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The map label for this gene is relA [H]

Identifier: 34499157

GI number: 34499157

Start: 4001202

End: 4003406

Strand: Reverse

Name: relA [H]

Synonym: CV_3702

Alternate gene names: 34499157

Gene position: 4003406-4001202 (Counterclockwise)

Preceding gene: 34499158

Following gene: 34499156

Centisome position: 84.26

GC content: 66.94

Gene sequence:

>2205_bases
ATGGTTTCCGTAGTCCGCACCGTTGCCGATACCCTGGCCGACGCCGCCGACCCGGCGCGCTGGCTGGAGCATATGTCCGC
CGCTTTTCCCGACGAGGACGGCGCGCTGCTGGCGCGCGCCTTTCACGCCGCGCGCGAACTGTACGCGGGCAAGACCGTCC
CCGCCACCGGCGAAGACCTGTTCACCCACGCGGTGGCCGCTGCGGCCGTCGTCGCCGACCTGAACCTGTTGCCTGACGCC
ATCGTCGCCACCTTGCTGTTCTCGGCGCCGGATTTTCACCCGGAGTGGCAGGCCTGGCTAACGGAAACCTTCAACCCGAC
GGTGGCGATGCTGGTGGACGGTGTGGGCGGCGTGCGCCGCATCACCGAGTTCGCCCGCATCGACAGGATGGCCACGCCGG
AGGACTGCGCGCGCCAGGCCGAGACCATGCGCAAGATGCTGCTGGCCATGGTGGCCGACATCCGCGTGGTGCTGATCAAG
CTGGCGTGGCGCACCCAGACCATGCACTACTTGGCCAATGTGGCCGACGAGGCGGTGCGCCGCCGCATCGCCGGCGAGAC
GCTGGAGCTGTTCGCGCCGCTCGCCAACCGCCTGGGCGTGTGGCAGATCAAGTGGGAGCTGGAGGACCTGGGCCTCAGGC
ACACCGAGCCCGACACCTACAAGAAGATCGCCAAACTGTTGGACGAGCGCCGGCTGGAGCGCATCGACTATATCGAGCGG
GTGCTGGACGTCTTGCGCGACGAGCTGAAAAAGGCCGGCGTCAGGGCCGAGGTGGCCGGCCGCCCCAAGCACATCTATTC
CATCTGGAAGAAGATGAAGAAGAAAAAGCTCGATTTCACCGAGCTTTACGACATCCGCGCGGTGCGCATCCTGGTGGACA
AGCTGCCGGACTGCTACACCGCGCTCGGCATCATCCACGGCATGTGGCAGCCGATACGCGGCGAGTTCGACGACTACATC
TCCCATCCCAAGGCCAACAACTACCGCAGCCTGCACACCGCGGTGGTGGGCCCGGAGGACAAGGCGCTGGAGGTGCAGAT
CCGCACCTTCGAGATGCACGAGCACGCCGAGTTCGGCGTGGCCGCGCACTGGCGCTACAAGGAGGGCGGCAAGGGCGACG
CCGCCTACGAGGAGAAGATCTCCTGGCTGCGCCAGCTGCTGGACTGGCGCGAGGAAATGTCTGACCGCGAAGGCCTGGCC
GAGGCGTTCAAGACCGAGCTGTTCGCCGACACCATCTACGTGTTGACGCCGCAGGGCAAGGTACTGGCGCTGCCGCAGGG
CGCGACGCCGATCGATTTCGCCTACGCCATCCACTCCGGGCTGGGCAACCGTTGCCGCGGCGCCAAGGTGGAGGGGCAGA
TCGTGCCGCTGTCCACGCCGCTGCAGAACGGCCAGCGGGTGGAGGTGCTGGTGGCCAAGGAGGGCGGCCCGTCGGTTAAC
TGGCTGCACGACGGCTGGGTGAAGAGCCACCGCGCCATCTCCAAGATCCGCCAGTACATCCGGCTGCAAAACGCCGACAC
CGTGCGCGAGACCGGCAAGGCGCTGTTCGAGCGCGAGCTGGCGCGGCGGCCGCACATCCAGCCTAATCTGCAGCAGCTGG
CGGAGAAGCTGGGCTACGACAAGCTGGACGAAGTCTACGGCGCGCTGGGCCATGGCGAGTTGACGATACGCGCAGTCAGC
AACGCAATCACCAGCTTCGCGCCGCCGCCGGCGGTGGAGGTGCAGCCGGAAAGCCTGATCCGCGCCAGCAAAGGCGGCCA
CGATGCCGGCGGCGTGCTGATCGAGGGCGTGGACAATCTGATGACGGTGCTGGCCAAGTGCTGCAAACCGGCGCCGCCCG
ACCAGGTGATGGGCTTCGTCACCAAGGGGCGCGGCATCTCCATCCACCGCAGTAGTTGCCTGACGCTGAAGAAGCTGTCG
CAGGAGGTGCCCGAGCGCCTGATCGCCGCCGAATGGGGCGACCAGCGCAACAGCGTGTTCCCGATCGACATCGAGGTGAT
GTCGCAGGACCGGCCGGGCCTGCTGCGCGACATCTCCGACGTGCTGTCGCGGGAGAAGCTCAACCTGATCGGCGTCAACA
CCCTGTCGCGCGACCTGAAGAGCCGCTTGCGGCTGACGGTGGAAGTGCGCCAGGTGCAGGACATCAGCCGCGTGCTGTCG
CGCCTGATGGAACTGTCCGGCGTGCAGGAAGCCCGCCGGGTTTGA

Upstream 100 bases:

>100_bases
TCGGATTGACGAGGGCGGACGAGGGTCCGCCGATTGTGGCAAATGCCGGGCGCGCCCCGGCTTACAATTGAAGACGGCGA
GCCCGTCCAGATAGACAGAT

Downstream 100 bases:

>100_bases
GCTAAAACCATGAACCGGCTGGAATGCCCGTGGATCGGGCGTTTCAGCCGGTTCCGCTTTTGGCGGGCGAGCCCGGCCGG
CGCCGGGCGGTTTGCGTTTA

Product: GTP diphosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 734; Mature: 734

Protein sequence:

>734_residues
MVSVVRTVADTLADAADPARWLEHMSAAFPDEDGALLARAFHAARELYAGKTVPATGEDLFTHAVAAAAVVADLNLLPDA
IVATLLFSAPDFHPEWQAWLTETFNPTVAMLVDGVGGVRRITEFARIDRMATPEDCARQAETMRKMLLAMVADIRVVLIK
LAWRTQTMHYLANVADEAVRRRIAGETLELFAPLANRLGVWQIKWELEDLGLRHTEPDTYKKIAKLLDERRLERIDYIER
VLDVLRDELKKAGVRAEVAGRPKHIYSIWKKMKKKKLDFTELYDIRAVRILVDKLPDCYTALGIIHGMWQPIRGEFDDYI
SHPKANNYRSLHTAVVGPEDKALEVQIRTFEMHEHAEFGVAAHWRYKEGGKGDAAYEEKISWLRQLLDWREEMSDREGLA
EAFKTELFADTIYVLTPQGKVLALPQGATPIDFAYAIHSGLGNRCRGAKVEGQIVPLSTPLQNGQRVEVLVAKEGGPSVN
WLHDGWVKSHRAISKIRQYIRLQNADTVRETGKALFERELARRPHIQPNLQQLAEKLGYDKLDEVYGALGHGELTIRAVS
NAITSFAPPPAVEVQPESLIRASKGGHDAGGVLIEGVDNLMTVLAKCCKPAPPDQVMGFVTKGRGISIHRSSCLTLKKLS
QEVPERLIAAEWGDQRNSVFPIDIEVMSQDRPGLLRDISDVLSREKLNLIGVNTLSRDLKSRLRLTVEVRQVQDISRVLS
RLMELSGVQEARRV

Sequences:

>Translated_734_residues
MVSVVRTVADTLADAADPARWLEHMSAAFPDEDGALLARAFHAARELYAGKTVPATGEDLFTHAVAAAAVVADLNLLPDA
IVATLLFSAPDFHPEWQAWLTETFNPTVAMLVDGVGGVRRITEFARIDRMATPEDCARQAETMRKMLLAMVADIRVVLIK
LAWRTQTMHYLANVADEAVRRRIAGETLELFAPLANRLGVWQIKWELEDLGLRHTEPDTYKKIAKLLDERRLERIDYIER
VLDVLRDELKKAGVRAEVAGRPKHIYSIWKKMKKKKLDFTELYDIRAVRILVDKLPDCYTALGIIHGMWQPIRGEFDDYI
SHPKANNYRSLHTAVVGPEDKALEVQIRTFEMHEHAEFGVAAHWRYKEGGKGDAAYEEKISWLRQLLDWREEMSDREGLA
EAFKTELFADTIYVLTPQGKVLALPQGATPIDFAYAIHSGLGNRCRGAKVEGQIVPLSTPLQNGQRVEVLVAKEGGPSVN
WLHDGWVKSHRAISKIRQYIRLQNADTVRETGKALFERELARRPHIQPNLQQLAEKLGYDKLDEVYGALGHGELTIRAVS
NAITSFAPPPAVEVQPESLIRASKGGHDAGGVLIEGVDNLMTVLAKCCKPAPPDQVMGFVTKGRGISIHRSSCLTLKKLS
QEVPERLIAAEWGDQRNSVFPIDIEVMSQDRPGLLRDISDVLSREKLNLIGVNTLSRDLKSRLRLTVEVRQVQDISRVLS
RLMELSGVQEARRV
>Mature_734_residues
MVSVVRTVADTLADAADPARWLEHMSAAFPDEDGALLARAFHAARELYAGKTVPATGEDLFTHAVAAAAVVADLNLLPDA
IVATLLFSAPDFHPEWQAWLTETFNPTVAMLVDGVGGVRRITEFARIDRMATPEDCARQAETMRKMLLAMVADIRVVLIK
LAWRTQTMHYLANVADEAVRRRIAGETLELFAPLANRLGVWQIKWELEDLGLRHTEPDTYKKIAKLLDERRLERIDYIER
VLDVLRDELKKAGVRAEVAGRPKHIYSIWKKMKKKKLDFTELYDIRAVRILVDKLPDCYTALGIIHGMWQPIRGEFDDYI
SHPKANNYRSLHTAVVGPEDKALEVQIRTFEMHEHAEFGVAAHWRYKEGGKGDAAYEEKISWLRQLLDWREEMSDREGLA
EAFKTELFADTIYVLTPQGKVLALPQGATPIDFAYAIHSGLGNRCRGAKVEGQIVPLSTPLQNGQRVEVLVAKEGGPSVN
WLHDGWVKSHRAISKIRQYIRLQNADTVRETGKALFERELARRPHIQPNLQQLAEKLGYDKLDEVYGALGHGELTIRAVS
NAITSFAPPPAVEVQPESLIRASKGGHDAGGVLIEGVDNLMTVLAKCCKPAPPDQVMGFVTKGRGISIHRSSCLTLKKLS
QEVPERLIAAEWGDQRNSVFPIDIEVMSQDRPGLLRDISDVLSREKLNLIGVNTLSRDLKSRLRLTVEVRQVQDISRVLS
RLMELSGVQEARRV

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1789147, Length=697, Percent_Identity=41.6068866571019, Blast_Score=543, Evalue=1e-155,
Organism=Escherichia coli, GI1790082, Length=694, Percent_Identity=35.3025936599424, Blast_Score=424, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82298; Mature: 82298

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSVVRTVADTLADAADPARWLEHMSAAFPDEDGALLARAFHAARELYAGKTVPATGEDL
CHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHH
FTHAVAAAAVVADLNLLPDAIVATLLFSAPDFHPEWQAWLTETFNPTVAMLVDGVGGVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHCCCHHHH
ITEFARIDRMATPEDCARQAETMRKMLLAMVADIRVVLIKLAWRTQTMHYLANVADEAVR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRIAGETLELFAPLANRLGVWQIKWELEDLGLRHTEPDTYKKIAKLLDERRLERIDYIER
HHHCCHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLDVLRDELKKAGVRAEVAGRPKHIYSIWKKMKKKKLDFTELYDIRAVRILVDKLPDCYT
HHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHH
ALGIIHGMWQPIRGEFDDYISHPKANNYRSLHTAVVGPEDKALEVQIRTFEMHEHAEFGV
HHHHHHHHCHHHCCCHHHHHCCCCCCCCCHHHHEEECCCCCEEEEEEEEEEHHHCCCCCC
AAHWRYKEGGKGDAAYEEKISWLRQLLDWREEMSDREGLAEAFKTELFADTIYVLTPQGK
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCC
VLALPQGATPIDFAYAIHSGLGNRCRGAKVEGQIVPLSTPLQNGQRVEVLVAKEGGPSVN
EEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC
WLHDGWVKSHRAISKIRQYIRLQNADTVRETGKALFERELARRPHIQPNLQQLAEKLGYD
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
KLDEVYGALGHGELTIRAVSNAITSFAPPPAVEVQPESLIRASKGGHDAGGVLIEGVDNL
HHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
MTVLAKCCKPAPPDQVMGFVTKGRGISIHRSSCLTLKKLSQEVPERLIAAEWGDQRNSVF
HHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
PIDIEVMSQDRPGLLRDISDVLSREKLNLIGVNTLSRDLKSRLRLTVEVRQVQDISRVLS
EEEEEEECCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMELSGVQEARRV
HHHHHHCHHHHHCC
>Mature Secondary Structure
MVSVVRTVADTLADAADPARWLEHMSAAFPDEDGALLARAFHAARELYAGKTVPATGEDL
CHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHH
FTHAVAAAAVVADLNLLPDAIVATLLFSAPDFHPEWQAWLTETFNPTVAMLVDGVGGVRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHCCCHHHH
ITEFARIDRMATPEDCARQAETMRKMLLAMVADIRVVLIKLAWRTQTMHYLANVADEAVR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRIAGETLELFAPLANRLGVWQIKWELEDLGLRHTEPDTYKKIAKLLDERRLERIDYIER
HHHCCHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLDVLRDELKKAGVRAEVAGRPKHIYSIWKKMKKKKLDFTELYDIRAVRILVDKLPDCYT
HHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHH
ALGIIHGMWQPIRGEFDDYISHPKANNYRSLHTAVVGPEDKALEVQIRTFEMHEHAEFGV
HHHHHHHHCHHHCCCHHHHHCCCCCCCCCHHHHEEECCCCCEEEEEEEEEEHHHCCCCCC
AAHWRYKEGGKGDAAYEEKISWLRQLLDWREEMSDREGLAEAFKTELFADTIYVLTPQGK
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCC
VLALPQGATPIDFAYAIHSGLGNRCRGAKVEGQIVPLSTPLQNGQRVEVLVAKEGGPSVN
EEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCC
WLHDGWVKSHRAISKIRQYIRLQNADTVRETGKALFERELARRPHIQPNLQQLAEKLGYD
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
KLDEVYGALGHGELTIRAVSNAITSFAPPPAVEVQPESLIRASKGGHDAGGVLIEGVDNL
HHHHHHHCCCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHH
MTVLAKCCKPAPPDQVMGFVTKGRGISIHRSSCLTLKKLSQEVPERLIAAEWGDQRNSVF
HHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
PIDIEVMSQDRPGLLRDISDVLSREKLNLIGVNTLSRDLKSRLRLTVEVRQVQDISRVLS
EEEEEEECCCCCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLMELSGVQEARRV
HHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7928955 [H]