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The map label for this gene is cueR [H]

Identifier: 34498690

GI number: 34498690

Start: 3517176

End: 3517589

Strand: Reverse

Name: cueR [H]

Synonym: CV_3235

Alternate gene names: 34498690

Gene position: 3517589-3517176 (Counterclockwise)

Preceding gene: 34498691

Following gene: 34498678

Centisome position: 74.04

GC content: 63.04

Gene sequence:

>414_bases
ATGAAAATCGGAGAACTGGCCAAACGGAGCGGCATGGCGGCCTCGGCCATCCGCTTCGATGAGTCCAAAGGCTTGTTGCA
GTCGGCCAGCGGCCAGGCGAACGGTTATCGGGACTATCCTCCGGAGACGGCTGCGGCGCTGGCCATCATCCGCGACGCGC
AGCAGTCCGGCTTCTCGCTGGACGAGATCAGGCAGATTCTGCCGGCGGGCGTTTCATCCTGGCGGCACGACGAGTTGTTG
GCCACGCTCAGGCGCAAGGTGGCGGATATCGAGTCGCTGCAGGCGCGGCTGGCGCAGAACAAATCGCACATCCAGTCCCT
GATCCAGCTGATCGAATCCAAGCCCGGGGACATGGACTGCGCCGACAATGCCGCCAGAGTGATGGCGGTCATGGGCATTG
GCGGCGACAAATAA

Upstream 100 bases:

>100_bases
GCTGGCCCAGGCTTTGCTGGCGGCGCTGCGCAATGCGCAAGCCCGGTAGGCCGGCCGTGTGATCCGACGAGATTCAGGCA
AGGGCCGAAGCAGGAGCGAT

Downstream 100 bases:

>100_bases
GGAAGCCCTTTTTAGGCTGGGCGCGTCAACGGCAGCCTGTCCCGCTCAGCGCCGGAATAACCAGACCATGGGTGCCGCGC
GGTCACCCGCAGAGCGAAGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MKIGELAKRSGMAASAIRFDESKGLLQSASGQANGYRDYPPETAAALAIIRDAQQSGFSLDEIRQILPAGVSSWRHDELL
ATLRRKVADIESLQARLAQNKSHIQSLIQLIESKPGDMDCADNAARVMAVMGIGGDK

Sequences:

>Translated_137_residues
MKIGELAKRSGMAASAIRFDESKGLLQSASGQANGYRDYPPETAAALAIIRDAQQSGFSLDEIRQILPAGVSSWRHDELL
ATLRRKVADIESLQARLAQNKSHIQSLIQLIESKPGDMDCADNAARVMAVMGIGGDK
>Mature_137_residues
MKIGELAKRSGMAASAIRFDESKGLLQSASGQANGYRDYPPETAAALAIIRDAQQSGFSLDEIRQILPAGVSSWRHDELL
ATLRRKVADIESLQARLAQNKSHIQSLIQLIESKPGDMDCADNAARVMAVMGIGGDK

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=122, Percent_Identity=31.9672131147541, Blast_Score=62, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14752; Mature: 14752

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGELAKRSGMAASAIRFDESKGLLQSASGQANGYRDYPPETAAALAIIRDAQQSGFSL
CCHHHHHHHCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCH
DEIRQILPAGVSSWRHDELLATLRRKVADIESLQARLAQNKSHIQSLIQLIESKPGDMDC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
ADNAARVMAVMGIGGDK
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKIGELAKRSGMAASAIRFDESKGLLQSASGQANGYRDYPPETAAALAIIRDAQQSGFSL
CCHHHHHHHCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCH
DEIRQILPAGVSSWRHDELLATLRRKVADIESLQARLAQNKSHIQSLIQLIESKPGDMDC
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
ADNAARVMAVMGIGGDK
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]