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The map label for this gene is sph [H]

Identifier: 34498730

GI number: 34498730

Start: 3566601

End: 3568133

Strand: Reverse

Name: sph [H]

Synonym: CV_3275

Alternate gene names: 34498730

Gene position: 3568133-3566601 (Counterclockwise)

Preceding gene: 34498731

Following gene: 34498729

Centisome position: 75.1

GC content: 68.36

Gene sequence:

>1533_bases
ATGAAAGCCTGGCGTTTTCTGCTGTGCGCGGCGCTGTCGCTGCCCGCCGCCTCTCATGCCGCCGATCCCGAAGACCTGAA
GCTGGCCACCTGGAACGCGATGCTGCTGCCGCAGGCGCTGTATCCCAATTACGGCCAGATGCGGCGCGTCGAGCTGATGG
CCGCCGCGCCGATTCTGCAAGCCCAGGACGTGCTGGTGTTCCAGGAACTGCAGGACAACGCCGCGTCGGACAAGCTGCTG
GCGCTGCTGAAGCCGCGCTTTCCCTACCAGACGCCGGTGATAGGCCGCGCGCAACAGGGCTGGGACGGCACCGAAGGGTG
GAATGGCATGAAGCCCGAGGACGGCGGCGTCGCCATCGCCAGCCGCTGGCCCATCGTCGAGAAGCGGCAGTACCTGTTCC
AGACGCCCGGCTGCAGCTGGGACGGGCAGGCGCTGAAGGGCTTCGCCTACGCCAGGATAGCCGTGAACGGCCAGTTTTAT
CATGTGATCGGCACCCATCTGCAGTCGGAAGACAGCGGCTGCGCCAATCACGCCGACATCGGCGTGCGCCAGGCGCAGCT
GCGCGAGATCGCCGCCTGGGTGCAGTCGCGCCATCTGCCGGTAGAGGAGACGGTGATCGTCGCCGGCGACATGAACATCG
ACCGCTACAAGAGCGCCGAATACCGGGCGATGCTGGACATCCTGCAGGCCGGCGAGCCGCGTTACGCCGGCATGCCGCAC
AGCTTCGACACCGCCGGCAACGGCATCGCGCTGGAGCGCTACGGCGCGCGCGGCGGCGACGCGCCCGAGTACCTGGACTA
CATCCTGACGCTGAAAGGCCACCGCCAGCCCGCGGCTTGGCACAACCAGGCGCTGGACGCGCCGTCGCCGCAGTGGACGG
CGCAGTCGGCGGTGGCGAAGCAGACCTACGCCTACGCCGATTTCAGCGACCACTACCCGGTGCAGGCCTTCGCCTGGGCC
GATGCCGCGACGCCGACGCGCTCGCTGAGCGCGCAGCCGGGCGCTTACCGCCAGATCAGCCTGCAGAACCTGGCCAGCGG
CCGTTATGTCCAGGCCGGCGACGCCAATGACGGCTGGCTGAAGACCGACGCGGCGGCGGCGGGCGCGCGGGCGCGCTTCA
ATCTGTCCAACAACTTTTCCATGCGCGACAACGGCTGCATCCGCTCCGGCGAATACGTGAGGCTGGAGCGCGCCGACCGT
CCCGGCTGGTTCTGGGCCTGGTGGGGCGGCGTGGGGGGCAACCAGTACGCGTACTACACCGCCCAGGGGCCGCTCAATCG
TTCCGCCGAGCTGCGCCTGATCAATCACAGCCGGCCGGACGGCTGCCTGCAGGACGGCGACGTGGTGTCGTTCAAGGATT
GGGCGCGCGCGGCCGACTACTACCTGACCGCCTGGGTTGGCGGCAGCCATGCCGACCAGCTGTATCTGTGGCAGCCGGCG
TCTGGGGATGGGGAACGATTCCGGCTGCGGATGGGCGCATCGCCGCAGTATCTGGACTGGCGCGGACTATTGCGTTTCGC
CAAACGCCGTTGA

Upstream 100 bases:

>100_bases
TTGAAAATGTAAATGACATATTAATTTTCTGATAATTAACCATATTGAAAGAAAACTGCTCCAGCCTTTGCCGCTTCCTC
CACCCACCAAAGGATGTCCG

Downstream 100 bases:

>100_bases
GGGATTGCTTGGCTTTTGTATCCAATTCTCCACGTCATGCCCTGACCCTTGGAACAGTATTAGCCACATTGTCAGACAAT
ATGGTTGATGAATGAGTCCG

Product: sphingomyelinase/beta-hemolysin

Products: NA

Alternate protein names: Sphingomyelin phosphodiesterase; SMase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MKAWRFLLCAALSLPAASHAADPEDLKLATWNAMLLPQALYPNYGQMRRVELMAAAPILQAQDVLVFQELQDNAASDKLL
ALLKPRFPYQTPVIGRAQQGWDGTEGWNGMKPEDGGVAIASRWPIVEKRQYLFQTPGCSWDGQALKGFAYARIAVNGQFY
HVIGTHLQSEDSGCANHADIGVRQAQLREIAAWVQSRHLPVEETVIVAGDMNIDRYKSAEYRAMLDILQAGEPRYAGMPH
SFDTAGNGIALERYGARGGDAPEYLDYILTLKGHRQPAAWHNQALDAPSPQWTAQSAVAKQTYAYADFSDHYPVQAFAWA
DAATPTRSLSAQPGAYRQISLQNLASGRYVQAGDANDGWLKTDAAAAGARARFNLSNNFSMRDNGCIRSGEYVRLERADR
PGWFWAWWGGVGGNQYAYYTAQGPLNRSAELRLINHSRPDGCLQDGDVVSFKDWARAADYYLTAWVGGSHADQLYLWQPA
SGDGERFRLRMGASPQYLDWRGLLRFAKRR

Sequences:

>Translated_510_residues
MKAWRFLLCAALSLPAASHAADPEDLKLATWNAMLLPQALYPNYGQMRRVELMAAAPILQAQDVLVFQELQDNAASDKLL
ALLKPRFPYQTPVIGRAQQGWDGTEGWNGMKPEDGGVAIASRWPIVEKRQYLFQTPGCSWDGQALKGFAYARIAVNGQFY
HVIGTHLQSEDSGCANHADIGVRQAQLREIAAWVQSRHLPVEETVIVAGDMNIDRYKSAEYRAMLDILQAGEPRYAGMPH
SFDTAGNGIALERYGARGGDAPEYLDYILTLKGHRQPAAWHNQALDAPSPQWTAQSAVAKQTYAYADFSDHYPVQAFAWA
DAATPTRSLSAQPGAYRQISLQNLASGRYVQAGDANDGWLKTDAAAAGARARFNLSNNFSMRDNGCIRSGEYVRLERADR
PGWFWAWWGGVGGNQYAYYTAQGPLNRSAELRLINHSRPDGCLQDGDVVSFKDWARAADYYLTAWVGGSHADQLYLWQPA
SGDGERFRLRMGASPQYLDWRGLLRFAKRR
>Mature_510_residues
MKAWRFLLCAALSLPAASHAADPEDLKLATWNAMLLPQALYPNYGQMRRVELMAAAPILQAQDVLVFQELQDNAASDKLL
ALLKPRFPYQTPVIGRAQQGWDGTEGWNGMKPEDGGVAIASRWPIVEKRQYLFQTPGCSWDGQALKGFAYARIAVNGQFY
HVIGTHLQSEDSGCANHADIGVRQAQLREIAAWVQSRHLPVEETVIVAGDMNIDRYKSAEYRAMLDILQAGEPRYAGMPH
SFDTAGNGIALERYGARGGDAPEYLDYILTLKGHRQPAAWHNQALDAPSPQWTAQSAVAKQTYAYADFSDHYPVQAFAWA
DAATPTRSLSAQPGAYRQISLQNLASGRYVQAGDANDGWLKTDAAAAGARARFNLSNNFSMRDNGCIRSGEYVRLERADR
PGWFWAWWGGVGGNQYAYYTAQGPLNRSAELRLINHSRPDGCLQDGDVVSFKDWARAADYYLTAWVGGSHADQLYLWQPA
SGDGERFRLRMGASPQYLDWRGLLRFAKRR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005135
- InterPro:   IPR017766 [H]

Pfam domain/function: PF03372 Exo_endo_phos [H]

EC number: =3.1.4.12 [H]

Molecular weight: Translated: 56686; Mature: 56686

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAWRFLLCAALSLPAASHAADPEDLKLATWNAMLLPQALYPNYGQMRRVELMAAAPILQ
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEECCHHHCCCCCCHHEEEHHHHCCCHH
AQDVLVFQELQDNAASDKLLALLKPRFPYQTPVIGRAQQGWDGTEGWNGMKPEDGGVAIA
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SRWPIVEKRQYLFQTPGCSWDGQALKGFAYARIAVNGQFYHVIGTHLQSEDSGCANHADI
ECCCCHHHHHHHEECCCCCCCCHHHCCEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCC
GVRQAQLREIAAWVQSRHLPVEETVIVAGDMNIDRYKSAEYRAMLDILQAGEPRYAGMPH
CHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCC
SFDTAGNGIALERYGARGGDAPEYLDYILTLKGHRQPAAWHNQALDAPSPQWTAQSAVAK
CCCCCCCCEEEEECCCCCCCCHHHHHHHEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHH
QTYAYADFSDHYPVQAFAWADAATPTRSLSAQPGAYRQISLQNLASGRYVQAGDANDGWL
HHEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHCCCCEEECCCCCCCEE
KTDAAAAGARARFNLSNNFSMRDNGCIRSGEYVRLERADRPGWFWAWWGGVGGNQYAYYT
ECCHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEE
AQGPLNRSAELRLINHSRPDGCLQDGDVVSFKDWARAADYYLTAWVGGSHADQLYLWQPA
ECCCCCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHCCEEEEEEECCCCCCEEEEECCC
SGDGERFRLRMGASPQYLDWRGLLRFAKRR
CCCCCEEEEEECCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MKAWRFLLCAALSLPAASHAADPEDLKLATWNAMLLPQALYPNYGQMRRVELMAAAPILQ
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEECCHHHCCCCCCHHEEEHHHHCCCHH
AQDVLVFQELQDNAASDKLLALLKPRFPYQTPVIGRAQQGWDGTEGWNGMKPEDGGVAIA
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
SRWPIVEKRQYLFQTPGCSWDGQALKGFAYARIAVNGQFYHVIGTHLQSEDSGCANHADI
ECCCCHHHHHHHEECCCCCCCCHHHCCEEEEEEEECCEEEEEEECCCCCCCCCCCCCCCC
GVRQAQLREIAAWVQSRHLPVEETVIVAGDMNIDRYKSAEYRAMLDILQAGEPRYAGMPH
CHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCCCC
SFDTAGNGIALERYGARGGDAPEYLDYILTLKGHRQPAAWHNQALDAPSPQWTAQSAVAK
CCCCCCCCEEEEECCCCCCCCHHHHHHHEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHH
QTYAYADFSDHYPVQAFAWADAATPTRSLSAQPGAYRQISLQNLASGRYVQAGDANDGWL
HHEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEHHHHCCCCEEECCCCCCCEE
KTDAAAAGARARFNLSNNFSMRDNGCIRSGEYVRLERADRPGWFWAWWGGVGGNQYAYYT
ECCHHHCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEE
AQGPLNRSAELRLINHSRPDGCLQDGDVVSFKDWARAADYYLTAWVGGSHADQLYLWQPA
ECCCCCCCCEEEEEECCCCCCCCCCCCEEEHHHHHHHCCEEEEEEECCCCCCEEEEECCC
SGDGERFRLRMGASPQYLDWRGLLRFAKRR
CCCCCEEEEEECCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2163985 [H]