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The map label for this gene is glmU [H]

Identifier: 37520040

GI number: 37520040

Start: 503871

End: 504854

Strand: Direct

Name: glmU [H]

Synonym: glr0471

Alternate gene names: 37520040

Gene position: 503871-504854 (Clockwise)

Preceding gene: 37520039

Following gene: 37520041

Centisome position: 10.81

GC content: 64.63

Gene sequence:

>984_bases
ATGAAAGCATTTGTGCTCGCCGCCGGCAAAGGCACCCGCCTGCGCCCCTTCACCGACGCCCTCCCTAAACCCCTGATGCC
CGTCGTCAACAAACCGGTCATGACCCACATCTTGGCCCTGTGCCGCAAACACGGCTTCGACCAGATCGTCGCCAACCTCC
ACTACCGCGGTGAAAAAATCGCCGAGCGCTTCGCGGACGGACACCGCCACGGCGTCGAGCTGCGCTACTCCTGGGAAGAA
CAACTCCTCGGCACCGCCGGCGGCGTGCGCAGGCAGGCGGACTTTTTGGCCGGCGACGCCTTTTTGGTTATCTCCGGCGA
CGTGATGACCGATTTGGACCTGGGCGCCCTGGTGCGCTTCCACAAGCAATCCGGCGCCGTCGCCACCATGGCCGTCAAAG
AAGTCGGCGACCCGAGCCGCTTCGGCGTCGTCCTCACCGACCCCGACGGCCGCGTCGAGAGCTTTCAAGAAAAGCCCGCC
AAGGGCAGCGAGCGCTCGCGTCTGGCGAACACGGGCATCTACGTGCTGGAGCCTGAGGTGTTCGAGCACATCCCCGAGGC
GGCCTTTTTCGATTTCGGCAACGACCTGTTTCCGCTGCTGGTCTCTAAGGGAGCACCGGTATATGCAATGCGCACGGGGG
CGTACTGGTCGGATGTCGGGACGCTCTCGCAGTATCTGTACACGCACTGGGAGTTGTTGACCCATCCCGAATTGAAGCAG
CGGGTGGGGGCGAACACGGTGGTCGAGTCCGGGGCGGTGGTCTCCGAACAGGCTCTGATCGGTTCCGGGTGCACGATCGA
GAAGGGTGCGCGGGTACTGGGGTACAGCTGCGTGAGCGACGGGTGCACGATCCGCGCGGGCAGCGTGGTGGTGGACAGCG
TGGTGTGGACGAGCGCGCGGTGGGGCCACAAGCTCAAGGGCGACCTGGTGCGTTCGATCTGGGGCGACGGGATGCAGGTC
TCACTCGGACTGCCCAATCTCTAG

Upstream 100 bases:

>100_bases
GATCCGCTCGATTTGCCCACTTATCCGTAAGGCCCTGGGATGCGGTTCCAGCCACGCCGAAGGCCACCGACCGTCAAACT
ATCCGATTGGAGCAAACCGA

Downstream 100 bases:

>100_bases
GAAGATGCATGGCCACCGCAGTGCCGTCGCCTGTGAACGGCCAGTATCAGGGCTCCGGGATTTCTCGGAGCCAGAATTTT
TGTGTGACGCTTCAGACAGT

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKAFVLAAGKGTRLRPFTDALPKPLMPVVNKPVMTHILALCRKHGFDQIVANLHYRGEKIAERFADGHRHGVELRYSWEE
QLLGTAGGVRRQADFLAGDAFLVISGDVMTDLDLGALVRFHKQSGAVATMAVKEVGDPSRFGVVLTDPDGRVESFQEKPA
KGSERSRLANTGIYVLEPEVFEHIPEAAFFDFGNDLFPLLVSKGAPVYAMRTGAYWSDVGTLSQYLYTHWELLTHPELKQ
RVGANTVVESGAVVSEQALIGSGCTIEKGARVLGYSCVSDGCTIRAGSVVVDSVVWTSARWGHKLKGDLVRSIWGDGMQV
SLGLPNL

Sequences:

>Translated_327_residues
MKAFVLAAGKGTRLRPFTDALPKPLMPVVNKPVMTHILALCRKHGFDQIVANLHYRGEKIAERFADGHRHGVELRYSWEE
QLLGTAGGVRRQADFLAGDAFLVISGDVMTDLDLGALVRFHKQSGAVATMAVKEVGDPSRFGVVLTDPDGRVESFQEKPA
KGSERSRLANTGIYVLEPEVFEHIPEAAFFDFGNDLFPLLVSKGAPVYAMRTGAYWSDVGTLSQYLYTHWELLTHPELKQ
RVGANTVVESGAVVSEQALIGSGCTIEKGARVLGYSCVSDGCTIRAGSVVVDSVVWTSARWGHKLKGDLVRSIWGDGMQV
SLGLPNL
>Mature_327_residues
MKAFVLAAGKGTRLRPFTDALPKPLMPVVNKPVMTHILALCRKHGFDQIVANLHYRGEKIAERFADGHRHGVELRYSWEE
QLLGTAGGVRRQADFLAGDAFLVISGDVMTDLDLGALVRFHKQSGAVATMAVKEVGDPSRFGVVLTDPDGRVESFQEKPA
KGSERSRLANTGIYVLEPEVFEHIPEAAFFDFGNDLFPLLVSKGAPVYAMRTGAYWSDVGTLSQYLYTHWELLTHPELKQ
RVGANTVVESGAVVSEQALIGSGCTIEKGARVLGYSCVSDGCTIRAGSVVVDSVVWTSARWGHKLKGDLVRSIWGDGMQV
SLGLPNL

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=299, Percent_Identity=32.1070234113712, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI11761619, Length=299, Percent_Identity=32.1070234113712, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI31881779, Length=355, Percent_Identity=27.6056338028169, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI45447090, Length=355, Percent_Identity=27.6056338028169, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788351, Length=229, Percent_Identity=30.1310043668122, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789837, Length=345, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790224, Length=185, Percent_Identity=30.2702702702703, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=303, Percent_Identity=33.003300330033, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17509979, Length=314, Percent_Identity=29.6178343949045, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17509981, Length=303, Percent_Identity=28.7128712871287, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=343, Percent_Identity=31.4868804664723, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI21355443, Length=299, Percent_Identity=31.7725752508361, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24644084, Length=299, Percent_Identity=31.7725752508361, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24653912, Length=363, Percent_Identity=26.4462809917355, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35596; Mature: 35596

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFVLAAGKGTRLRPFTDALPKPLMPVVNKPVMTHILALCRKHGFDQIVANLHYRGEKI
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCHHHH
AERFADGHRHGVELRYSWEEQLLGTAGGVRRQADFLAGDAFLVISGDVMTDLDLGALVRF
HHHHHCCCCCCEEEEECHHHHHHHCCCCCHHHHHHHCCCEEEEEECCHHCCCCHHHHHHH
HKQSGAVATMAVKEVGDPSRFGVVLTDPDGRVESFQEKPAKGSERSRLANTGIYVLEPEV
HHCCCCEEEEHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCHHHHHHHCCEEEECCHH
FEHIPEAAFFDFGNDLFPLLVSKGAPVYAMRTGAYWSDVGTLSQYLYTHWELLTHPELKQ
HHHCCCHHHHHCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHH
RVGANTVVESGAVVSEQALIGSGCTIEKGARVLGYSCVSDGCTIRAGSVVVDSVVWTSAR
HCCCCHHHHCCCEEEHHHHHCCCCCHHCCCCEEEEHHHCCCCEEEECCEEEHHHHHHCCC
WGHKLKGDLVRSIWGDGMQVSLGLPNL
CCCCHHHHHHHHHCCCCEEEEECCCCC
>Mature Secondary Structure
MKAFVLAAGKGTRLRPFTDALPKPLMPVVNKPVMTHILALCRKHGFDQIVANLHYRGEKI
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHCHHHH
AERFADGHRHGVELRYSWEEQLLGTAGGVRRQADFLAGDAFLVISGDVMTDLDLGALVRF
HHHHHCCCCCCEEEEECHHHHHHHCCCCCHHHHHHHCCCEEEEEECCHHCCCCHHHHHHH
HKQSGAVATMAVKEVGDPSRFGVVLTDPDGRVESFQEKPAKGSERSRLANTGIYVLEPEV
HHCCCCEEEEHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCHHHHHHHCCEEEECCHH
FEHIPEAAFFDFGNDLFPLLVSKGAPVYAMRTGAYWSDVGTLSQYLYTHWELLTHPELKQ
HHHCCCHHHHHCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHH
RVGANTVVESGAVVSEQALIGSGCTIEKGARVLGYSCVSDGCTIRAGSVVVDSVVWTSAR
HCCCCHHHHCCCEEEHHHHHCCCCCHHCCCCEEEEHHHCCCCEEEECCEEEHHHHHHCCC
WGHKLKGDLVRSIWGDGMQVSLGLPNL
CCCCHHHHHHHHHCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]