCT
GGCCTGA

Upstream 100 bases:

>100_bases
GCGACATCAATGCTTTTGTGCTGCGCAGCCCTGAAGGCGACGAGATTCGGCGGTGGGCGCGCGATCATGCCGATCCGGCC
TTTGCCTGCTCCTGCTGCTG

Downstream 100 bases:

>100_bases
AAGGCCGGGAAGCAGGAAACTTCCCGGCTTTATCCAGACCTACCTATGCGAACTTAATGCGGGGTGTGCGGATCTTTGGG
CTGTGGTTCGAGTGGTTCGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: Dihydropteroate pyrophosphorylase type II; Dihydropteroate synthase type II; DHPS [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTQIVGIVNITTDSFSDGGQFLDAERAIGHARRLRGEGAHWIDLGAESSNPDGEQVTAEIEAERLAPVVAALSADGVSVA
VDTCKSSVMVRCLELGARMINDITALADPRSVEVLKTFRVPVVLMFARNRQARAEQRPGDCETVWNEIEAFFSGRIDRLL
GAGLQERQLILDPGMGFFLGSNPEPSLRVLAHVDRLGRFGLPVYLSVSRKSFIGSVLGGRPAGGRDHGTLAAEIWAYLAG
VDYLRTHAVAPLSDAIRVIAAIRAQALA

Sequences:

>Translated_268_residues
MTQIVGIVNITTDSFSDGGQFLDAERAIGHARRLRGEGAHWIDLGAESSNPDGEQVTAEIEAERLAPVVAALSADGVSVA
VDTCKSSVMVRCLELGARMINDITALADPRSVEVLKTFRVPVVLMFARNRQARAEQRPGDCETVWNEIEAFFSGRIDRLL
GAGLQERQLILDPGMGFFLGSNPEPSLRVLAHVDRLGRFGLPVYLSVSRKSFIGSVLGGRPAGGRDHGTLAAEIWAYLAG
VDYLRTHAVAPLSDAIRVIAAIRAQALA
>Mature_267_residues
TQIVGIVNITTDSFSDGGQFLDAERAIGHARRLRGEGAHWIDLGAESSNPDGEQVTAEIEAERLAPVVAALSADGVSVAV
DTCKSSVMVRCLELGARMINDITALADPRSVEVLKTFRVPVVLMFARNRQARAEQRPGDCETVWNEIEAFFSGRIDRLLG
AGLQERQLILDPGMGFFLGSNPEPSLRVLAHVDRLGRFGLPVYLSVSRKSFIGSVLGGRPAGGRDHGTLAAEIWAYLAGV
DYLRTHAVAPLSDAIRVIAAIRAQALA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=260, Percent_Identity=35.3846153846154, Blast_Score=150, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28800; Mature: 28669

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIVGIVNITTDSFSDGGQFLDAERAIGHARRLRGEGAHWIDLGAESSNPDGEQVTAEI
CCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHEEHHH
EAERLAPVVAALSADGVSVAVDTCKSSVMVRCLELGARMINDITALADPRSVEVLKTFRV
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
PVVLMFARNRQARAEQRPGDCETVWNEIEAFFSGRIDRLLGAGLQERQLILDPGMGFFLG
HEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCEEEC
SNPEPSLRVLAHVDRLGRFGLPVYLSVSRKSFIGSVLGGRPAGGRDHGTLAAEIWAYLAG
CCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VDYLRTHAVAPLSDAIRVIAAIRAQALA
HHHHHHHCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQIVGIVNITTDSFSDGGQFLDAERAIGHARRLRGEGAHWIDLGAESSNPDGEQVTAEI
CEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHEEHHH
EAERLAPVVAALSADGVSVAVDTCKSSVMVRCLELGARMINDITALADPRSVEVLKTFRV
HHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
PVVLMFARNRQARAEQRPGDCETVWNEIEAFFSGRIDRLLGAGLQERQLILDPGMGFFLG
HEEEEECCCCHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEECCCCCEEEC
SNPEPSLRVLAHVDRLGRFGLPVYLSVSRKSFIGSVLGGRPAGGRDHGTLAAEIWAYLAG
CCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
VDYLRTHAVAPLSDAIRVIAAIRAQALA
HHHHHHHCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3075438 [H]