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The map label for this gene is htrA [H]

Identifier: 34498749

GI number: 34498749

Start: 3584613

End: 3586079

Strand: Direct

Name: htrA [H]

Synonym: CV_3294

Alternate gene names: 34498749

Gene position: 3584613-3586079 (Clockwise)

Preceding gene: 34498748

Following gene: 34498750

Centisome position: 75.45

GC content: 67.89

Gene sequence:

>1467_bases
ATGGCCGGCGCCCTGCTCGCGGCGTCGTTACTGTCCGGCTGCGACAGGATCGAGCAGTTTGTCAAAGGCAGCAACCAGCC
AGCCCCCGTCGCCATTCCTGCCCAGCAGGACGGCCGCGTAGCCATGCTGCTGCCCGACTTCACTCAGCTGGTCAGCCGGG
ACGGCCCGGCCGTGGTCAATATCCAGGCCACCCGCGAAGGCGGCGGAGCCGCGCCGCAGCAAAGCGGCAACATGCCCTTC
CCGGTGCCGGAAGACGACCCGCTGTACGACTTCTTCCGCCGCTTCATGCCCAACCAGCCGCCGCAACAGGAGCAGGGCCC
GGAGGAAAGCGTGTCCTACGGTTCCGGCTTCATCATCAGCAGCGACGGCTTCATCCTGACCAACGCCCACGTGGTGGCCG
ACGGCGGCCAGATCCGCGTCACGCTGACCGACAAGCGCGAACTGCGCGCCAAGCTGGTGGGCCTGGACAAGCGCAGCGAC
GTGGCCTTGCTCAAGGTGGCCGCGGCCGACCTGCCGGTGGCCAAGATCGGCAATCCGGCCGACCTGAAGGTCGGCGAATG
GGTGGCCGCCATCGGCGCGCCGTTCGGCTTCGACAACACCGTCACCGCCGGCATCGTATCGGCCAAGGGCCGCAGCCTGC
CCGACGAGACCCTGGTGCCCTTCATCCAGACCGACGTGGCGATCAACCCAGGCAACTCCGGCGGCCCGCTGTTCAACCTG
CGCGGCGAGGTGGTCGGCATCAACTCGCAGATCTACAGCCGTTCAGGCGGCTTCATGGGCATCTCCTTCGCCATCCCGAT
CGACCTGGCGATGCAAGTGGCCGACCAGCTGAAGACCAAGGGCAAGGTCAGCCGCGGCCAGCTGGGCGTCAACATCCAGG
AAGTGACCCAGGAGCTGGCGCAATCGTTCGGCCTGCAGCGGCCCTCCGGCGCGCTGGTGGTGCGCGTCGACCCCAAGGGC
CCCGCCGCCAGGGCGGGCCTGCAGGCTGGCGACATCATCCTGAAGCTCAACAACCAGTCCATCGACAGCTCCAAGGATCT
GCCGATGCTGGTGGGCTCGCTGGGCCCCGGCACCAAGATCAAGCTGGTGGTGTGGCGCAAGGGTTTCGAGAAGACGATGG
AAGCCACACTGGTGGAACAGGCACAGGAACCCGGCAGCAACACGAAACCGGCCAGCGACAACTCGCCGCAAGGCTACCAG
TTCGGCAAGCTGGGCCTGACGCTGTCCGAGCTGACGGCGGAGCAGCGCGGCGACCTCGGCATCCGCGGCGGCCTGCTGAT
CCAGAAGTCGCAAGGCCCGGCCGCGCGCTCCGGCCTGATGCCGGGCGACATCATCCTGGGACTGAACCAGAACGACATCA
CCAGCATCAGCGCCTTCGAGAAAGCGCTGGCCAGCGCCGGCGGCCACGCCGCGCTGCTGGTGCGCCGCGGCGAGGCGGTG
CTCTACATCGCGCTGCGCACCGACTGA

Upstream 100 bases:

>100_bases
TGACAGAAAACGGCTTGTATATTCCACTATTCGCCCCAATATGCCTTTTCGAATCAGCCAGCTACCAAGAGGATTGCCTG
TGACAACGAGTCTTCGCATC

Downstream 100 bases:

>100_bases
GCCTTGCCCCGCTCCGACGAAAAACGCCGCCTTCCGGGCGGCGTTTTTTTGTCCATCGCAAACCGTCTATAAATCCTGCA
TGACAAACGCTTTCCGCCGA

Product: serine protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MAGALLAASLLSGCDRIEQFVKGSNQPAPVAIPAQQDGRVAMLLPDFTQLVSRDGPAVVNIQATREGGGAAPQQSGNMPF
PVPEDDPLYDFFRRFMPNQPPQQEQGPEESVSYGSGFIISSDGFILTNAHVVADGGQIRVTLTDKRELRAKLVGLDKRSD
VALLKVAAADLPVAKIGNPADLKVGEWVAAIGAPFGFDNTVTAGIVSAKGRSLPDETLVPFIQTDVAINPGNSGGPLFNL
RGEVVGINSQIYSRSGGFMGISFAIPIDLAMQVADQLKTKGKVSRGQLGVNIQEVTQELAQSFGLQRPSGALVVRVDPKG
PAARAGLQAGDIILKLNNQSIDSSKDLPMLVGSLGPGTKIKLVVWRKGFEKTMEATLVEQAQEPGSNTKPASDNSPQGYQ
FGKLGLTLSELTAEQRGDLGIRGGLLIQKSQGPAARSGLMPGDIILGLNQNDITSISAFEKALASAGGHAALLVRRGEAV
LYIALRTD

Sequences:

>Translated_488_residues
MAGALLAASLLSGCDRIEQFVKGSNQPAPVAIPAQQDGRVAMLLPDFTQLVSRDGPAVVNIQATREGGGAAPQQSGNMPF
PVPEDDPLYDFFRRFMPNQPPQQEQGPEESVSYGSGFIISSDGFILTNAHVVADGGQIRVTLTDKRELRAKLVGLDKRSD
VALLKVAAADLPVAKIGNPADLKVGEWVAAIGAPFGFDNTVTAGIVSAKGRSLPDETLVPFIQTDVAINPGNSGGPLFNL
RGEVVGINSQIYSRSGGFMGISFAIPIDLAMQVADQLKTKGKVSRGQLGVNIQEVTQELAQSFGLQRPSGALVVRVDPKG
PAARAGLQAGDIILKLNNQSIDSSKDLPMLVGSLGPGTKIKLVVWRKGFEKTMEATLVEQAQEPGSNTKPASDNSPQGYQ
FGKLGLTLSELTAEQRGDLGIRGGLLIQKSQGPAARSGLMPGDIILGLNQNDITSISAFEKALASAGGHAALLVRRGEAV
LYIALRTD
>Mature_487_residues
AGALLAASLLSGCDRIEQFVKGSNQPAPVAIPAQQDGRVAMLLPDFTQLVSRDGPAVVNIQATREGGGAAPQQSGNMPFP
VPEDDPLYDFFRRFMPNQPPQQEQGPEESVSYGSGFIISSDGFILTNAHVVADGGQIRVTLTDKRELRAKLVGLDKRSDV
ALLKVAAADLPVAKIGNPADLKVGEWVAAIGAPFGFDNTVTAGIVSAKGRSLPDETLVPFIQTDVAINPGNSGGPLFNLR
GEVVGINSQIYSRSGGFMGISFAIPIDLAMQVADQLKTKGKVSRGQLGVNIQEVTQELAQSFGLQRPSGALVVRVDPKGP
AARAGLQAGDIILKLNNQSIDSSKDLPMLVGSLGPGTKIKLVVWRKGFEKTMEATLVEQAQEPGSNTKPASDNSPQGYQF
GKLGLTLSELTAEQRGDLGIRGGLLIQKSQGPAARSGLMPGDIILGLNQNDITSISAFEKALASAGGHAALLVRRGEAVL
YIALRTD

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=289, Percent_Identity=37.3702422145329, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI22129776, Length=256, Percent_Identity=39.84375, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24308541, Length=253, Percent_Identity=37.9446640316205, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI7019477, Length=259, Percent_Identity=38.6100386100386, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1789629, Length=448, Percent_Identity=37.5, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1786356, Length=381, Percent_Identity=37.2703412073491, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=39.4927536231884, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24646839, Length=290, Percent_Identity=35.5172413793103, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51245; Mature: 51114

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGALLAASLLSGCDRIEQFVKGSNQPAPVAIPAQQDGRVAMLLPDFTQLVSRDGPAVVN
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECCCHHHHHCCCCCEEEE
IQATREGGGAAPQQSGNMPFPVPEDDPLYDFFRRFMPNQPPQQEQGPEESVSYGSGFIIS
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCHHHHCCCCCEEEE
SDGFILTNAHVVADGGQIRVTLTDKRELRAKLVGLDKRSDVALLKVAAADLPVAKIGNPA
CCCEEEECCEEEECCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHCCCCC
DLKVGEWVAAIGAPFGFDNTVTAGIVSAKGRSLPDETLVPFIQTDVAINPGNSGGPLFNL
CCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHCCCEEEECEEECCCCCCCCEEEE
RGEVVGINSQIYSRSGGFMGISFAIPIDLAMQVADQLKTKGKVSRGQLGVNIQEVTQELA
CCCEEEECHHHEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QSFGLQRPSGALVVRVDPKGPAARAGLQAGDIILKLNNQSIDSSKDLPMLVGSLGPGTKI
HHHCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCEE
KLVVWRKGFEKTMEATLVEQAQEPGSNTKPASDNSPQGYQFGKLGLTLSELTAEQRGDLG
EEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCC
IRGGLLIQKSQGPAARSGLMPGDIILGLNQNDITSISAFEKALASAGGHAALLVRRGEAV
CCCCEEEECCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEE
LYIALRTD
EEEEEECC
>Mature Secondary Structure 
AGALLAASLLSGCDRIEQFVKGSNQPAPVAIPAQQDGRVAMLLPDFTQLVSRDGPAVVN
CHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECCCHHHHHCCCCCEEEE
IQATREGGGAAPQQSGNMPFPVPEDDPLYDFFRRFMPNQPPQQEQGPEESVSYGSGFIIS
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHCCCHHHHCCCCCEEEE
SDGFILTNAHVVADGGQIRVTLTDKRELRAKLVGLDKRSDVALLKVAAADLPVAKIGNPA
CCCEEEECCEEEECCCEEEEEECCCHHHHHHHHCCCCCCCEEEEEEECCCCCHHHCCCCC
DLKVGEWVAAIGAPFGFDNTVTAGIVSAKGRSLPDETLVPFIQTDVAINPGNSGGPLFNL
CCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHCCCEEEECEEECCCCCCCCEEEE
RGEVVGINSQIYSRSGGFMGISFAIPIDLAMQVADQLKTKGKVSRGQLGVNIQEVTQELA
CCCEEEECHHHEECCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
QSFGLQRPSGALVVRVDPKGPAARAGLQAGDIILKLNNQSIDSSKDLPMLVGSLGPGTKI
HHHCCCCCCCEEEEEECCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCEE
KLVVWRKGFEKTMEATLVEQAQEPGSNTKPASDNSPQGYQFGKLGLTLSELTAEQRGDLG
EEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCC
IRGGLLIQKSQGPAARSGLMPGDIILGLNQNDITSISAFEKALASAGGHAALLVRRGEAV
CCCCEEEECCCCCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEE
LYIALRTD
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]