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The map label for this gene is folP [H]

Identifier: 34499251

GI number: 34499251

Start: 4093240

End: 4094076

Strand: Reverse

Name: folP [H]

Synonym: CV_3796

Alternate gene names: 34499251

Gene position: 4094076-4093240 (Counterclockwise)

Preceding gene: 34499252

Following gene: 34499250

Centisome position: 86.17

GC content: 69.3

Gene sequence:

>837_bases
ATGAAAACCTTGCAATGCGGGCGTTTCGCGCTCGAGTTGTCCCGTCCGCTGGTGATGGGCATCCTGAATGTCACGCCGGA
TTCCTTCTCCGACGGCGGCCGCTTCAACCGCATCGACGACGCGCTCGCGCGCGCCGAGGCGATGCTGGCCGAAGGCGCGG
ACATCCTCGACATCGGCGGCGAGTCCACCCGCCCCGGCGCGCCTTTCGTCAGCGCGGAAGAGGAGATGGCGCGGGTGCTG
CCGGTGCTGGAGAAGCTGCGCGGCATCGGCGTGCCGCTGTCGCTGGACACGCGCCGGGCCGAGGTGATGCGCGAGGCATT
GCTGCTGGGCGCGGTGGATTTGATCAACGACGTGTCCGCGCTGGAAGACGAGGGCGCGTTGCCGCTGGTTGCCGCCAGCC
GCGCCGCGGTGTGCCTGATGCATAAGCAGGGCAACCCGGACACGATGCAAGACCGGCCCGAATATGGCGACGTGGTGGCC
GAGGTGGCCGATTACCTGAAGCGCCGGGTCCAGCTGTGTCTGGACGCCGGCATCGTCCGCGAGCGTCTGTTGGTCGATCC
GGGCTTCGGCTTCGGCAAGACGCTGGAGCACAATCTGGCCTTGCTCAAACGGCTGGACGAGATCGAACGCATCGCCGGCG
CGCCGCAGCTGGTGGGCCTGTCGCGCAAGTCCATGCTGGGCGCGATCACGGGCGAGCGTGAGCCCTCCCTGCGGCTGGGC
GCCAGCGTCGCCGCGGCGCTGGAGTCGGCGCGGCGCGGCGCGGCGGTGATCCGCGTGCACGATGTCCAGGCGACTCGGCA
GGCGCTGCAACTGTGGCAGGCGCTGCGGGATTCTTGA

Upstream 100 bases:

>100_bases
CCGCCGCATTCTCTTCAACCGGGCAAGCCTTTGCGGGCTTGCCCGGTTTTGCTTTCCGCTCCCCGTCGCTCCGGCGGGGG
CGCCAGGAACCAGAGTCAAA

Downstream 100 bases:

>100_bases
TTTGAAGCTGGTTTTCCACCCGGCGGTGGTGGCAAAATGGCGGGCATCGAGCCTGTCAAGGCATTGAACCGATACAGAGA
ATACTGAATGAGTCGCAAAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MKTLQCGRFALELSRPLVMGILNVTPDSFSDGGRFNRIDDALARAEAMLAEGADILDIGGESTRPGAPFVSAEEEMARVL
PVLEKLRGIGVPLSLDTRRAEVMREALLLGAVDLINDVSALEDEGALPLVAASRAAVCLMHKQGNPDTMQDRPEYGDVVA
EVADYLKRRVQLCLDAGIVRERLLVDPGFGFGKTLEHNLALLKRLDEIERIAGAPQLVGLSRKSMLGAITGEREPSLRLG
ASVAAALESARRGAAVIRVHDVQATRQALQLWQALRDS

Sequences:

>Translated_278_residues
MKTLQCGRFALELSRPLVMGILNVTPDSFSDGGRFNRIDDALARAEAMLAEGADILDIGGESTRPGAPFVSAEEEMARVL
PVLEKLRGIGVPLSLDTRRAEVMREALLLGAVDLINDVSALEDEGALPLVAASRAAVCLMHKQGNPDTMQDRPEYGDVVA
EVADYLKRRVQLCLDAGIVRERLLVDPGFGFGKTLEHNLALLKRLDEIERIAGAPQLVGLSRKSMLGAITGEREPSLRLG
ASVAAALESARRGAAVIRVHDVQATRQALQLWQALRDS
>Mature_278_residues
MKTLQCGRFALELSRPLVMGILNVTPDSFSDGGRFNRIDDALARAEAMLAEGADILDIGGESTRPGAPFVSAEEEMARVL
PVLEKLRGIGVPLSLDTRRAEVMREALLLGAVDLINDVSALEDEGALPLVAASRAAVCLMHKQGNPDTMQDRPEYGDVVA
EVADYLKRRVQLCLDAGIVRERLLVDPGFGFGKTLEHNLALLKRLDEIERIAGAPQLVGLSRKSMLGAITGEREPSLRLG
ASVAAALESARRGAAVIRVHDVQATRQALQLWQALRDS

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=266, Percent_Identity=51.8796992481203, Blast_Score=260, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6324073, Length=322, Percent_Identity=29.1925465838509, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29994; Mature: 29994

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLQCGRFALELSRPLVMGILNVTPDSFSDGGRFNRIDDALARAEAMLAEGADILDIGG
CCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCC
ESTRPGAPFVSAEEEMARVLPVLEKLRGIGVPLSLDTRRAEVMREALLLGAVDLINDVSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEDEGALPLVAASRAAVCLMHKQGNPDTMQDRPEYGDVVAEVADYLKRRVQLCLDAGIVR
HHCCCCCCEEECCHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLLVDPGFGFGKTLEHNLALLKRLDEIERIAGAPQLVGLSRKSMLGAITGEREPSLRLG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCCCCCHHHH
ASVAAALESARRGAAVIRVHDVQATRQALQLWQALRDS
HHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTLQCGRFALELSRPLVMGILNVTPDSFSDGGRFNRIDDALARAEAMLAEGADILDIGG
CCCCHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCC
ESTRPGAPFVSAEEEMARVLPVLEKLRGIGVPLSLDTRRAEVMREALLLGAVDLINDVSA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LEDEGALPLVAASRAAVCLMHKQGNPDTMQDRPEYGDVVAEVADYLKRRVQLCLDAGIVR
HHCCCCCCEEECCHHHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLLVDPGFGFGKTLEHNLALLKRLDEIERIAGAPQLVGLSRKSMLGAITGEREPSLRLG
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHCCCCCCCHHHH
ASVAAALESARRGAAVIRVHDVQATRQALQLWQALRDS
HHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400191; 7642493; 10710307 [H]