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The map label for this gene is metH [H]

Identifier: 37520046

GI number: 37520046

Start: 510418

End: 514008

Strand: Reverse

Name: metH [H]

Synonym: gvip051

Alternate gene names: 37520046

Gene position: 514008-510418 (Counterclockwise)

Preceding gene: 37520047

Following gene: 37520042

Centisome position: 11.03

GC content: 62.91

Gene sequence:

>3591_bases
ATGACCCACCCGTTTCTGGAACTGTTGCGCCACAAGATCGTTGTCTTCGACGGGGCGATGGGCACCTCGATCCAAAAAAT
GGGCCTGGGACCGGAGGACTTTGGCGGCGCCCACCTCGAAGGGTGCAACGAATATCTGGTGTTCTCCAAACCGGAGGCCA
TCGAGCAGGTGCACGCGAGCTTTCTGGAGGCCGGGGCCGATGTGATCGAGACCGATACGTTCGGCTGTAGCACAATCGTC
CTGGCCGAATACGGCATCGAAGCGATGGCTTATGAGCTGTCGAAGGTGGCGGCGGCCCTGGCCCGGCAGGTGGCGGCTCG
CTACTCTACCCTGGATAAGCCGCGCTTCGTCGCAGGCTCGATCGGTCCCGGCACCAAGATTGCCACCCTCGGCCAGACCG
ATTACGACGCGCTCAAAGAAGCTTACCTGGACAACGTGCGCGGCCTCATCGACGGTGGGGCGGACGTGCTGATGATCGAG
ACCTGCCAGGATCTGCTGCAGATCAAGGCCGTGCTCGCGGCGGCGGAGATTGCCTTTGACGAGCGGGGGGTGCGCCTGCC
GGTGATCACCTCGGTGACCCTGGAGCGCGACGACCGCAACGTGGCGGACAAGATGCTGGTGGGTTCGGACATCGCCACGG
TGGTGAGCGCCCTGCAGCCCTACACCATCGACGTACTGGGCCTCAACTGCGCTACCGGCCCCGACTTGATGAGCGAGAAT
ATCCGCTATCTGTCGCACAACTCGCCTTTTTATATTTCGGTGATCCCCAACGCCGGCTTGCCGGAGAATATCGGCGGCCA
CGCCCACTATCACCTCACCCCCGGAGAACTGGTGCGCTACGTGCGCCACTACGTGGACGAACTGGGGATCAATATCGTGG
GCGGCTGCTGCGGCACCACCCCAGACCACATCCGGGCATTGGCGACGGCGGTTTCGGGCGTCAAACCCCGCAATCGCTCC
GTGGAAGTGGTGCCCCAGGTCAGTTCGCTCTACAGCGCAGTGCCGATGCACATGGATCCGGCGCCGTTGCTGGTGGGCGA
GCGTCTCAACTCCAACGGCTCCAAAAAATTCCGCGAATTGCTGCTGGCCGAAGATTGGGACGGCATCGCCGGGATGGCCC
GCGAGCAGGAGCGCGAGGGGGCGCATGTGCTCGATGTGTGCGTCGATTACGTGGGGCGCGACGGCGTGCGCGACATGGGC
GAGGTGGTCTCCCGCCTCAAGACCCGCTCGACGCTGCCCCTGATGATCGATTCGACCGAGGTGCCGGTCATCCATACCGC
CCTCAAGCAACTGGGCGGACGGGCCATCGTCAATTCGATCAACCTCGAAGACGGCGAGGTGCGTCTGCAAAAACTGCTGC
CTTTGTGCCGTGAATTCGGTTCGGCGGTAGTAGCGCTCACCATCGACGAAGGGGAGGGCATGGCCCGCACGGCGGAGCGC
AAGCTGGAGGTGGCCCGGCGCATCCACGATCTGACCGTGCACAAGTACGGGATGAAAAGCGAAGATCTGATCTTCGACCC
GCTCACCTTTACGCTCGGATCCGGCGATGCCGACTCGCGCCGCCTCGGCATCGAGACCCTCGAAGGCATTCGCCTAATTA
AAGAAAACCTGCCCGGTGTGCGCACGATCCTGGGCCTGTCGAACATTTCCTTTGGCCTCAACCCGGGTGCCCGCCAGGCG
CTCAATTCGGTCTATCTCTACTATGCGGTCCAAAACGGCCTGGATATGGCCATCGTGCACGCCTCCAAGATTCTGCCCCT
CAACCGCATCGACGCAGAGGAGCGCGAATTGCACCGCAAGTTGATCTTTGACGAGCACGACAACGGCGATCCGCTGCAAA
ATCTGCTCGCCTTCTACGCCAAGCAAGAGGGCGGCGGCAAGGCGCGCAAAACAGCGGTGGTCGATGCCTCCGCCCCGATC
GAGGAGCGTCTGCGGCGGCGGATCATCGACGGCAACCGCGTCGGGCTCGACAAAGATCTCACTGAAGCGCTCCGGATCTA
CGCACCCCTCGACATCATCAATCAGCACCTGCTGGACGGCATGCGGGTGGTGGGCGAACTGTTCGGCAGCGGCCAGATGC
AGTTGCCCTTCGTGTTGCAGTCAGCCGAGACGATGAAGGCGGCGGTGGGTTATCTCGAGCCGTTCATGGAAAAAAGCGAT
CATTCCGCCAAGGGCACGGTGGTGATCGCCACGGTCAAAGGCGACGTGCACGACATCGGCAAAAACCTGGTCGATATTAT
TCTTTCCAACAACGGATACCGGGTCGTCAACCTCGGTATCCGCCAGCCGGTCGAGAACATTATTGCTGCCTTCGGGGAGC
ACCAGGCCGACTGCATCGCCATGAGCGGTCTGCTGGTCAAATCGACCGCCTTCATGAAAGAAAACCTCGAAATCTTCAAC
GAGCGCGGCATCACCGCCCCGGTGATTTTGGGCGGCGCGGCCCTGACGCGCCGGTTTGTCGAATCCGACTGCCAGCAGGT
CTACCGGGGCAAAGTGATCTACGGCAAGGACGCCTTTGCGGATCTGCACTTTCTGGACGCGCTGGTGGAGGCCAAGGCCA
AAAGCGCCTGGAAGGACGGCGAGGGCTTCGTAGACGGCTTCGCGCCTGTGGGCGAAGAACTGAAGCGCCTGATGGCAAGC
TCCGAGGGTGGCGCCCCGCCCGCCCCGGCCAGTTTTCGCTCCAGCGAAGCGCTCGTCCAGCCTCCGGAGGACGGCCCCAT
TGTTCGCTCTCGGGTGGCTATTGGTGTGCCGCGCCCGCGCCCGCCCTTTTGGGGCACCCGCGTCCTGGGAGGTTCGGACG
GACCGGATCTAAGCGAAGTGTTCCGGTATCTAGATCTCAACGCCCTGTTCGCCGGGCAGTGGAATTACCGCAAAAGCCCG
GATCAAAGCCGCGCCGAGTACGAAGCGAAGCGCGACACCGAGATGGGACCGGTGCTCGAACGGCTCAAGTGCGAGGTGAT
CGACCAGCAACTGTTGCACCCGCAGGTGGCCTACGGCTACTTCCCCTGCCAGGCGGAGAGCAACAGTCTGCGCATCTACA
GTCTCGAATCGTTCGAGAGGTTCCAACAAAGCGGCGACCCGGCAGATCTGTTGGTGTGCGCCCGCCTCGCCTTCCCGCGC
CAGAAGGGGCAGGACCACCTGTGCATTGCCGATTACTTCGCCGATGCGGCAAGCGGACAGATCGACGCCCTTGCCCTACA
GGCGGTGACCGTGGGCCACGTCGCGAGCGAACATGGCCAGAAGCTCTTTAAAGCCGACCGCTACAGCGAGTACCTCTACT
ACTACGGTCTATCGGTGCAAACCGCCGAGGCCCTGGCCGACTGGACCCACGCCCGCATCCGCCGCGAACTGGGCATCGAC
GGCCAGGACACAGCCGAGATGCGCAGGCTCGTTGCCGGGGGCTACCAGGGGGCGCGCTTCAGCTACGGCTACCCGGCCTG
CCCCAACCTCGAAGACCAGGCGATCCTGCTCGATTTGGTGGGCGCTCGCCGCATCGACTTGGCCATGGACGAGAGCCACC
AGCTGTTGCCGGAGCAATCGACCACCGCCATCGTCTGCCATCACCCCGAAGCCCGCTACTTTGCGGTCTAA

Upstream 100 bases:

>100_bases
GACCCTGTCCATGCGCGCAGCAAACAAAAATCTGTATCGCGCCTGGACCGGTAAAATGATCTGACGGCCGCGAAACGCCA
ATTTTGGACGGTATCCCACC

Downstream 100 bases:

>100_bases
GCCTACCGCAGCCGCTCGCCTGCAAGGGCAAATTACAGTGTTGGGTTCGAGCAGAGATTGACTATGCCGAGCCCCAGCGG
TAGGCAGCCGTCAACCTGTC

Product: 5-methyltetrahydrofolate--homocysteine S-methyltransferase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]

Number of amino acids: Translated: 1196; Mature: 1195

Protein sequence:

>1196_residues
MTHPFLELLRHKIVVFDGAMGTSIQKMGLGPEDFGGAHLEGCNEYLVFSKPEAIEQVHASFLEAGADVIETDTFGCSTIV
LAEYGIEAMAYELSKVAAALARQVAARYSTLDKPRFVAGSIGPGTKIATLGQTDYDALKEAYLDNVRGLIDGGADVLMIE
TCQDLLQIKAVLAAAEIAFDERGVRLPVITSVTLERDDRNVADKMLVGSDIATVVSALQPYTIDVLGLNCATGPDLMSEN
IRYLSHNSPFYISVIPNAGLPENIGGHAHYHLTPGELVRYVRHYVDELGINIVGGCCGTTPDHIRALATAVSGVKPRNRS
VEVVPQVSSLYSAVPMHMDPAPLLVGERLNSNGSKKFRELLLAEDWDGIAGMAREQEREGAHVLDVCVDYVGRDGVRDMG
EVVSRLKTRSTLPLMIDSTEVPVIHTALKQLGGRAIVNSINLEDGEVRLQKLLPLCREFGSAVVALTIDEGEGMARTAER
KLEVARRIHDLTVHKYGMKSEDLIFDPLTFTLGSGDADSRRLGIETLEGIRLIKENLPGVRTILGLSNISFGLNPGARQA
LNSVYLYYAVQNGLDMAIVHASKILPLNRIDAEERELHRKLIFDEHDNGDPLQNLLAFYAKQEGGGKARKTAVVDASAPI
EERLRRRIIDGNRVGLDKDLTEALRIYAPLDIINQHLLDGMRVVGELFGSGQMQLPFVLQSAETMKAAVGYLEPFMEKSD
HSAKGTVVIATVKGDVHDIGKNLVDIILSNNGYRVVNLGIRQPVENIIAAFGEHQADCIAMSGLLVKSTAFMKENLEIFN
ERGITAPVILGGAALTRRFVESDCQQVYRGKVIYGKDAFADLHFLDALVEAKAKSAWKDGEGFVDGFAPVGEELKRLMAS
SEGGAPPAPASFRSSEALVQPPEDGPIVRSRVAIGVPRPRPPFWGTRVLGGSDGPDLSEVFRYLDLNALFAGQWNYRKSP
DQSRAEYEAKRDTEMGPVLERLKCEVIDQQLLHPQVAYGYFPCQAESNSLRIYSLESFERFQQSGDPADLLVCARLAFPR
QKGQDHLCIADYFADAASGQIDALALQAVTVGHVASEHGQKLFKADRYSEYLYYYGLSVQTAEALADWTHARIRRELGID
GQDTAEMRRLVAGGYQGARFSYGYPACPNLEDQAILLDLVGARRIDLAMDESHQLLPEQSTTAIVCHHPEARYFAV

Sequences:

>Translated_1196_residues
MTHPFLELLRHKIVVFDGAMGTSIQKMGLGPEDFGGAHLEGCNEYLVFSKPEAIEQVHASFLEAGADVIETDTFGCSTIV
LAEYGIEAMAYELSKVAAALARQVAARYSTLDKPRFVAGSIGPGTKIATLGQTDYDALKEAYLDNVRGLIDGGADVLMIE
TCQDLLQIKAVLAAAEIAFDERGVRLPVITSVTLERDDRNVADKMLVGSDIATVVSALQPYTIDVLGLNCATGPDLMSEN
IRYLSHNSPFYISVIPNAGLPENIGGHAHYHLTPGELVRYVRHYVDELGINIVGGCCGTTPDHIRALATAVSGVKPRNRS
VEVVPQVSSLYSAVPMHMDPAPLLVGERLNSNGSKKFRELLLAEDWDGIAGMAREQEREGAHVLDVCVDYVGRDGVRDMG
EVVSRLKTRSTLPLMIDSTEVPVIHTALKQLGGRAIVNSINLEDGEVRLQKLLPLCREFGSAVVALTIDEGEGMARTAER
KLEVARRIHDLTVHKYGMKSEDLIFDPLTFTLGSGDADSRRLGIETLEGIRLIKENLPGVRTILGLSNISFGLNPGARQA
LNSVYLYYAVQNGLDMAIVHASKILPLNRIDAEERELHRKLIFDEHDNGDPLQNLLAFYAKQEGGGKARKTAVVDASAPI
EERLRRRIIDGNRVGLDKDLTEALRIYAPLDIINQHLLDGMRVVGELFGSGQMQLPFVLQSAETMKAAVGYLEPFMEKSD
HSAKGTVVIATVKGDVHDIGKNLVDIILSNNGYRVVNLGIRQPVENIIAAFGEHQADCIAMSGLLVKSTAFMKENLEIFN
ERGITAPVILGGAALTRRFVESDCQQVYRGKVIYGKDAFADLHFLDALVEAKAKSAWKDGEGFVDGFAPVGEELKRLMAS
SEGGAPPAPASFRSSEALVQPPEDGPIVRSRVAIGVPRPRPPFWGTRVLGGSDGPDLSEVFRYLDLNALFAGQWNYRKSP
DQSRAEYEAKRDTEMGPVLERLKCEVIDQQLLHPQVAYGYFPCQAESNSLRIYSLESFERFQQSGDPADLLVCARLAFPR
QKGQDHLCIADYFADAASGQIDALALQAVTVGHVASEHGQKLFKADRYSEYLYYYGLSVQTAEALADWTHARIRRELGID
GQDTAEMRRLVAGGYQGARFSYGYPACPNLEDQAILLDLVGARRIDLAMDESHQLLPEQSTTAIVCHHPEARYFAV
>Mature_1195_residues
THPFLELLRHKIVVFDGAMGTSIQKMGLGPEDFGGAHLEGCNEYLVFSKPEAIEQVHASFLEAGADVIETDTFGCSTIVL
AEYGIEAMAYELSKVAAALARQVAARYSTLDKPRFVAGSIGPGTKIATLGQTDYDALKEAYLDNVRGLIDGGADVLMIET
CQDLLQIKAVLAAAEIAFDERGVRLPVITSVTLERDDRNVADKMLVGSDIATVVSALQPYTIDVLGLNCATGPDLMSENI
RYLSHNSPFYISVIPNAGLPENIGGHAHYHLTPGELVRYVRHYVDELGINIVGGCCGTTPDHIRALATAVSGVKPRNRSV
EVVPQVSSLYSAVPMHMDPAPLLVGERLNSNGSKKFRELLLAEDWDGIAGMAREQEREGAHVLDVCVDYVGRDGVRDMGE
VVSRLKTRSTLPLMIDSTEVPVIHTALKQLGGRAIVNSINLEDGEVRLQKLLPLCREFGSAVVALTIDEGEGMARTAERK
LEVARRIHDLTVHKYGMKSEDLIFDPLTFTLGSGDADSRRLGIETLEGIRLIKENLPGVRTILGLSNISFGLNPGARQAL
NSVYLYYAVQNGLDMAIVHASKILPLNRIDAEERELHRKLIFDEHDNGDPLQNLLAFYAKQEGGGKARKTAVVDASAPIE
ERLRRRIIDGNRVGLDKDLTEALRIYAPLDIINQHLLDGMRVVGELFGSGQMQLPFVLQSAETMKAAVGYLEPFMEKSDH
SAKGTVVIATVKGDVHDIGKNLVDIILSNNGYRVVNLGIRQPVENIIAAFGEHQADCIAMSGLLVKSTAFMKENLEIFNE
RGITAPVILGGAALTRRFVESDCQQVYRGKVIYGKDAFADLHFLDALVEAKAKSAWKDGEGFVDGFAPVGEELKRLMASS
EGGAPPAPASFRSSEALVQPPEDGPIVRSRVAIGVPRPRPPFWGTRVLGGSDGPDLSEVFRYLDLNALFAGQWNYRKSPD
QSRAEYEAKRDTEMGPVLERLKCEVIDQQLLHPQVAYGYFPCQAESNSLRIYSLESFERFQQSGDPADLLVCARLAFPRQ
KGQDHLCIADYFADAASGQIDALALQAVTVGHVASEHGQKLFKADRYSEYLYYYGLSVQTAEALADWTHARIRRELGIDG
QDTAEMRRLVAGGYQGARFSYGYPACPNLEDQAILLDLVGARRIDLAMDESHQLLPEQSTTAIVCHHPEARYFAV

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1256, Percent_Identity=31.7675159235669, Blast_Score=539, Evalue=1e-153,
Organism=Escherichia coli, GI1790450, Length=1235, Percent_Identity=31.9838056680162, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1786456, Length=324, Percent_Identity=28.7037037037037, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17535405, Length=1249, Percent_Identity=31.6253002401922, Blast_Score=529, Evalue=1e-150,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 130892; Mature: 130761

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPFLELLRHKIVVFDGAMGTSIQKMGLGPEDFGGAHLEGCNEYLVFSKPEAIEQVHAS
CCCHHHHHHHCEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHH
FLEAGADVIETDTFGCSTIVLAEYGIEAMAYELSKVAAALARQVAARYSTLDKPRFVAGS
HHHCCCCEEECCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
IGPGTKIATLGQTDYDALKEAYLDNVRGLIDGGADVLMIETCQDLLQIKAVLAAAEIAFD
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHC
ERGVRLPVITSVTLERDDRNVADKMLVGSDIATVVSALQPYTIDVLGLNCATGPDLMSEN
CCCCEEEEEEEEEEECCCCHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHCC
IRYLSHNSPFYISVIPNAGLPENIGGHAHYHLTPGELVRYVRHYVDELGINIVGGCCGTT
CCEEECCCCEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCC
PDHIRALATAVSGVKPRNRSVEVVPQVSSLYSAVPMHMDPAPLLVGERLNSNGSKKFREL
HHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHH
LLAEDWDGIAGMAREQEREGAHVLDVCVDYVGRDGVRDMGEVVSRLKTRSTLPLMIDSTE
HHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCC
VPVIHTALKQLGGRAIVNSINLEDGEVRLQKLLPLCREFGSAVVALTIDEGEGMARTAER
CCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHH
KLEVARRIHDLTVHKYGMKSEDLIFDPLTFTLGSGDADSRRLGIETLEGIRLIKENLPGV
HHHHHHHHHHHHHHHCCCCCCCEEECCEEEEECCCCCCCHHHCHHHHHHHHHHHHCCCHH
RTILGLSNISFGLNPGARQALNSVYLYYAVQNGLDMAIVHASKILPLNRIDAEERELHRK
HHHHHHCCCCCCCCCCHHHHHHHEEEEEEECCCCCEEEEEHHHCCCCCCCCHHHHHHHHH
LIFDEHDNGDPLQNLLAFYAKQEGGGKARKTAVVDASAPIEERLRRRIIDGNRVGLDKDL
HCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHH
TEALRIYAPLDIINQHLLDGMRVVGELFGSGQMQLPFVLQSAETMKAAVGYLEPFMEKSD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
HSAKGTVVIATVKGDVHDIGKNLVDIILSNNGYRVVNLGIRQPVENIIAAFGEHQADCIA
CCCCCEEEEEEECCCHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHCCCCCHHHH
MSGLLVKSTAFMKENLEIFNERGITAPVILGGAALTRRFVESDCQQVYRGKVIYGKDAFA
HCCHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCEEECCHHHH
DLHFLDALVEAKAKSAWKDGEGFVDGFAPVGEELKRLMASSEGGAPPAPASFRSSEALVQ
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PPEDGPIVRSRVAIGVPRPRPPFWGTRVLGGSDGPDLSEVFRYLDLNALFAGQWNYRKSP
CCCCCCEEHHHEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCC
DQSRAEYEAKRDTEMGPVLERLKCEVIDQQLLHPQVAYGYFPCQAESNSLRIYSLESFER
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHCEEECCCCCCCEEEEEHHHHHH
FQQSGDPADLLVCARLAFPRQKGQDHLCIADYFADAASGQIDALALQAVTVGHVASEHGQ
HHHCCCCHHHHHHHHHHCHHHCCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
KLFKADRYSEYLYYYGLSVQTAEALADWTHARIRRELGIDGQDTAEMRRLVAGGYQGARF
HHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC
SYGYPACPNLEDQAILLDLVGARRIDLAMDESHQLLPEQSTTAIVCHHPEARYFAV
CCCCCCCCCCCCCEEHEEHHCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCEECC
>Mature Secondary Structure 
THPFLELLRHKIVVFDGAMGTSIQKMGLGPEDFGGAHLEGCNEYLVFSKPEAIEQVHAS
CCHHHHHHHCEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHH
FLEAGADVIETDTFGCSTIVLAEYGIEAMAYELSKVAAALARQVAARYSTLDKPRFVAGS
HHHCCCCEEECCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
IGPGTKIATLGQTDYDALKEAYLDNVRGLIDGGADVLMIETCQDLLQIKAVLAAAEIAFD
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHC
ERGVRLPVITSVTLERDDRNVADKMLVGSDIATVVSALQPYTIDVLGLNCATGPDLMSEN
CCCCEEEEEEEEEEECCCCHHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHCC
IRYLSHNSPFYISVIPNAGLPENIGGHAHYHLTPGELVRYVRHYVDELGINIVGGCCGTT
CCEEECCCCEEEEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCC
PDHIRALATAVSGVKPRNRSVEVVPQVSSLYSAVPMHMDPAPLLVGERLNSNGSKKFREL
HHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHH
LLAEDWDGIAGMAREQEREGAHVLDVCVDYVGRDGVRDMGEVVSRLKTRSTLPLMIDSTE
HHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCC
VPVIHTALKQLGGRAIVNSINLEDGEVRLQKLLPLCREFGSAVVALTIDEGEGMARTAER
CCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHH
KLEVARRIHDLTVHKYGMKSEDLIFDPLTFTLGSGDADSRRLGIETLEGIRLIKENLPGV
HHHHHHHHHHHHHHHCCCCCCCEEECCEEEEECCCCCCCHHHCHHHHHHHHHHHHCCCHH
RTILGLSNISFGLNPGARQALNSVYLYYAVQNGLDMAIVHASKILPLNRIDAEERELHRK
HHHHHHCCCCCCCCCCHHHHHHHEEEEEEECCCCCEEEEEHHHCCCCCCCCHHHHHHHHH
LIFDEHDNGDPLQNLLAFYAKQEGGGKARKTAVVDASAPIEERLRRRIIDGNRVGLDKDL
HCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHH
TEALRIYAPLDIINQHLLDGMRVVGELFGSGQMQLPFVLQSAETMKAAVGYLEPFMEKSD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCC
HSAKGTVVIATVKGDVHDIGKNLVDIILSNNGYRVVNLGIRQPVENIIAAFGEHQADCIA
CCCCCEEEEEEECCCHHHHHHHHHHHEECCCCEEEEECCHHHHHHHHHHHHCCCCCHHHH
MSGLLVKSTAFMKENLEIFNERGITAPVILGGAALTRRFVESDCQQVYRGKVIYGKDAFA
HCCHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCEEECCHHHH
DLHFLDALVEAKAKSAWKDGEGFVDGFAPVGEELKRLMASSEGGAPPAPASFRSSEALVQ
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PPEDGPIVRSRVAIGVPRPRPPFWGTRVLGGSDGPDLSEVFRYLDLNALFAGQWNYRKSP
CCCCCCEEHHHEEECCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCC
DQSRAEYEAKRDTEMGPVLERLKCEVIDQQLLHPQVAYGYFPCQAESNSLRIYSLESFER
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHCEEECCCCCCCEEEEEHHHHHH
FQQSGDPADLLVCARLAFPRQKGQDHLCIADYFADAASGQIDALALQAVTVGHVASEHGQ
HHHCCCCHHHHHHHHHHCHHHCCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
KLFKADRYSEYLYYYGLSVQTAEALADWTHARIRRELGIDGQDTAEMRRLVAGGYQGARF
HHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCC
SYGYPACPNLEDQAILLDLVGARRIDLAMDESHQLLPEQSTTAIVCHHPEARYFAV
CCCCCCCCCCCCCEEHEEHHCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]