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The map label for this gene is garR [H]

Identifier: 34499325

GI number: 34499325

Start: 4174186

End: 4175052

Strand: Reverse

Name: garR [H]

Synonym: CV_3870

Alternate gene names: 34499325

Gene position: 4175052-4174186 (Counterclockwise)

Preceding gene: 34499326

Following gene: 34499323

Centisome position: 87.88

GC content: 66.78

Gene sequence:

>867_bases
ATGCGCATCGGCTATATCGGTCTGGGCATCATGGGGCGTCCCTGCGTCCTCAATCTATTGAAAGCGGGCTTGCCCGTCAG
CGTATGGGCGCGGCGGCGCGAGAGCGCGGCTTCTTTGCTGGAGGCCGGCGCAGCCTGGGCGGACAGCCCGGCGGAACTGG
CCGGTCAGGTGGACGTGCTGGTGACCAATGTGTCGGACACCGCCGACGTCGAGGCGGTGCTGCTGGGCGAGCAGGGCGCG
ATCCATGGCGCGAAACCGGGACTGGTTTGCGTCGACATGAGCACCATCTCGCCGAACGGCGCGCGCCGGATCGCCGCCGC
GCTGGCGGAAAAGGGCGTGGATTTCCTGGACTGCCCGGTATCCGGCGGCGAGGTGGGCGCCATCAACGGCACGCTGACCA
TCATGGCCGGGGGCCGGGAGGAGGCGCTGGAGAAGGCTAGGCCGGCATTACAGGCGATGGGGCAGACCATTACCCACATC
GGCGCCAGCGGCGCCGGCCAAGTGGCCAAGGCTTGCAACCAGATCGCGGTGGCGGTCGGCGTGGCCGCTGTCGCCGAGAT
CGTCAAGCTGGCAAAGGCCTGCGACGTGGATCCCGCCCCGGTGCGCGCCGCGCTGATGGGCGGCTTCGCGCAGAGCCGGG
TGCTAGATGTGCATGGCCAGCGGATGATAGACGACAATTACGCGCCGGGTTTCAAGGCCAAATTGCACGCCAAGGACATG
CATATCGTGATCGATACCGCGCGGGAACAGGGCATCAGCCTGCCGGCGGCGGAGCGGACGATGCGATTGATAGACCAGCT
GGTTGAGCAGGGGGACGGCGAACTCGACTCTTCCGCTATCGCCAGGTTGATCTGGCAGCAGAACTGA

Upstream 100 bases:

>100_bases
CGGCCGCCGGGAGGCCGCCGGCAACCCCTGAGCGCCTCTGGCGCGCTCGACCGCAATCCCCTATCCTCACCCGATCGCTG
TTTTTCTATCGGAGAGCGGA

Downstream 100 bases:

>100_bases
CGTCAGGACATCCAAGCAAAAGGGCCGCGGAATCGCGGCCCTTTTTCATGTTCGGCTCATGCGCGCATCAGGCGATGCGG
TCTTTCAGCTGCTTGCTGGC

Product: oxidoreductase protein

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MRIGYIGLGIMGRPCVLNLLKAGLPVSVWARRRESAASLLEAGAAWADSPAELAGQVDVLVTNVSDTADVEAVLLGEQGA
IHGAKPGLVCVDMSTISPNGARRIAAALAEKGVDFLDCPVSGGEVGAINGTLTIMAGGREEALEKARPALQAMGQTITHI
GASGAGQVAKACNQIAVAVGVAAVAEIVKLAKACDVDPAPVRAALMGGFAQSRVLDVHGQRMIDDNYAPGFKAKLHAKDM
HIVIDTAREQGISLPAAERTMRLIDQLVEQGDGELDSSAIARLIWQQN

Sequences:

>Translated_288_residues
MRIGYIGLGIMGRPCVLNLLKAGLPVSVWARRRESAASLLEAGAAWADSPAELAGQVDVLVTNVSDTADVEAVLLGEQGA
IHGAKPGLVCVDMSTISPNGARRIAAALAEKGVDFLDCPVSGGEVGAINGTLTIMAGGREEALEKARPALQAMGQTITHI
GASGAGQVAKACNQIAVAVGVAAVAEIVKLAKACDVDPAPVRAALMGGFAQSRVLDVHGQRMIDDNYAPGFKAKLHAKDM
HIVIDTAREQGISLPAAERTMRLIDQLVEQGDGELDSSAIARLIWQQN
>Mature_288_residues
MRIGYIGLGIMGRPCVLNLLKAGLPVSVWARRRESAASLLEAGAAWADSPAELAGQVDVLVTNVSDTADVEAVLLGEQGA
IHGAKPGLVCVDMSTISPNGARRIAAALAEKGVDFLDCPVSGGEVGAINGTLTIMAGGREEALEKARPALQAMGQTITHI
GASGAGQVAKACNQIAVAVGVAAVAEIVKLAKACDVDPAPVRAALMGGFAQSRVLDVHGQRMIDDNYAPGFKAKLHAKDM
HIVIDTAREQGISLPAAERTMRLIDQLVEQGDGELDSSAIARLIWQQN

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=292, Percent_Identity=28.0821917808219, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI40556376, Length=244, Percent_Identity=32.3770491803279, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI145693186, Length=281, Percent_Identity=43.4163701067616, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI1786719, Length=282, Percent_Identity=41.8439716312057, Blast_Score=224, Evalue=4e-60,
Organism=Escherichia coli, GI1789092, Length=288, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790315, Length=280, Percent_Identity=31.4285714285714, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788341, Length=190, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557316, Length=247, Percent_Identity=30.7692307692308, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24655230, Length=293, Percent_Identity=30.0341296928328, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI19922568, Length=293, Percent_Identity=30.0341296928328, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28574115, Length=279, Percent_Identity=24.3727598566308, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 29826; Mature: 29826

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGYIGLGIMGRPCVLNLLKAGLPVSVWARRRESAASLLEAGAAWADSPAELAGQVDVL
CEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEE
VTNVSDTADVEAVLLGEQGAIHGAKPGLVCVDMSTISPNGARRIAAALAEKGVDFLDCPV
EECCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCC
SGGEVGAINGTLTIMAGGREEALEKARPALQAMGQTITHIGASGAGQVAKACNQIAVAVG
CCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VAAVAEIVKLAKACDVDPAPVRAALMGGFAQSRVLDVHGQRMIDDNYAPGFKAKLHAKDM
HHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHEEECCCCEEECCCCCCCCCEEEECCCE
HIVIDTAREQGISLPAAERTMRLIDQLVEQGDGELDSSAIARLIWQQN
EEEEECHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRIGYIGLGIMGRPCVLNLLKAGLPVSVWARRRESAASLLEAGAAWADSPAELAGQVDVL
CEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCEEEE
VTNVSDTADVEAVLLGEQGAIHGAKPGLVCVDMSTISPNGARRIAAALAEKGVDFLDCPV
EECCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEECCC
SGGEVGAINGTLTIMAGGREEALEKARPALQAMGQTITHIGASGAGQVAKACNQIAVAVG
CCCCEEEECCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VAAVAEIVKLAKACDVDPAPVRAALMGGFAQSRVLDVHGQRMIDDNYAPGFKAKLHAKDM
HHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHEEECCCCEEECCCCCCCCCEEEECCCE
HIVIDTAREQGISLPAAERTMRLIDQLVEQGDGELDSSAIARLIWQQN
EEEEECHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]