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The map label for this gene is pydA [H]

Identifier: 34499006

GI number: 34499006

Start: 3859540

End: 3860490

Strand: Reverse

Name: pydA [H]

Synonym: CV_3551

Alternate gene names: 34499006

Gene position: 3860490-3859540 (Counterclockwise)

Preceding gene: 34499007

Following gene: 34499002

Centisome position: 81.25

GC content: 68.35

Gene sequence:

>951_bases
ATGTCCCACGACCACGCCATCGATCTGTCCGTCACCTGGCTGGGCCAGACCATGCCGGGCTGCCTGTACAATGCCTCCGG
CGTCTGGTGCCGCGAGGAGGACGAACTGGAGGTGCTGCTCGCCTCCGACGCCGCCGCGGTGATCAGCAAGAGCGCCACGC
TGGCGCCGCGCGACGGCAATCCCGAGCCGCGCTATTGCCGCACCGCCATGGGCAGCATCAATTCCATGGGCCTGCCCAAC
CGCGGCTTCGACTATTACCTGGACTACGCGCGCCGCTATCGCTACGGCAGCGGCAAGCCGTTGTTCCTGTCCCTGTCCGG
CCTGTCGCTGGACGACAATTGCGCGATGCTGCGCCGTCTGGCCGAGGAGGGCTTGCCGGCGGTACCGGAGATCAATCTGT
CCTGCCCCAACGTGCCGGGCAAGCCGCAGTTGGGCTACGACTTCGCCGCCACCGCCGAGGCGCTGGGCGCTTTCGACGCC
GCCTATTCCGGCCTGTACGGCGTCAAGCTGCCGCCTTACTTCGATCCCGCCCATTTCGCCGCGATGGCGGAGATATTGAA
CCGCCATCCGCGCCTGGCCTTCGTCACCTGCATCAACTCGATAGGCAACGGCCTGGTGGTGGACATCGACAGCGAGGCGG
TGGTGATCAAGCCCAAGGACGGCCTGGGCGGCCTGGGCGGCGACTACGTGTTGCCGACCGCGCTGGCCAATGTGCGGGAG
TTTTACCGGCTGCTGCCGGGCAAGGACGTGGTCGGCTGCGGCGGGGTGAAGAGCGGCCGCGAGGCTTTCATGCACATCCT
GGCCGGCGCGCGCGCGGTGCAGGTGGGCACCTGCCTGTATCACGAGGGGCCGGGCGCCTTCGCCCGCATCGCCGGCGAGC
TGGCGGCGCTGATGCGGGTCAAGGGTTACCGCCGCCTGGACGATTTCCGCGGCAGGCTGCGCACCCTGTAG

Upstream 100 bases:

>100_bases
CTTTGGCGGCCATCGCCGCCATGTTTGACCCCGCTCAGCGCGTCCGGGCGTTCTGTCCCGCAAAATCAAGGACATCTCAA
GCTCCTGACGAAAGCGTCCG

Downstream 100 bases:

>100_bases
GCGCTTTTGCTCAGTCGAAGCGCCAGCACGCCATCGACAGCGAACCCATGCGCCAGTCGTCGTGCAGCTTGACCGGAACC
GCGTCGTCATCCGACGCGCC

Product: dihydroorotate dehydrogenase 1A

Products: NA

Alternate protein names: DHOdehase A; DHOD A; DHODase A; Dihydroorotate oxidase A [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSHDHAIDLSVTWLGQTMPGCLYNASGVWCREEDELEVLLASDAAAVISKSATLAPRDGNPEPRYCRTAMGSINSMGLPN
RGFDYYLDYARRYRYGSGKPLFLSLSGLSLDDNCAMLRRLAEEGLPAVPEINLSCPNVPGKPQLGYDFAATAEALGAFDA
AYSGLYGVKLPPYFDPAHFAAMAEILNRHPRLAFVTCINSIGNGLVVDIDSEAVVIKPKDGLGGLGGDYVLPTALANVRE
FYRLLPGKDVVGCGGVKSGREAFMHILAGARAVQVGTCLYHEGPGAFARIAGELAALMRVKGYRRLDDFRGRLRTL

Sequences:

>Translated_316_residues
MSHDHAIDLSVTWLGQTMPGCLYNASGVWCREEDELEVLLASDAAAVISKSATLAPRDGNPEPRYCRTAMGSINSMGLPN
RGFDYYLDYARRYRYGSGKPLFLSLSGLSLDDNCAMLRRLAEEGLPAVPEINLSCPNVPGKPQLGYDFAATAEALGAFDA
AYSGLYGVKLPPYFDPAHFAAMAEILNRHPRLAFVTCINSIGNGLVVDIDSEAVVIKPKDGLGGLGGDYVLPTALANVRE
FYRLLPGKDVVGCGGVKSGREAFMHILAGARAVQVGTCLYHEGPGAFARIAGELAALMRVKGYRRLDDFRGRLRTL
>Mature_315_residues
SHDHAIDLSVTWLGQTMPGCLYNASGVWCREEDELEVLLASDAAAVISKSATLAPRDGNPEPRYCRTAMGSINSMGLPNR
GFDYYLDYARRYRYGSGKPLFLSLSGLSLDDNCAMLRRLAEEGLPAVPEINLSCPNVPGKPQLGYDFAATAEALGAFDAA
YSGLYGVKLPPYFDPAHFAAMAEILNRHPRLAFVTCINSIGNGLVVDIDSEAVVIKPKDGLGGLGGDYVLPTALANVREF
YRLLPGKDVVGCGGVKSGREAFMHILAGARAVQVGTCLYHEGPGAFARIAGELAALMRVKGYRRLDDFRGRLRTL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=276, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322633, Length=311, Percent_Identity=52.411575562701, Blast_Score=330, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 34053; Mature: 33922

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDHAIDLSVTWLGQTMPGCLYNASGVWCREEDELEVLLASDAAAVISKSATLAPRDGN
CCCCCEEEEEEEECCCCCCCCEECCCCCEECCCCCEEEEEECCHHHHHHCCCEECCCCCC
PEPRYCRTAMGSINSMGLPNRGFDYYLDYARRYRYGSGKPLFLSLSGLSLDDNCAMLRRL
CCHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHH
AEEGLPAVPEINLSCPNVPGKPQLGYDFAATAEALGAFDAAYSGLYGVKLPPYFDPAHFA
HHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AMAEILNRHPRLAFVTCINSIGNGLVVDIDSEAVVIKPKDGLGGLGGDYVLPTALANVRE
HHHHHHHCCCCEEHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
FYRLLPGKDVVGCGGVKSGREAFMHILAGARAVQVGTCLYHEGPGAFARIAGELAALMRV
HHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
KGYRRLDDFRGRLRTL
HCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SHDHAIDLSVTWLGQTMPGCLYNASGVWCREEDELEVLLASDAAAVISKSATLAPRDGN
CCCCEEEEEEEECCCCCCCCEECCCCCEECCCCCEEEEEECCHHHHHHCCCEECCCCCC
PEPRYCRTAMGSINSMGLPNRGFDYYLDYARRYRYGSGKPLFLSLSGLSLDDNCAMLRRL
CCHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHH
AEEGLPAVPEINLSCPNVPGKPQLGYDFAATAEALGAFDAAYSGLYGVKLPPYFDPAHFA
HHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AMAEILNRHPRLAFVTCINSIGNGLVVDIDSEAVVIKPKDGLGGLGGDYVLPTALANVRE
HHHHHHHCCCCEEHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
FYRLLPGKDVVGCGGVKSGREAFMHILAGARAVQVGTCLYHEGPGAFARIAGELAALMRV
HHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHH
KGYRRLDDFRGRLRTL
HCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]