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The map label for this gene is hlfC [H]

Identifier: 34498768

GI number: 34498768

Start: 3605622

End: 3606500

Strand: Direct

Name: hlfC [H]

Synonym: CV_3313

Alternate gene names: 34498768

Gene position: 3605622-3606500 (Clockwise)

Preceding gene: 34498767

Following gene: 34498769

Centisome position: 75.89

GC content: 69.74

Gene sequence:

>879_bases
ATGGATAAGCAGTGGCGCGGAATCGGCTGGGCGGCGGGCCTGGCGGTCGTATGGCTGGCGCTGTCGGCGCAATACACGCT
GAACGAGGGGCAGAAGGCGCTGGTGGTGCGCCTGGGCGCGCCGGTCAACGTGGACGGCGAGCCGGGGCTGAAATTCAAGC
TGCCGCTGGTGGACAGCGTGCAGTACTACGATACCCGGCTGCAGATGCTGGCCCCGCCGCCGGAGCAGGTGATCCTGGGC
GACGAGAAGCGGCTGGAGGTGGAAACCTACACCCGCTACCGCATCGCCGACACGCTGCGCTTCTACCAGGCGCTGCGCAC
CGAGGAGCAGGCGCGCGCGCAGCTGGCGCAGTTGGTCAGCACCTCGCTGCGGCGCGAGCTGGGCAAGGCGCCGCTGACCG
ATCTGCTGTCGCCGCGCCGGCGCGCCATCGTCGCCCGCATCCAGCAGGAAGTGGCGGAACGCGGCCGGCCGCTGGGCCTG
GAGGTGACCGAGGTGCAGCTGCACCGCGCCGACCTGCCGCTGGAAACCAGCCAGGCCATCTACGACCGGATGAAGTCGGC
CCGCCAGCAGGAGGCCAAGGAATTGCGCGCCCAGGGCGCGGAATGGGCGCAACAGATCCAGGCCAAGGCCGAGCGCGACC
GCACCGTGATCCTGTCCGAGGCGCAGCGGCAAAGCGCCATCATCCACGGCGAGGCCGACGCAGAGGCCGGCCGCACCCTG
GCCCAGGCCTTCAGCAAGGATCCCAAGTTCTACAAGTTCTACCGCTCGCTGCAAACCTACCGCCAGTCGCTGGCCGACTC
CGCGCCGACGCTGGTGCTGTCGCCCGACTCCGCGCTGCTGCATGACCTGAAAACCGGTCCGGCGGGCGGCAAGCCATGA

Upstream 100 bases:

>100_bases
CCAGCAAGGTGGTGATAGACGGCAGCGGCAAGAGCGGCGCCGGCGTGTTGCCGCTGCTGCAGCTGCAGGACAAACCCAAG
GCCGGCAAGGAGAACCGCTG

Downstream 100 bases:

>100_bases
GCGGGACCGACATGCCGCTGCAACCATCGGCGCTGCGCCGGCTGCGCCACCTGCTGGCCGCGCTCGGCCCCGGCCTGGTG
GTGATGCTGGCCGACACCGA

Product: hflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MDKQWRGIGWAAGLAVVWLALSAQYTLNEGQKALVVRLGAPVNVDGEPGLKFKLPLVDSVQYYDTRLQMLAPPPEQVILG
DEKRLEVETYTRYRIADTLRFYQALRTEEQARAQLAQLVSTSLRRELGKAPLTDLLSPRRRAIVARIQQEVAERGRPLGL
EVTEVQLHRADLPLETSQAIYDRMKSARQQEAKELRAQGAEWAQQIQAKAERDRTVILSEAQRQSAIIHGEADAEAGRTL
AQAFSKDPKFYKFYRSLQTYRQSLADSAPTLVLSPDSALLHDLKTGPAGGKP

Sequences:

>Translated_292_residues
MDKQWRGIGWAAGLAVVWLALSAQYTLNEGQKALVVRLGAPVNVDGEPGLKFKLPLVDSVQYYDTRLQMLAPPPEQVILG
DEKRLEVETYTRYRIADTLRFYQALRTEEQARAQLAQLVSTSLRRELGKAPLTDLLSPRRRAIVARIQQEVAERGRPLGL
EVTEVQLHRADLPLETSQAIYDRMKSARQQEAKELRAQGAEWAQQIQAKAERDRTVILSEAQRQSAIIHGEADAEAGRTL
AQAFSKDPKFYKFYRSLQTYRQSLADSAPTLVLSPDSALLHDLKTGPAGGKP
>Mature_292_residues
MDKQWRGIGWAAGLAVVWLALSAQYTLNEGQKALVVRLGAPVNVDGEPGLKFKLPLVDSVQYYDTRLQMLAPPPEQVILG
DEKRLEVETYTRYRIADTLRFYQALRTEEQARAQLAQLVSTSLRRELGKAPLTDLLSPRRRAIVARIQQEVAERGRPLGL
EVTEVQLHRADLPLETSQAIYDRMKSARQQEAKELRAQGAEWAQQIQAKAERDRTVILSEAQRQSAIIHGEADAEAGRTL
AQAFSKDPKFYKFYRSLQTYRQSLADSAPTLVLSPDSALLHDLKTGPAGGKP

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=308, Percent_Identity=31.4935064935065, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1786697, Length=242, Percent_Identity=25.6198347107438, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790616, Length=262, Percent_Identity=24.0458015267176, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71989955, Length=158, Percent_Identity=27.8481012658228, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71989948, Length=158, Percent_Identity=27.8481012658228, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17569493, Length=174, Percent_Identity=28.1609195402299, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21356845, Length=216, Percent_Identity=25.9259259259259, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 32700; Mature: 32700

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQWRGIGWAAGLAVVWLALSAQYTLNEGQKALVVRLGAPVNVDGEPGLKFKLPLVDSV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHH
QYYDTRLQMLAPPPEQVILGDEKRLEVETYTRYRIADTLRFYQALRTEEQARAQLAQLVS
HHHHHHHHHCCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLRRELGKAPLTDLLSPRRRAIVARIQQEVAERGRPLGLEVTEVQLHRADLPLETSQAI
HHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCCHHHHH
YDRMKSARQQEAKELRAQGAEWAQQIQAKAERDRTVILSEAQRQSAIIHGEADAEAGRTL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEHHHHHHHEEEECCCCHHHHHHH
AQAFSKDPKFYKFYRSLQTYRQSLADSAPTLVLSPDSALLHDLKTGPAGGKP
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDKQWRGIGWAAGLAVVWLALSAQYTLNEGQKALVVRLGAPVNVDGEPGLKFKLPLVDSV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHH
QYYDTRLQMLAPPPEQVILGDEKRLEVETYTRYRIADTLRFYQALRTEEQARAQLAQLVS
HHHHHHHHHCCCCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TSLRRELGKAPLTDLLSPRRRAIVARIQQEVAERGRPLGLEVTEVQLHRADLPLETSQAI
HHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCCHHHHH
YDRMKSARQQEAKELRAQGAEWAQQIQAKAERDRTVILSEAQRQSAIIHGEADAEAGRTL
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEEEEHHHHHHHEEEECCCCHHHHHHH
AQAFSKDPKFYKFYRSLQTYRQSLADSAPTLVLSPDSALLHDLKTGPAGGKP
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]