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The map label for this gene is mhpT [H]

Identifier: 34499055

GI number: 34499055

Start: 3907015

End: 3908343

Strand: Reverse

Name: mhpT [H]

Synonym: CV_3600

Alternate gene names: 34499055

Gene position: 3908343-3907015 (Counterclockwise)

Preceding gene: 34499056

Following gene: 34499054

Centisome position: 82.26

GC content: 70.28

Gene sequence:

>1329_bases
ATGTCGGCCAGGCAACTGGATGTCGGCGATCTGATCAATCGCCAGCGCTTTTCCGCGCGGCAATGGCGCATTCTGATGCT
GTGCTTCCTGATCGTGCTGTGCGATGGTTTCGATACCGCCGCCATCGGCTATATCGCGCCGGCCGTGATCCGCGACTGGG
GCGTGGCGCGCACCCAACTGGGGCCGGTGATGAGCGCCGCGCTGTGGGGCTTGGCCGCGGGCGCGCTGCTGGCGGGGCCG
CTGGCCGACCGCATCGGCCGCAAGCGCGTGCTGCTGGGCGCGGTGCTGCTGTTCGGCGCGATGAGCGTCGCGACCTCCGC
CGCCGCCGATCTGGCCGCGCTGGCCTGGCTGCGTTTCGCCACCGGACTGGGCCTGGGCGCGGCGATGGCCAACGCGGTGA
CGCTGACGTCCGAGTATTCGCCGGAGCCGCGGCGGGCCTTCATCGTCAGCGCGATGTTCTGCGGCTTTCCGCTGGGCGCG
GCCTGCGGCGGGTTGCTGGCGTCGTGGCTGGTGCCGCATGCCGGCTGGCGCAGCGTGCTGTTGCTGGGCGGCATCGCGCC
GCTGCTGCTGCTGCCGCCGATGTGGCTGTCGCTGCCTGAGTCGCTGCGTTTTCTGATACTGCGCGGCAGAGAGGGCGAAG
CCCGCCGCATCCTCAGGCGGCTGCTGCCCGACGCGCCGTTGCGCGACGGCGACAGGCTGGTGCTGCGCGAGGCCGAGCGG
ATGCCGGGCTTGCGGCTGGTCTGGTCCGCAGATTACCGGACGGGCACGCTGTTGCTGGCTCTGGCTTATTTCATGGGCCT
GCTGATCTTCTATCTGTTGACCAGCTGGCTGCCCATCCTGATCAGCGACAGCGGCATGGATTTGCGGCAAGCGGCGTTGC
TGACCGCGCTGTTCCCGTTCGGCGGCCTGCTGGGCAGCACGCTGACCGGCTGGCTGATGGACCGCTGCGACGCGCACCGC
GTGCTGGCGCTCGCCTATCTGCTGACCGGCGCGCTGGTGTTCTGCATCGGCCAGGCGCTGAACAATCACGGCCTGCTGGC
GGCGGTGATCTGCCTGGCCGGCATCGCGATGAACGGCGCGCAGGCATCGATGCCGTCGCTGGCCGCCGGCTATTACCCGA
CGGCGGGCCGGGCCAGCGGCGTGGCGTGGATGATGGGCATGGGCCGCTTCGGCGGCATCGCCGGCGCGATGCTGGGCGCG
ACGCTGCTGAAGCTGCAACTGGGCCTGCCGCTGTTCTTCGCGCTGCTGTCGCTGCCGGCGCTGCTGGCGGCAGCGGCCTT
GCTGCTCAAGCGCCGTTCCATCGCGATGGCGAGGAGGGCATGGGCATGA

Upstream 100 bases:

>100_bases
CATAATGAATATTTTGTTTGACTTCGGCGGGCATTGTTGCGCACCATATATTTGAAATCAATATATTTTTATGAATCAAA
ATTCTATGGGAGAGCTGTCG

Downstream 100 bases:

>100_bases
GCGAGAGGACGATAGCCGGCGTGCTGGAGGCCGTGCGCCGCCAGGCTTTGCCGGCCGACGACCGGGAGTTCTGCGTCGCG
CTGCACGACTACGTGCGCGA

Product: 3-hydroxyphenylpropionic acid transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSARQLDVGDLINRQRFSARQWRILMLCFLIVLCDGFDTAAIGYIAPAVIRDWGVARTQLGPVMSAALWGLAAGALLAGP
LADRIGRKRVLLGAVLLFGAMSVATSAAADLAALAWLRFATGLGLGAAMANAVTLTSEYSPEPRRAFIVSAMFCGFPLGA
ACGGLLASWLVPHAGWRSVLLLGGIAPLLLLPPMWLSLPESLRFLILRGREGEARRILRRLLPDAPLRDGDRLVLREAER
MPGLRLVWSADYRTGTLLLALAYFMGLLIFYLLTSWLPILISDSGMDLRQAALLTALFPFGGLLGSTLTGWLMDRCDAHR
VLALAYLLTGALVFCIGQALNNHGLLAAVICLAGIAMNGAQASMPSLAAGYYPTAGRASGVAWMMGMGRFGGIAGAMLGA
TLLKLQLGLPLFFALLSLPALLAAAALLLKRRSIAMARRAWA

Sequences:

>Translated_442_residues
MSARQLDVGDLINRQRFSARQWRILMLCFLIVLCDGFDTAAIGYIAPAVIRDWGVARTQLGPVMSAALWGLAAGALLAGP
LADRIGRKRVLLGAVLLFGAMSVATSAAADLAALAWLRFATGLGLGAAMANAVTLTSEYSPEPRRAFIVSAMFCGFPLGA
ACGGLLASWLVPHAGWRSVLLLGGIAPLLLLPPMWLSLPESLRFLILRGREGEARRILRRLLPDAPLRDGDRLVLREAER
MPGLRLVWSADYRTGTLLLALAYFMGLLIFYLLTSWLPILISDSGMDLRQAALLTALFPFGGLLGSTLTGWLMDRCDAHR
VLALAYLLTGALVFCIGQALNNHGLLAAVICLAGIAMNGAQASMPSLAAGYYPTAGRASGVAWMMGMGRFGGIAGAMLGA
TLLKLQLGLPLFFALLSLPALLAAAALLLKRRSIAMARRAWA
>Mature_441_residues
SARQLDVGDLINRQRFSARQWRILMLCFLIVLCDGFDTAAIGYIAPAVIRDWGVARTQLGPVMSAALWGLAAGALLAGPL
ADRIGRKRVLLGAVLLFGAMSVATSAAADLAALAWLRFATGLGLGAAMANAVTLTSEYSPEPRRAFIVSAMFCGFPLGAA
CGGLLASWLVPHAGWRSVLLLGGIAPLLLLPPMWLSLPESLRFLILRGREGEARRILRRLLPDAPLRDGDRLVLREAERM
PGLRLVWSADYRTGTLLLALAYFMGLLIFYLLTSWLPILISDSGMDLRQAALLTALFPFGGLLGSTLTGWLMDRCDAHRV
LALAYLLTGALVFCIGQALNNHGLLAAVICLAGIAMNGAQASMPSLAAGYYPTAGRASGVAWMMGMGRFGGIAGAMLGAT
LLKLQLGLPLFFALLSLPALLAAAALLLKRRSIAMARRAWA

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=448, Percent_Identity=26.7857142857143, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI166064021, Length=246, Percent_Identity=31.7073170731707, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI7662270, Length=309, Percent_Identity=22.6537216828479, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI154350196, Length=396, Percent_Identity=22.7272727272727, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI87081723, Length=410, Percent_Identity=34.390243902439, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082231, Length=428, Percent_Identity=24.5327102803738, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87082404, Length=423, Percent_Identity=23.6406619385343, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1786229, Length=191, Percent_Identity=30.3664921465969, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082159, Length=380, Percent_Identity=26.8421052631579, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788074, Length=357, Percent_Identity=26.3305322128852, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082320, Length=305, Percent_Identity=22.6229508196721, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI48994889, Length=129, Percent_Identity=36.4341085271318, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=441, Percent_Identity=24.4897959183673, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19922874, Length=209, Percent_Identity=29.6650717703349, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640198, Length=463, Percent_Identity=22.6781857451404, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640196, Length=463, Percent_Identity=22.6781857451404, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640200, Length=463, Percent_Identity=22.6781857451404, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47039; Mature: 46908

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARQLDVGDLINRQRFSARQWRILMLCFLIVLCDGFDTAAIGYIAPAVIRDWGVARTQL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
GPVMSAALWGLAAGALLAGPLADRIGRKRVLLGAVLLFGAMSVATSAAADLAALAWLRFA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLGLGAAMANAVTLTSEYSPEPRRAFIVSAMFCGFPLGAACGGLLASWLVPHAGWRSVL
HHCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
LLGGIAPLLLLPPMWLSLPESLRFLILRGREGEARRILRRLLPDAPLRDGDRLVLREAER
HHHHHHHHHHCCCHHHCCHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MPGLRLVWSADYRTGTLLLALAYFMGLLIFYLLTSWLPILISDSGMDLRQAALLTALFPF
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
GGLLGSTLTGWLMDRCDAHRVLALAYLLTGALVFCIGQALNNHGLLAAVICLAGIAMNGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
QASMPSLAAGYYPTAGRASGVAWMMGMGRFGGIAGAMLGATLLKLQLGLPLFFALLSLPA
HHCCCHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAAALLLKRRSIAMARRAWA
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SARQLDVGDLINRQRFSARQWRILMLCFLIVLCDGFDTAAIGYIAPAVIRDWGVARTQL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
GPVMSAALWGLAAGALLAGPLADRIGRKRVLLGAVLLFGAMSVATSAAADLAALAWLRFA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLGLGAAMANAVTLTSEYSPEPRRAFIVSAMFCGFPLGAACGGLLASWLVPHAGWRSVL
HHCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHH
LLGGIAPLLLLPPMWLSLPESLRFLILRGREGEARRILRRLLPDAPLRDGDRLVLREAER
HHHHHHHHHHCCCHHHCCHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MPGLRLVWSADYRTGTLLLALAYFMGLLIFYLLTSWLPILISDSGMDLRQAALLTALFPF
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
GGLLGSTLTGWLMDRCDAHRVLALAYLLTGALVFCIGQALNNHGLLAAVICLAGIAMNGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCC
QASMPSLAAGYYPTAGRASGVAWMMGMGRFGGIAGAMLGATLLKLQLGLPLFFALLSLPA
HHCCCHHHCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAAALLLKRRSIAMARRAWA
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]