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The map label for this gene is mco [H]

Identifier: 34499098

GI number: 34499098

Start: 3939933

End: 3941429

Strand: Reverse

Name: mco [H]

Synonym: CV_3643

Alternate gene names: 34499098

Gene position: 3941429-3939933 (Counterclockwise)

Preceding gene: 34499099

Following gene: 34499097

Centisome position: 82.96

GC content: 69.07

Gene sequence:

>1497_bases
ATGGAGCATGCGATGCAAAGACGTCAAATGATGCGCTGGGGCGCCGCGCTGGCCCTGTCCCCGTGGCTGCTCAGACCGGC
GGCGGCCGCGTCCGCCCATGCGGGCCACGGCGGAATGGCGATGGGGCAGGCGGCGCCGCTGCCGGCCGCCGCCGCGCTGG
GCCTGGCCAGGGGCCTGCAGCTGCCGGATTTGAAGCGGCTGCCGTTGGAGCGCAAGGACGGCGCGTTGCGAGGCTGCCTG
ACCGCGGCCGCGGTGAGCCTGCCCTTGCTGCCCGGCAAGCCTGCCACCGAGTTCTGGGCCTACAACGACAGCGTGCCCGG
TCCTGCGATTGAATTGTTCGAGGGCGAGACGCTGGGCCTGCGTTTCGACAACCGCCTGCCGCAGCCTACCACCGTGCATT
GGCATGGCCTGCCGATTCCGTCCGACCAGGACGGCAATCCGCATGATCCGGTGCCGCCCGGCCAGGGCCGCGACTACCGC
TTTTCCCTGCCGGAGGACAGCGCGGGCAGCTACTGGTACCACCCGCATCCGCACGGCCATACCGCCGAGCAGGCTTACCG
CGGGCTCGCCGGCGTATTCGTGGTGAAAAGCCGCAACGATCCGCTGGCCCATCTGCCGGAACGCTGGCTGGTGCTGTCCG
ACCTGAAGCTGGACCCGGACGGCAAGATCGCCGCCAATAGCGACGCGGACCGGATGGACGGCCGCGAGGGACAGTTCGTG
CTGGTCAACGGCGCATGGCAGCCAAAGCTGGCGCTGGGCCGCGGCGAGCGCCAGCGCTGGCGGATCTGGAACGCCACCAG
CGCGCGGGTGCTGAAGCTGGCGCTGCCGGCCCACGAGGTCTGGCTGGTGGGCACCGATGGCGGCCTGATTGAAAAGCCGC
GCCGCGTCGAATATCTATTGCTGCCGCCGGGCGCGCGCGCCGAGCTGGCCGTCACCGGCCGCTTCGCCGCCGGCAAGCCG
GCCGGCCTGGTCGCGCTGCCGTACGCGCGCGGCAAGATGATGGGGCCGGAGCAAGGCCAGGCGCTGCCGCTGCTGGACAT
CGAGGCCGGCGGGGGCATGGCCACCGCGTCCTTGCCGGAGCGGCTGCGCCGGATCGATCCCTTGCTCAAGGCTTCGGTGA
CGCGGCGCGTGGTCTTCAGCGAGGACATGGCCAATCCGGCGGCGATGTTCCTGATCAACGGCAAGACTTTCGATATGAAC
CGGATGGATTTCACCGGCCAGGTGGGCGCGGTGGAGGAGTGGGAAATCGACAATCAGGCCGATATGGACCACCCCTTTCA
CTTGCATGGCACCCAGTTCCAGGTGACGGAACGGCATGACGGCAAGGGGTGGAGGGCCGAGTCCTATCTCGCTTGGCGCG
ACGTGGTCAACGTGCCGCCGGGGCAGAAAGTCAGGCTGAGGTTCCGCCAGGACATGCCGGGTCCGCGCATGTTTCACTGC
CACATCCTGGAGCACGAGGACGCCGGGATGATGGGCACGCTGGATGTCCGTGCCTAG

Upstream 100 bases:

>100_bases
CCATCAGGCCTGCCGTTTTTTTTGCCCTCGCAAGCACAGCGCGCGGAACTGTTGCCATCGCGGCCGCTCTAGGTTCAATA
TACCTGCTAGGGGTATCTGT

Downstream 100 bases:

>100_bases
CGCGGACGGATGGGCGATAATGCCGATATGAAAAATCCGGGAACCGTCATGGACGATACACATTCCAGCCAGGCGTGCTG
TCATGAAGAGGCGCAGGCCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MEHAMQRRQMMRWGAALALSPWLLRPAAAASAHAGHGGMAMGQAAPLPAAAALGLARGLQLPDLKRLPLERKDGALRGCL
TAAAVSLPLLPGKPATEFWAYNDSVPGPAIELFEGETLGLRFDNRLPQPTTVHWHGLPIPSDQDGNPHDPVPPGQGRDYR
FSLPEDSAGSYWYHPHPHGHTAEQAYRGLAGVFVVKSRNDPLAHLPERWLVLSDLKLDPDGKIAANSDADRMDGREGQFV
LVNGAWQPKLALGRGERQRWRIWNATSARVLKLALPAHEVWLVGTDGGLIEKPRRVEYLLLPPGARAELAVTGRFAAGKP
AGLVALPYARGKMMGPEQGQALPLLDIEAGGGMATASLPERLRRIDPLLKASVTRRVVFSEDMANPAAMFLINGKTFDMN
RMDFTGQVGAVEEWEIDNQADMDHPFHLHGTQFQVTERHDGKGWRAESYLAWRDVVNVPPGQKVRLRFRQDMPGPRMFHC
HILEHEDAGMMGTLDVRA

Sequences:

>Translated_498_residues
MEHAMQRRQMMRWGAALALSPWLLRPAAAASAHAGHGGMAMGQAAPLPAAAALGLARGLQLPDLKRLPLERKDGALRGCL
TAAAVSLPLLPGKPATEFWAYNDSVPGPAIELFEGETLGLRFDNRLPQPTTVHWHGLPIPSDQDGNPHDPVPPGQGRDYR
FSLPEDSAGSYWYHPHPHGHTAEQAYRGLAGVFVVKSRNDPLAHLPERWLVLSDLKLDPDGKIAANSDADRMDGREGQFV
LVNGAWQPKLALGRGERQRWRIWNATSARVLKLALPAHEVWLVGTDGGLIEKPRRVEYLLLPPGARAELAVTGRFAAGKP
AGLVALPYARGKMMGPEQGQALPLLDIEAGGGMATASLPERLRRIDPLLKASVTRRVVFSEDMANPAAMFLINGKTFDMN
RMDFTGQVGAVEEWEIDNQADMDHPFHLHGTQFQVTERHDGKGWRAESYLAWRDVVNVPPGQKVRLRFRQDMPGPRMFHC
HILEHEDAGMMGTLDVRA
>Mature_498_residues
MEHAMQRRQMMRWGAALALSPWLLRPAAAASAHAGHGGMAMGQAAPLPAAAALGLARGLQLPDLKRLPLERKDGALRGCL
TAAAVSLPLLPGKPATEFWAYNDSVPGPAIELFEGETLGLRFDNRLPQPTTVHWHGLPIPSDQDGNPHDPVPPGQGRDYR
FSLPEDSAGSYWYHPHPHGHTAEQAYRGLAGVFVVKSRNDPLAHLPERWLVLSDLKLDPDGKIAANSDADRMDGREGQFV
LVNGAWQPKLALGRGERQRWRIWNATSARVLKLALPAHEVWLVGTDGGLIEKPRRVEYLLLPPGARAELAVTGRFAAGKP
AGLVALPYARGKMMGPEQGQALPLLDIEAGGGMATASLPERLRRIDPLLKASVTRRVVFSEDMANPAAMFLINGKTFDMN
RMDFTGQVGAVEEWEIDNQADMDHPFHLHGTQFQVTERHDGKGWRAESYLAWRDVVNVPPGQKVRLRFRQDMPGPRMFHC
HILEHEDAGMMGTLDVRA

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=548, Percent_Identity=30.4744525547445, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789394, Length=474, Percent_Identity=28.0590717299578, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24650186, Length=258, Percent_Identity=27.1317829457364, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI18859919, Length=233, Percent_Identity=28.755364806867, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 54733; Mature: 54733

Theoretical pI: Translated: 7.93; Mature: 7.93

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHAMQRRQMMRWGAALALSPWLLRPAAAASAHAGHGGMAMGQAAPLPAAAALGLARGLQ
CCHHHHHHHHHHHCHHHHCCHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
LPDLKRLPLERKDGALRGCLTAAAVSLPLLPGKPATEFWAYNDSVPGPAIELFEGETLGL
CCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCCCCEEEEECCCEEEE
RFDNRLPQPTTVHWHGLPIPSDQDGNPHDPVPPGQGRDYRFSLPEDSAGSYWYHPHPHGH
EECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCCCC
TAEQAYRGLAGVFVVKSRNDPLAHLPERWLVLSDLKLDPDGKIAANSDADRMDGREGQFV
CHHHHHCCCEEEEEEECCCCCHHHCCCCEEEEECCEECCCCCEEECCCHHHCCCCCCCEE
LVNGAWQPKLALGRGERQRWRIWNATSARVLKLALPAHEVWLVGTDGGLIEKPRRVEYLL
EEECCCCCEEECCCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCCEEEEE
LPPGARAELAVTGRFAAGKPAGLVALPYARGKMMGPEQGQALPLLDIEAGGGMATASLPE
ECCCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEHHHHH
RLRRIDPLLKASVTRRVVFSEDMANPAAMFLINGKTFDMNRMDFTGQVGAVEEWEIDNQA
HHHHHHHHHHHHHHHEEEEHHCCCCCEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCC
DMDHPFHLHGTQFQVTERHDGKGWRAESYLAWRDVVNVPPGQKVRLRFRQDMPGPRMFHC
CCCCCEEECCCEEEEEECCCCCCCCCCCEEEEHHHCCCCCCCEEEEEEECCCCCCEEEEE
HILEHEDAGMMGTLDVRA
EEEEECCCCCEEEEEECC
>Mature Secondary Structure
MEHAMQRRQMMRWGAALALSPWLLRPAAAASAHAGHGGMAMGQAAPLPAAAALGLARGLQ
CCHHHHHHHHHHHCHHHHCCHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
LPDLKRLPLERKDGALRGCLTAAAVSLPLLPGKPATEFWAYNDSVPGPAIELFEGETLGL
CCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHEEEECCCCCCCEEEEECCCEEEE
RFDNRLPQPTTVHWHGLPIPSDQDGNPHDPVPPGQGRDYRFSLPEDSAGSYWYHPHPHGH
EECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCCCC
TAEQAYRGLAGVFVVKSRNDPLAHLPERWLVLSDLKLDPDGKIAANSDADRMDGREGQFV
CHHHHHCCCEEEEEEECCCCCHHHCCCCEEEEECCEECCCCCEEECCCHHHCCCCCCCEE
LVNGAWQPKLALGRGERQRWRIWNATSARVLKLALPAHEVWLVGTDGGLIEKPRRVEYLL
EEECCCCCEEECCCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCCCCEEEEE
LPPGARAELAVTGRFAAGKPAGLVALPYARGKMMGPEQGQALPLLDIEAGGGMATASLPE
ECCCCCEEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEHHHHH
RLRRIDPLLKASVTRRVVFSEDMANPAAMFLINGKTFDMNRMDFTGQVGAVEEWEIDNQA
HHHHHHHHHHHHHHHEEEEHHCCCCCEEEEEECCCEEECCCCCCCCCCCCCEEECCCCCC
DMDHPFHLHGTQFQVTERHDGKGWRAESYLAWRDVVNVPPGQKVRLRFRQDMPGPRMFHC
CCCCCEEECCCEEEEEECCCCCCCCCCCEEEEHHHCCCCCCCEEEEEEECCCCCCEEEEE
HILEHEDAGMMGTLDVRA
EEEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA