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The map label for this gene is metC [H]

Identifier: 34498849

GI number: 34498849

Start: 3687960

End: 3689102

Strand: Reverse

Name: metC [H]

Synonym: CV_3394

Alternate gene names: 34498849

Gene position: 3689102-3687960 (Counterclockwise)

Preceding gene: 34498850

Following gene: 34498848

Centisome position: 77.65

GC content: 68.68

Gene sequence:

>1143_bases
ATGACCGATTTCCACACCCTGGCCGTGACCGCCGGCGCGCACGAGGACCCGTTCGGCGCGGTGATGCCGCCGATCTACGC
CACCTCCACCTACCGCCAGCACGCGCCGGGCGAGCACACCGGCTACGAGTATTCCCGCTCGCAGAACCCGACCCGCGAGG
CGCTGGAGCGCGCGGTGGCCGAACTGGAAGGCGGCATCCGCGGCTACGCTTTCGGCTCCGGCTTGGCGGCGATCTCCACC
GTGCTGGAGCTGCTGCCGGCCGGCAGCCACCTGATCGCGGTCAACGACCTGTACGGCGGCACCTATCGTCTGTTCGAGAA
GGTGCGCAAGGCCAGCGCCAACCTGGAAGTGACCTATGTCGCCTCCGACGACAGCGCCGCGCTGGAGGCCGCCATCCGCC
CGAACACCCGGATGATCTGGGTGGAAACGCCGTCCAATCCGTTGAACCAGCTGGTGGACCTGCAACAGGTGTCGGCCATC
GCCCGCCGCCACAAGCTGATCGGCGTGGTCGACAACACTTTCGCCTCGCCGGTCAACCAGCGGCCGCTGGACTTCGGCTT
CGACATCGTCGTCCACTCCGCCACCAAATACCTGAACGGCCATTCCGACGTGGTGGCCGGCGTGGCTGTGGTCAGCCGCG
ACCAGCCGGAACTGGCCGAACAGCTGGCCTTCCTGCATAACGCGGTGGGCGCCATCCTGGACGCCTTCCCCAGCTTCCTG
GTGCTGCGCGGCTTGCGCACGCTGGCGCTGCGCATCGAGCAGCACAACCGCAACGGCCTGGCCATCGCGCGCTGGCTGGA
GGCGCAGCCTTGGGTGGAAAAGGTGCTGTACCCAGGCTTGGAAAGCCATCCGCAGCACGCGCTGGCGCGCCGCCAGATGC
AGGGCTACGGCGGCATCGTGTCGTTCTATCTGAAGGGCGACGTCAAGGCCTTCCTGGCCAGGCTCAAGCTGTTCGCGCTG
GCCGAAAGCCTGGGCGGCGTCGAAAGCCTGGTCTGCCTGCCGGCGGCGATGACCCACGCGTCGATTCCGGCCGAGCGCCG
CGCCGCGCTCGGCATCCACGACAACCTGATCCGCCTGTCGGTCGGCGTCGAGGGCGAGGCGGCGCTGATCGCCGACCTGG
AGCAGGCGCGGCGGGACAGCTGA

Upstream 100 bases:

>100_bases
CTGCTGTCGTTCTGGCGCCGCCAGCCGCGCGCCGCTTAAGCCGATTTCCCGCCCTGGCCGATTGCGCCGGGGCGCATGAT
TTTGAGAGAGGATTGAAAAC

Downstream 100 bases:

>100_bases
GCGCTTTGCCGCTAGAATCGGCCGTCATGCCCACCTACCCATCGATATGGAGAACGATATGAGCATTTACCGTCACAAGC
AGGGCGCCCGCCTGGCCGAG

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTDFHTLAVTAGAHEDPFGAVMPPIYATSTYRQHAPGEHTGYEYSRSQNPTREALERAVAELEGGIRGYAFGSGLAAIST
VLELLPAGSHLIAVNDLYGGTYRLFEKVRKASANLEVTYVASDDSAALEAAIRPNTRMIWVETPSNPLNQLVDLQQVSAI
ARRHKLIGVVDNTFASPVNQRPLDFGFDIVVHSATKYLNGHSDVVAGVAVVSRDQPELAEQLAFLHNAVGAILDAFPSFL
VLRGLRTLALRIEQHNRNGLAIARWLEAQPWVEKVLYPGLESHPQHALARRQMQGYGGIVSFYLKGDVKAFLARLKLFAL
AESLGGVESLVCLPAAMTHASIPAERRAALGIHDNLIRLSVGVEGEAALIADLEQARRDS

Sequences:

>Translated_380_residues
MTDFHTLAVTAGAHEDPFGAVMPPIYATSTYRQHAPGEHTGYEYSRSQNPTREALERAVAELEGGIRGYAFGSGLAAIST
VLELLPAGSHLIAVNDLYGGTYRLFEKVRKASANLEVTYVASDDSAALEAAIRPNTRMIWVETPSNPLNQLVDLQQVSAI
ARRHKLIGVVDNTFASPVNQRPLDFGFDIVVHSATKYLNGHSDVVAGVAVVSRDQPELAEQLAFLHNAVGAILDAFPSFL
VLRGLRTLALRIEQHNRNGLAIARWLEAQPWVEKVLYPGLESHPQHALARRQMQGYGGIVSFYLKGDVKAFLARLKLFAL
AESLGGVESLVCLPAAMTHASIPAERRAALGIHDNLIRLSVGVEGEAALIADLEQARRDS
>Mature_379_residues
TDFHTLAVTAGAHEDPFGAVMPPIYATSTYRQHAPGEHTGYEYSRSQNPTREALERAVAELEGGIRGYAFGSGLAAISTV
LELLPAGSHLIAVNDLYGGTYRLFEKVRKASANLEVTYVASDDSAALEAAIRPNTRMIWVETPSNPLNQLVDLQQVSAIA
RRHKLIGVVDNTFASPVNQRPLDFGFDIVVHSATKYLNGHSDVVAGVAVVSRDQPELAEQLAFLHNAVGAILDAFPSFLV
LRGLRTLALRIEQHNRNGLAIARWLEAQPWVEKVLYPGLESHPQHALARRQMQGYGGIVSFYLKGDVKAFLARLKLFALA
ESLGGVESLVCLPAAMTHASIPAERRAALGIHDNLIRLSVGVEGEAALIADLEQARRDS

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=347, Percent_Identity=52.1613832853026, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=46.3013698630137, Blast_Score=314, Evalue=9e-86,
Organism=Homo sapiens, GI25453487, Length=346, Percent_Identity=46.8208092485549, Blast_Score=299, Evalue=2e-81,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=46.2962962962963, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1789383, Length=368, Percent_Identity=32.8804347826087, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17538055, Length=382, Percent_Identity=49.2146596858639, Blast_Score=357, Evalue=8e-99,
Organism=Caenorhabditis elegans, GI17560056, Length=382, Percent_Identity=48.9528795811518, Blast_Score=354, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI71980708, Length=380, Percent_Identity=37.6315789473684, Blast_Score=237, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6319307, Length=386, Percent_Identity=47.1502590673575, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6321254, Length=411, Percent_Identity=34.0632603406326, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323333, Length=408, Percent_Identity=34.5588235294118, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321170, Length=329, Percent_Identity=31.9148936170213, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=400, Percent_Identity=30.25, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322590, Length=249, Percent_Identity=28.9156626506024, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322970, Length=235, Percent_Identity=31.063829787234, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19922554, Length=380, Percent_Identity=47.3684210526316, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41239; Mature: 41108

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFHTLAVTAGAHEDPFGAVMPPIYATSTYRQHAPGEHTGYEYSRSQNPTREALERAVA
CCCCEEEEEECCCCCCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELEGGIRGYAFGSGLAAISTVLELLPAGSHLIAVNDLYGGTYRLFEKVRKASANLEVTYV
HHCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEE
ASDDSAALEAAIRPNTRMIWVETPSNPLNQLVDLQQVSAIARRHKLIGVVDNTFASPVNQ
ECCCCHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCC
RPLDFGFDIVVHSATKYLNGHSDVVAGVAVVSRDQPELAEQLAFLHNAVGAILDAFPSFL
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLRGLRTLALRIEQHNRNGLAIARWLEAQPWVEKVLYPGLESHPQHALARRQMQGYGGIV
HHHHHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEE
SFYLKGDVKAFLARLKLFALAESLGGVESLVCLPAAMTHASIPAERRAALGIHDNLIRLS
EEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEE
VGVEGEAALIADLEQARRDS
ECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDFHTLAVTAGAHEDPFGAVMPPIYATSTYRQHAPGEHTGYEYSRSQNPTREALERAVA
CCCEEEEEECCCCCCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELEGGIRGYAFGSGLAAISTVLELLPAGSHLIAVNDLYGGTYRLFEKVRKASANLEVTYV
HHCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEE
ASDDSAALEAAIRPNTRMIWVETPSNPLNQLVDLQQVSAIARRHKLIGVVDNTFASPVNQ
ECCCCHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHCCCCCC
RPLDFGFDIVVHSATKYLNGHSDVVAGVAVVSRDQPELAEQLAFLHNAVGAILDAFPSFL
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLRGLRTLALRIEQHNRNGLAIARWLEAQPWVEKVLYPGLESHPQHALARRQMQGYGGIV
HHHHHHHHHHHHHHCCCCCEEEHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCEE
SFYLKGDVKAFLARLKLFALAESLGGVESLVCLPAAMTHASIPAERRAALGIHDNLIRLS
EEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEE
VGVEGEAALIADLEQARRDS
ECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]