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The map label for this gene is pth

Identifier: 34499511

GI number: 34499511

Start: 4387173

End: 4387754

Strand: Reverse

Name: pth

Synonym: CV_4056

Alternate gene names: 34499511

Gene position: 4387754-4387173 (Counterclockwise)

Preceding gene: 34499512

Following gene: 34499510

Centisome position: 92.35

GC content: 64.09

Gene sequence:

>582_bases
ATGTCCGGCATCCGCCTGATTGTCGGCCTGGGCAACCCGGGCCCCGAATACGAAAAGACGCGCCACAATGCCGGTTTCTG
GCTGGTGGACGAACTGTGCTGGCAGTTCAAGGGCAACTGGCGCAGCGAAGGCAAATTCCATGGCGATGTCGCCAGGATCC
AAATCGAAGGACAGGACGTCTGGCTGCTGAAGCCGATGACCTATATGAACCTGTCCGGCCAGGCCGTGCTGGCGCTGGCG
CATTTTTACAAGATACTGCCGGACGAGATCCTGGTCGTGCACGATGAACTGGATCTCGCGCCCGGCGTCGCCCGCTTCAA
GCAGGGCGGCGGCCACGGCGGCCACAATGGCCTGAAGGACATCGCGGCGCGTTTGAGCTCGCCGGCTTTCTGGCGCCTCC
GGCTCGGCATCGGCCATCCGGGAGACAAGAAGGAAGTAGCCAACTTCGTGCTGAAGAAGCCGCGCGCCGAGGAGCAGCAG
GCGCTGGACGAGGCCGTTCTGGCCTCGCTGCGCGAGCTGCCGCGCGCCGTTTCCGGGAAGATGGCCGAGGCGATGAAGGC
GCTGCACACCGAAGCCAAGTGA

Upstream 100 bases:

>100_bases
GTGTGTAATCCCTGCTGCCGTCGCCGCGCGCGGTGACGGTGAAAAGCCCGTTGTGCGCCCAGGTGGCGGGCAGCGGGCTT
TTTTCATTGGAATGAGCGAT

Downstream 100 bases:

>100_bases
TCGCGGGCTGGCAGTCGGACCGGCTGCCGCCATAATGGATTGAAATACGAAAGTTTAGGAAAACAGTCATGAGTCTGAAA
TGCGGTATCGTCGGCTTGCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSGIRLIVGLGNPGPEYEKTRHNAGFWLVDELCWQFKGNWRSEGKFHGDVARIQIEGQDVWLLKPMTYMNLSGQAVLALA
HFYKILPDEILVVHDELDLAPGVARFKQGGGHGGHNGLKDIAARLSSPAFWRLRLGIGHPGDKKEVANFVLKKPRAEEQQ
ALDEAVLASLRELPRAVSGKMAEAMKALHTEAK

Sequences:

>Translated_193_residues
MSGIRLIVGLGNPGPEYEKTRHNAGFWLVDELCWQFKGNWRSEGKFHGDVARIQIEGQDVWLLKPMTYMNLSGQAVLALA
HFYKILPDEILVVHDELDLAPGVARFKQGGGHGGHNGLKDIAARLSSPAFWRLRLGIGHPGDKKEVANFVLKKPRAEEQQ
ALDEAVLASLRELPRAVSGKMAEAMKALHTEAK
>Mature_192_residues
SGIRLIVGLGNPGPEYEKTRHNAGFWLVDELCWQFKGNWRSEGKFHGDVARIQIEGQDVWLLKPMTYMNLSGQAVLALAH
FYKILPDEILVVHDELDLAPGVARFKQGGGHGGHNGLKDIAARLSSPAFWRLRLGIGHPGDKKEVANFVLKKPRAEEQQA
LDEAVLASLRELPRAVSGKMAEAMKALHTEAK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=159, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=3e-17,
Organism=Escherichia coli, GI1787455, Length=187, Percent_Identity=56.1497326203209, Blast_Score=186, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_CHRVO (Q7NQT1)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903726.1
- ProteinModelPortal:   Q7NQT1
- SMR:   Q7NQT1
- GeneID:   2546932
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_4056
- NMPDR:   fig|243365.1.peg.4056
- HOGENOM:   HBG610927
- OMA:   SHAGHNG
- PhylomeDB:   Q7NQT1
- ProtClustDB:   PRK05426
- BioCyc:   CVIO243365:CV_4056-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 21367; Mature: 21236

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIRLIVGLGNPGPEYEKTRHNAGFWLVDELCWQFKGNWRSEGKFHGDVARIQIEGQDV
CCCEEEEEECCCCCCCHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCE
WLLKPMTYMNLSGQAVLALAHFYKILPDEILVVHDELDLAPGVARFKQGGGHGGHNGLKD
EEECCHHEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCHHH
IAARLSSPAFWRLRLGIGHPGDKKEVANFVLKKPRAEEQQALDEAVLASLRELPRAVSGK
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHH
MAEAMKALHTEAK
HHHHHHHHHHCCC
>Mature Secondary Structure 
SGIRLIVGLGNPGPEYEKTRHNAGFWLVDELCWQFKGNWRSEGKFHGDVARIQIEGQDV
CCEEEEEECCCCCCCHHHHCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCE
WLLKPMTYMNLSGQAVLALAHFYKILPDEILVVHDELDLAPGVARFKQGGGHGGHNGLKD
EEECCHHEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCHHH
IAARLSSPAFWRLRLGIGHPGDKKEVANFVLKKPRAEEQQALDEAVLASLRELPRAVSGK
HHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHH
MAEAMKALHTEAK
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782