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The map label for this gene is moaA1 [H]

Identifier: 34498973

GI number: 34498973

Start: 3814165

End: 3815139

Strand: Reverse

Name: moaA1 [H]

Synonym: CV_3518

Alternate gene names: 34498973

Gene position: 3815139-3814165 (Counterclockwise)

Preceding gene: 34498975

Following gene: 34498961

Centisome position: 80.3

GC content: 65.95

Gene sequence:

>975_bases
ATGCTGATTGATCGTTTTGGACGGGCCATAGAATACCTGCGACTGTCCGTCACAGACCGCTGTGACCTGCGCTGCAGCTA
CTGTCTGCCCAAGGGTTTCAAGCATTTCGAAGAGCCGGAAAACTGGCTCACCTTCGACGAAATCGAGCGGGTGGTGGCGG
CCTTCGCCAGGCTTGGCACCCGCCGGGTGCGGCTGACCGGCGGCGAGCCGCTGCTGCGGCGCAATCTGCCGCAGCTCGCC
GCGCGCTTGTCGGCGCTGCCGGGCCTGGACGACCTGTCGCTGACCACCAATGGCACCCAGCTGAGCAGGCAGGCGGCCGA
GCTCCATGCCGCCGGCGTGCGGCGCATCAATCTGAGTCTGGACTCGTTGCGCCGGGACTGTGTTGAAGAGATCACCGGCA
GCGACAGCCTGCCCAAGGTGCTGGATGGCCTAATGGCCGCCAAGAAGGCAGGTTTCGCGCCGATCAAAATCAATATGGTG
GCGATGCGCGGCGTCAACGAGCAGGACATCGAGGCGATGACCGCCTTCTGCATCGAGCACGGTTTCATCCTGCGCCTGAT
CGAGGCGATGCCGATGGGGGACACCGGCCGCTCCGCGCATTACCTGGATCTGCAACCGGTGCTGCGGCGCCTGTGCGCGC
AGTTCGATCTGGTCGAGCAAGCCAGAACGCTGGGCGGCGGCCCGGCCCGTTACTGGAGCAGCCGCGACGGCGGCTTCTCG
CTGGGGGTGATCACGCCCATCTCGCAGCATTTCTGCGCCACCTGCAACCGGGTGCGGCTGTCGGTGGACGGCACGCTGTA
CATGTGCCTGGGACAGGAGGAGAAGATGGAGCTGCGTCCTCTGCTGCGCGCCGGCATCGACGACGCCGGCCTGGAGGCGG
CGCTGCGCGAGGCGATAGAGCTGAAGCCGGAGCGGCACGAGTTCCGCGAGCAGCCGCAGAAACTGGTCCGCTTCATGTCC
ATGACCGGCGGCTGA

Upstream 100 bases:

>100_bases
GGCGGGGGAAGCTCGCGATCCGCCGCGGCTGCGAGACGATGTCAGATTGTCCGTGCAGTGCCGACTAAATGAGACACAGG
GGGAGCGCTGCGGAGGATGC

Downstream 100 bases:

>100_bases
GAGCCTGCCACGGTTTTGCCGCCACGGGTCCGCGGCCAGGCAGGCGTCCGGTTGACGGCGTTGATGCCGATGACCGGCGT
TAACGCTCCAGGATCGCCCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MLIDRFGRAIEYLRLSVTDRCDLRCSYCLPKGFKHFEEPENWLTFDEIERVVAAFARLGTRRVRLTGGEPLLRRNLPQLA
ARLSALPGLDDLSLTTNGTQLSRQAAELHAAGVRRINLSLDSLRRDCVEEITGSDSLPKVLDGLMAAKKAGFAPIKINMV
AMRGVNEQDIEAMTAFCIEHGFILRLIEAMPMGDTGRSAHYLDLQPVLRRLCAQFDLVEQARTLGGGPARYWSSRDGGFS
LGVITPISQHFCATCNRVRLSVDGTLYMCLGQEEKMELRPLLRAGIDDAGLEAALREAIELKPERHEFREQPQKLVRFMS
MTGG

Sequences:

>Translated_324_residues
MLIDRFGRAIEYLRLSVTDRCDLRCSYCLPKGFKHFEEPENWLTFDEIERVVAAFARLGTRRVRLTGGEPLLRRNLPQLA
ARLSALPGLDDLSLTTNGTQLSRQAAELHAAGVRRINLSLDSLRRDCVEEITGSDSLPKVLDGLMAAKKAGFAPIKINMV
AMRGVNEQDIEAMTAFCIEHGFILRLIEAMPMGDTGRSAHYLDLQPVLRRLCAQFDLVEQARTLGGGPARYWSSRDGGFS
LGVITPISQHFCATCNRVRLSVDGTLYMCLGQEEKMELRPLLRAGIDDAGLEAALREAIELKPERHEFREQPQKLVRFMS
MTGG
>Mature_324_residues
MLIDRFGRAIEYLRLSVTDRCDLRCSYCLPKGFKHFEEPENWLTFDEIERVVAAFARLGTRRVRLTGGEPLLRRNLPQLA
ARLSALPGLDDLSLTTNGTQLSRQAAELHAAGVRRINLSLDSLRRDCVEEITGSDSLPKVLDGLMAAKKAGFAPIKINMV
AMRGVNEQDIEAMTAFCIEHGFILRLIEAMPMGDTGRSAHYLDLQPVLRRLCAQFDLVEQARTLGGGPARYWSSRDGGFS
LGVITPISQHFCATCNRVRLSVDGTLYMCLGQEEKMELRPLLRAGIDDAGLEAALREAIELKPERHEFREQPQKLVRFMS
MTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=307, Percent_Identity=34.5276872964169, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI116734668, Length=307, Percent_Identity=34.5276872964169, Blast_Score=183, Evalue=2e-46,
Organism=Escherichia coli, GI1786999, Length=326, Percent_Identity=38.6503067484663, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=32.8990228013029, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI32566331, Length=330, Percent_Identity=32.1212121212121, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=317, Percent_Identity=31.8611987381703, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28574490, Length=313, Percent_Identity=35.1437699680511, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574488, Length=313, Percent_Identity=35.1437699680511, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36191; Mature: 36191

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS01305 MOAA_NIFB_PQQE ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDRFGRAIEYLRLSVTDRCDLRCSYCLPKGFKHFEEPENWLTFDEIERVVAAFARLGT
CCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
RRVRLTGGEPLLRRNLPQLAARLSALPGLDDLSLTTNGTQLSRQAAELHAAGVRRINLSL
CEEEEECCCHHHHCCHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHEEECCH
DSLRRDCVEEITGSDSLPKVLDGLMAAKKAGFAPIKINMVAMRGVNEQDIEAMTAFCIEH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
GFILRLIEAMPMGDTGRSAHYLDLQPVLRRLCAQFDLVEQARTLGGGPARYWSSRDGGFS
HHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEE
LGVITPISQHFCATCNRVRLSVDGTLYMCLGQEEKMELRPLLRAGIDDAGLEAALREAIE
EEECCHHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
LKPERHEFREQPQKLVRFMSMTGG
CCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIDRFGRAIEYLRLSVTDRCDLRCSYCLPKGFKHFEEPENWLTFDEIERVVAAFARLGT
CCHHHHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
RRVRLTGGEPLLRRNLPQLAARLSALPGLDDLSLTTNGTQLSRQAAELHAAGVRRINLSL
CEEEEECCCHHHHCCHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHEEECCH
DSLRRDCVEEITGSDSLPKVLDGLMAAKKAGFAPIKINMVAMRGVNEQDIEAMTAFCIEH
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
GFILRLIEAMPMGDTGRSAHYLDLQPVLRRLCAQFDLVEQARTLGGGPARYWSSRDGGFS
HHHHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEE
LGVITPISQHFCATCNRVRLSVDGTLYMCLGQEEKMELRPLLRAGIDDAGLEAALREAIE
EEECCHHHHHHHHHHHHEEEEECCEEEEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
LKPERHEFREQPQKLVRFMSMTGG
CCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA