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The map label for this gene is proA

Identifier: 34499744

GI number: 34499744

Start: 4628418

End: 4629677

Strand: Direct

Name: proA

Synonym: CV_4289

Alternate gene names: 34499744

Gene position: 4628418-4629677 (Clockwise)

Preceding gene: 34499743

Following gene: 34499745

Centisome position: 97.42

GC content: 69.44

Gene sequence:

>1260_bases
ATGAACGTCAAAGAATACATGCAGCAGTTGGGCCAGGCCGCGCGCAAGGCGTCGCGCCTGCTGGCCCGCGCCGACACCAA
TCAGAAGAACGCCGCGCTTCACGCCATCGCCGACGCCATCGTCCGCGAGCAGGAGGCGCTGCTGGCCGCCAACCGCCAGG
ACCTGGACGCCGCGCGCCAGGCCGGCCTGGACGACGCGATGCTGGACCGGCTGACCCTGTCCGCCAAGGGCGTGCTGGCG
ATGGCCGACGGCCTGCGCCAGATCGCCGCGCTGCCGGACCCGGTGGGTGAAATCGACGACATGTGCTACCGCCCGTCCGG
CATCCAGCTGGGCAAGATGCGCGTGCCGCTGGGCGTGGTGGGCATCATCTACGAGGCCCGCCCCAACGTCACCGCCGACG
CCGCCGGCCTGTGCCTGAAGTCCGGCAACGCCACCATCCTGCGCGGCGGCTCCGAAGCCTTCCACAGCAACCAGGCCATC
GCCGCCTGCGTGCACGAGGGCCTGGCCGCCGCCGGCCTGCCGGCCGAGGCGGTGCAGGTGCTGGCCACCACCGACCGCGC
CGCGGTGGGCGAGCTGATCGCGATGCCCGAATACGTCGACGTGATCGTGCCGCGCGGCGGCAAGGGCCTGATCGCGCGCA
TCAGCGCCGAGGCGCGGGTGCCGGTGATCAAGCATCTGGACGGCAACTGCCACGTCTACATCGACGACACCGCCAACCCG
GACAAGGCGTTCAACATCGCCCTCAACGCCAAGACCCACCGCTACGGCACCTGCAACACCATGGAAACGCTGCTGGTGCA
CACGGCCTTCGCCGAATTCATGCTGCCGCGCCTGGCCGAGGCCTATTGGGAAAAAGGCGTGGAGCTGCGCGGCTGCGAAC
GCGTCCGCGCCATCCTGGGCGAGCCGGTCAAGGCAGCCACCGACGAGGACTGGGCCACCGAATACCTGGCGCCGGTGCTG
GCGGTGAAGGTGGTGAAGGACATCGACGAGGCGATCGAGCACATCAACCGCTGGGGCAGCCACCACACCGACGCCATCGT
CACCGAGGACTACGGCCGCTCGCGCCGCTTCCTGCGCGAGGTGGACTCCGCCAGCGTGATGGTCAACGCCTCCACCCGCT
TCGCCGACGGCTTCGAATACGGCCTGGGCGCGGAAATCGGCATCTCCACCGACAAGATCCACGCCCGCGGCCCGGTCGGC
CTCAACGGCCTGACCAGCCAGAAGTGGATCGTGCTGGGGGATGGCCAAGTGCGCTCATGA

Upstream 100 bases:

>100_bases
CGACAATAACCAATCTACATGCCGACTGTCTCTGTTCGCAGTCGCCGCTTTGGTTTAAGCTGCAAACAATCCGAAAACGA
CAGCACCGGGGCTCTCCGTC

Downstream 100 bases:

>100_bases
TCCAATTGGCAAATGACTTTTGCGCAGGAATTCCAATAACATCAAAATGGATTAAACTCACCGATTCTTTCTTGATGAGT
ACCGTTTCTGCATGAATGCC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNVKEYMQQLGQAARKASRLLARADTNQKNAALHAIADAIVREQEALLAANRQDLDAARQAGLDDAMLDRLTLSAKGVLA
MADGLRQIAALPDPVGEIDDMCYRPSGIQLGKMRVPLGVVGIIYEARPNVTADAAGLCLKSGNATILRGGSEAFHSNQAI
AACVHEGLAAAGLPAEAVQVLATTDRAAVGELIAMPEYVDVIVPRGGKGLIARISAEARVPVIKHLDGNCHVYIDDTANP
DKAFNIALNAKTHRYGTCNTMETLLVHTAFAEFMLPRLAEAYWEKGVELRGCERVRAILGEPVKAATDEDWATEYLAPVL
AVKVVKDIDEAIEHINRWGSHHTDAIVTEDYGRSRRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVG
LNGLTSQKWIVLGDGQVRS

Sequences:

>Translated_419_residues
MNVKEYMQQLGQAARKASRLLARADTNQKNAALHAIADAIVREQEALLAANRQDLDAARQAGLDDAMLDRLTLSAKGVLA
MADGLRQIAALPDPVGEIDDMCYRPSGIQLGKMRVPLGVVGIIYEARPNVTADAAGLCLKSGNATILRGGSEAFHSNQAI
AACVHEGLAAAGLPAEAVQVLATTDRAAVGELIAMPEYVDVIVPRGGKGLIARISAEARVPVIKHLDGNCHVYIDDTANP
DKAFNIALNAKTHRYGTCNTMETLLVHTAFAEFMLPRLAEAYWEKGVELRGCERVRAILGEPVKAATDEDWATEYLAPVL
AVKVVKDIDEAIEHINRWGSHHTDAIVTEDYGRSRRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVG
LNGLTSQKWIVLGDGQVRS
>Mature_419_residues
MNVKEYMQQLGQAARKASRLLARADTNQKNAALHAIADAIVREQEALLAANRQDLDAARQAGLDDAMLDRLTLSAKGVLA
MADGLRQIAALPDPVGEIDDMCYRPSGIQLGKMRVPLGVVGIIYEARPNVTADAAGLCLKSGNATILRGGSEAFHSNQAI
AACVHEGLAAAGLPAEAVQVLATTDRAAVGELIAMPEYVDVIVPRGGKGLIARISAEARVPVIKHLDGNCHVYIDDTANP
DKAFNIALNAKTHRYGTCNTMETLLVHTAFAEFMLPRLAEAYWEKGVELRGCERVRAILGEPVKAATDEDWATEYLAPVL
AVKVVKDIDEAIEHINRWGSHHTDAIVTEDYGRSRRFLREVDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVG
LNGLTSQKWIVLGDGQVRS

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=421, Percent_Identity=37.5296912114014, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI21361368, Length=421, Percent_Identity=37.5296912114014, Blast_Score=276, Evalue=4e-74,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=46.875, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17569969, Length=423, Percent_Identity=35.2245862884161, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17569967, Length=423, Percent_Identity=35.2245862884161, Blast_Score=261, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=433, Percent_Identity=39.7228637413395, Blast_Score=305, Evalue=1e-83,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=39.0663390663391, Blast_Score=271, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CHRVO (Q7NQ51)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903959.1
- ProteinModelPortal:   Q7NQ51
- SMR:   Q7NQ51
- GeneID:   2549610
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4289
- NMPDR:   fig|243365.1.peg.4289
- HOGENOM:   HBG318080
- OMA:   GICGAME
- PhylomeDB:   Q7NQ51
- ProtClustDB:   PRK00197
- BioCyc:   CVIO243365:CV_4289-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45048; Mature: 45048

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVKEYMQQLGQAARKASRLLARADTNQKNAALHAIADAIVREQEALLAANRQDLDAARQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGLDDAMLDRLTLSAKGVLAMADGLRQIAALPDPVGEIDDMCYRPSGIQLGKMRVPLGVV
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEECEEECCEEEE
GIIYEARPNVTADAAGLCLKSGNATILRGGSEAFHSNQAIAACVHEGLAAAGLPAEAVQV
EEEEECCCCCCCCCCCEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHH
LATTDRAAVGELIAMPEYVDVIVPRGGKGLIARISAEARVPVIKHLDGNCHVYIDDTANP
HHHCCHHHHHHHHCCCCHHEEEECCCCCCEEEEECCCCCCCHHEECCCCEEEEECCCCCC
DKAFNIALNAKTHRYGTCNTMETLLVHTAFAEFMLPRLAEAYWEKGVELRGCERVRAILG
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
EPVKAATDEDWATEYLAPVLAVKVVKDIDEAIEHINRWGSHHTDAIVTEDYGRSRRFLRE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
VDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLNGLTSQKWIVLGDGQVRS
CCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MNVKEYMQQLGQAARKASRLLARADTNQKNAALHAIADAIVREQEALLAANRQDLDAARQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGLDDAMLDRLTLSAKGVLAMADGLRQIAALPDPVGEIDDMCYRPSGIQLGKMRVPLGVV
CCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEECEEECCEEEE
GIIYEARPNVTADAAGLCLKSGNATILRGGSEAFHSNQAIAACVHEGLAAAGLPAEAVQV
EEEEECCCCCCCCCCCEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHH
LATTDRAAVGELIAMPEYVDVIVPRGGKGLIARISAEARVPVIKHLDGNCHVYIDDTANP
HHHCCHHHHHHHHCCCCHHEEEECCCCCCEEEEECCCCCCCHHEECCCCEEEEECCCCCC
DKAFNIALNAKTHRYGTCNTMETLLVHTAFAEFMLPRLAEAYWEKGVELRGCERVRAILG
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
EPVKAATDEDWATEYLAPVLAVKVVKDIDEAIEHINRWGSHHTDAIVTEDYGRSRRFLRE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHH
VDSASVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLNGLTSQKWIVLGDGQVRS
CCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14500782