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The map label for this gene is bioA [H]

Identifier: 34499665

GI number: 34499665

Start: 4543394

End: 4544740

Strand: Direct

Name: bioA [H]

Synonym: CV_4210

Alternate gene names: 34499665

Gene position: 4543394-4544740 (Clockwise)

Preceding gene: 34499661

Following gene: 34499666

Centisome position: 95.63

GC content: 66.37

Gene sequence:

>1347_bases
ATGAGCAACCAAGCCTGGCTGGAACGCAGTTTCGCCGCCGTCTGGCATCCCTGCACCCAGATGAAGCGCCATGAGAGGCT
GCCCATCGTGCCGATCGCCTCGGCGGACGGCGTCTGGCTGACCGACTTCGACGGCAAGCGCTACCTGGACGGCGTCAGCT
CCTGGTGGGTGAACCTGTTCGGCCACGGCCATCCGCGCATCAAGCAGGCAGTGCGCAAGCAACTGGACAGCTTGGAGCAT
GTGATGCTGGCCGGCTTCACCCACCGCCCGGTGGTGGAGCTGTCCGAGCGCCTCGCGGCGCTGTCCGGCCTAGGCCACGC
CTTCTACGGCTCCGACGGCGCCAGCGCCACCGAAATCGCGCTGAAGATGAGCTTCCATTACTGGAAGAACGTAGGCCGGC
CGCAAAAGACCCGCTTCGTCAGCCTGGAAAACAGCTACCACGGCGAGACCGTCGGCGCGCTGGCGGTCACCGATGTGCCG
CTGTTCTCGTCCACCTACGCCGAGCTGCTGAAGCCGGGCCTGCGCGCGCCATCGCCTGACGCCCGGCAAGCCGTACCAGG
CGAGCGCGCCGCCGACGTCGCGCTGCGCGCCGCCCGCTCGCTGGAAAACCTGCTGGCCAAGCATGGCGGCGAGATCGCAG
CGGTGATCGTCGAGCCGCTGGTCCAGGGCGCCGCCGGCATGGCGATGCACGACCCGATCTACCTGACCGAGCTGCGCCGG
CTGTGCGACCAATACCAGGTCCATCTGATCGCGGACGAAATCGCCGTCGGCTTCGGCCGCACCGGCAGTTTCTTCGCCTA
TCAGCAGGCCGGCATCACACCGGATTTCCTCTGTCTGTCCAAAGGCATCACCGGCGGCTTCCTGCCGCTGTCCTGCGTGC
TGACCCGCGACGAAATCTACCAGGCCTTCTACCACGACGACGTGGCGCGCGGCTTCCTGCATTCGCACAGCTATACCGGC
AACGCGCTCGCCTGCGCGGCGGCGCTGGCGGTGCTGGACATCTTCGACGACGAAGACGTGCTGGAGGCCAACCGCGTCAA
GGCCGAGGGATTCACCCGGCAAATGCGCCCGCTGGCCGAGCGGCCCGAGATCCGCCATTTCCGCCAGCGCGGCATGATCT
GGGCCTTCGACGTCGATACGGCGCGTTCCGACTTTGCATTGGCCTATTTTTCGGCCATGCTGAATCGCGGATGCCTGTTG
CGGCCGATAGGAAAGTCGGTCTATTTCATGCCGCCGTACACACTGAAATCCGAAGAGATGGACTGGCTGGCATCGGCCAG
CGTCGACGCGCTGGACGAGGTGCTGGCCGGAGAGAGCGTCGGCGGCGATCCGACCGCGCTGCCCTGA

Upstream 100 bases:

>100_bases
CTTGTCAGCATAGGTCAGAAACTGCCGTTTTTCGTCACCCGGACTGCCCGTTCGGACTGTGCTAGCATCGCTTTCCCACC
CGCGACACAGGAGCCGCCTC

Downstream 100 bases:

>100_bases
GCCGGCGGCGTTCCATTCCCTTCCTTAGCGCCCGTCTCGGAGCCCTGTCCGGATGCCACCACTCGTTTTGCCGAAGAAGG
ATATGGACCCGCAACTCGTC

Product: adenosylmethionine-8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSNQAWLERSFAAVWHPCTQMKRHERLPIVPIASADGVWLTDFDGKRYLDGVSSWWVNLFGHGHPRIKQAVRKQLDSLEH
VMLAGFTHRPVVELSERLAALSGLGHAFYGSDGASATEIALKMSFHYWKNVGRPQKTRFVSLENSYHGETVGALAVTDVP
LFSSTYAELLKPGLRAPSPDARQAVPGERAADVALRAARSLENLLAKHGGEIAAVIVEPLVQGAAGMAMHDPIYLTELRR
LCDQYQVHLIADEIAVGFGRTGSFFAYQQAGITPDFLCLSKGITGGFLPLSCVLTRDEIYQAFYHDDVARGFLHSHSYTG
NALACAAALAVLDIFDDEDVLEANRVKAEGFTRQMRPLAERPEIRHFRQRGMIWAFDVDTARSDFALAYFSAMLNRGCLL
RPIGKSVYFMPPYTLKSEEMDWLASASVDALDEVLAGESVGGDPTALP

Sequences:

>Translated_448_residues
MSNQAWLERSFAAVWHPCTQMKRHERLPIVPIASADGVWLTDFDGKRYLDGVSSWWVNLFGHGHPRIKQAVRKQLDSLEH
VMLAGFTHRPVVELSERLAALSGLGHAFYGSDGASATEIALKMSFHYWKNVGRPQKTRFVSLENSYHGETVGALAVTDVP
LFSSTYAELLKPGLRAPSPDARQAVPGERAADVALRAARSLENLLAKHGGEIAAVIVEPLVQGAAGMAMHDPIYLTELRR
LCDQYQVHLIADEIAVGFGRTGSFFAYQQAGITPDFLCLSKGITGGFLPLSCVLTRDEIYQAFYHDDVARGFLHSHSYTG
NALACAAALAVLDIFDDEDVLEANRVKAEGFTRQMRPLAERPEIRHFRQRGMIWAFDVDTARSDFALAYFSAMLNRGCLL
RPIGKSVYFMPPYTLKSEEMDWLASASVDALDEVLAGESVGGDPTALP
>Mature_447_residues
SNQAWLERSFAAVWHPCTQMKRHERLPIVPIASADGVWLTDFDGKRYLDGVSSWWVNLFGHGHPRIKQAVRKQLDSLEHV
MLAGFTHRPVVELSERLAALSGLGHAFYGSDGASATEIALKMSFHYWKNVGRPQKTRFVSLENSYHGETVGALAVTDVPL
FSSTYAELLKPGLRAPSPDARQAVPGERAADVALRAARSLENLLAKHGGEIAAVIVEPLVQGAAGMAMHDPIYLTELRRL
CDQYQVHLIADEIAVGFGRTGSFFAYQQAGITPDFLCLSKGITGGFLPLSCVLTRDEIYQAFYHDDVARGFLHSHSYTGN
ALACAAALAVLDIFDDEDVLEANRVKAEGFTRQMRPLAERPEIRHFRQRGMIWAFDVDTARSDFALAYFSAMLNRGCLLR
PIGKSVYFMPPYTLKSEEMDWLASASVDALDEVLAGESVGGDPTALP

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=27.4111675126904, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI13994255, Length=332, Percent_Identity=29.8192771084337, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI37574042, Length=427, Percent_Identity=26.2295081967213, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI284507298, Length=211, Percent_Identity=31.7535545023697, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI226442705, Length=427, Percent_Identity=25.7611241217799, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI226442709, Length=397, Percent_Identity=26.1964735516373, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI24119277, Length=320, Percent_Identity=26.5625, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI188536080, Length=425, Percent_Identity=23.7647058823529, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI38679950, Length=425, Percent_Identity=23.7647058823529, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI38679946, Length=425, Percent_Identity=23.7647058823529, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786991, Length=423, Percent_Identity=38.0614657210402, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI145693181, Length=400, Percent_Identity=29.75, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1789759, Length=394, Percent_Identity=28.9340101522843, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788044, Length=334, Percent_Identity=29.3413173652695, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789016, Length=348, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1787560, Length=413, Percent_Identity=28.3292978208232, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1786349, Length=303, Percent_Identity=29.042904290429, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=24.1545893719807, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=428, Percent_Identity=25, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25144274, Length=292, Percent_Identity=24.6575342465753, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71992977, Length=434, Percent_Identity=26.036866359447, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=455, Percent_Identity=29.8901098901099, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323470, Length=423, Percent_Identity=27.8959810874704, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=408, Percent_Identity=27.9411764705882, Blast_Score=129, Evalue=8e-31,
Organism=Drosophila melanogaster, GI21357415, Length=401, Percent_Identity=25.6857855361596, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=25, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574759, Length=395, Percent_Identity=26.8354430379747, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356575, Length=359, Percent_Identity=27.5766016713092, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49384; Mature: 49253

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQAWLERSFAAVWHPCTQMKRHERLPIVPIASADGVWLTDFDGKRYLDGVSSWWVNLF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHH
GHGHPRIKQAVRKQLDSLEHVMLAGFTHRPVVELSERLAALSGLGHAFYGSDGASATEIA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHH
LKMSFHYWKNVGRPQKTRFVSLENSYHGETVGALAVTDVPLFSSTYAELLKPGLRAPSPD
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCC
ARQAVPGERAADVALRAARSLENLLAKHGGEIAAVIVEPLVQGAAGMAMHDPIYLTELRR
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHH
LCDQYQVHLIADEIAVGFGRTGSFFAYQQAGITPDFLCLSKGITGGFLPLSCVLTRDEIY
HHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHHCCCCCCCCHHHEEEEHHHHH
QAFYHDDVARGFLHSHSYTGNALACAAALAVLDIFDDEDVLEANRVKAEGFTRQMRPLAE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
RPEIRHFRQRGMIWAFDVDTARSDFALAYFSAMLNRGCLLRPIGKSVYFMPPYTLKSEEM
CHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCH
DWLASASVDALDEVLAGESVGGDPTALP
HHHHHCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SNQAWLERSFAAVWHPCTQMKRHERLPIVPIASADGVWLTDFDGKRYLDGVSSWWVNLF
CCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCHHHHHHHHHHHHHHH
GHGHPRIKQAVRKQLDSLEHVMLAGFTHRPVVELSERLAALSGLGHAFYGSDGASATEIA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHH
LKMSFHYWKNVGRPQKTRFVSLENSYHGETVGALAVTDVPLFSSTYAELLKPGLRAPSPD
HHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCC
ARQAVPGERAADVALRAARSLENLLAKHGGEIAAVIVEPLVQGAAGMAMHDPIYLTELRR
HHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHH
LCDQYQVHLIADEIAVGFGRTGSFFAYQQAGITPDFLCLSKGITGGFLPLSCVLTRDEIY
HHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCHHHHHHHCCCCCCCCHHHEEEEHHHHH
QAFYHDDVARGFLHSHSYTGNALACAAALAVLDIFDDEDVLEANRVKAEGFTRQMRPLAE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHC
RPEIRHFRQRGMIWAFDVDTARSDFALAYFSAMLNRGCLLRPIGKSVYFMPPYTLKSEEM
CHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCH
DWLASASVDALDEVLAGESVGGDPTALP
HHHHHCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]