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The map label for this gene is tpx [H]

Identifier: 34499163

GI number: 34499163

Start: 4009691

End: 4010353

Strand: Direct

Name: tpx [H]

Synonym: CV_3708

Alternate gene names: 34499163

Gene position: 4009691-4010353 (Clockwise)

Preceding gene: 34499162

Following gene: 34499165

Centisome position: 84.4

GC content: 64.25

Gene sequence:

>663_bases
ATGGAAGACTTTTGGGTACAGTATGGCGACGAAATGTTGCCCGTCATCGGCGATTTCCCGCGCAAGGGAGACTATCTGCC
CAGCTTCATGCTGGTGGACGACCAGAAACACGACGCCGCGCTGGAGAGCTTCTCCCACACGCCCAAACTGATCGTCACCC
TGCTGTCGGTGGACGAGGACGAGCACGCCGGTCTGCTGCTGCTGCGCGAAACCCGGCGCTTTCTGGACAGCTGGCCGCAC
CTGAAGCTGATCGTGATCACCGTCGACTCGCCATCGTCGCTGGCGCGCGCCCGGCACGAGCACGGTCTGCCCAACATCGC
GCTGCTGTCCACGCTGCGCGGCCGCGACTTCCACAAGCGCTACGGCGTGCTGATCACCGAATACCCGCTCAGCGGCTACA
CCTCGCCGGCCATCATCCTGGCCGACGCCGCCAATGTGGTCCATTACTCGGAGCGGCTGGCCAATACGCGGGACTTCTTT
GATTTCGACGCCATAGAGAAACTGCTGCAGGAAGGCGAGCAGCAGGCGATGGCCGCCGAGCGCGAGGCGGCGGAAGCGAG
GCAGGAGCAGGACGCGGAGCGGGAAAAAGGCACCGAACGGCTGCTGGAGAAGGCCAAGCTGATCCAGGACCAGCTGAACA
GGAACGGCGACCCCGGCCGCTGA

Upstream 100 bases:

>100_bases
ACCCAACCCGCTGCGAAGCGGGTTTTTTCGTTTTATTTAGGACGAAATTCTTGATTTCGCCGTTCGCTCGTCCACGATAG
AAATTCGAGGAGGAGCTGAA

Downstream 100 bases:

>100_bases
TCATCAGCCTGCCGCAAACAAGCGAAAACCGCCCGTTTCCGGGCGGTTTCTCATTCACCGATGGGCTGCCGTCAGCCTCA
GCTGTTCAGCTCCTTGGCCA

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MEDFWVQYGDEMLPVIGDFPRKGDYLPSFMLVDDQKHDAALESFSHTPKLIVTLLSVDEDEHAGLLLLRETRRFLDSWPH
LKLIVITVDSPSSLARARHEHGLPNIALLSTLRGRDFHKRYGVLITEYPLSGYTSPAIILADAANVVHYSERLANTRDFF
DFDAIEKLLQEGEQQAMAAEREAAEARQEQDAEREKGTERLLEKAKLIQDQLNRNGDPGR

Sequences:

>Translated_220_residues
MEDFWVQYGDEMLPVIGDFPRKGDYLPSFMLVDDQKHDAALESFSHTPKLIVTLLSVDEDEHAGLLLLRETRRFLDSWPH
LKLIVITVDSPSSLARARHEHGLPNIALLSTLRGRDFHKRYGVLITEYPLSGYTSPAIILADAANVVHYSERLANTRDFF
DFDAIEKLLQEGEQQAMAAEREAAEARQEQDAEREKGTERLLEKAKLIQDQLNRNGDPGR
>Mature_220_residues
MEDFWVQYGDEMLPVIGDFPRKGDYLPSFMLVDDQKHDAALESFSHTPKLIVTLLSVDEDEHAGLLLLRETRRFLDSWPH
LKLIVITVDSPSSLARARHEHGLPNIALLSTLRGRDFHKRYGVLITEYPLSGYTSPAIILADAANVVHYSERLANTRDFF
DFDAIEKLLQEGEQQAMAAEREAAEARQEQDAEREKGTERLLEKAKLIQDQLNRNGDPGR

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 25055; Mature: 25055

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDFWVQYGDEMLPVIGDFPRKGDYLPSFMLVDDQKHDAALESFSHTPKLIVTLLSVDED
CCCHHHHCCCCHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHCCCC
EHAGLLLLRETRRFLDSWPHLKLIVITVDSPSSLARARHEHGLPNIALLSTLRGRDFHKR
CCCCEEHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHH
YGVLITEYPLSGYTSPAIILADAANVVHYSERLANTRDFFDFDAIEKLLQEGEQQAMAAE
HCEEEEECCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
REAAEARQEQDAEREKGTERLLEKAKLIQDQLNRNGDPGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEDFWVQYGDEMLPVIGDFPRKGDYLPSFMLVDDQKHDAALESFSHTPKLIVTLLSVDED
CCCHHHHCCCCHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHHCCCC
EHAGLLLLRETRRFLDSWPHLKLIVITVDSPSSLARARHEHGLPNIALLSTLRGRDFHKR
CCCCEEHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHH
YGVLITEYPLSGYTSPAIILADAANVVHYSERLANTRDFFDFDAIEKLLQEGEQQAMAAE
HCEEEEECCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
REAAEARQEQDAEREKGTERLLEKAKLIQDQLNRNGDPGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]