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The map label for this gene is catF [H]

Identifier: 34499746

GI number: 34499746

Start: 4630686

End: 4631888

Strand: Reverse

Name: catF [H]

Synonym: CV_4291

Alternate gene names: 34499746

Gene position: 4631888-4630686 (Counterclockwise)

Preceding gene: 34499747

Following gene: 34499736

Centisome position: 97.49

GC content: 63.76

Gene sequence:

>1203_bases
ATGAAAAATGCTTATATCTGCGATGCCGTGCGTACCCCCTTTGGTCGTTACGGCGGTTCTCTGTCTTCCATTCGCGGCGA
CGAGCTGGCGGCGCTGCCCATCCAGGCCTTGCTGGCGAGGAACCCGCAATTGGGCGCGGCTTCGATCGACGATGTGATCT
ATGGATGCGCCAACCAGGCCGGAGAGGACAATCGGAACGTGGCGCGCATGGCGGCGCTGCTGGCGGGGTTGCCGGCAGCC
GTGCCGGGCACTACGGTCAACCGCTTGTGCGGTTCCAGCCTGGATGCGCTGGCGATGTCGGCGCGGGCGTTGAAAAGCGG
CGAAGCGGAGCTGCTTGTCGCCGGCGGGGTGGAAAGCATGAGCAGGGCACCTTACGTGGTGGGCAAAGCGGACAGCGTGT
TCTCGCGCTCTCTGAAGATGGAGGACACCACCATGGGTTGGCGTTTCGTCAATCCGAGAATGAAGACCCTGTATGGCGTG
GATACCATGCCGGAAACCGCGGAAAACGTGGCGAAGGAGTTCGGCGTGTCACGGTCCGACCAAGATGCGTTCGCCTTGTT
GAGCCAGCAACGGACCGCAGCGGCCTATGAGCGGGGTTTTTTTGCCGATGAGCTGATGGAGGTGCGTATTCCGCAGCGGA
AGGGCGAGGACAAGATATTTGCCCAGGACGAGCATCCGAGGCAAACCTCGCTGGAGGAACTGGCGCGGCTCAAAGGCGTT
GTCACTCCGGATGGCACGGTGACTGCCGGAAACGCTTCAGGCATCAATGACGGCGCTTGCGCATTGCTGTTGGCGGGCGA
GGAGGGGATTCGCCGCCATGGACTGGTACCGCGCGCCCGCATCTTGGCGGCAGCGGCAGCGGGAGTAGCGCCCCGAGTGA
TGGGAATGGGGCCGGTGCCGGCGATCAACAAGGCCTTGGCGCTGGCGGGGTTGAGGCTGGAGCAGATCGACCACATAGAA
TTGAATGAAGCGTTCGCTGCCCAGGCGCTGGCGGTGCTGCGGGAGTTGCGTCTGTCGGACGACGATAGCCGAGTCAACCC
CAATGGCGGGGCCATCGCGTTGGGCCATCCGCTTGGCGCCAGCGGCGCGCGGCTGGTCTCCACCGCGGTGTACCACCTGG
CGCGGACGGGGGGACGCTACGCGCTGTGTTCCATGTGCGTGGGCGTAGGCCAGGGCATCGCTATGGTGATTGAGCGGATT
TAA

Upstream 100 bases:

>100_bases
GATGGAGCGGCATCGCGGCGTTGGGCTTGGCTGCGTCGACCGTCGTGATTGTTTTAAATGCGAATGCCATCGTGGCGCTG
CGCCTGATCTGGAGAGTTTC

Downstream 100 bases:

>100_bases
CGGGAGGCGGGCAGGCATCCGCCGATGCGGACTTGCCCGAGATGGTTGCTCAGGGCCTGGTGGAAAACCTCCAGCTTGGC
CGACATCTTGGGCAGGGCCC

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKNAYICDAVRTPFGRYGGSLSSIRGDELAALPIQALLARNPQLGAASIDDVIYGCANQAGEDNRNVARMAALLAGLPAA
VPGTTVNRLCGSSLDALAMSARALKSGEAELLVAGGVESMSRAPYVVGKADSVFSRSLKMEDTTMGWRFVNPRMKTLYGV
DTMPETAENVAKEFGVSRSDQDAFALLSQQRTAAAYERGFFADELMEVRIPQRKGEDKIFAQDEHPRQTSLEELARLKGV
VTPDGTVTAGNASGINDGACALLLAGEEGIRRHGLVPRARILAAAAAGVAPRVMGMGPVPAINKALALAGLRLEQIDHIE
LNEAFAAQALAVLRELRLSDDDSRVNPNGGAIALGHPLGASGARLVSTAVYHLARTGGRYALCSMCVGVGQGIAMVIERI

Sequences:

>Translated_400_residues
MKNAYICDAVRTPFGRYGGSLSSIRGDELAALPIQALLARNPQLGAASIDDVIYGCANQAGEDNRNVARMAALLAGLPAA
VPGTTVNRLCGSSLDALAMSARALKSGEAELLVAGGVESMSRAPYVVGKADSVFSRSLKMEDTTMGWRFVNPRMKTLYGV
DTMPETAENVAKEFGVSRSDQDAFALLSQQRTAAAYERGFFADELMEVRIPQRKGEDKIFAQDEHPRQTSLEELARLKGV
VTPDGTVTAGNASGINDGACALLLAGEEGIRRHGLVPRARILAAAAAGVAPRVMGMGPVPAINKALALAGLRLEQIDHIE
LNEAFAAQALAVLRELRLSDDDSRVNPNGGAIALGHPLGASGARLVSTAVYHLARTGGRYALCSMCVGVGQGIAMVIERI
>Mature_400_residues
MKNAYICDAVRTPFGRYGGSLSSIRGDELAALPIQALLARNPQLGAASIDDVIYGCANQAGEDNRNVARMAALLAGLPAA
VPGTTVNRLCGSSLDALAMSARALKSGEAELLVAGGVESMSRAPYVVGKADSVFSRSLKMEDTTMGWRFVNPRMKTLYGV
DTMPETAENVAKEFGVSRSDQDAFALLSQQRTAAAYERGFFADELMEVRIPQRKGEDKIFAQDEHPRQTSLEELARLKGV
VTPDGTVTAGNASGINDGACALLLAGEEGIRRHGLVPRARILAAAAAGVAPRVMGMGPVPAINKALALAGLRLEQIDHIE
LNEAFAAQALAVLRELRLSDDDSRVNPNGGAIALGHPLGASGARLVSTAVYHLARTGGRYALCSMCVGVGQGIAMVIERI

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=401, Percent_Identity=42.3940149625935, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=38.7909319899244, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI4557237, Length=405, Percent_Identity=36.2962962962963, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=39.746835443038, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4504327, Length=432, Percent_Identity=32.6388888888889, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=29.923273657289, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=63.3416458852868, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1788554, Length=401, Percent_Identity=46.3840399002494, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=42.7160493827161, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI87082165, Length=400, Percent_Identity=42, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1788683, Length=426, Percent_Identity=32.8638497652582, Blast_Score=162, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=42.8927680798005, Blast_Score=300, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=35.6608478802993, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=33.9152119700748, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=433, Percent_Identity=33.256351039261, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=407, Percent_Identity=29.7297297297297, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=36.0493827160494, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=34.5771144278607, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=43.142144638404, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI17648125, Length=403, Percent_Identity=39.454094292804, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=34.8484848484849, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=34.8837209302326, Blast_Score=194, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 42070; Mature: 42070

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNAYICDAVRTPFGRYGGSLSSIRGDELAALPIQALLARNPQLGAASIDDVIYGCANQA
CCCCEEEHHHHCCHHHHCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
GEDNRNVARMAALLAGLPAAVPGTTVNRLCGSSLDALAMSARALKSGEAELLVAGGVESM
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHH
SRAPYVVGKADSVFSRSLKMEDTTMGWRFVNPRMKTLYGVDTMPETAENVAKEFGVSRSD
CCCCEEEECCHHHHHHHCCCCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHCCCCCC
QDAFALLSQQRTAAAYERGFFADELMEVRIPQRKGEDKIFAQDEHPRQTSLEELARLKGV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCC
VTPDGTVTAGNASGINDGACALLLAGEEGIRRHGLVPRARILAAAAAGVAPRVMGMGPVP
CCCCCCEECCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCH
AINKALALAGLRLEQIDHIELNEAFAAQALAVLRELRLSDDDSRVNPNGGAIALGHPLGA
HHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCC
SGARLVSTAVYHLARTGGRYALCSMCVGVGQGIAMVIERI
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MKNAYICDAVRTPFGRYGGSLSSIRGDELAALPIQALLARNPQLGAASIDDVIYGCANQA
CCCCEEEHHHHCCHHHHCCCHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
GEDNRNVARMAALLAGLPAAVPGTTVNRLCGSSLDALAMSARALKSGEAELLVAGGVESM
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCHHHH
SRAPYVVGKADSVFSRSLKMEDTTMGWRFVNPRMKTLYGVDTMPETAENVAKEFGVSRSD
CCCCEEEECCHHHHHHHCCCCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHCCCCCC
QDAFALLSQQRTAAAYERGFFADELMEVRIPQRKGEDKIFAQDEHPRQTSLEELARLKGV
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHCCC
VTPDGTVTAGNASGINDGACALLLAGEEGIRRHGLVPRARILAAAAAGVAPRVMGMGPVP
CCCCCCEECCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCHHHHCCCCCH
AINKALALAGLRLEQIDHIELNEAFAAQALAVLRELRLSDDDSRVNPNGGAIALGHPLGA
HHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCC
SGARLVSTAVYHLARTGGRYALCSMCVGVGQGIAMVIERI
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]