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The map label for this gene is ttcA

Identifier: 34499586

GI number: 34499586

Start: 4471063

End: 4472022

Strand: Reverse

Name: ttcA

Synonym: CV_4131

Alternate gene names: 34499586

Gene position: 4472022-4471063 (Counterclockwise)

Preceding gene: 34499587

Following gene: 34499585

Centisome position: 94.13

GC content: 62.92

Gene sequence:

>960_bases
CTGAACGCCGCGCTCGACGACAAGGCCGCCAAGAAGGCCGCGTTTGAAGGCAACAAACTGGCCAAGCGCCTGCGCCACCA
CGTTGGTGACGCCATCAATGATTTCAACATGATCGAAGAGGGCGACCGGGTGATGGTCTGCCTGTCGGGCGGCAAGGACA
GCTATACCTTGCTGGACATCCTGCGGGGCCTGCAGAAGTCCGCGCCGATCAACTTCTCCATCGTCGCGGTCAACCTGGAC
CAGAAGCAGCCGGGCTTCCCCGAGCACGTGCTGCCGGAGTATCTCAAGTCCATCGGCGTGGAGTACCGCATCGTCGAGGA
AGACACCTACTCCATCGTCAAGCGGCTGGTGCCGGAAGGCAAGACCACCTGCAGCCTGTGCTCGCGCCTGCGCCGCGGCA
TCCTGTACCGCGTGGCCGACGAATTGGGCGCCACCAAGATCGCGCTGGGCCACCACCGCGACGACATCCTGCACACGCTG
TTCCTGAACATGTTCTACGGCGGCAAGATGAAGGCGATGCCGCCCAAGCTGGTGTCCGACGACGGCCGCCACATGGTGAT
CCGCCCGCTGGCTTACTGCCGCGAGAAGGACATCATCCGCTACGCCGATTGGAAAGCCTTCCCGATCATTCCGTGCAATC
TGTGCGGCTCGCAGCCCAATCTGCAGCGCCAGGTGGTGAAGGAAATGGTCAATGACTGGGACAAGCGTTTCCCCGGCCGC
GTCGAGAGCATGTTCCGCGCGCTGCAGAACGTGGTTCCGTCGCATCTGGCTGATCCGAAGCTGTTCGACTTTGTCGGTTT
GCAGACCGGCGACGCGCCGTTCGCCGATGGAGACACCGCCTTCGACAAGGAGGAATTCCGCGATCCGGCGCCGGACGCGG
ACGATGTGGAGGACGCGCCGAAAAAACGCACCATCAGCATTCTGGATTCGCGCGGCAAGGAGAGCGGCTGTGGCGCGTAG

Upstream 100 bases:

>100_bases
CAGCATCGTGTTGTAGGCGCTTTCCGCCGCCATGGCTTTTGGCGGCGGGAGGGGGTAAAATCGCCTGTTTTTCAATTTCT
TAGCCGTACCCATGTCCGAA

Downstream 100 bases:

>100_bases
GGCGCTGCATCCGTTCCGCCGCCGCGTGCGGCCGGCGGTGGAGGCGATGCCGGAGGTTGAGATCTCGGAAGAGGGCAACA
TCCGCTCGCTGCACTTGGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNAALDDKAAKKAAFEGNKLAKRLRHHVGDAINDFNMIEEGDRVMVCLSGGKDSYTLLDILRGLQKSAPINFSIVAVNLD
QKQPGFPEHVLPEYLKSIGVEYRIVEEDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVADELGATKIALGHHRDDILHTL
FLNMFYGGKMKAMPPKLVSDDGRHMVIRPLAYCREKDIIRYADWKAFPIIPCNLCGSQPNLQRQVVKEMVNDWDKRFPGR
VESMFRALQNVVPSHLADPKLFDFVGLQTGDAPFADGDTAFDKEEFRDPAPDADDVEDAPKKRTISILDSRGKESGCGA

Sequences:

>Translated_319_residues
MNAALDDKAAKKAAFEGNKLAKRLRHHVGDAINDFNMIEEGDRVMVCLSGGKDSYTLLDILRGLQKSAPINFSIVAVNLD
QKQPGFPEHVLPEYLKSIGVEYRIVEEDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVADELGATKIALGHHRDDILHTL
FLNMFYGGKMKAMPPKLVSDDGRHMVIRPLAYCREKDIIRYADWKAFPIIPCNLCGSQPNLQRQVVKEMVNDWDKRFPGR
VESMFRALQNVVPSHLADPKLFDFVGLQTGDAPFADGDTAFDKEEFRDPAPDADDVEDAPKKRTISILDSRGKESGCGA
>Mature_319_residues
MNAALDDKAAKKAAFEGNKLAKRLRHHVGDAINDFNMIEEGDRVMVCLSGGKDSYTLLDILRGLQKSAPINFSIVAVNLD
QKQPGFPEHVLPEYLKSIGVEYRIVEEDTYSIVKRLVPEGKTTCSLCSRLRRGILYRVADELGATKIALGHHRDDILHTL
FLNMFYGGKMKAMPPKLVSDDGRHMVIRPLAYCREKDIIRYADWKAFPIIPCNLCGSQPNLQRQVVKEMVNDWDKRFPGR
VESMFRALQNVVPSHLADPKLFDFVGLQTGDAPFADGDTAFDKEEFRDPAPDADDVEDAPKKRTISILDSRGKESGCGA

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=281, Percent_Identity=76.5124555160142, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI193211090, Length=228, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17540090, Length=264, Percent_Identity=25.7575757575758, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24651972, Length=224, Percent_Identity=29.0178571428571, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_CHRVO (Q7NQK6)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903801.1
- ProteinModelPortal:   Q7NQK6
- GeneID:   2549656
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4131
- NMPDR:   fig|243365.1.peg.4131
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- PhylomeDB:   Q7NQK6
- BioCyc:   CVIO243365:CV_4131-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 35721; Mature: 35721

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAALDDKAAKKAAFEGNKLAKRLRHHVGDAINDFNMIEEGDRVMVCLSGGKDSYTLLDI
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
LRGLQKSAPINFSIVAVNLDQKQPGFPEHVLPEYLKSIGVEYRIVEEDTYSIVKRLVPEG
HHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCC
KTTCSLCSRLRRGILYRVADELGATKIALGHHRDDILHTLFLNMFYGGKMKAMPPKLVSD
CHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
DGRHMVIRPLAYCREKDIIRYADWKAFPIIPCNLCGSQPNLQRQVVKEMVNDWDKRFPGR
CCCEEEEHHHHHHHHCCCEEECCCCCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
VESMFRALQNVVPSHLADPKLFDFVGLQTGDAPFADGDTAFDKEEFRDPAPDADDVEDAP
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHCCC
KKRTISILDSRGKESGCGA
CHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNAALDDKAAKKAAFEGNKLAKRLRHHVGDAINDFNMIEEGDRVMVCLSGGKDSYTLLDI
CCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
LRGLQKSAPINFSIVAVNLDQKQPGFPEHVLPEYLKSIGVEYRIVEEDTYSIVKRLVPEG
HHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCC
KTTCSLCSRLRRGILYRVADELGATKIALGHHRDDILHTLFLNMFYGGKMKAMPPKLVSD
CHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCC
DGRHMVIRPLAYCREKDIIRYADWKAFPIIPCNLCGSQPNLQRQVVKEMVNDWDKRFPGR
CCCEEEEHHHHHHHHCCCEEECCCCCCCCEEHHCCCCCCCHHHHHHHHHHHHHHHHCCHH
VESMFRALQNVVPSHLADPKLFDFVGLQTGDAPFADGDTAFDKEEFRDPAPDADDVEDAP
HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHCCC
KKRTISILDSRGKESGCGA
CHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782