Click here to switch to the map view.

The map label for this gene is hda

Identifier: 34499141

GI number: 34499141

Start: 3987918

End: 3988877

Strand: Direct

Name: hda

Synonym: CV_3686

Alternate gene names: NA

Gene position: 3987918-3988877 (Clockwise)

Preceding gene: 34499137

Following gene: 34499142

Centisome position: 83.94

GC content: 66.77

Gene sequence:

>960_bases
GTGTTCACTTGGCTGAAAAACCGCCTGCAGCGGAACGGACTGACCGCCTACGTCACCCATCCCGACTGCCTGCAACACAA
TATGGGGGTGGGCCACCCCGAGTGCCCGGAACGATTGACCGCCATCCGCGACCAGCTGATGGCTTCCCAGATATTCGATT
CTCTGCAGGAAATCGAGGCGCCCGAAGTCAGCTACGAACAGCTGGCCCGGGTGCACCCGCCCCGCTACGTCGAATACCTG
GAGGCCTGCGCGCCCAGCGTGGGCACCTTCCGCATGGACCCGGACACCGCGATGTCGCCCGGCACGCTGAAAGCCGCGCG
CCGCGCCGCCGGCGCGGTAGTGAAGGCGGTGGAGCTGGTGGCCGAGGACAAGGCCCCCAACGCCTTCTGCGCGATCCGCC
CGCCCGGCCACCACGCCGAGAGCGACAAGGCGATGGGCTTCTGCTTCTTCAACAACCTCGCCGTCGGCGTCACCCACGCG
CTGGCCCACTACAAGTTCGAACGGGTGGCGGTGGTGGACTTCGACGTCCACCACGGCAACGGCACCGAGGAAATCCTGCA
CGACGATCCTCGGGTGCTGATGGTGTCCGTCTTCCAGCACCCGTTCTACCCGTACAGCGGCGACGAGCCGATGGGGCCCA
ACATGCACAATGTGCCGCTGAAGGCAGGCAGCGGCGGGCGGGAATTCCGCGAGGCGGTGGAGAATGTCTGGCTGCCGCAA
CTGCACGAATTCCAGCCGCAGATGCTGTTCATCTCCGCCGGCTTCGACGCCCACCGCGAGGACGACATGGGCTCGCTGGG
TCTTACCGAGTCCGACTACGAGTGGGTGACCCGCCACTTGGTGCAGATCGCCGACCAATATTGCGCCGGCCGGGTGGTGT
CGGTGCTGGAGGGCGGCTACGACCTGTCGGCGCTGGGCCGCAGCGTCGCCGCCCACATCCGCGTGCTGTCCGACGGCTGA

Upstream 100 bases:

>100_bases
CCGGTAGGCCTGGGAGAGTGATTGCATTTGCCTCCGCTTGCGCGCAGTATTTATTAAAATCACATATCGCCATCCCATTG
TAAGCGCGCAGGGAGCCTTC

Downstream 100 bases:

>100_bases
CCTAACGACTAGGAATCGATATGAAAAACTGGCTGCAAAACAACCGCGGCTTTCTCGTCTTTTTGCTGCTGTTCGGCTTG
TTCCGCACCGCGGTGGCGGA

Product: histone deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MFTWLKNRLQRNGLTAYVTHPDCLQHNMGVGHPECPERLTAIRDQLMASQIFDSLQEIEAPEVSYEQLARVHPPRYVEYL
EACAPSVGTFRMDPDTAMSPGTLKAARRAAGAVVKAVELVAEDKAPNAFCAIRPPGHHAESDKAMGFCFFNNLAVGVTHA
LAHYKFERVAVVDFDVHHGNGTEEILHDDPRVLMVSVFQHPFYPYSGDEPMGPNMHNVPLKAGSGGREFREAVENVWLPQ
LHEFQPQMLFISAGFDAHREDDMGSLGLTESDYEWVTRHLVQIADQYCAGRVVSVLEGGYDLSALGRSVAAHIRVLSDG

Sequences:

>Translated_319_residues
MFTWLKNRLQRNGLTAYVTHPDCLQHNMGVGHPECPERLTAIRDQLMASQIFDSLQEIEAPEVSYEQLARVHPPRYVEYL
EACAPSVGTFRMDPDTAMSPGTLKAARRAAGAVVKAVELVAEDKAPNAFCAIRPPGHHAESDKAMGFCFFNNLAVGVTHA
LAHYKFERVAVVDFDVHHGNGTEEILHDDPRVLMVSVFQHPFYPYSGDEPMGPNMHNVPLKAGSGGREFREAVENVWLPQ
LHEFQPQMLFISAGFDAHREDDMGSLGLTESDYEWVTRHLVQIADQYCAGRVVSVLEGGYDLSALGRSVAAHIRVLSDG
>Mature_319_residues
MFTWLKNRLQRNGLTAYVTHPDCLQHNMGVGHPECPERLTAIRDQLMASQIFDSLQEIEAPEVSYEQLARVHPPRYVEYL
EACAPSVGTFRMDPDTAMSPGTLKAARRAAGAVVKAVELVAEDKAPNAFCAIRPPGHHAESDKAMGFCFFNNLAVGVTHA
LAHYKFERVAVVDFDVHHGNGTEEILHDDPRVLMVSVFQHPFYPYSGDEPMGPNMHNVPLKAGSGGREFREAVENVWLPQ
LHEFQPQMLFISAGFDAHREDDMGSLGLTESDYEWVTRHLVQIADQYCAGRVVSVLEGGYDLSALGRSVAAHIRVLSDG

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=326, Percent_Identity=34.3558282208589, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI13128864, Length=304, Percent_Identity=33.2236842105263, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI17158039, Length=356, Percent_Identity=30.3370786516854, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI30795202, Length=356, Percent_Identity=30.3370786516854, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI30795204, Length=356, Percent_Identity=30.3370786516854, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI62750349, Length=335, Percent_Identity=29.8507462686567, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI62750347, Length=335, Percent_Identity=29.8507462686567, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI148539870, Length=337, Percent_Identity=31.7507418397626, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI169234807, Length=326, Percent_Identity=32.2085889570552, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI153085395, Length=227, Percent_Identity=36.5638766519824, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI226529806, Length=326, Percent_Identity=32.2085889570552, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI13128862, Length=275, Percent_Identity=25.8181818181818, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI8923769, Length=293, Percent_Identity=24.5733788395904, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI13128860, Length=273, Percent_Identity=24.1758241758242, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI293336691, Length=272, Percent_Identity=23.1617647058824, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI217272877, Length=282, Percent_Identity=26.5957446808511, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=25.1121076233184, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI209862883, Length=276, Percent_Identity=26.4492753623188, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073088, Length=181, Percent_Identity=28.1767955801105, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=34.6278317152104, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=34.6278317152104, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=34.6278317152104, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI193209491, Length=336, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25154020, Length=293, Percent_Identity=30.7167235494881, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25154022, Length=295, Percent_Identity=30.5084745762712, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17537347, Length=305, Percent_Identity=30.8196721311475, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17534739, Length=325, Percent_Identity=26.1538461538462, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17561978, Length=271, Percent_Identity=25.4612546125461, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17508561, Length=258, Percent_Identity=25.1937984496124, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=316, Percent_Identity=30.0632911392405, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6323999, Length=273, Percent_Identity=24.9084249084249, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325141, Length=285, Percent_Identity=26.3157894736842, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321244, Length=264, Percent_Identity=23.4848484848485, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325325, Length=176, Percent_Identity=26.7045454545455, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281360899, Length=304, Percent_Identity=31.9078947368421, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24642144, Length=304, Percent_Identity=31.9078947368421, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24642146, Length=304, Percent_Identity=31.9078947368421, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24642142, Length=304, Percent_Identity=31.9078947368421, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24641720, Length=345, Percent_Identity=31.0144927536232, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281360801, Length=345, Percent_Identity=31.0144927536232, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281360799, Length=345, Percent_Identity=31.0144927536232, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24657891, Length=273, Percent_Identity=25.6410256410256, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644244, Length=325, Percent_Identity=22.1538461538462, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 35394; Mature: 35394

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTWLKNRLQRNGLTAYVTHPDCLQHNMGVGHPECPERLTAIRDQLMASQIFDSLQEIEA
CCHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PEVSYEQLARVHPPRYVEYLEACAPSVGTFRMDPDTAMSPGTLKAARRAAGAVVKAVELV
CCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AEDKAPNAFCAIRPPGHHAESDKAMGFCFFNNLAVGVTHALAHYKFERVAVVDFDVHHGN
HHCCCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHEEEEEEEEEEECCC
GTEEILHDDPRVLMVSVFQHPFYPYSGDEPMGPNMHNVPLKAGSGGREFREAVENVWLPQ
CHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCC
LHEFQPQMLFISAGFDAHREDDMGSLGLTESDYEWVTRHLVQIADQYCAGRVVSVLEGGY
HHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DLSALGRSVAAHIRVLSDG
CHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MFTWLKNRLQRNGLTAYVTHPDCLQHNMGVGHPECPERLTAIRDQLMASQIFDSLQEIEA
CCHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PEVSYEQLARVHPPRYVEYLEACAPSVGTFRMDPDTAMSPGTLKAARRAAGAVVKAVELV
CCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
AEDKAPNAFCAIRPPGHHAESDKAMGFCFFNNLAVGVTHALAHYKFERVAVVDFDVHHGN
HHCCCCCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHEEEEEEEEEEECCC
GTEEILHDDPRVLMVSVFQHPFYPYSGDEPMGPNMHNVPLKAGSGGREFREAVENVWLPQ
CHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCCCC
LHEFQPQMLFISAGFDAHREDDMGSLGLTESDYEWVTRHLVQIADQYCAGRVVSVLEGGY
HHCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DLSALGRSVAAHIRVLSDG
CHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]