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The map label for this gene is fadD [C]

Identifier: 34499506

GI number: 34499506

Start: 4381411

End: 4383174

Strand: Direct

Name: fadD [C]

Synonym: CV_4051

Alternate gene names: 34499506

Gene position: 4381411-4383174 (Clockwise)

Preceding gene: 34499505

Following gene: 34499517

Centisome position: 92.22

GC content: 66.55

Gene sequence:

>1764_bases
ATGAAGCTAGAACGCGTTTTTGACATCCTGTCCCACCAGCTGGCCAACCATCCGCGCCCGGACTGCCTGTCGGCGAAATC
CGGCAAGGCCTGGCGGCAATTGTCGACGGCCGAGGTCCGGGACACCGTCAACCGCGTCAGCCTGGGCCTGATGGAAATGG
GCATCCAGCGCGGCGACAAGGTGGCCATCGCCGCCGACAACAGCATCGAATGGGTGCTGGCGGATATCGCGCTGCAACAA
ATCGGCGCGGTCAGCGTGCCGCTGTACCCCACCATCACCCTCGATGATGCACGCTATATCCTGGCGCATGCCGAGGTCAA
GCTCGCTTTCGCCGGCAGTGCTGCATTGCAACGAAAACTGCACGAGGCATTGGGCAGGCTGTCCTGCCCGATCTACGGCC
TGGCCGACATCGACGGCGCGCCGTCCTGGCGCGAGATCGCCGAGCGCGCGCGGCCGGAACGGATGGCCGAGCTGGACGCG
CTGCGCGACGCGGTGCGCGCCGACGACGTCTATACCATCATTTACACCTCCGGCACCACCGGCCGCTCCAAGGGCGTGAT
GCTGAGCCACCGCAACGTGCTGAGCACCGTGGTGGCCACCGCCGCCTTCACCGGCCTGCCGCAGGGCCGCTGCCGCGCGC
TGAGCTTCCTGCCGCTGTCGCACATCTTCGAGCGCGCCGGCGTGTTCTACTACCTGTACAGCGGCACCGGCATCTACTTC
GCCAGCGTGGAATGCCTGTCGTCGGCGCTGGCCGACGTGAAGCCGCATACCTTCAGCTCCGTGCCGCGCGTGCTGGAGAA
GGTGCACGAGAAGCTGGTGGGCAAGGCGCGCGACCTGACCGGCGCCAAGCGCCGCATCTATCAATGGGCGCTGGCCCGCG
CCGAAAACTTCGACCCCAACCGCCGCCGCTCTCCGCTGGACGCGATCCAGCACGCGCTGGCCGACAAGCTGGTGTACAGC
AAATGGCGCGCGGCGATGGGCGGCGAGCTGATCTCCATCAATGTCGGCTCCGCCGCGCTGCAGCCGCGGCTGGCGCGCAT
GTTCTGGGCCGCCGGCATCGCCGTGGCCGAGGGCTACGGCATGACCGAGAGCTCGCCGGTGATCTCAGCCAATCCGTTCA
CCGCCCGCGGCGTGCGCATCGGCAGCGTCGGCCTGCCCCTGCCCGGCGTGGAAGTGCGCCTGGCCGACGATGGCGAGATC
CTGGTGCGCGGCGACAACGTGATGTCCGGCTACTACAAGGAGCCGGAACAGACCTCGGACGCGCTGCGCGACGGCTGGCT
GCACACCGGCGACATCGGCGTGCTGGAGGACGGCTACCTGCGCATCACCGACCGCAAGAAGGAAATGTTCAAGACCAGCA
ACGGCAAGTACATCGCGCCGCAGGCGCTGGAGAACAAGCTGAAGGAATCGGCCTTCATCGACCAGATCATGGTGGTGGGC
GACGGCCAGAAGTACGCGGCCGCGCTGATCGTGCCGCTGTTCGAGAAGCTGAAGGAATGGTGCGCCGAGCACGGCATCTC
CTACACCACCGACTGCGAAATGAGCCGCCATCCCAAGGTGGTGGAGCTGATCGACCGCGAGGTGAAGCGCTTCAACCGCT
ATTTCGGCAGCTGGGAGCACATCAAGAAGTTCTCGCTGCTGGACAAGCCGTGGTGCGTGGACGCCGGCGAGCTGGCGCCC
ACCTTGAAGCTGCGCCGCAAGGTGATCACCGAGCGCTGCCGCGCCTTGATAGACGGCATGTACGGCATGCCGGAGCCGGC
GTAA

Upstream 100 bases:

>100_bases
CAAATTGTCCTGATTTTCGCCAAGCGAGCGCCGTTTTTTACTTTACAGCGGCCGCCAATAGGGCTATTTTGCTGCGTTTC
GCATTAAAACCATCGTTTGC

Downstream 100 bases:

>100_bases
ACGAAAAGCCCCGCATCGCGGGGCTTTTTCCTATGCCAGCTGTCACGCTCAGCGCTGGTGCGCCAGGTTGAGCCGGTTTT
CCACGTGGCGCTGCAAGCGC

Product: long chain fatty-acid CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MKLERVFDILSHQLANHPRPDCLSAKSGKAWRQLSTAEVRDTVNRVSLGLMEMGIQRGDKVAIAADNSIEWVLADIALQQ
IGAVSVPLYPTITLDDARYILAHAEVKLAFAGSAALQRKLHEALGRLSCPIYGLADIDGAPSWREIAERARPERMAELDA
LRDAVRADDVYTIIYTSGTTGRSKGVMLSHRNVLSTVVATAAFTGLPQGRCRALSFLPLSHIFERAGVFYYLYSGTGIYF
ASVECLSSALADVKPHTFSSVPRVLEKVHEKLVGKARDLTGAKRRIYQWALARAENFDPNRRRSPLDAIQHALADKLVYS
KWRAAMGGELISINVGSAALQPRLARMFWAAGIAVAEGYGMTESSPVISANPFTARGVRIGSVGLPLPGVEVRLADDGEI
LVRGDNVMSGYYKEPEQTSDALRDGWLHTGDIGVLEDGYLRITDRKKEMFKTSNGKYIAPQALENKLKESAFIDQIMVVG
DGQKYAAALIVPLFEKLKEWCAEHGISYTTDCEMSRHPKVVELIDREVKRFNRYFGSWEHIKKFSLLDKPWCVDAGELAP
TLKLRRKVITERCRALIDGMYGMPEPA

Sequences:

>Translated_587_residues
MKLERVFDILSHQLANHPRPDCLSAKSGKAWRQLSTAEVRDTVNRVSLGLMEMGIQRGDKVAIAADNSIEWVLADIALQQ
IGAVSVPLYPTITLDDARYILAHAEVKLAFAGSAALQRKLHEALGRLSCPIYGLADIDGAPSWREIAERARPERMAELDA
LRDAVRADDVYTIIYTSGTTGRSKGVMLSHRNVLSTVVATAAFTGLPQGRCRALSFLPLSHIFERAGVFYYLYSGTGIYF
ASVECLSSALADVKPHTFSSVPRVLEKVHEKLVGKARDLTGAKRRIYQWALARAENFDPNRRRSPLDAIQHALADKLVYS
KWRAAMGGELISINVGSAALQPRLARMFWAAGIAVAEGYGMTESSPVISANPFTARGVRIGSVGLPLPGVEVRLADDGEI
LVRGDNVMSGYYKEPEQTSDALRDGWLHTGDIGVLEDGYLRITDRKKEMFKTSNGKYIAPQALENKLKESAFIDQIMVVG
DGQKYAAALIVPLFEKLKEWCAEHGISYTTDCEMSRHPKVVELIDREVKRFNRYFGSWEHIKKFSLLDKPWCVDAGELAP
TLKLRRKVITERCRALIDGMYGMPEPA
>Mature_587_residues
MKLERVFDILSHQLANHPRPDCLSAKSGKAWRQLSTAEVRDTVNRVSLGLMEMGIQRGDKVAIAADNSIEWVLADIALQQ
IGAVSVPLYPTITLDDARYILAHAEVKLAFAGSAALQRKLHEALGRLSCPIYGLADIDGAPSWREIAERARPERMAELDA
LRDAVRADDVYTIIYTSGTTGRSKGVMLSHRNVLSTVVATAAFTGLPQGRCRALSFLPLSHIFERAGVFYYLYSGTGIYF
ASVECLSSALADVKPHTFSSVPRVLEKVHEKLVGKARDLTGAKRRIYQWALARAENFDPNRRRSPLDAIQHALADKLVYS
KWRAAMGGELISINVGSAALQPRLARMFWAAGIAVAEGYGMTESSPVISANPFTARGVRIGSVGLPLPGVEVRLADDGEI
LVRGDNVMSGYYKEPEQTSDALRDGWLHTGDIGVLEDGYLRITDRKKEMFKTSNGKYIAPQALENKLKESAFIDQIMVVG
DGQKYAAALIVPLFEKLKEWCAEHGISYTTDCEMSRHPKVVELIDREVKRFNRYFGSWEHIKKFSLLDKPWCVDAGELAP
TLKLRRKVITERCRALIDGMYGMPEPA

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=603, Percent_Identity=30.8457711442786, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI42794760, Length=619, Percent_Identity=29.7253634894992, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI42794758, Length=619, Percent_Identity=29.7253634894992, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI42794756, Length=617, Percent_Identity=29.8217179902755, Blast_Score=230, Evalue=4e-60,
Organism=Homo sapiens, GI57165412, Length=602, Percent_Identity=30.8970099667774, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI57165410, Length=603, Percent_Identity=30.6799336650083, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI83745141, Length=605, Percent_Identity=28.7603305785124, Blast_Score=219, Evalue=8e-57,
Organism=Homo sapiens, GI27477105, Length=612, Percent_Identity=28.1045751633987, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI42794754, Length=583, Percent_Identity=26.4150943396226, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI42794752, Length=583, Percent_Identity=26.4150943396226, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI12669909, Length=624, Percent_Identity=24.1987179487179, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI4758332, Length=620, Percent_Identity=24.1935483870968, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI156151445, Length=136, Percent_Identity=33.8235294117647, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788107, Length=468, Percent_Identity=26.4957264957265, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI221142682, Length=192, Percent_Identity=26.0416666666667, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789201, Length=363, Percent_Identity=24.7933884297521, Blast_Score=73, Evalue=6e-14,
Organism=Escherichia coli, GI145693145, Length=158, Percent_Identity=32.2784810126582, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788595, Length=150, Percent_Identity=30, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17541856, Length=593, Percent_Identity=30.8600337268128, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17556552, Length=586, Percent_Identity=29.3515358361775, Blast_Score=218, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17510401, Length=586, Percent_Identity=29.6928327645051, Blast_Score=211, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI193204819, Length=622, Percent_Identity=27.8135048231511, Blast_Score=204, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI25147511, Length=594, Percent_Identity=26.7676767676768, Blast_Score=192, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17564090, Length=580, Percent_Identity=26.551724137931, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17553312, Length=606, Percent_Identity=26.0726072607261, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17558820, Length=454, Percent_Identity=27.3127753303965, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI133901848, Length=213, Percent_Identity=33.8028169014084, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=479, Percent_Identity=25.0521920668058, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17559526, Length=370, Percent_Identity=30, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17531443, Length=336, Percent_Identity=25.5952380952381, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71996755, Length=157, Percent_Identity=31.8471337579618, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320852, Length=653, Percent_Identity=26.4931087289433, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324893, Length=617, Percent_Identity=26.580226904376, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322182, Length=440, Percent_Identity=28.1818181818182, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323903, Length=443, Percent_Identity=27.9909706546275, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI281366413, Length=573, Percent_Identity=32.4607329842932, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24666501, Length=573, Percent_Identity=32.4607329842932, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24666497, Length=573, Percent_Identity=32.4607329842932, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI19921316, Length=618, Percent_Identity=28.9644012944984, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17933690, Length=617, Percent_Identity=25.9319286871961, Blast_Score=204, Evalue=2e-52,
Organism=Drosophila melanogaster, GI62471689, Length=601, Percent_Identity=26.1231281198003, Blast_Score=177, Evalue=3e-44,
Organism=Drosophila melanogaster, GI62471681, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI62471687, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24586634, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI22026970, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI62471679, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI62471683, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI62471685, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24586636, Length=601, Percent_Identity=26.1231281198003, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21355181, Length=479, Percent_Identity=23.3820459290188, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18859661, Length=486, Percent_Identity=26.7489711934156, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648260, Length=504, Percent_Identity=25.1984126984127, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653035, Length=454, Percent_Identity=24.8898678414097, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21356947, Length=170, Percent_Identity=32.9411764705882, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI161076582, Length=453, Percent_Identity=24.5033112582781, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281365686, Length=150, Percent_Identity=32, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 65024; Mature: 65024

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLERVFDILSHQLANHPRPDCLSAKSGKAWRQLSTAEVRDTVNRVSLGLMEMGIQRGDK
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VAIAADNSIEWVLADIALQQIGAVSVPLYPTITLDDARYILAHAEVKLAFAGSAALQRKL
EEEEECCCCHHHHHHHHHHHCCCEECCCEEEEEECCCEEEEEEEEEEEEECCHHHHHHHH
HEALGRLSCPIYGLADIDGAPSWREIAERARPERMAELDALRDAVRADDVYTIIYTSGTT
HHHHHHCCCCCEEECCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEEEECCCC
GRSKGVMLSHRNVLSTVVATAAFTGLPQGRCRALSFLPLSHIFERAGVFYYLYSGTGIYF
CCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHEEHHCHHHHHHHHCCEEEEEEECCEEEE
ASVECLSSALADVKPHTFSSVPRVLEKVHEKLVGKARDLTGAKRRIYQWALARAENFDPN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
RRRSPLDAIQHALADKLVYSKWRAAMGGELISINVGSAALQPRLARMFWAAGIAVAEGYG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC
MTESSPVISANPFTARGVRIGSVGLPLPGVEVRLADDGEILVRGDNVMSGYYKEPEQTSD
CCCCCCEEECCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHH
ALRDGWLHTGDIGVLEDGYLRITDRKKEMFKTSNGKYIAPQALENKLKESAFIDQIMVVG
HHHHCCEECCCCCEECCCEEEEECCHHHHHHCCCCCEECHHHHHHHHHHHHHHHHEEEEE
DGQKYAAALIVPLFEKLKEWCAEHGISYTTDCEMSRHPKVVELIDREVKRFNRYFGSWEH
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHH
IKKFSLLDKPWCVDAGELAPTLKLRRKVITERCRALIDGMYGMPEPA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLERVFDILSHQLANHPRPDCLSAKSGKAWRQLSTAEVRDTVNRVSLGLMEMGIQRGDK
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VAIAADNSIEWVLADIALQQIGAVSVPLYPTITLDDARYILAHAEVKLAFAGSAALQRKL
EEEEECCCCHHHHHHHHHHHCCCEECCCEEEEEECCCEEEEEEEEEEEEECCHHHHHHHH
HEALGRLSCPIYGLADIDGAPSWREIAERARPERMAELDALRDAVRADDVYTIIYTSGTT
HHHHHHCCCCCEEECCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCEEEEEEECCCC
GRSKGVMLSHRNVLSTVVATAAFTGLPQGRCRALSFLPLSHIFERAGVFYYLYSGTGIYF
CCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHEEHHCHHHHHHHHCCEEEEEEECCEEEE
ASVECLSSALADVKPHTFSSVPRVLEKVHEKLVGKARDLTGAKRRIYQWALARAENFDPN
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCC
RRRSPLDAIQHALADKLVYSKWRAAMGGELISINVGSAALQPRLARMFWAAGIAVAEGYG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCC
MTESSPVISANPFTARGVRIGSVGLPLPGVEVRLADDGEILVRGDNVMSGYYKEPEQTSD
CCCCCCEEECCCCCCCCEEECCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCHHHHH
ALRDGWLHTGDIGVLEDGYLRITDRKKEMFKTSNGKYIAPQALENKLKESAFIDQIMVVG
HHHHCCEECCCCCEECCCEEEEECCHHHHHHCCCCCEECHHHHHHHHHHHHHHHHEEEEE
DGQKYAAALIVPLFEKLKEWCAEHGISYTTDCEMSRHPKVVELIDREVKRFNRYFGSWEH
CCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHH
IKKFSLLDKPWCVDAGELAPTLKLRRKVITERCRALIDGMYGMPEPA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]