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The map label for this gene is mrdA [H]

Identifier: 34499815

GI number: 34499815

Start: 4700339

End: 4702279

Strand: Direct

Name: mrdA [H]

Synonym: CV_4360

Alternate gene names: 34499815

Gene position: 4700339-4702279 (Clockwise)

Preceding gene: 34499814

Following gene: 34499816

Centisome position: 98.93

GC content: 65.17

Gene sequence:

>1941_bases
ATGCGCCGCCCGTCCCGTTTCAAGAACCCGCAGTCCGAAGAGGCCCAGTTCGAGCTGCGGCTGGTCATCGCCTACGCGCT
GATCATCCTGATGTTCCTCATCCTGCTCGCGCGCTTCGTCTGGCTGCAGGTGCTGCAGCACGACCATTTCTCGACGCTGG
CGCAGAACAACCGCATCTCGCTGGTGCCCATTCTGCCCAACCGCGGCCTGATCCTGGACCGCAACGGCATCGTGCTGGCG
CAGAACTACTCCGCCTACACGCTGGAGCTGACGCCAAGCAAGATTTCCGACCTCGCCGCCACCATCGCCAAGCTGAAGAC
GCTGGCCGACGTCAGCCCGCGCGACGAAAAGCTGTTCAAGAAGCTGTTGGCCGAGAGCAAGACCTTCGAGGCGATTCCGC
TGAAGGTCAAGCTGACCGACGACGAAGCCGCGCGCGTCGCCGCCCATGGCTTCGAGCTGCCCGGCGTCGAGGTCAGGGCG
CGGCTGTTCCGCGACTATCCGTATAAAGAGATGACCAGCCACGTGCTGGGCTATATCGGCCGCATCAACCAGAAGGACAA
GGAGCGGCTGGAAGAGGAAGACAAGACCACCAATTACAAGGGCACCAACTACATCGGCAAGACCGGCCTGGAAGCGGTGT
ACGAGGACGACCTGCACGGCCAGGTGGGCTTCGAGGAGATGGAAACCGACTCCGGCGGCCGCGCGGTGCGCAGCCTGCGC
CGCACGCCGCCGGTCAACGGCAACACGCTGAAGCTGGCGCTGGACATCCGGCTGCAGGAAATGGCCGACAAGCTGTTCGG
CGACCGCCGCGGCGCGCTGGTGGCGATCGACCCCAACACCGGCGGCGTGCTGGCCTTCCTGTCCAAGCCGGGTTTCGATC
CCAGCCTGTTCATCGACGGCATCGACACCCAGACCTGGACCGCGTTGAACACCGACTGGCAGAAGCCGCTGATCAACCGC
GCGCTGCGCGGCACCTATCCACCCGGCTCCACCTTCAAGCCCTTCATGGCGATGGCCGCGCTGAACACCCACAGCATAGG
CATGCACGACATCCGTCCGGCGCCCGGCTACTTCACGCTGCCCGGCTCCAGCCACCAGTTCCGCGACAGCAAGAAGAGCG
GCAACGGCATGGTCAACCTGCAGCGCGCGATCACCGTGTCCAGCGACACCTTCTTCTACAAGCTGGCCTGGGACATGGGC
ATAGACAAGATCCACCCGGTGGTCGGCTCCTTCGGCCTGGGCAGCAAGACCGGCATCGACCTGGACGGCGAGGCCACCGG
CGTGCTGCCCTCCAAGGAGTGGAAGGCCAAGCGTTTCGCCCGCTACAAGCCCGAGGTGCGGCGCTGGTATCCGGCCGATG
TGGTCAGCATCGGCATCGGCCAGGGCTTCAACGCCTACACCCCGCTGCAGATGGCCAACGCCACCGCCATCATGGCCAAC
GGCGGCCAGGTGTTCAAACCGCACCTGGTGCAGCAGGTGGTGGACTCCAAAACCGGAAAATCCCGCCAGATCGAGCCGCA
GCCGATTCGGCAGCTGCCTTACCCGAAGGAATACTTCGACTACATCAAGGAAGGCATGCGCAACGTGATGATCTCCGGCA
CCGGCGCCCGCGTCGGCGCCGGCCTGCAGTACACGATGGCCGGCAAGACCGGCACCGCCCAGGTGGTGGCGATCAAGCAG
GGCGCCAAATACAACGCCGCCGCGCTGGCCGAGCAGTACCGCGACCACAGCTGGTTCATCGCCTTCGCGCCGGTGGAGCA
GCCCAAGATCGCGGTGGCCATCATCGTCGAGAACGCCGGCTTCGGCGCCGCCGCCGCCGCGCCGGTGGCGCGCGGCCTGT
TCGACTTCTACCTGACCGGCAAGGTGCGCAACGACCTGGCCGGCATGCTCAAGACCGTGCCGATGGAAAACGGAGACGTA
CGTGAAGACGCCGCTGATTAA

Upstream 100 bases:

>100_bases
ACTTCCTGCCGCCCCTGATTGGCGCGCTGCTGTGGCCGCTGCTGACCAAGCTGATGCTGATCCCCTACCGCCAACACACG
GCATGAAACTCGACTGACCC

Downstream 100 bases:

>100_bases
GCACATCTGGCAGCAGATAAAAGAGCCGCTGGACGGCTGGCTGATGCTGTTCCTCGGCCTGATCTTCGCGGTCAGCATGG
TGCTGCTGTACTCCGCCAAC

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MRRPSRFKNPQSEEAQFELRLVIAYALIILMFLILLARFVWLQVLQHDHFSTLAQNNRISLVPILPNRGLILDRNGIVLA
QNYSAYTLELTPSKISDLAATIAKLKTLADVSPRDEKLFKKLLAESKTFEAIPLKVKLTDDEAARVAAHGFELPGVEVRA
RLFRDYPYKEMTSHVLGYIGRINQKDKERLEEEDKTTNYKGTNYIGKTGLEAVYEDDLHGQVGFEEMETDSGGRAVRSLR
RTPPVNGNTLKLALDIRLQEMADKLFGDRRGALVAIDPNTGGVLAFLSKPGFDPSLFIDGIDTQTWTALNTDWQKPLINR
ALRGTYPPGSTFKPFMAMAALNTHSIGMHDIRPAPGYFTLPGSSHQFRDSKKSGNGMVNLQRAITVSSDTFFYKLAWDMG
IDKIHPVVGSFGLGSKTGIDLDGEATGVLPSKEWKAKRFARYKPEVRRWYPADVVSIGIGQGFNAYTPLQMANATAIMAN
GGQVFKPHLVQQVVDSKTGKSRQIEPQPIRQLPYPKEYFDYIKEGMRNVMISGTGARVGAGLQYTMAGKTGTAQVVAIKQ
GAKYNAAALAEQYRDHSWFIAFAPVEQPKIAVAIIVENAGFGAAAAAPVARGLFDFYLTGKVRNDLAGMLKTVPMENGDV
REDAAD

Sequences:

>Translated_646_residues
MRRPSRFKNPQSEEAQFELRLVIAYALIILMFLILLARFVWLQVLQHDHFSTLAQNNRISLVPILPNRGLILDRNGIVLA
QNYSAYTLELTPSKISDLAATIAKLKTLADVSPRDEKLFKKLLAESKTFEAIPLKVKLTDDEAARVAAHGFELPGVEVRA
RLFRDYPYKEMTSHVLGYIGRINQKDKERLEEEDKTTNYKGTNYIGKTGLEAVYEDDLHGQVGFEEMETDSGGRAVRSLR
RTPPVNGNTLKLALDIRLQEMADKLFGDRRGALVAIDPNTGGVLAFLSKPGFDPSLFIDGIDTQTWTALNTDWQKPLINR
ALRGTYPPGSTFKPFMAMAALNTHSIGMHDIRPAPGYFTLPGSSHQFRDSKKSGNGMVNLQRAITVSSDTFFYKLAWDMG
IDKIHPVVGSFGLGSKTGIDLDGEATGVLPSKEWKAKRFARYKPEVRRWYPADVVSIGIGQGFNAYTPLQMANATAIMAN
GGQVFKPHLVQQVVDSKTGKSRQIEPQPIRQLPYPKEYFDYIKEGMRNVMISGTGARVGAGLQYTMAGKTGTAQVVAIKQ
GAKYNAAALAEQYRDHSWFIAFAPVEQPKIAVAIIVENAGFGAAAAAPVARGLFDFYLTGKVRNDLAGMLKTVPMENGDV
REDAAD
>Mature_646_residues
MRRPSRFKNPQSEEAQFELRLVIAYALIILMFLILLARFVWLQVLQHDHFSTLAQNNRISLVPILPNRGLILDRNGIVLA
QNYSAYTLELTPSKISDLAATIAKLKTLADVSPRDEKLFKKLLAESKTFEAIPLKVKLTDDEAARVAAHGFELPGVEVRA
RLFRDYPYKEMTSHVLGYIGRINQKDKERLEEEDKTTNYKGTNYIGKTGLEAVYEDDLHGQVGFEEMETDSGGRAVRSLR
RTPPVNGNTLKLALDIRLQEMADKLFGDRRGALVAIDPNTGGVLAFLSKPGFDPSLFIDGIDTQTWTALNTDWQKPLINR
ALRGTYPPGSTFKPFMAMAALNTHSIGMHDIRPAPGYFTLPGSSHQFRDSKKSGNGMVNLQRAITVSSDTFFYKLAWDMG
IDKIHPVVGSFGLGSKTGIDLDGEATGVLPSKEWKAKRFARYKPEVRRWYPADVVSIGIGQGFNAYTPLQMANATAIMAN
GGQVFKPHLVQQVVDSKTGKSRQIEPQPIRQLPYPKEYFDYIKEGMRNVMISGTGARVGAGLQYTMAGKTGTAQVVAIKQ
GAKYNAAALAEQYRDHSWFIAFAPVEQPKIAVAIIVENAGFGAAAAAPVARGLFDFYLTGKVRNDLAGMLKTVPMENGDV
REDAAD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=629, Percent_Identity=41.4944356120827, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1786272, Length=627, Percent_Identity=24.5614035087719, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71453; Mature: 71453

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPSRFKNPQSEEAQFELRLVIAYALIILMFLILLARFVWLQVLQHDHFSTLAQNNRIS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEE
LVPILPNRGLILDRNGIVLAQNYSAYTLELTPSKISDLAATIAKLKTLADVSPRDEKLFK
EEEECCCCCEEEECCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KLLAESKTFEAIPLKVKLTDDEAARVAAHGFELPGVEVRARLFRDYPYKEMTSHVLGYIG
HHHHCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
RINQKDKERLEEEDKTTNYKGTNYIGKTGLEAVYEDDLHGQVGFEEMETDSGGRAVRSLR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHCCCCCCHHHHHHH
RTPPVNGNTLKLALDIRLQEMADKLFGDRRGALVAIDPNTGGVLAFLSKPGFDPSLFIDG
CCCCCCCCEEEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCEEEEC
IDTQTWTALNTDWQKPLINRALRGTYPPGSTFKPFMAMAALNTHSIGMHDIRPAPGYFTL
CCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEC
PGSSHQFRDSKKSGNGMVNLQRAITVSSDTFFYKLAWDMGIDKIHPVVGSFGLGSKTGID
CCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCC
LDGEATGVLPSKEWKAKRFARYKPEVRRWYPADVVSIGIGQGFNAYTPLQMANATAIMAN
CCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCEEEEECCCCCCCCCCHHHCCCEEEEEC
GGQVFKPHLVQQVVDSKTGKSRQIEPQPIRQLPYPKEYFDYIKEGMRNVMISGTGARVGA
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHEEEEECCCCCCCC
GLQYTMAGKTGTAQVVAIKQGAKYNAAALAEQYRDHSWFIAFAPVEQPKIAVAIIVENAG
CEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCC
FGAAAAAPVARGLFDFYLTGKVRNDLAGMLKTVPMENGDVREDAAD
CCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRPSRFKNPQSEEAQFELRLVIAYALIILMFLILLARFVWLQVLQHDHFSTLAQNNRIS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEE
LVPILPNRGLILDRNGIVLAQNYSAYTLELTPSKISDLAATIAKLKTLADVSPRDEKLFK
EEEECCCCCEEEECCCEEEEECCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KLLAESKTFEAIPLKVKLTDDEAARVAAHGFELPGVEVRARLFRDYPYKEMTSHVLGYIG
HHHHCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHH
RINQKDKERLEEEDKTTNYKGTNYIGKTGLEAVYEDDLHGQVGFEEMETDSGGRAVRSLR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHCCCCCCHHHHHHH
RTPPVNGNTLKLALDIRLQEMADKLFGDRRGALVAIDPNTGGVLAFLSKPGFDPSLFIDG
CCCCCCCCEEEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCEEEEC
IDTQTWTALNTDWQKPLINRALRGTYPPGSTFKPFMAMAALNTHSIGMHDIRPAPGYFTL
CCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEC
PGSSHQFRDSKKSGNGMVNLQRAITVSSDTFFYKLAWDMGIDKIHPVVGSFGLGSKTGID
CCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCC
LDGEATGVLPSKEWKAKRFARYKPEVRRWYPADVVSIGIGQGFNAYTPLQMANATAIMAN
CCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCEEEEECCCCCCCCCCHHHCCCEEEEEC
GGQVFKPHLVQQVVDSKTGKSRQIEPQPIRQLPYPKEYFDYIKEGMRNVMISGTGARVGA
CCCCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHEEEEECCCCCCCC
GLQYTMAGKTGTAQVVAIKQGAKYNAAALAEQYRDHSWFIAFAPVEQPKIAVAIIVENAG
CEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCC
FGAAAAAPVARGLFDFYLTGKVRNDLAGMLKTVPMENGDVREDAAD
CCCHHHHHHHHHHHHHEEECHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]