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The map label for this gene is glsA

Identifier: 34499613

GI number: 34499613

Start: 4500580

End: 4501494

Strand: Direct

Name: glsA

Synonym: CV_4158

Alternate gene names: 34499613

Gene position: 4500580-4501494 (Clockwise)

Preceding gene: 34499612

Following gene: 34499658

Centisome position: 94.73

GC content: 66.78

Gene sequence:

>915_bases
ATGAATCTGCAAGCGCTCATTGAAGATATCCGGCAGCAAGTGCTGCCTTTCTACGACCAGGGCCGGGTGGCCGACTACAT
CCCGGCGCTGGCCTCGGTGCCGCCGCATCAGTTCGGCATCGCCATCCACACGCTGGACGGCCGCGAACACGCCTGCGGCG
ATGCCGACACTCCCTTCTCCATCCAGAGCATCAGCAAGGCCTTCATGCTGGCGCTGACGCTGCAGGCCGACGGCGAGCAA
CTGTGGCGCCACGTCGGCAAGGAGCCTTCCGGCAACCCGTTCAACTCGCTGGTGCAGCTGGAGTACGAGCACGGCATCCC
GCGCAATCCCTTCATCAACGCCGGCGCCCTGGTCGTCACCGACCGCGCGATCGGCCATTTCGGCGATGCCCACGCCCGGC
TGCTGGCCTGGCTGCGCGAAGAGACCGGCAACGCCGGCCTGATGGCCGACCAAGCCATCGCCGCTTCCGAACGCGCGCAC
GGCGACCGCAACGCGGCGCTCGCCCATTTCATGAAGAGCTACGGCAACCTCGGCCACCCGGTGGAAACCGTGCTGGACCA
GTATTTTCACAACTGCAGCATCGCGATGAGCTGCCGCGAACTGGCCCGCGCCGGCCTGTTCCTAGCCAATCACGGCCTGT
CGCCTCAAACCGGAACACAGTACCTGAGCCGCAGCCAGGCCAAACAGGTGAACGCCGTCATGCTGACCTGCGGCACCTAT
GACGCCGCCGGCGAATTCGCCTACCGCGTCGGCCTGCCGGTGAAGAGCGGCGTCGGCGGCGGCCTGCTGGCGGTGATTCC
CGGCAAGATGGCCATCGCCGCGTGGAGCCCGCAACTGGACGCGCGCGGCAACTCGGTGCTGGGCCTGGAGGCGTTGGATC
GCTTCACCACGCGCACCGGGCTCTCCATCTTCTAG

Upstream 100 bases:

>100_bases
TCGCAACGAGGGCGTGCTGGAGCTGGGCGCGCCGGTCGAAGTGCTGGAGCAGCGCTACAGCTTCTAGACTGCCCCCGCCG
CGCATGCTTACAATCGCTGA

Downstream 100 bases:

>100_bases
ATGCGGCGAAGCCGGGTTCGCCAACGCCAACCCGGCTGTTCAAGACATGAAAAAAGCCAGCTCCTGAGAGCTGGCTTTTT
CTTTCAACTGCGTCGATTAC

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNLQALIEDIRQQVLPFYDQGRVADYIPALASVPPHQFGIAIHTLDGREHACGDADTPFSIQSISKAFMLALTLQADGEQ
LWRHVGKEPSGNPFNSLVQLEYEHGIPRNPFINAGALVVTDRAIGHFGDAHARLLAWLREETGNAGLMADQAIAASERAH
GDRNAALAHFMKSYGNLGHPVETVLDQYFHNCSIAMSCRELARAGLFLANHGLSPQTGTQYLSRSQAKQVNAVMLTCGTY
DAAGEFAYRVGLPVKSGVGGGLLAVIPGKMAIAAWSPQLDARGNSVLGLEALDRFTTRTGLSIF

Sequences:

>Translated_304_residues
MNLQALIEDIRQQVLPFYDQGRVADYIPALASVPPHQFGIAIHTLDGREHACGDADTPFSIQSISKAFMLALTLQADGEQ
LWRHVGKEPSGNPFNSLVQLEYEHGIPRNPFINAGALVVTDRAIGHFGDAHARLLAWLREETGNAGLMADQAIAASERAH
GDRNAALAHFMKSYGNLGHPVETVLDQYFHNCSIAMSCRELARAGLFLANHGLSPQTGTQYLSRSQAKQVNAVMLTCGTY
DAAGEFAYRVGLPVKSGVGGGLLAVIPGKMAIAAWSPQLDARGNSVLGLEALDRFTTRTGLSIF
>Mature_304_residues
MNLQALIEDIRQQVLPFYDQGRVADYIPALASVPPHQFGIAIHTLDGREHACGDADTPFSIQSISKAFMLALTLQADGEQ
LWRHVGKEPSGNPFNSLVQLEYEHGIPRNPFINAGALVVTDRAIGHFGDAHARLLAWLREETGNAGLMADQAIAASERAH
GDRNAALAHFMKSYGNLGHPVETVLDQYFHNCSIAMSCRELARAGLFLANHGLSPQTGTQYLSRSQAKQVNAVMLTCGTY
DAAGEFAYRVGLPVKSGVGGGLLAVIPGKMAIAAWSPQLDARGNSVLGLEALDRFTTRTGLSIF

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=274, Percent_Identity=40.5109489051095, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI20336214, Length=285, Percent_Identity=35.7894736842105, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1787804, Length=301, Percent_Identity=52.1594684385382, Blast_Score=312, Evalue=1e-86,
Organism=Escherichia coli, GI1786693, Length=285, Percent_Identity=37.5438596491228, Blast_Score=178, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17507019, Length=302, Percent_Identity=36.0927152317881, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17532727, Length=278, Percent_Identity=38.8489208633094, Blast_Score=189, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193204073, Length=308, Percent_Identity=37.012987012987, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI193204075, Length=310, Percent_Identity=36.7741935483871, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI281363241, Length=305, Percent_Identity=38.0327868852459, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24653162, Length=291, Percent_Identity=38.4879725085911, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI281363239, Length=291, Percent_Identity=38.4879725085911, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24653166, Length=291, Percent_Identity=38.4879725085911, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI116008307, Length=291, Percent_Identity=38.4879725085911, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24653164, Length=291, Percent_Identity=38.4879725085911, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24653156, Length=291, Percent_Identity=38.4879725085911, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24653158, Length=291, Percent_Identity=38.4879725085911, Blast_Score=195, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_CHRVO (Q7NQH9)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903828.1
- ProteinModelPortal:   Q7NQH9
- SMR:   Q7NQH9
- GeneID:   2549795
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4158
- NMPDR:   fig|243365.1.peg.4158
- HOGENOM:   HBG512335
- OMA:   NALMLTC
- PhylomeDB:   Q7NQH9
- ProtClustDB:   PRK00971
- BioCyc:   CVIO243365:CV_4158-MONOMER
- BRENDA:   3.5.1.2
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 32748; Mature: 32748

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQALIEDIRQQVLPFYDQGRVADYIPALASVPPHQFGIAIHTLDGREHACGDADTPFS
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHCEEEEEECCCCCCCCCCCCCCH
IQSISKAFMLALTLQADGEQLWRHVGKEPSGNPFNSLVQLEYEHGIPRNPFINAGALVVT
HHHHHHHHHHHEEEECCHHHHHHHHCCCCCCCCHHHHEEEEHHCCCCCCCCCCCCEEEEE
DRAIGHFGDAHARLLAWLREETGNAGLMADQAIAASERAHGDRNAALAHFMKSYGNLGHP
CCHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCH
VETVLDQYFHNCSIAMSCRELARAGLFLANHGLSPQTGTQYLSRSQAKQVNAVMLTCGTY
HHHHHHHHHHCCHHHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCC
DAAGEFAYRVGLPVKSGVGGGLLAVIPGKMAIAAWSPQLDARGNSVLGLEALDRFTTRTG
CCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEHHHHHHHHHCCC
LSIF
CCCC
>Mature Secondary Structure
MNLQALIEDIRQQVLPFYDQGRVADYIPALASVPPHQFGIAIHTLDGREHACGDADTPFS
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHCEEEEEECCCCCCCCCCCCCCH
IQSISKAFMLALTLQADGEQLWRHVGKEPSGNPFNSLVQLEYEHGIPRNPFINAGALVVT
HHHHHHHHHHHEEEECCHHHHHHHHCCCCCCCCHHHHEEEEHHCCCCCCCCCCCCEEEEE
DRAIGHFGDAHARLLAWLREETGNAGLMADQAIAASERAHGDRNAALAHFMKSYGNLGHP
CCHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCH
VETVLDQYFHNCSIAMSCRELARAGLFLANHGLSPQTGTQYLSRSQAKQVNAVMLTCGTY
HHHHHHHHHHCCHHHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCC
DAAGEFAYRVGLPVKSGVGGGLLAVIPGKMAIAAWSPQLDARGNSVLGLEALDRFTTRTG
CCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEHHHHHHHHHCCC
LSIF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782