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The map label for this gene is coaE

Identifier: 34499280

GI number: 34499280

Start: 4122912

End: 4123526

Strand: Reverse

Name: coaE

Synonym: CV_3825

Alternate gene names: 34499280

Gene position: 4123526-4122912 (Counterclockwise)

Preceding gene: 34499281

Following gene: 34499279

Centisome position: 86.79

GC content: 66.83

Gene sequence:

>615_bases
ATGGCTATCCCGGTAGTGGGGCTGACCGGCGGCATCGGCTCAGGCAAGAGCGCGGCGGCGGACCGCTTCGCCGAGCTGGG
CGTGCCGGTCATCGATACCGACAGCATCGCCCACCAGTTGACGGGGCCGGGCGGCGCGGCAATGACCGAGATCGTCCGCG
TCTTTGGCCCGGGCGTCGTCGCCGGTGACGGTTCGCTGGACCGCGCGGCGATGCGGGCGCGGGTGTTCGCCGCGCCGGAG
GAGAGAAAGCGGCTGGAGGCCATCCTGCATCCGGCCATTCACGCGGAGAGCGTGCGGCGCCTGCAGGCGGCGGTCGGAGA
CTACGCGGTGCTGGTGGTGCCTTTGCTGTTTGAGAGCGACCGCTACGCGCCGCTGCTGGCGCGCGCTCTGGTGGTCGACT
GCAGCGAGGAAGTCCAGGTGGAGCGGGTGATGCGGCGCAGCAAGTTGAGCGCGGACGCGGTGCGCGCGATCATGGCCGCC
CAACTGCCGAGGTCGGAGAGGCTGCGCCGCGCCGACGATGTCATCGACAATAGCGGCGGCTTGGCAGAATTGAGGCTTCA
AGTTGATGCCAAACACAGTTATTATCTGGCAAATCTTGTCAAAGCAATGTTATAA

Upstream 100 bases:

>100_bases
GCGTTGGCCGGGGGCAGGAAATCCCGTTCGGCCCCTATCTTTCGGCCGCCGGCTGGATCGCGCTGGTGTGGGGGCCGCAG
ATCATGAATGGATATTTGAC

Downstream 100 bases:

>100_bases
GGCTTGCTGCAAGCCGTGGAGAAGGGCAGATCTGCCGTGATCAGTTTCGAATTTCCTGTCACCGAGCGCACCCGTATTCT
GCTCCGTCTGGAGTATCTGT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MAIPVVGLTGGIGSGKSAAADRFAELGVPVIDTDSIAHQLTGPGGAAMTEIVRVFGPGVVAGDGSLDRAAMRARVFAAPE
ERKRLEAILHPAIHAESVRRLQAAVGDYAVLVVPLLFESDRYAPLLARALVVDCSEEVQVERVMRRSKLSADAVRAIMAA
QLPRSERLRRADDVIDNSGGLAELRLQVDAKHSYYLANLVKAML

Sequences:

>Translated_204_residues
MAIPVVGLTGGIGSGKSAAADRFAELGVPVIDTDSIAHQLTGPGGAAMTEIVRVFGPGVVAGDGSLDRAAMRARVFAAPE
ERKRLEAILHPAIHAESVRRLQAAVGDYAVLVVPLLFESDRYAPLLARALVVDCSEEVQVERVMRRSKLSADAVRAIMAA
QLPRSERLRRADDVIDNSGGLAELRLQVDAKHSYYLANLVKAML
>Mature_203_residues
AIPVVGLTGGIGSGKSAAADRFAELGVPVIDTDSIAHQLTGPGGAAMTEIVRVFGPGVVAGDGSLDRAAMRARVFAAPEE
RKRLEAILHPAIHAESVRRLQAAVGDYAVLVVPLLFESDRYAPLLARALVVDCSEEVQVERVMRRSKLSADAVRAIMAAQ
LPRSERLRRADDVIDNSGGLAELRLQVDAKHSYYLANLVKAML

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=192, Percent_Identity=36.9791666666667, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI191252795, Length=192, Percent_Identity=36.9791666666667, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI110227607, Length=161, Percent_Identity=31.6770186335404, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI110227605, Length=161, Percent_Identity=31.6770186335404, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI110227603, Length=161, Percent_Identity=31.6770186335404, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI110227601, Length=161, Percent_Identity=31.6770186335404, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI205277394, Length=161, Percent_Identity=31.6770186335404, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786292, Length=192, Percent_Identity=46.875, Blast_Score=160, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17554944, Length=193, Percent_Identity=36.7875647668394, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320402, Length=198, Percent_Identity=34.3434343434343, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24644728, Length=182, Percent_Identity=33.5164835164835, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24658602, Length=170, Percent_Identity=37.6470588235294, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_CHRVO (Q7NRF7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903495.1
- ProteinModelPortal:   Q7NRF7
- SMR:   Q7NRF7
- GeneID:   2546938
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3825
- NMPDR:   fig|243365.1.peg.3825
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- PhylomeDB:   Q7NRF7
- BioCyc:   CVIO243365:CV_3825-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21747; Mature: 21616

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS51219 DPCK; PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIPVVGLTGGIGSGKSAAADRFAELGVPVIDTDSIAHQLTGPGGAAMTEIVRVFGPGVV
CCCEEEEECCCCCCCCHHHHHHHHHCCCCEEECHHHHHHHCCCCHHHHHHHHHHHCCCEE
AGDGSLDRAAMRARVFAAPEERKRLEAILHPAIHAESVRRLQAAVGDYAVLVVPLLFESD
ECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
RYAPLLARALVVDCSEEVQVERVMRRSKLSADAVRAIMAAQLPRSERLRRADDVIDNSGG
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
LAELRLQVDAKHSYYLANLVKAML
EEEEEEEECCCHHHHHHHHHHHHC
>Mature Secondary Structure 
AIPVVGLTGGIGSGKSAAADRFAELGVPVIDTDSIAHQLTGPGGAAMTEIVRVFGPGVV
CCEEEEECCCCCCCCHHHHHHHHHCCCCEEECHHHHHHHCCCCHHHHHHHHHHHCCCEE
AGDGSLDRAAMRARVFAAPEERKRLEAILHPAIHAESVRRLQAAVGDYAVLVVPLLFESD
ECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
RYAPLLARALVVDCSEEVQVERVMRRSKLSADAVRAIMAAQLPRSERLRRADDVIDNSGG
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCC
LAELRLQVDAKHSYYLANLVKAML
EEEEEEEECCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782