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The map label for this gene is luxQ [H]

Identifier: 37519945

GI number: 37519945

Start: 392640

End: 394373

Strand: Direct

Name: luxQ [H]

Synonym: glr0376

Alternate gene names: 37519945

Gene position: 392640-394373 (Clockwise)

Preceding gene: 37519944

Following gene: 37519950

Centisome position: 8.43

GC content: 62.86

Gene sequence:

>1734_bases
ATGAGGCGACGCGGCCCCGACGGCCATTTCGTCCGCAACTATGCCCAGCCCAAGCAGAGCCGCACACTGCGCCTGACCGA
GACCGCCTGGGCCGCGCTGGTCGAGTTGGCCCGGCAGCGGGGGATTAGCACTTCTGATCTGATTGAGCAGTGGGCGCGTG
GGCAATTTGCCTTTCCGAGCGGGCCGATCGGGGACGATGGCGAGGCGAGGCCGGTGGGTGTCGGCGCTGCCCTCGCCGTG
CGACCCTGCGACGAGCAGGCCGAAGGGGAGCAGGTCTCGAAGATTTTGGAGAGCATCACCGATGCCTTTTTTGCCCTCGA
CGAGCACTGGTGCTTCACCTATCTCAACCGGCAGGCGGAGCGGCTGCTTTCGCGCTCGCGCGAGGAGTTGATCGGCAAGA
ACATTTGGGTGGAGTTTCCGGAGGCGCTCGGCACGACTTTTGACAGAGAGTACCACCGGGCGGTCGAGCGACAGGTGCGC
GTCGGGTTTGAAGAGTTTTATGCTCCCCTCGATATCTGGCTGGCGGTGCGCGCCTATCCGACCGCCAAGGGACTGGCGGT
CTATTTTCTGGACATTGCCGAGCGCAAGCGCGCCGAACAGGCCCTGCTGGCCAGCGAGCAAAATTTTCGTTTCCTCGCCG
ATACGATTCCCCAGATGGTCTGGACCACCCGGCCGGATGGCTATCACGATTTTTTCAACCGACGCTGGTTCGAGTACACC
GGCATGAACCTCGAGCAGACCCAGGGATGGGGCTGGAGCCATCTGCTGCATCCGCACGATCTGGACAAATGCCTGCACCT
TTGGAAGTATTCCCTCGCCACCGGGGAGCCCTACGACATCGAGTACCGTTTTCGGCGCGCCTCAGACGGCGTCTACCGCT
GGCAGCTTGGGCGGGCGTTGCCGCTGCGCGACCCCCAGGGAAACATCCTCAGGTGGTTCGGCACCTGCACCGACATCGAC
GATCAAAAGCGCGCCGAGCAGGAGCGCACCCACTTGCTTGAGCGCGAACGGCAGGCCCGGGCTGAAGCGGAGGCGGCCAA
CCGGGCCAAGGACGAATTTCTGGCGATGCTCAGCCACGAACTGCGCACCCCCCTCAACCCGATCATCGGCTGGACCCAGA
TGCTCAGGCGCGGCAATCTCACCCCTGAGATGCAGGCGAAAGCCCTGGAGACCATCGAGCGCAACGGCAAGCTCCAGAAC
CAGCTCATCGAAGATCTGCTCGATATTTCCCGCATTATCCGGGGCAAGTTCAGCATCGCCCCAATACCGATCGAATTGCC
GCCGGTGCTGCATTCGGCAATAGAAGCGGTGCGCAACCTGGCCGAGCAGAAGGAAGTACTGCTGGACTGCCGGTGCGAGC
CGTCGGCCTTGAACCGCCAAGTTTCCGCCGATCCGACCCGCCTGCAGCAGGTGATCTGGAATTTGCTCACCAACGCCATC
AAGTTCACCCCCAAAGGCGGCCGGGTGGAAGTGGATCTAGCTGGCGACAGCGCCAATCTCTACGTTGCCGTGCGCGACAA
CGGCATGGGAATTGCGCCCGAGTTTTTGCCCTACATGTTCGAGCGCTTCCGGCAGGCGGACAGCCGCAGCACCCGCAAGG
AGGGAGGATTGGGGCTGGGATTGTTCATCGTGCGCCACATCGTCGAATTGCACGGGGGAATGGTCCAAGCCGAGAGCGAG
GGCGAGGGCAAAGGGGCCGTTTTTACCGTCGAGCTGCCGGCTCTGGGCGGATAA

Upstream 100 bases:

>100_bases
GTGATCTACCGCGACGCCGAGCGCTTCGCAAACGGGGGAGAAGCCTCCCGCAATCCGAAGGAGCGCTTGCTACAATCCAT
GTGATACATGGAGGGTTGCC

Downstream 100 bases:

>100_bases
TCAGCAACGAAAAATAGGGCAGCCGTTCGGCCGCAGCGGGCAGCCGCCGGTAGATCCGCTCTTCCTTTGCGCTTACCCAG
CAGAGCAGGTGGGCCTGCTC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MRRRGPDGHFVRNYAQPKQSRTLRLTETAWAALVELARQRGISTSDLIEQWARGQFAFPSGPIGDDGEARPVGVGAALAV
RPCDEQAEGEQVSKILESITDAFFALDEHWCFTYLNRQAERLLSRSREELIGKNIWVEFPEALGTTFDREYHRAVERQVR
VGFEEFYAPLDIWLAVRAYPTAKGLAVYFLDIAERKRAEQALLASEQNFRFLADTIPQMVWTTRPDGYHDFFNRRWFEYT
GMNLEQTQGWGWSHLLHPHDLDKCLHLWKYSLATGEPYDIEYRFRRASDGVYRWQLGRALPLRDPQGNILRWFGTCTDID
DQKRAEQERTHLLERERQARAEAEAANRAKDEFLAMLSHELRTPLNPIIGWTQMLRRGNLTPEMQAKALETIERNGKLQN
QLIEDLLDISRIIRGKFSIAPIPIELPPVLHSAIEAVRNLAEQKEVLLDCRCEPSALNRQVSADPTRLQQVIWNLLTNAI
KFTPKGGRVEVDLAGDSANLYVAVRDNGMGIAPEFLPYMFERFRQADSRSTRKEGGLGLGLFIVRHIVELHGGMVQAESE
GEGKGAVFTVELPALGG

Sequences:

>Translated_577_residues
MRRRGPDGHFVRNYAQPKQSRTLRLTETAWAALVELARQRGISTSDLIEQWARGQFAFPSGPIGDDGEARPVGVGAALAV
RPCDEQAEGEQVSKILESITDAFFALDEHWCFTYLNRQAERLLSRSREELIGKNIWVEFPEALGTTFDREYHRAVERQVR
VGFEEFYAPLDIWLAVRAYPTAKGLAVYFLDIAERKRAEQALLASEQNFRFLADTIPQMVWTTRPDGYHDFFNRRWFEYT
GMNLEQTQGWGWSHLLHPHDLDKCLHLWKYSLATGEPYDIEYRFRRASDGVYRWQLGRALPLRDPQGNILRWFGTCTDID
DQKRAEQERTHLLERERQARAEAEAANRAKDEFLAMLSHELRTPLNPIIGWTQMLRRGNLTPEMQAKALETIERNGKLQN
QLIEDLLDISRIIRGKFSIAPIPIELPPVLHSAIEAVRNLAEQKEVLLDCRCEPSALNRQVSADPTRLQQVIWNLLTNAI
KFTPKGGRVEVDLAGDSANLYVAVRDNGMGIAPEFLPYMFERFRQADSRSTRKEGGLGLGLFIVRHIVELHGGMVQAESE
GEGKGAVFTVELPALGG
>Mature_577_residues
MRRRGPDGHFVRNYAQPKQSRTLRLTETAWAALVELARQRGISTSDLIEQWARGQFAFPSGPIGDDGEARPVGVGAALAV
RPCDEQAEGEQVSKILESITDAFFALDEHWCFTYLNRQAERLLSRSREELIGKNIWVEFPEALGTTFDREYHRAVERQVR
VGFEEFYAPLDIWLAVRAYPTAKGLAVYFLDIAERKRAEQALLASEQNFRFLADTIPQMVWTTRPDGYHDFFNRRWFEYT
GMNLEQTQGWGWSHLLHPHDLDKCLHLWKYSLATGEPYDIEYRFRRASDGVYRWQLGRALPLRDPQGNILRWFGTCTDID
DQKRAEQERTHLLERERQARAEAEAANRAKDEFLAMLSHELRTPLNPIIGWTQMLRRGNLTPEMQAKALETIERNGKLQN
QLIEDLLDISRIIRGKFSIAPIPIELPPVLHSAIEAVRNLAEQKEVLLDCRCEPSALNRQVSADPTRLQQVIWNLLTNAI
KFTPKGGRVEVDLAGDSANLYVAVRDNGMGIAPEFLPYMFERFRQADSRSTRKEGGLGLGLFIVRHIVELHGGMVQAESE
GEGKGAVFTVELPALGG

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=37.4468085106383, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI145693157, Length=267, Percent_Identity=35.2059925093633, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI48994928, Length=435, Percent_Identity=28.0459770114943, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788713, Length=459, Percent_Identity=23.9651416122004, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI87081816, Length=503, Percent_Identity=28.0318091451292, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=32.0175438596491, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786912, Length=249, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=30.6772908366534, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=30.9090909090909, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=248, Percent_Identity=28.2258064516129, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1788279, Length=225, Percent_Identity=29.7777777777778, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1789403, Length=234, Percent_Identity=30.3418803418803, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=31.1627906976744, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=29.7777777777778, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787894, Length=225, Percent_Identity=28.8888888888889, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=27.8884462151394, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=211, Percent_Identity=27.4881516587678, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65853; Mature: 65853

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRGPDGHFVRNYAQPKQSRTLRLTETAWAALVELARQRGISTSDLIEQWARGQFAFPS
CCCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
GPIGDDGEARPVGVGAALAVRPCDEQAEGEQVSKILESITDAFFALDEHWCFTYLNRQAE
CCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLSRSREELIGKNIWVEFPEALGTTFDREYHRAVERQVRVGFEEFYAPLDIWLAVRAYP
HHHHHHHHHHHCCCCEEECHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
TAKGLAVYFLDIAERKRAEQALLASEQNFRFLADTIPQMVWTTRPDGYHDFFNRRWFEYT
CCCCHHEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHCC
GMNLEQTQGWGWSHLLHPHDLDKCLHLWKYSLATGEPYDIEYRFRRASDGVYRWQLGRAL
CCCCHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCC
PLRDPQGNILRWFGTCTDIDDQKRAEQERTHLLERERQARAEAEAANRAKDEFLAMLSHE
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTPLNPIIGWTQMLRRGNLTPEMQAKALETIERNGKLQNQLIEDLLDISRIIRGKFSIA
HHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
PIPIELPPVLHSAIEAVRNLAEQKEVLLDCRCEPSALNRQVSADPTRLQQVIWNLLTNAI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
KFTPKGGRVEVDLAGDSANLYVAVRDNGMGIAPEFLPYMFERFRQADSRSTRKEGGLGLG
EECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LFIVRHIVELHGGMVQAESEGEGKGAVFTVELPALGG
HHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MRRRGPDGHFVRNYAQPKQSRTLRLTETAWAALVELARQRGISTSDLIEQWARGQFAFPS
CCCCCCCCHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCC
GPIGDDGEARPVGVGAALAVRPCDEQAEGEQVSKILESITDAFFALDEHWCFTYLNRQAE
CCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLSRSREELIGKNIWVEFPEALGTTFDREYHRAVERQVRVGFEEFYAPLDIWLAVRAYP
HHHHHHHHHHHCCCCEEECHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
TAKGLAVYFLDIAERKRAEQALLASEQNFRFLADTIPQMVWTTRPDGYHDFFNRRWFEYT
CCCCHHEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCHHCC
GMNLEQTQGWGWSHLLHPHDLDKCLHLWKYSLATGEPYDIEYRFRRASDGVYRWQLGRAL
CCCCHHCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCC
PLRDPQGNILRWFGTCTDIDDQKRAEQERTHLLERERQARAEAEAANRAKDEFLAMLSHE
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRTPLNPIIGWTQMLRRGNLTPEMQAKALETIERNGKLQNQLIEDLLDISRIIRGKFSIA
HHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCC
PIPIELPPVLHSAIEAVRNLAEQKEVLLDCRCEPSALNRQVSADPTRLQQVIWNLLTNAI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHH
KFTPKGGRVEVDLAGDSANLYVAVRDNGMGIAPEFLPYMFERFRQADSRSTRKEGGLGLG
EECCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LFIVRHIVELHGGMVQAESEGEGKGAVFTVELPALGG
HHHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]