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The map label for this gene is crtE [C]

Identifier: 37519985

GI number: 37519985

Start: 437071

End: 437958

Strand: Reverse

Name: crtE [C]

Synonym: gvip043

Alternate gene names: 37519985

Gene position: 437958-437071 (Counterclockwise)

Preceding gene: 37519986

Following gene: 37519984

Centisome position: 9.4

GC content: 66.33

Gene sequence:

>888_bases
ATGTCACAGTTCGACCTCGACGCTTACCTGCGCCAGTGCCGCTCGCAGGTGGAAGCCGCCCTCGACCGCTATTTGCCCCA
GCAGTACCCGGACAAGCTCTACGAAGCGATGCGCTATTCGCTGCTGGCGGGAGGCAAGCGCCTGCGGCCGATTTTGTGCC
TGACCAGCTGCCGGATGTCCGGCGGCAGTGCGGATTTGGCGATGCCCACCGCCTGCGCCTTGGAGATGGTGCACACCATG
TCGCTCATCCACGACGACCTGCCCGCCATGGACGACGACGACTACCGCCGGGGCAAGCTCACCAACCACAAAGTCTACGG
CGAGGACATGGCCATCCTGGCGGGCGACGCCCTGCTCGCCTACGCCTTTCAACTGATCGCCGAGAAAACCGTGGGGGCGC
AGCCCGAGCGCGTCGTCGAGGTGCTCGGCCGTCTGGGCAAAGCGGCGAGCGGCGCCGGTCTGGTGGGAGGCCAGGTGGTC
GATCTCGAATCGGAAGGCCGGACAATCACCCTCGAAACCCTCGAATACATCCACACCCACAAGACCGGTGCCTTGCTCGA
GGTCTCGGTGATCTCCGGCGCCATCCTGGCCGGGGCCGACGGCGGGGTCGTCGAGCGGTTGACCCGCTACAGCCGCTGCA
TCGGACTGGCCTTCCAAATCCGCGACGATCTGCTCGACATCACCGCCACCCAGGCTGAACTGGGCAAGACCGCCGGTAAG
GACTTGCGCGACCGCAAGGCGACCTACCCGAGCCTGCTGGGCTACGACGGCGCGCGCGACCGCGCCGAGCAGTTGCGGGA
GCAGGCGGTGGCGGAACTGGCGGATTTTGGGGCATCGGCGCGACCGCTGACCGCCCTTGCCGAATTTATCGTGCAACGGC
GCCATTAA

Upstream 100 bases:

>100_bases
GCTCAACGCCTTCAACAACGGCCCCGCCAGCCACGCGGCGGTGCTGGAGCGCCTGGAGAGCTAGGGTCCGGTACAATTTC
TGTGCAGCAAACCGCAAGCC

Downstream 100 bases:

>100_bases
AAAACTGTGCCCGGCGCGAAATCGTATGCGATTATGATTCTGGACCACGTGTGCGCTGAATGGTTGAGGAGTGTTAACAA
TGCGACATGCTTACGTAAGC

Product: geranylgeranyl pyrophosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSQFDLDAYLRQCRSQVEAALDRYLPQQYPDKLYEAMRYSLLAGGKRLRPILCLTSCRMSGGSADLAMPTACALEMVHTM
SLIHDDLPAMDDDDYRRGKLTNHKVYGEDMAILAGDALLAYAFQLIAEKTVGAQPERVVEVLGRLGKAASGAGLVGGQVV
DLESEGRTITLETLEYIHTHKTGALLEVSVISGAILAGADGGVVERLTRYSRCIGLAFQIRDDLLDITATQAELGKTAGK
DLRDRKATYPSLLGYDGARDRAEQLREQAVAELADFGASARPLTALAEFIVQRRH

Sequences:

>Translated_295_residues
MSQFDLDAYLRQCRSQVEAALDRYLPQQYPDKLYEAMRYSLLAGGKRLRPILCLTSCRMSGGSADLAMPTACALEMVHTM
SLIHDDLPAMDDDDYRRGKLTNHKVYGEDMAILAGDALLAYAFQLIAEKTVGAQPERVVEVLGRLGKAASGAGLVGGQVV
DLESEGRTITLETLEYIHTHKTGALLEVSVISGAILAGADGGVVERLTRYSRCIGLAFQIRDDLLDITATQAELGKTAGK
DLRDRKATYPSLLGYDGARDRAEQLREQAVAELADFGASARPLTALAEFIVQRRH
>Mature_294_residues
SQFDLDAYLRQCRSQVEAALDRYLPQQYPDKLYEAMRYSLLAGGKRLRPILCLTSCRMSGGSADLAMPTACALEMVHTMS
LIHDDLPAMDDDDYRRGKLTNHKVYGEDMAILAGDALLAYAFQLIAEKTVGAQPERVVEVLGRLGKAASGAGLVGGQVVD
LESEGRTITLETLEYIHTHKTGALLEVSVISGAILAGADGGVVERLTRYSRCIGLAFQIRDDLLDITATQAELGKTAGKD
LRDRKATYPSLLGYDGARDRAEQLREQAVAELADFGASARPLTALAEFIVQRRH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=238, Percent_Identity=31.5126050420168, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1786623, Length=298, Percent_Identity=42.2818791946309, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1789578, Length=230, Percent_Identity=32.6086956521739, Blast_Score=108, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=245, Percent_Identity=33.0612244897959, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24651612, Length=227, Percent_Identity=31.2775330396476, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32150; Mature: 32019

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQFDLDAYLRQCRSQVEAALDRYLPQQYPDKLYEAMRYSLLAGGKRLRPILCLTSCRMS
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
GGSADLAMPTACALEMVHTMSLIHDDLPAMDDDDYRRGKLTNHKVYGEDMAILAGDALLA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHH
YAFQLIAEKTVGAQPERVVEVLGRLGKAASGAGLVGGQVVDLESEGRTITLETLEYIHTH
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHC
KTGALLEVSVISGAILAGADGGVVERLTRYSRCIGLAFQIRDDLLDITATQAELGKTAGK
CCCCEEEHHHHHCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLRDRKATYPSLLGYDGARDRAEQLREQAVAELADFGASARPLTALAEFIVQRRH
HHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQFDLDAYLRQCRSQVEAALDRYLPQQYPDKLYEAMRYSLLAGGKRLRPILCLTSCRMS
CCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
GGSADLAMPTACALEMVHTMSLIHDDLPAMDDDDYRRGKLTNHKVYGEDMAILAGDALLA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHH
YAFQLIAEKTVGAQPERVVEVLGRLGKAASGAGLVGGQVVDLESEGRTITLETLEYIHTH
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHHHHHHHHHC
KTGALLEVSVISGAILAGADGGVVERLTRYSRCIGLAFQIRDDLLDITATQAELGKTAGK
CCCCEEEHHHHHCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLRDRKATYPSLLGYDGARDRAEQLREQAVAELADFGASARPLTALAEFIVQRRH
HHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]