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The map label for this gene is fabH

Identifier: 34498871

GI number: 34498871

Start: 3709440

End: 3710399

Strand: Reverse

Name: fabH

Synonym: CV_3416

Alternate gene names: 34498871

Gene position: 3710399-3709440 (Counterclockwise)

Preceding gene: 34498872

Following gene: 34498870

Centisome position: 78.1

GC content: 66.77

Gene sequence:

>960_bases
ATGGGCTATTCCCGCATTCTCGGCACCGGCAGCTTCCTGCCGTCCCAGGTGCTTACCAATGCGCAGTTGGCCGAACGGGT
GGAAACCAGCGACGAGTGGATCGTCTCTCGTACCGGCATCCGCGCGCGCCATATTGCCGACGAAGGGCACAAGACCAGCG
ATCTGGCGCTGAGGGCGGCGCAAGCCGCCATCGCCAGCGCCGGCATCGACAAGGGCGAGATCGACCTGATCATCGTCGCC
ACCACCACCCCCGACATGGTTTTTCCCAGCACCGCCTGCATCCTGCAGGAGAAGCTGGGATTGCCCGGCGTGCAGGCCTT
TGACGTGCAGGCCGTGTGCGCCGGCTTCGTCTACGCGCTGACCACGGCCAACGCCTACATCAAGAGCGGCCTGGCCAAGA
AGGCGCTGGTGGTCGGCGCCGAAATCATGTCGCGCGTGCTGGACTGGGATGATCGCCGCACCTGCGTGCTGTTCGGCGAC
GGCGCCGGCGCCGTGGTACTGGGCGAGTCCGACGAGCCTGGCATCCTGCATGCCAAGCTGGCGGCGGACGGCCGCTACCA
GGGCTTGCTCAACACGCCGGCGCAGATTTCCGGCGGCAAGATCCAGGGCATCCCCTATCTGCACATGGACGGCCCGGCGG
TGTTCAAGTTCGCCGTCAAGTCGCTGTCCGAGATCGCCACCGCCACGCTGGCCGAGGCCGGCGTCGAACAGGCCAGCCTG
GACTGGCTGGTGCCGCACCAGGCCAATCTGCGCATCATCGAATCCACCGCCAAGCATCTTGGCCTGCCGATGGACAAGGT
GGTCGTCACCTTGCCGGAGCAGGGCAATACCTCGGCGGCTTCCATTCCGCTGGCGCTGGACGTCGCGGTGCGCGACGGAC
GCATCCGGCGCGGCCAGACCGTGATGCTGGAAGGCATTGGCGGCGGTTTCGCCTGGGGCGCGGTGCTGCTGACCTTCTGA

Upstream 100 bases:

>100_bases
GCGAGGAGGCCGGTTCCGACGTTATTGCACACATCGCCGATCGGGTTGCCAAACAACTAGACAACCTCAAGCAATCCGAG
GCGGAAGCGAACTGAAAAAT

Downstream 100 bases:

>100_bases
TTGGCATTCCGCAAAGTGGCTTTTTCGCCGCATGATCGCCGATAATGACAGCGTTTATTGATCGGCGACGTGGCGCGCAT
GGCCGCTTTGCGTCATCCTT

Product: 3-oxoacyl-ACP synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MGYSRILGTGSFLPSQVLTNAQLAERVETSDEWIVSRTGIRARHIADEGHKTSDLALRAAQAAIASAGIDKGEIDLIIVA
TTTPDMVFPSTACILQEKLGLPGVQAFDVQAVCAGFVYALTTANAYIKSGLAKKALVVGAEIMSRVLDWDDRRTCVLFGD
GAGAVVLGESDEPGILHAKLAADGRYQGLLNTPAQISGGKIQGIPYLHMDGPAVFKFAVKSLSEIATATLAEAGVEQASL
DWLVPHQANLRIIESTAKHLGLPMDKVVVTLPEQGNTSAASIPLALDVAVRDGRIRRGQTVMLEGIGGGFAWGAVLLTF

Sequences:

>Translated_319_residues
MGYSRILGTGSFLPSQVLTNAQLAERVETSDEWIVSRTGIRARHIADEGHKTSDLALRAAQAAIASAGIDKGEIDLIIVA
TTTPDMVFPSTACILQEKLGLPGVQAFDVQAVCAGFVYALTTANAYIKSGLAKKALVVGAEIMSRVLDWDDRRTCVLFGD
GAGAVVLGESDEPGILHAKLAADGRYQGLLNTPAQISGGKIQGIPYLHMDGPAVFKFAVKSLSEIATATLAEAGVEQASL
DWLVPHQANLRIIESTAKHLGLPMDKVVVTLPEQGNTSAASIPLALDVAVRDGRIRRGQTVMLEGIGGGFAWGAVLLTF
>Mature_318_residues
GYSRILGTGSFLPSQVLTNAQLAERVETSDEWIVSRTGIRARHIADEGHKTSDLALRAAQAAIASAGIDKGEIDLIIVAT
TTPDMVFPSTACILQEKLGLPGVQAFDVQAVCAGFVYALTTANAYIKSGLAKKALVVGAEIMSRVLDWDDRRTCVLFGDG
AGAVVLGESDEPGILHAKLAADGRYQGLLNTPAQISGGKIQGIPYLHMDGPAVFKFAVKSLSEIATATLAEAGVEQASLD
WLVPHQANLRIIESTAKHLGLPMDKVVVTLPEQGNTSAASIPLALDVAVRDGRIRRGQTVMLEGIGGGFAWGAVLLTF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=55.8359621451104, Blast_Score=344, Evalue=4e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CHRVO (Q7NSK7)

Other databases:

- EMBL:   AE016825
- RefSeq:   NP_903086.1
- ProteinModelPortal:   Q7NSK7
- SMR:   Q7NSK7
- GeneID:   2548497
- GenomeReviews:   AE016825_GR
- KEGG:   cvi:CV_3416
- NMPDR:   fig|243365.1.peg.3416
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- PhylomeDB:   Q7NSK7
- ProtClustDB:   PRK09352
- BioCyc:   CVIO243365:CV_3416-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 33557; Mature: 33426

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: ACT_SITE 113-113 ACT_SITE 246-246 ACT_SITE 276-276

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYSRILGTGSFLPSQVLTNAQLAERVETSDEWIVSRTGIRARHIADEGHKTSDLALRAA
CCCHHEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHCCCCCCCHHHHHHHH
QAAIASAGIDKGEIDLIIVATTTPDMVFPSTACILQEKLGLPGVQAFDVQAVCAGFVYAL
HHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
TTANAYIKSGLAKKALVVGAEIMSRVLDWDDRRTCVLFGDGAGAVVLGESDEPGILHAKL
HHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCEEEEEE
AADGRYQGLLNTPAQISGGKIQGIPYLHMDGPAVFKFAVKSLSEIATATLAEAGVEQASL
ECCCCCCCCCCCCCCCCCCEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DWLVPHQANLRIIESTAKHLGLPMDKVVVTLPEQGNTSAASIPLALDVAVRDGRIRRGQT
EEECCCCCCEEEEEHHHHHHCCCHHHEEEECCCCCCCCCEECEEEEEEEEECCCCCCCCE
VMLEGIGGGFAWGAVLLTF
EEEEECCCCHHHHHHEECC
>Mature Secondary Structure 
GYSRILGTGSFLPSQVLTNAQLAERVETSDEWIVSRTGIRARHIADEGHKTSDLALRAA
CCHHEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCEEEHHCCCCCCCHHHHHHHH
QAAIASAGIDKGEIDLIIVATTTPDMVFPSTACILQEKLGLPGVQAFDVQAVCAGFVYAL
HHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHH
TTANAYIKSGLAKKALVVGAEIMSRVLDWDDRRTCVLFGDGAGAVVLGESDEPGILHAKL
HHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCCCCEEEEEE
AADGRYQGLLNTPAQISGGKIQGIPYLHMDGPAVFKFAVKSLSEIATATLAEAGVEQASL
ECCCCCCCCCCCCCCCCCCEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DWLVPHQANLRIIESTAKHLGLPMDKVVVTLPEQGNTSAASIPLALDVAVRDGRIRRGQT
EEECCCCCCEEEEEHHHHHHCCCHHHEEEECCCCCCCCCEECEEEEEEEEECCCCCCCCE
VMLEGIGGGFAWGAVLLTF
EEEEECCCCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14500782