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The map label for this gene is upp

Identifier: 34499076

GI number: 34499076

Start: 3926262

End: 3926894

Strand: Direct

Name: upp

Synonym: CV_3621

Alternate gene names: 34499076

Gene position: 3926262-3926894 (Clockwise)

Preceding gene: 34499075

Following gene: 34499077

Centisome position: 82.64

GC content: 63.35

Gene sequence:

>633_bases
TTGAACATCACCATCGTTGATCATCCGCTGGTACAGCACAAGCTGGGCCTGCTGCGCGAAGCCGACACCAGCACCATGAA
GTTCCGCCAGCTGACCCAGGAACTGGCCCGGCTGCTCGCCTACGAAGCCACCCGCGACTTCGAGCTGGAAAGCGTCACCA
TAGACGGCTGGTGCGGCAAGATCGACGTCAAGCAGATCAAGGGCAAGAAAGTCACCGTGGTGCCCATCCTGCGCGCCGGC
ATCGGCATGCTGGACGGCGTGCTCGACCTGGTGCCGTCGGCCAAGATCAGCGTGGTGGGCCTGGCCCGCAACGAAGAGAC
GCTGGAGCCGGTGTCCTATTTCGAGAAATTCGTCGGCAACCTGGACGAACGCATCGCCATCATCATCGACCCGATGCTGG
CCACCGGCGGCTCGCTGGTCGCCACCATCGACCTGCTCAAGCGCAATGGCTGCAAACACATCAAGGCCGTGGTGATGGTG
GCCGCGCCGGAAGGCGTGAAGATCGTCAACGACGCCCATCCGGACGTGCAGATCTACGCCGCCTCGCTCGACAGCCACCT
GAACGAGCACGGCTACATCATCCCGGGCCTCGGCGACGCCGGCGACAAGATCTTCGGCACCAAGCAGGCCTGA

Upstream 100 bases:

>100_bases
CATACCATCCACGGCAGCCCTGCGGCTGCCGCTGTCATATGTATTGAAAGCTGTTTGCCTTCGCCGGCAAGCAGCTTTTT
GCCAAGGTAGGGAGCCGAAA

Downstream 100 bases:

>100_bases
GCGCCATGCATCCCGATCAGCCGCCCGTTGCTTCCGCAGCCGGCGGCTTTTTTGCAAGTCCGAGGACAGTTCCATGCTGA
TACGCAAGGCCGACGCCCAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MNITIVDHPLVQHKLGLLREADTSTMKFRQLTQELARLLAYEATRDFELESVTIDGWCGKIDVKQIKGKKVTVVPILRAG
IGMLDGVLDLVPSAKISVVGLARNEETLEPVSYFEKFVGNLDERIAIIIDPMLATGGSLVATIDLLKRNGCKHIKAVVMV
AAPEGVKIVNDAHPDVQIYAASLDSHLNEHGYIIPGLGDAGDKIFGTKQA

Sequences:

>Translated_210_residues
MNITIVDHPLVQHKLGLLREADTSTMKFRQLTQELARLLAYEATRDFELESVTIDGWCGKIDVKQIKGKKVTVVPILRAG
IGMLDGVLDLVPSAKISVVGLARNEETLEPVSYFEKFVGNLDERIAIIIDPMLATGGSLVATIDLLKRNGCKHIKAVVMV
AAPEGVKIVNDAHPDVQIYAASLDSHLNEHGYIIPGLGDAGDKIFGTKQA
>Mature_210_residues
MNITIVDHPLVQHKLGLLREADTSTMKFRQLTQELARLLAYEATRDFELESVTIDGWCGKIDVKQIKGKKVTVVPILRAG
IGMLDGVLDLVPSAKISVVGLARNEETLEPVSYFEKFVGNLDERIAIIIDPMLATGGSLVATIDLLKRNGCKHIKAVVMV
AAPEGVKIVNDAHPDVQIYAASLDSHLNEHGYIIPGLGDAGDKIFGTKQA

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=26.7326732673267, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=26.7326732673267, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=68.75, Blast_Score=308, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.3781094527363, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.3781094527363, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=207, Percent_Identity=31.8840579710145, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45550449, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573516, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573514, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573512, Length=208, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_CHRVO (Q7NS06)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903291.1
- ProteinModelPortal:   Q7NS06
- SMR:   Q7NS06
- GeneID:   2548120
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3621
- NMPDR:   fig|243365.1.peg.3621
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   Q7NS06
- ProtClustDB:   PRK00129
- BioCyc:   CVIO243365:CV_3621-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22807; Mature: 22807

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITIVDHPLVQHKLGLLREADTSTMKFRQLTQELARLLAYEATRDFELESVTIDGWCGK
CEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
IDVKQIKGKKVTVVPILRAGIGMLDGVLDLVPSAKISVVGLARNEETLEPVSYFEKFVGN
EEHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCC
LDERIAIIIDPMLATGGSLVATIDLLKRNGCKHIKAVVMVAAPEGVKIVNDAHPDVQIYA
CCCEEEEEEECHHHCCCCCEEHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCCCEEEEE
ASLDSHLNEHGYIIPGLGDAGDKIFGTKQA
EEHHHCCCCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNITIVDHPLVQHKLGLLREADTSTMKFRQLTQELARLLAYEATRDFELESVTIDGWCGK
CEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
IDVKQIKGKKVTVVPILRAGIGMLDGVLDLVPSAKISVVGLARNEETLEPVSYFEKFVGN
EEHHHCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCC
LDERIAIIIDPMLATGGSLVATIDLLKRNGCKHIKAVVMVAAPEGVKIVNDAHPDVQIYA
CCCEEEEEEECHHHCCCCCEEHHHHHHCCCCCCEEEEEEEECCCCEEEEECCCCCEEEEE
ASLDSHLNEHGYIIPGLGDAGDKIFGTKQA
EEHHHCCCCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782