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The map label for this gene is goaG [H]

Identifier: 34499381

GI number: 34499381

Start: 4241280

End: 4242545

Strand: Direct

Name: goaG [H]

Synonym: CV_3926

Alternate gene names: 34499381

Gene position: 4241280-4242545 (Clockwise)

Preceding gene: 34499380

Following gene: 34499382

Centisome position: 89.27

GC content: 67.61

Gene sequence:

>1266_bases
ATGAGCCAGCAGCAACTGATGCAACGCAAATCCGACGCCACCCCGCGCGGCGTCGGCGTGATGTGCAGTTTCTTCGCCGA
CCGCGCCAAGAACGCGGAAGTGTGGGATACCGAGGGCCGGCGCTACATCGACTTCGCCGGCGGCATCGGCGTGCTCAACA
CCGGCCACCTGCATCCGAAAGTGGAAGCCGCGGTGGCCGAGCAGCTGTCCCGCTTCAGCCACACCTGCTACCAGGTGGTG
CCGTACGAGTCCTACATCAGCCTGGCGGAAAAACTGAACGCGCTGGCCCCGGGCAAGCACGCCAAGAAGACCGCCTTCTT
CACCACCGGCGCCGAGGCGGTGGAAAACGCGGTGAAGATCGCCCGCGCCGCCACCGGCCGCCCCGGCGTCATCGCCTTCG
GCGGCGCCTTCCACGGCCGCACGCTGATGGGCATGGCGCTGACCGGCAAAGTGGCGCCGTACAAGCTCGGTTTCGGTCCC
TTCCCTTCCGACGTCTACCACGCCCCGTATCCGAACACGCTGCACGGCGTGTCGGTGCAGGATTCGCTGGTCGGCCTGGA
AAAACTGTTCAAGTTCGACATCGACCCGGCCCGCGTCGCCGCCATCATCTACGAGCCGGTGCAGGGCGAAGGCGGTTTCT
ACGCCGCGCCGGCCGAATGGGTGAAGGCGCTGCGCGAACTGTGCGACCGCCACGGCATCCTGCTGATCGCCGACGAGGTG
CAGTCGGGCTTCGCCCGCACCGGCAAGCTGCTGGCCAGCGAGCATTTCGACGCGGTGCCTGACCTGATCACCATGGCCAA
GTCGCTGGCCGGCGGCTTCCCGCTGTCCGCCGTCACCGGCCGCGCCGAAGTGATGGACGCGCCTGCGCCGGGCGGCCTGG
GCGGCACCTACGCCGGCAACCCGCTGGCGCTGGCCGCCGCTCACGCGGTGCTGGATGTCATCGACAGCGAGAAGCTGGCC
GAGCGCGCCCAGCGCCTGGGCGACGCGCTGAAGGAAAAACTGAACGGCCTCAAATCCGCGGTGCCGCAGATCGCCGAAGT
GCGCGGCCTGGGCGCGATGATCGCCGTCGAATTCAATCAACCCGGCAGCCATCAGCCGGATCCGGACTTCGCCAAGAAAG
TGCAGCAGCACGCGCTGGCCAACGGCCTGATCCTGCTCACCTGCGGCATCTACGCCAACGTGGTGCGCTTCCTGTTCCCG
CTGACCATCGAAGACGAGATCTTCGCCGAGGCGCTCGGCAAGCTGGAAGCGGCGCTCAAGGCCTGA

Upstream 100 bases:

>100_bases
AAACACCCTCATAGAATGATCCGCTGACGCGCCATCCATCCCGGCGCCATATCGACCCGCCGCGGCGGCGCCACGATCGC
CCGGCCCCGAGGAGACTTCC

Downstream 100 bases:

>100_bases
TCGACACACGCCAATGCGAGCGGCCGCGCAAGACGGCGCGTCCGCTCTTTTGCTCAAGGAATGCCCGACATGTTGAATCT
GCAAGACCCCTCGCTGCTGC

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSQQQLMQRKSDATPRGVGVMCSFFADRAKNAEVWDTEGRRYIDFAGGIGVLNTGHLHPKVEAAVAEQLSRFSHTCYQVV
PYESYISLAEKLNALAPGKHAKKTAFFTTGAEAVENAVKIARAATGRPGVIAFGGAFHGRTLMGMALTGKVAPYKLGFGP
FPSDVYHAPYPNTLHGVSVQDSLVGLEKLFKFDIDPARVAAIIYEPVQGEGGFYAAPAEWVKALRELCDRHGILLIADEV
QSGFARTGKLLASEHFDAVPDLITMAKSLAGGFPLSAVTGRAEVMDAPAPGGLGGTYAGNPLALAAAHAVLDVIDSEKLA
ERAQRLGDALKEKLNGLKSAVPQIAEVRGLGAMIAVEFNQPGSHQPDPDFAKKVQQHALANGLILLTCGIYANVVRFLFP
LTIEDEIFAEALGKLEAALKA

Sequences:

>Translated_421_residues
MSQQQLMQRKSDATPRGVGVMCSFFADRAKNAEVWDTEGRRYIDFAGGIGVLNTGHLHPKVEAAVAEQLSRFSHTCYQVV
PYESYISLAEKLNALAPGKHAKKTAFFTTGAEAVENAVKIARAATGRPGVIAFGGAFHGRTLMGMALTGKVAPYKLGFGP
FPSDVYHAPYPNTLHGVSVQDSLVGLEKLFKFDIDPARVAAIIYEPVQGEGGFYAAPAEWVKALRELCDRHGILLIADEV
QSGFARTGKLLASEHFDAVPDLITMAKSLAGGFPLSAVTGRAEVMDAPAPGGLGGTYAGNPLALAAAHAVLDVIDSEKLA
ERAQRLGDALKEKLNGLKSAVPQIAEVRGLGAMIAVEFNQPGSHQPDPDFAKKVQQHALANGLILLTCGIYANVVRFLFP
LTIEDEIFAEALGKLEAALKA
>Mature_420_residues
SQQQLMQRKSDATPRGVGVMCSFFADRAKNAEVWDTEGRRYIDFAGGIGVLNTGHLHPKVEAAVAEQLSRFSHTCYQVVP
YESYISLAEKLNALAPGKHAKKTAFFTTGAEAVENAVKIARAATGRPGVIAFGGAFHGRTLMGMALTGKVAPYKLGFGPF
PSDVYHAPYPNTLHGVSVQDSLVGLEKLFKFDIDPARVAAIIYEPVQGEGGFYAAPAEWVKALRELCDRHGILLIADEVQ
SGFARTGKLLASEHFDAVPDLITMAKSLAGGFPLSAVTGRAEVMDAPAPGGLGGTYAGNPLALAAAHAVLDVIDSEKLAE
RAQRLGDALKEKLNGLKSAVPQIAEVRGLGAMIAVEFNQPGSHQPDPDFAKKVQQHALANGLILLTCGIYANVVRFLFPL
TIEDEIFAEALGKLEAALKA

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=34.5, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI13994255, Length=423, Percent_Identity=31.9148936170213, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI284507298, Length=315, Percent_Identity=34.9206349206349, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=29.6912114014252, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=29.0476190476191, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI226442709, Length=375, Percent_Identity=30.4, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24119277, Length=407, Percent_Identity=27.027027027027, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI188536080, Length=466, Percent_Identity=25.9656652360515, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI38679950, Length=466, Percent_Identity=25.9656652360515, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI38679946, Length=466, Percent_Identity=25.9656652360515, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=67.8571428571429, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=58.495145631068, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1788044, Length=405, Percent_Identity=37.7777777777778, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=34.7290640394089, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI145693181, Length=381, Percent_Identity=35.6955380577428, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786991, Length=348, Percent_Identity=33.6206896551724, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=32.5648414985591, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=393, Percent_Identity=34.6055979643766, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=403, Percent_Identity=34.4913151364764, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=447, Percent_Identity=28.4116331096197, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25144274, Length=285, Percent_Identity=35.0877192982456, Blast_Score=141, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=400, Percent_Identity=28.5, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=153, Percent_Identity=32.6797385620915, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324432, Length=407, Percent_Identity=32.6781326781327, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=33.2506203473945, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=317, Percent_Identity=30.2839116719243, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=381, Percent_Identity=22.8346456692913, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357415, Length=393, Percent_Identity=34.8600508905852, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=31.6964285714286, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574759, Length=439, Percent_Identity=31.6628701594533, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=30, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI281366494, Length=380, Percent_Identity=27.6315789473684, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667139, Length=380, Percent_Identity=27.6315789473684, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667143, Length=380, Percent_Identity=27.6315789473684, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 44791; Mature: 44660

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQQLMQRKSDATPRGVGVMCSFFADRAKNAEVWDTEGRRYIDFAGGIGVLNTGHLHPK
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEEECCCCCCCCCCCCCCH
VEAAVAEQLSRFSHTCYQVVPYESYISLAEKLNALAPGKHAKKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHH
ARAATGRPGVIAFGGAFHGRTLMGMALTGKVAPYKLGFGPFPSDVYHAPYPNTLHGVSVQ
HHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCHH
DSLVGLEKLFKFDIDPARVAAIIYEPVQGEGGFYAAPAEWVKALRELCDRHGILLIADEV
HHHHHHHHHHHCCCCHHHEEEHEEECCCCCCCEEECHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLLASEHFDAVPDLITMAKSLAGGFPLSAVTGRAEVMDAPAPGGLGGTYAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCCCCCCCCCCCCCC
PLALAAAHAVLDVIDSEKLAERAQRLGDALKEKLNGLKSAVPQIAEVRGLGAMIAVEFNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
PGSHQPDPDFAKKVQQHALANGLILLTCGIYANVVRFLFPLTIEDEIFAEALGKLEAALK
CCCCCCCHHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
A
C
>Mature Secondary Structure 
SQQQLMQRKSDATPRGVGVMCSFFADRAKNAEVWDTEGRRYIDFAGGIGVLNTGHLHPK
CHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEEECCCCCCCCCCCCCCH
VEAAVAEQLSRFSHTCYQVVPYESYISLAEKLNALAPGKHAKKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHH
ARAATGRPGVIAFGGAFHGRTLMGMALTGKVAPYKLGFGPFPSDVYHAPYPNTLHGVSVQ
HHHCCCCCCEEEECCCCCCCCCEEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCHH
DSLVGLEKLFKFDIDPARVAAIIYEPVQGEGGFYAAPAEWVKALRELCDRHGILLIADEV
HHHHHHHHHHHCCCCHHHEEEHEEECCCCCCCEEECHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLLASEHFDAVPDLITMAKSLAGGFPLSAVTGRAEVMDAPAPGGLGGTYAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHCCCCCCCCCCCCCCCC
PLALAAAHAVLDVIDSEKLAERAQRLGDALKEKLNGLKSAVPQIAEVRGLGAMIAVEFNQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECC
PGSHQPDPDFAKKVQQHALANGLILLTCGIYANVVRFLFPLTIEDEIFAEALGKLEAALK
CCCCCCCHHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]