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The map label for this gene is adc

Identifier: 34498975

GI number: 34498975

Start: 3817570

End: 3818310

Strand: Reverse

Name: adc

Synonym: CV_3520

Alternate gene names: 34498975

Gene position: 3818310-3817570 (Counterclockwise)

Preceding gene: 34498977

Following gene: 34498973

Centisome position: 80.37

GC content: 63.56

Gene sequence:

>741_bases
ATGAAGCAACAGGAAGTCCGCCAGCGCGCGTTCGCGATGCCCTTGACCAGTCCTGCCTTTCCGCCGGGGCCTTATCGTTT
CGTCAACCGCGAATACATGATCATCACCTACCGCACCGATCCCGCCGCGATCGAAGCGGTCTTGCCTGAGCCGCTGCAGA
TGGCGGAGCCGGTGGTCCGGTATGAGTTCATCCGCATGCCGGATTCGACCGGATTTGGCGATTACTCGGAAAGCGGGCAG
GTGATTCCCGTGACGTTCCGCGGCGAGCGCGGCAGCTATACCCTGGCGATGTTTCTGGACGATCAGCCGCCGTTGGCAGG
CGGGCGCGAGTTGTGGGGCTTCCCGAAAAAGGCGGGCAAGCCCAGGCTGGAGGTGCATCAGGACACCCTGGTGGGAAGCC
TGGATTTCGGCCCGGTCCGCATCGCCACCGGCACCATGGGCTACAAGTACGAAGCGCTGGATCGTTCAGCCTTGCTGGCC
AGCCTGGCCGAACCCAATTTCCTGCTGAAGATCATCCCGCATGTGGACGGCTCGCCGCGCATCTGCGAGTTGGTGCGCTA
CCATACCACCGATGTCGCGATCAAAGGCGCGTGGAGCGCGCCGGGGTCGCTGGAGCTGCATCCGCACGCGCTGGCGCCGG
TTGCGGCCTTGCCGGTGCTGGAAGTGCTGTCGGCGCGGCATTTCGTCTGCGATCTGACGCTGGATCTGGGAACCGTGGTG
TTCGATTACCTGCGGCAATAA

Upstream 100 bases:

>100_bases
GTGGAAAACTGGCCTTCCAGGCAGGAATGAATGTTGCGTTGCAGTATCTGCTTCATATTGCCGATGGTCCGCATGCCATC
CTGCTTGAAGGGAGTTAGCC

Downstream 100 bases:

>100_bases
CGGCGGCTGCGAGAAAAACGGCCCCTTTGGGGCCGTTTCTCATTGCCGGTTCGCGCTTCAGAACCAGAAGTAGCGCCGCA
GCGCGGCATCCAGGTTGGCC

Product: acetoacetate decarboxylase

Products: NA

Alternate protein names: AAD; ADC

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKQQEVRQRAFAMPLTSPAFPPGPYRFVNREYMIITYRTDPAAIEAVLPEPLQMAEPVVRYEFIRMPDSTGFGDYSESGQ
VIPVTFRGERGSYTLAMFLDDQPPLAGGRELWGFPKKAGKPRLEVHQDTLVGSLDFGPVRIATGTMGYKYEALDRSALLA
SLAEPNFLLKIIPHVDGSPRICELVRYHTTDVAIKGAWSAPGSLELHPHALAPVAALPVLEVLSARHFVCDLTLDLGTVV
FDYLRQ

Sequences:

>Translated_246_residues
MKQQEVRQRAFAMPLTSPAFPPGPYRFVNREYMIITYRTDPAAIEAVLPEPLQMAEPVVRYEFIRMPDSTGFGDYSESGQ
VIPVTFRGERGSYTLAMFLDDQPPLAGGRELWGFPKKAGKPRLEVHQDTLVGSLDFGPVRIATGTMGYKYEALDRSALLA
SLAEPNFLLKIIPHVDGSPRICELVRYHTTDVAIKGAWSAPGSLELHPHALAPVAALPVLEVLSARHFVCDLTLDLGTVV
FDYLRQ
>Mature_246_residues
MKQQEVRQRAFAMPLTSPAFPPGPYRFVNREYMIITYRTDPAAIEAVLPEPLQMAEPVVRYEFIRMPDSTGFGDYSESGQ
VIPVTFRGERGSYTLAMFLDDQPPLAGGRELWGFPKKAGKPRLEVHQDTLVGSLDFGPVRIATGTMGYKYEALDRSALLA
SLAEPNFLLKIIPHVDGSPRICELVRYHTTDVAIKGAWSAPGSLELHPHALAPVAALPVLEVLSARHFVCDLTLDLGTVV
FDYLRQ

Specific function: Catalyzes the conversion of acetoacetate to acetone and carbon dioxide

COG id: COG4689

COG function: function code Q; Acetoacetate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ADC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADC_CHRVO (Q7NSA6)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903190.1
- PDB:   3BGT
- PDB:   3BH3
- PDBsum:   3BGT
- PDBsum:   3BH3
- ProteinModelPortal:   Q7NSA6
- SMR:   Q7NSA6
- GeneID:   2548254
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3520
- NMPDR:   fig|243365.1.peg.3520
- HOGENOM:   HBG294597
- OMA:   MGYKHRP
- ProtClustDB:   PRK02265
- BioCyc:   CVIO243365:CV_3520-MONOMER
- BRENDA:   4.1.1.4
- HAMAP:   MF_00597
- InterPro:   IPR010451

Pfam domain/function: PF06314 ADC

EC number: =4.1.1.4

Molecular weight: Translated: 27300; Mature: 27300

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQEVRQRAFAMPLTSPAFPPGPYRFVNREYMIITYRTDPAAIEAVLPEPLQMAEPVVR
CCHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEEEEECCCCHHHHHHCCCCHHHHCHHHE
YEFIRMPDSTGFGDYSESGQVIPVTFRGERGSYTLAMFLDDQPPLAGGRELWGFPKKAGK
EEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCHHHCCCCHHCCC
PRLEVHQDTLVGSLDFGPVRIATGTMGYKYEALDRSALLASLAEPNFLLKIIPHVDGSPR
CCEEEECCCEEECCCCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
ICELVRYHTTDVAIKGAWSAPGSLELHPHALAPVAALPVLEVLSARHFVCDLTLDLGTVV
HHHHHHHCCCCEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHH
FDYLRQ
HHHHCC
>Mature Secondary Structure
MKQQEVRQRAFAMPLTSPAFPPGPYRFVNREYMIITYRTDPAAIEAVLPEPLQMAEPVVR
CCHHHHHHHHHCCCCCCCCCCCCCCEEECCEEEEEEECCCCHHHHHHCCCCHHHHCHHHE
YEFIRMPDSTGFGDYSESGQVIPVTFRGERGSYTLAMFLDDQPPLAGGRELWGFPKKAGK
EEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCHHHCCCCHHCCC
PRLEVHQDTLVGSLDFGPVRIATGTMGYKYEALDRSALLASLAEPNFLLKIIPHVDGSPR
CCEEEECCCEEECCCCCCEEEEECCCCEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCHH
ICELVRYHTTDVAIKGAWSAPGSLELHPHALAPVAALPVLEVLSARHFVCDLTLDLGTVV
HHHHHHHCCCCEEEEECCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHH
FDYLRQ
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782