Click here to switch to the map view.

The map label for this gene is ybdR [H]

Identifier: 34499400

GI number: 34499400

Start: 4265120

End: 4266166

Strand: Reverse

Name: ybdR [H]

Synonym: CV_3945

Alternate gene names: 34499400

Gene position: 4266166-4265120 (Counterclockwise)

Preceding gene: 34499401

Following gene: 34499399

Centisome position: 89.79

GC content: 74.02

Gene sequence:

>1047_bases
ATGAAGGCGGTGGTATGGGACGGGCCGCAACGGCTGAGGCTGGCGATGCTGCCGCGGCCGGCGCTGTTGGCGCCGGACGA
TGCGCTGCTCAGGGTTACCCACGCGTCCACCTGCGGCACCGATCTGCACATCTACCGCGGCGCGGTGCCGGGTTTCGAGC
CGGGCACGGTGATCGGGCACGAATTCGTCGGCGAGGTGGCGGCGGTGGGGGCGGCGGTCAGGCGGCTGCGGCCCGGACAG
CGCGCGGCCTGCGCCGATTTCGTCGCCTGCGGCGAATGCGAGTCTTGCGCGGCGGGCCGGCATGCCCAGTGCGGCGAACG
GCGGCTGTTCGGCTTCTCCGGCCTGCAGCCGCGGCTGGACGGCGGCCTGGCCGAATACGTGAGAGTGCCGCGGGCGGATG
TCGCGCTGAGCCCGCTGGCCGCTGGCGCCGACCCGCGCTTCGGCCTGTTGTCCGGCGACGTGATGCCGACCGCGCTGGGC
GCGCTGCAACGGCTGGCGCTGGCTCCGGGCGAACGTTTGGCGGTGGTCGGGGCCGGCCCGGTGGGCGTCTTGACCGCCTG
GCTGGCGGCGCGCCGGGGTGTCGAGGTCCTGTTGTTGGAGGCCAGCCCTGCCCGCGCGGCGCGCGCGCGCGGCGGGGGGC
TGGCGGTGGCGGAGATCGCGGTCGGGCAGCCGCTGTCGGACGCGGCGCCGGGCTTGGCCGGCGTTTTCGACGCCGCGGTG
GACGCGGTGGGCGGCGAAAGCGGCCTGAAAACCGCGCTGGCGGCATTGCGGCCGCGCGGCAGGCTGGTCGGCGCGGGATC
GCAAGCCGGCCGTTTCGAATTGGACTGGGGCGCGCTGATGCAGCGCGAGATCGCGCTGCAGTTCGTGATTGGCGATCCGA
TCGGCCTGCGCGGCGAGGTGGCGGCGGCGATGGCCGATTGCGCGCCGGCGCTGGACCTGATGTTTTCCGACAGATTGCGC
CTGGACGAGGTGCCGGATTACTTCGCCGCGCTGTACCGGCGCGAGCGCTTCAAGGCCTTGGTCGAGGTGGCGGGGGAGGC
GGCATGA

Upstream 100 bases:

>100_bases
GCACCGTGCTGGGGGCGGCCGACGGCGGCGTCTTGGGCGTCAATCTGGCCGCCGCGCTGCAGGCGGCCTACCGCTTTGCG
ATGGAGCTCAGATGAACACG

Downstream 100 bases:

>100_bases
GCAGGCGGAATGCGGGAAAACGGCTGGCGCTGATCGGCTGCGGCGCGATGGGAACCGCGCTGGGACTGCGGCTGCTGGGC
CTGGGCTGGGAGGTGCGGGT

Product: glutathione-dependent aldehyde dehydrogenase

Products: S-formylglutathione; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKAVVWDGPQRLRLAMLPRPALLAPDDALLRVTHASTCGTDLHIYRGAVPGFEPGTVIGHEFVGEVAAVGAAVRRLRPGQ
RAACADFVACGECESCAAGRHAQCGERRLFGFSGLQPRLDGGLAEYVRVPRADVALSPLAAGADPRFGLLSGDVMPTALG
ALQRLALAPGERLAVVGAGPVGVLTAWLAARRGVEVLLLEASPARAARARGGGLAVAEIAVGQPLSDAAPGLAGVFDAAV
DAVGGESGLKTALAALRPRGRLVGAGSQAGRFELDWGALMQREIALQFVIGDPIGLRGEVAAAMADCAPALDLMFSDRLR
LDEVPDYFAALYRRERFKALVEVAGEAA

Sequences:

>Translated_348_residues
MKAVVWDGPQRLRLAMLPRPALLAPDDALLRVTHASTCGTDLHIYRGAVPGFEPGTVIGHEFVGEVAAVGAAVRRLRPGQ
RAACADFVACGECESCAAGRHAQCGERRLFGFSGLQPRLDGGLAEYVRVPRADVALSPLAAGADPRFGLLSGDVMPTALG
ALQRLALAPGERLAVVGAGPVGVLTAWLAARRGVEVLLLEASPARAARARGGGLAVAEIAVGQPLSDAAPGLAGVFDAAV
DAVGGESGLKTALAALRPRGRLVGAGSQAGRFELDWGALMQREIALQFVIGDPIGLRGEVAAAMADCAPALDLMFSDRLR
LDEVPDYFAALYRRERFKALVEVAGEAA
>Mature_348_residues
MKAVVWDGPQRLRLAMLPRPALLAPDDALLRVTHASTCGTDLHIYRGAVPGFEPGTVIGHEFVGEVAAVGAAVRRLRPGQ
RAACADFVACGECESCAAGRHAQCGERRLFGFSGLQPRLDGGLAEYVRVPRADVALSPLAAGADPRFGLLSGDVMPTALG
ALQRLALAPGERLAVVGAGPVGVLTAWLAARRGVEVLLLEASPARAARARGGGLAVAEIAVGQPLSDAAPGLAGVFDAAV
DAVGGESGLKTALAALRPRGRLVGAGSQAGRFELDWGALMQREIALQFVIGDPIGLRGEVAAAMADCAPALDLMFSDRLR
LDEVPDYFAALYRRERFKALVEVAGEAA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=298, Percent_Identity=27.8523489932886, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=289, Percent_Identity=34.9480968858132, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI226510992, Length=360, Percent_Identity=26.9444444444444, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790045, Length=332, Percent_Identity=26.8072289156627, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790718, Length=268, Percent_Identity=27.9850746268657, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787863, Length=298, Percent_Identity=27.1812080536913, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=219, Percent_Identity=31.5068493150685, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788073, Length=296, Percent_Identity=27.7027027027027, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788075, Length=343, Percent_Identity=23.3236151603499, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082125, Length=290, Percent_Identity=28.9655172413793, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081918, Length=104, Percent_Identity=40.3846153846154, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=369, Percent_Identity=26.5582655826558, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=27.8443113772455, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=359, Percent_Identity=25.3481894150418, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=237, Percent_Identity=29.1139240506329, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=237, Percent_Identity=28.6919831223629, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737897, Length=264, Percent_Identity=28.030303030303, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137530, Length=304, Percent_Identity=26.9736842105263, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.2.1.1

Molecular weight: Translated: 36035; Mature: 36035

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVWDGPQRLRLAMLPRPALLAPDDALLRVTHASTCGTDLHIYRGAVPGFEPGTVIGH
CCEEEECCHHHEEEEECCCCCEECCCHHEEEEEECCCCCCCEEEEECCCCCCCCCCCHHH
EFVGEVAAVGAAVRRLRPGQRAACADFVACGECESCAAGRHAQCGERRLFGFSGLQPRLD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCEECCCCCCCCHHC
GGLAEYVRVPRADVALSPLAAGADPRFGLLSGDVMPTALGALQRLALAPGERLAVVGAGP
CCHHHHHHCCCCCHHHCCHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCH
VGVLTAWLAARRGVEVLLLEASPARAARARGGGLAVAEIAVGQPLSDAAPGLAGVFDAAV
HHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEEEECCCCCHHHCCCHHHHHHHHH
DAVGGESGLKTALAALRPRGRLVGAGSQAGRFELDWGALMQREIALQFVIGDPIGLRGEV
HHCCCCHHHHHHHHHHCCCCCEEECCCCCCCEEECHHHHHHHHHEEEEEECCCCCCCHHH
AAAMADCAPALDLMFSDRLRLDEVPDYFAALYRRERFKALVEVAGEAA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAVVWDGPQRLRLAMLPRPALLAPDDALLRVTHASTCGTDLHIYRGAVPGFEPGTVIGH
CCEEEECCHHHEEEEECCCCCEECCCHHEEEEEECCCCCCCEEEEECCCCCCCCCCCHHH
EFVGEVAAVGAAVRRLRPGQRAACADFVACGECESCAAGRHAQCGERRLFGFSGLQPRLD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCEECCCCCCCCHHC
GGLAEYVRVPRADVALSPLAAGADPRFGLLSGDVMPTALGALQRLALAPGERLAVVGAGP
CCHHHHHHCCCCCHHHCCHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEEEECCH
VGVLTAWLAARRGVEVLLLEASPARAARARGGGLAVAEIAVGQPLSDAAPGLAGVFDAAV
HHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEEEECCCCCHHHCCCHHHHHHHHH
DAVGGESGLKTALAALRPRGRLVGAGSQAGRFELDWGALMQREIALQFVIGDPIGLRGEV
HHCCCCHHHHHHHHHHCCCCCEEECCCCCCCEEECHHHHHHHHHEEEEEECCCCCCCHHH
AAAMADCAPALDLMFSDRLRLDEVPDYFAALYRRERFKALVEVAGEAA
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formaldehyde; glutathione; NAD+

Specific reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]