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The map label for this gene is fabF [H]

Identifier: 34498867

GI number: 34498867

Start: 3705799

End: 3707040

Strand: Reverse

Name: fabF [H]

Synonym: CV_3412

Alternate gene names: 34498867

Gene position: 3707040-3705799 (Counterclockwise)

Preceding gene: 34498868

Following gene: 34498866

Centisome position: 78.03

GC content: 67.31

Gene sequence:

>1242_bases
GTGTCCAAACGCAGAGTAGTAGTCACCGGCCTGGGCCATGTGTCCCCGGTCGGCAACGACGTCGCCACCGGCTGGGCCAA
TCTGTTGGCCGGCAAGAGCGGCATCGCCAAGATCACCCGTTTCGACGCCAGCGACATGGCCTGCCAGATCGCGGGCGAGG
TCAAGGACTTCAATATCGGCGACTACATTTCGCCGAAGGAAGCGCGTCGCAACGACCTGTTCATTCACTACGGCATCGCC
GCGGCCTTGCAGGCCGTCGCCGACGCCGGGCTGGACGACATCCCGGGCCTGGACAAGACCCGCGTCGGCGTCAACATCGG
CTCCGGCATCGGCGGCCTGCCGCTGATCGAGGAAACCGGCGTGGCGCTGATGGAAGGCGGTCCGCGCAAGATCGGCCCGT
TTTTCATCCCGGGCTCGCTGATCAACCTGATCGCCGGCCAGGTGTCCATCCTGAAGGGCTATCAAGGCCCCAGCTACGGC
ATCGTGTCCGCCTGCACCACCGGCGCGCACTGCATCGGCGACGCCGCGCGCCTGATCCAGTACGGCGACGCCGACATCAT
GGTCGCCGGCGGCGCCGAGGGCGCGGTGTCGCGCCTGGGCATCGGCGGCTTCGCCGCGATGAAGGCGCTGTCCACGCGCA
ACGACGACCCCGAGGCCGCCTCCCGTCCGTGGGACAAGGGCCGCGACGGCTTCGTGATGGGCGAGGGCGCCGGCGTGCTG
GTGCTGGAAGAGTACGAGCACGCGGTCAAGCGCGGCGCCAAGATCTATGCCGAGCTGATCGGTTTCGGCATGAGCTCGGA
CGCGCACCACATCACCGCGCCCAACGCCGAGGGCCCGGCCCGCGGCGTGGTCAACGCGCTGCGCGACGCCGGCATCAATG
CCGACGCGGTGCAGTACGTGAACGCGCACGGCACGTCCACCCCGCTGGGCGACGCCAACGAGACCAACGCGCTGAAGATC
GCTTTTGGCGATCACGCCAAGAAGCTGGTCGTCAACTCCACCAAGTCCATGACCGGCCACTTGCTGGGCGGCGCGGGCGG
CGTGGAGGCGATCTACACCATCCTGGCGATCCACAACCAGGTGTCTCCGCCGACCATCAACCTGGTCGAGCAGGATCTGG
AAGCCGGCTGCGATCTCGATTACGCGGCCAACACCGCGCGCGAGATGAAGATCGAGGTGGGCATTTCCAACTCCTTCGGC
TTCGGCGGCACCAACGGCACCCTGGTGTTCAAGCGCGTCTGA

Upstream 100 bases:

>100_bases
TTAAGAAGGTTCCAAACGCGCGTTTGAACCAAGCTTGTGTTCACCCGGCGCGCGTGGTTTCATCGGGAGACTGCCCTCCC
ATCTATCACGGAGATTCTTC

Downstream 100 bases:

>100_bases
TCGCCGCTGCCGGCGATTGACAGAGCGAACCGCTGCGCTACACTCGCAGCGGTTTTTCTTTTTTCGCCGCCGCTCAAGGC
GGGCGGCGAGTTGTCGCGAA

Product: 3-oxoacyl-ACP synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSKRRVVVTGLGHVSPVGNDVATGWANLLAGKSGIAKITRFDASDMACQIAGEVKDFNIGDYISPKEARRNDLFIHYGIA
AALQAVADAGLDDIPGLDKTRVGVNIGSGIGGLPLIEETGVALMEGGPRKIGPFFIPGSLINLIAGQVSILKGYQGPSYG
IVSACTTGAHCIGDAARLIQYGDADIMVAGGAEGAVSRLGIGGFAAMKALSTRNDDPEAASRPWDKGRDGFVMGEGAGVL
VLEEYEHAVKRGAKIYAELIGFGMSSDAHHITAPNAEGPARGVVNALRDAGINADAVQYVNAHGTSTPLGDANETNALKI
AFGDHAKKLVVNSTKSMTGHLLGGAGGVEAIYTILAIHNQVSPPTINLVEQDLEAGCDLDYAANTAREMKIEVGISNSFG
FGGTNGTLVFKRV

Sequences:

>Translated_413_residues
MSKRRVVVTGLGHVSPVGNDVATGWANLLAGKSGIAKITRFDASDMACQIAGEVKDFNIGDYISPKEARRNDLFIHYGIA
AALQAVADAGLDDIPGLDKTRVGVNIGSGIGGLPLIEETGVALMEGGPRKIGPFFIPGSLINLIAGQVSILKGYQGPSYG
IVSACTTGAHCIGDAARLIQYGDADIMVAGGAEGAVSRLGIGGFAAMKALSTRNDDPEAASRPWDKGRDGFVMGEGAGVL
VLEEYEHAVKRGAKIYAELIGFGMSSDAHHITAPNAEGPARGVVNALRDAGINADAVQYVNAHGTSTPLGDANETNALKI
AFGDHAKKLVVNSTKSMTGHLLGGAGGVEAIYTILAIHNQVSPPTINLVEQDLEAGCDLDYAANTAREMKIEVGISNSFG
FGGTNGTLVFKRV
>Mature_412_residues
SKRRVVVTGLGHVSPVGNDVATGWANLLAGKSGIAKITRFDASDMACQIAGEVKDFNIGDYISPKEARRNDLFIHYGIAA
ALQAVADAGLDDIPGLDKTRVGVNIGSGIGGLPLIEETGVALMEGGPRKIGPFFIPGSLINLIAGQVSILKGYQGPSYGI
VSACTTGAHCIGDAARLIQYGDADIMVAGGAEGAVSRLGIGGFAAMKALSTRNDDPEAASRPWDKGRDGFVMGEGAGVLV
LEEYEHAVKRGAKIYAELIGFGMSSDAHHITAPNAEGPARGVVNALRDAGINADAVQYVNAHGTSTPLGDANETNALKIA
FGDHAKKLVVNSTKSMTGHLLGGAGGVEAIYTILAIHNQVSPPTINLVEQDLEAGCDLDYAANTAREMKIEVGISNSFGF
GGTNGTLVFKRV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=47.0023980815348, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI223972627, Length=172, Percent_Identity=49.4186046511628, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI41872631, Length=420, Percent_Identity=23.3333333333333, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=62.0192307692308, Blast_Score=476, Evalue=1e-135,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=40.6779661016949, Blast_Score=261, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=420, Percent_Identity=38.0952380952381, Blast_Score=248, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=43.0769230769231, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI212642053, Length=421, Percent_Identity=24.9406175771971, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=263, Percent_Identity=26.615969581749, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=37.0786516853933, Blast_Score=249, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=40.7228915662651, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI19920632, Length=376, Percent_Identity=26.063829787234, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI221330659, Length=376, Percent_Identity=26.063829787234, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24581345, Length=432, Percent_Identity=23.6111111111111, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42668; Mature: 42537

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVVTGLGHVSPVGNDVATGWANLLAGKSGIAKITRFDASDMACQIAGEVKDFNIG
CCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCCCCCCC
DYISPKEARRNDLFIHYGIAAALQAVADAGLDDIPGLDKTRVGVNIGSGIGGLPLIEETG
CCCCCCHHCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHCC
VALMEGGPRKIGPFFIPGSLINLIAGQVSILKGYQGPSYGIVSACTTGAHCIGDAARLIQ
EEEECCCCCCCCCEEECHHHHHHHHHHHHEEECCCCCCCCHHHHHCCCCHHHHHHHHHHC
YGDADIMVAGGAEGAVSRLGIGGFAAMKALSTRNDDPEAASRPWDKGRDGFVMGEGAGVL
CCCCCEEEECCCCCHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEE
VLEEYEHAVKRGAKIYAELIGFGMSSDAHHITAPNAEGPARGVVNALRDAGINADAVQYV
EEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHHHEE
NAHGTSTPLGDANETNALKIAFGDHAKKLVVNSTKSMTGHLLGGAGGVEAIYTILAIHNQ
ECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHCCEEECCCCHHHHHHHHHHHHCC
VSPPTINLVEQDLEAGCDLDYAANTAREMKIEVGISNSFGFGGTNGTLVFKRV
CCCCCHHHHHHHHHCCCCCCHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SKRRVVVTGLGHVSPVGNDVATGWANLLAGKSGIAKITRFDASDMACQIAGEVKDFNIG
CCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCEEEEECCCCCCCCC
DYISPKEARRNDLFIHYGIAAALQAVADAGLDDIPGLDKTRVGVNIGSGIGGLPLIEETG
CCCCCCHHCCCCEEEEECHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHHCC
VALMEGGPRKIGPFFIPGSLINLIAGQVSILKGYQGPSYGIVSACTTGAHCIGDAARLIQ
EEEECCCCCCCCCEEECHHHHHHHHHHHHEEECCCCCCCCHHHHHCCCCHHHHHHHHHHC
YGDADIMVAGGAEGAVSRLGIGGFAAMKALSTRNDDPEAASRPWDKGRDGFVMGEGAGVL
CCCCCEEEECCCCCHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCEEEECCCCEE
VLEEYEHAVKRGAKIYAELIGFGMSSDAHHITAPNAEGPARGVVNALRDAGINADAVQYV
EEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHHHEE
NAHGTSTPLGDANETNALKIAFGDHAKKLVVNSTKSMTGHLLGGAGGVEAIYTILAIHNQ
ECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCHHCCEEECCCCHHHHHHHHHHHHCC
VSPPTINLVEQDLEAGCDLDYAANTAREMKIEVGISNSFGFGGTNGTLVFKRV
CCCCCHHHHHHHHHCCCCCCHHCCCCEEEEEEEECCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]