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The map label for this gene is FadH [H]

Identifier: 34499401

GI number: 34499401

Start: 4266172

End: 4268193

Strand: Reverse

Name: FadH [H]

Synonym: CV_3946

Alternate gene names: 34499401

Gene position: 4268193-4266172 (Counterclockwise)

Preceding gene: 34499402

Following gene: 34499400

Centisome position: 89.84

GC content: 72.9

Gene sequence:

>2022_bases
TTGCTCGGCCGGCTGTTCTCGCCCATCCGCCTGAACCGGCTGCGGCTGCCCAACCGGCTGCTGATGAGCTCGATGCACCT
CAACCTGGACGAGTGCGACGACGCCTGGCACAGGATGGCGGCGTTCTACGCGCTGCGCGCGCGCGAGGGCGTCGGCCTGA
TCGTCAGCGCCGGCTGCGCGCCGGACGAGGCCGGCAAGACCACCCAGGGGGGCTTCGCCCTGTGTCGCGACGACGAAATC
GCCGGGCATCGGCTGATCACCGGCGCGGTGCACGAGGCCGGCGGCCGCATCGCGCTGCAGATCCTGCATTTCGGCCGCGA
GGCCTTTCACGGCGGCATGGTGTCGTCGTCGGCCGAGCGGCTGCCGTCCAGCGTGTTCACGCCCAGGCCGCTGAGCGAGG
CCGAGATCCAGGCGACCATCGCCGCCCACGCCGATTGCGCGGCCCGCGCCGTCGCCGCCGGCTACGACGCGATCGAGCTG
CTGTTCGGCCAGGGCTTCCTGGTGCACCAATTCCTGGCCCCGGCTTGCAATAAGCGGACCGACCGCTGGGGAGGCGGCTT
CGACAACCGCGCGCGGCTGGCGGTGGAGATCGCCGCCGCGGTGCGCCGCCGCGTCGGCGCGGATTTTCCGCTGATCTTCC
GCCTGCCCTGCATGGACCTGCTGCCGGACGGGCTGGGCGCCGAGGAGTCGATGGCGCTGATCGGCAAGCTGCTGCCCTAC
GGCATCGACCTGCTCAACGTCAGCATAGGCTGGCACGAATCCGAGGTGCCGACGATCGCGGCGGCGGTGCCGCGCGCGGC
TTTCGCCGACGCCGCCCGGCTGGCGCGGCGTCGCTATCCGCAGCTGAAGCTGGCCGTCAGCAACCGCGTCAACGACCCGC
GCGACGGCGAAGCGCTGCTATTGGACGGCTGCGCCGATGTGATCGCGATGGCGCGCCCCTTTCTGGCCGACCCGGCGCTG
GCCAGCAAGGCCGAAAGCAACCGTTTCGACGAGATCAACGCCTGCATCGCCTGCAACCAGCGCTGTCTGGACCACGTGCT
GACTGGCCAGCCGGTCGGCTGCAGCGTCAATCCGGATTGCGGGCTGCCGGACGAAGGCCGCTATCCGCCGCTGCCGCGCG
CGATGGAGGTGGCGGTGGCCGGCGGCGGCATCAGCGGCATGGGCGCGGCCCTGTTCCTGGCGCGGCGCGGCGCGCGGGTG
ACGCTGTTTGAGGCCGGGGACGAACTGGGCGGCCAGTTGCGCCTGGCGGCGCGCATTCCGCAAAAGGAGGAGTTCGCCGC
CACCATCCGCCATTACCGCGGCGAGCTGCTGCGCGCGGGCGTGGCGGTGCGGCTGGGCTGCCGTTTCGACGCGCGCGCGC
TCGACGGCGCGCGTTGGGACCACGTGGTGCTGGCGCAGGGCGCCGCGCCGCGCCGGCCGGAAGGCGTGCCGGGGCTGGAG
CTGCCGCATGTGCGGGACTATGCCGAGGTGCTGGAGCAGGGCTGTCCGGTGGCGTTTCCGGTGGTGGTGATCGGCGGGGG
AGGCATCGCCTGCGACCTGGCGAAATACCTGGCAGCCAAGCGCGGCAAGCTGACCCGCGATGCGCGCGCCTATCTGGCGC
GGCATTTGCCGGCGGAGGCGCTGGCGCCGTACCTGGACGGCGGCGCGGACGACGAGGCGCCGGCGATCACGCTGCTGCAG
CGTTCCGGCCGCAAGTTCGCCCACCGCGTCGGCCGCACCACGCGCTGGATATTGATGGACGCGCTACGCCGCGACGGCGT
GCGCTTGCTGGGCCGGGTCGAAGTCGTCGAGATCACCGGCGACGCGGTGATCGTGCGCGAGCGCGGCGGCGCGGCGCGCA
GCCTGCCGGCGCGCAGCGTGGTGATCGCCGCCGGCCAGACGCCGCGGCCGGGGCCGGAGGAGGCGCTGAGGCGGGCCGGC
ATTCCCTGCACCGTGCTGGGGGCGGCCGACGGCGGCGTCTTGGGCGTCAATCTGGCCGCCGCGCTGCAGGCGGCCTACCG
CTTTGCGATGGAGCTCAGATGA

Upstream 100 bases:

>100_bases
GTGGCGCAGACCGTCGGCTTCCTGTGCTCGGGCGCGGCCAGCTATATCACCGGCCATGTGCTGGTCGTCGACGGAGGGCT
GTGTGCCTGAAGCCAGACCC

Downstream 100 bases:

>100_bases
ACACGATGAAGGCGGTGGTATGGGACGGGCCGCAACGGCTGAGGCTGGCGATGCTGCCGCGGCCGGCGCTGTTGGCGCCG
GACGATGCGCTGCTCAGGGT

Product: 2,4-dienoyl-CoA reductase

Products: NA

Alternate protein names: 2,4-dienoyl coenzyme A reductase [H]

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MLGRLFSPIRLNRLRLPNRLLMSSMHLNLDECDDAWHRMAAFYALRAREGVGLIVSAGCAPDEAGKTTQGGFALCRDDEI
AGHRLITGAVHEAGGRIALQILHFGREAFHGGMVSSSAERLPSSVFTPRPLSEAEIQATIAAHADCAARAVAAGYDAIEL
LFGQGFLVHQFLAPACNKRTDRWGGGFDNRARLAVEIAAAVRRRVGADFPLIFRLPCMDLLPDGLGAEESMALIGKLLPY
GIDLLNVSIGWHESEVPTIAAAVPRAAFADAARLARRRYPQLKLAVSNRVNDPRDGEALLLDGCADVIAMARPFLADPAL
ASKAESNRFDEINACIACNQRCLDHVLTGQPVGCSVNPDCGLPDEGRYPPLPRAMEVAVAGGGISGMGAALFLARRGARV
TLFEAGDELGGQLRLAARIPQKEEFAATIRHYRGELLRAGVAVRLGCRFDARALDGARWDHVVLAQGAAPRRPEGVPGLE
LPHVRDYAEVLEQGCPVAFPVVVIGGGGIACDLAKYLAAKRGKLTRDARAYLARHLPAEALAPYLDGGADDEAPAITLLQ
RSGRKFAHRVGRTTRWILMDALRRDGVRLLGRVEVVEITGDAVIVRERGGAARSLPARSVVIAAGQTPRPGPEEALRRAG
IPCTVLGAADGGVLGVNLAAALQAAYRFAMELR

Sequences:

>Translated_673_residues
MLGRLFSPIRLNRLRLPNRLLMSSMHLNLDECDDAWHRMAAFYALRAREGVGLIVSAGCAPDEAGKTTQGGFALCRDDEI
AGHRLITGAVHEAGGRIALQILHFGREAFHGGMVSSSAERLPSSVFTPRPLSEAEIQATIAAHADCAARAVAAGYDAIEL
LFGQGFLVHQFLAPACNKRTDRWGGGFDNRARLAVEIAAAVRRRVGADFPLIFRLPCMDLLPDGLGAEESMALIGKLLPY
GIDLLNVSIGWHESEVPTIAAAVPRAAFADAARLARRRYPQLKLAVSNRVNDPRDGEALLLDGCADVIAMARPFLADPAL
ASKAESNRFDEINACIACNQRCLDHVLTGQPVGCSVNPDCGLPDEGRYPPLPRAMEVAVAGGGISGMGAALFLARRGARV
TLFEAGDELGGQLRLAARIPQKEEFAATIRHYRGELLRAGVAVRLGCRFDARALDGARWDHVVLAQGAAPRRPEGVPGLE
LPHVRDYAEVLEQGCPVAFPVVVIGGGGIACDLAKYLAAKRGKLTRDARAYLARHLPAEALAPYLDGGADDEAPAITLLQ
RSGRKFAHRVGRTTRWILMDALRRDGVRLLGRVEVVEITGDAVIVRERGGAARSLPARSVVIAAGQTPRPGPEEALRRAG
IPCTVLGAADGGVLGVNLAAALQAAYRFAMELR
>Mature_673_residues
MLGRLFSPIRLNRLRLPNRLLMSSMHLNLDECDDAWHRMAAFYALRAREGVGLIVSAGCAPDEAGKTTQGGFALCRDDEI
AGHRLITGAVHEAGGRIALQILHFGREAFHGGMVSSSAERLPSSVFTPRPLSEAEIQATIAAHADCAARAVAAGYDAIEL
LFGQGFLVHQFLAPACNKRTDRWGGGFDNRARLAVEIAAAVRRRVGADFPLIFRLPCMDLLPDGLGAEESMALIGKLLPY
GIDLLNVSIGWHESEVPTIAAAVPRAAFADAARLARRRYPQLKLAVSNRVNDPRDGEALLLDGCADVIAMARPFLADPAL
ASKAESNRFDEINACIACNQRCLDHVLTGQPVGCSVNPDCGLPDEGRYPPLPRAMEVAVAGGGISGMGAALFLARRGARV
TLFEAGDELGGQLRLAARIPQKEEFAATIRHYRGELLRAGVAVRLGCRFDARALDGARWDHVVLAQGAAPRRPEGVPGLE
LPHVRDYAEVLEQGCPVAFPVVVIGGGGIACDLAKYLAAKRGKLTRDARAYLARHLPAEALAPYLDGGADDEAPAITLLQ
RSGRKFAHRVGRTTRWILMDALRRDGVRLLGRVEVVEITGDAVIVRERGGAARSLPARSVVIAAGQTPRPGPEEALRRAG
IPCTVLGAADGGVLGVNLAAALQAAYRFAMELR

Specific function: Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789463, Length=679, Percent_Identity=40.2061855670103, Blast_Score=447, Evalue=1e-126,
Organism=Escherichia coli, GI1787939, Length=358, Percent_Identity=28.7709497206704, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17559802, Length=248, Percent_Identity=25.8064516129032, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564188, Length=248, Percent_Identity=26.2096774193548, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17559804, Length=213, Percent_Identity=26.7605633802817, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565138, Length=219, Percent_Identity=26.027397260274, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI72001454, Length=290, Percent_Identity=24.1379310344828, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321973, Length=228, Percent_Identity=25.8771929824561, Blast_Score=81, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325086, Length=230, Percent_Identity=24.7826086956522, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 71896; Mature: 71896

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGRLFSPIRLNRLRLPNRLLMSSMHLNLDECDDAWHRMAAFYALRAREGVGLIVSAGCA
CCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
PDEAGKTTQGGFALCRDDEIAGHRLITGAVHEAGGRIALQILHFGREAFHGGMVSSSAER
CCCCCCCCCCCEEEEECCCCCCCEEEEHHHHHCCCCEEEHHHHHHHHHHCCCCCCCHHHH
LPSSVFTPRPLSEAEIQATIAAHADCAARAVAAGYDAIELLFGQGFLVHQFLAPACNKRT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCC
DRWGGGFDNRARLAVEIAAAVRRRVGADFPLIFRLPCMDLLPDGLGAEESMALIGKLLPY
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHC
GIDLLNVSIGWHESEVPTIAAAVPRAAFADAARLARRRYPQLKLAVSNRVNDPRDGEALL
CCEEEEEEECCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEE
LDGCADVIAMARPFLADPALASKAESNRFDEINACIACNQRCLDHVLTGQPVGCSVNPDC
EHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCC
GLPDEGRYPPLPRAMEVAVAGGGISGMGAALFLARRGARVTLFEAGDELGGQLRLAARIP
CCCCCCCCCCCCHHHEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCC
QKEEFAATIRHYRGELLRAGVAVRLGCRFDARALDGARWDHVVLAQGAAPRRPEGVPGLE
CHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCCCEEEEECCCCCCCCCCCCCCC
LPHVRDYAEVLEQGCPVAFPVVVIGGGGIACDLAKYLAAKRGKLTRDARAYLARHLPAEA
CCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
LAPYLDGGADDEAPAITLLQRSGRKFAHRVGRTTRWILMDALRRDGVRLLGRVEVVEITG
HHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCEECCEEEEEEEEC
DAVIVRERGGAARSLPARSVVIAAGQTPRPGPEEALRRAGIPCTVLGAADGGVLGVNLAA
CEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEHHHHH
ALQAAYRFAMELR
HHHHHHHHHHCCC
>Mature Secondary Structure
MLGRLFSPIRLNRLRLPNRLLMSSMHLNLDECDDAWHRMAAFYALRAREGVGLIVSAGCA
CCCCCCCCHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
PDEAGKTTQGGFALCRDDEIAGHRLITGAVHEAGGRIALQILHFGREAFHGGMVSSSAER
CCCCCCCCCCCEEEEECCCCCCCEEEEHHHHHCCCCEEEHHHHHHHHHHCCCCCCCHHHH
LPSSVFTPRPLSEAEIQATIAAHADCAARAVAAGYDAIELLFGQGFLVHQFLAPACNKRT
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCC
DRWGGGFDNRARLAVEIAAAVRRRVGADFPLIFRLPCMDLLPDGLGAEESMALIGKLLPY
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHC
GIDLLNVSIGWHESEVPTIAAAVPRAAFADAARLARRRYPQLKLAVSNRVNDPRDGEALL
CCEEEEEEECCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEE
LDGCADVIAMARPFLADPALASKAESNRFDEINACIACNQRCLDHVLTGQPVGCSVNPDC
EHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCC
GLPDEGRYPPLPRAMEVAVAGGGISGMGAALFLARRGARVTLFEAGDELGGQLRLAARIP
CCCCCCCCCCCCHHHEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCC
QKEEFAATIRHYRGELLRAGVAVRLGCRFDARALDGARWDHVVLAQGAAPRRPEGVPGLE
CHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHCCCCCCCEEEEECCCCCCCCCCCCCCC
LPHVRDYAEVLEQGCPVAFPVVVIGGGGIACDLAKYLAAKRGKLTRDARAYLARHLPAEA
CCCHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
LAPYLDGGADDEAPAITLLQRSGRKFAHRVGRTTRWILMDALRRDGVRLLGRVEVVEITG
HHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCCEECCEEEEEEEEC
DAVIVRERGGAARSLPARSVVIAAGQTPRPGPEEALRRAGIPCTVLGAADGGVLGVNLAA
CEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCCEEEHHHHH
ALQAAYRFAMELR
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9346310; 9278503 [H]