Click here to switch to the map view.

The map label for this gene is fabG [C]

Identifier: 34498682

GI number: 34498682

Start: 3509317

End: 3510633

Strand: Direct

Name: fabG [C]

Synonym: CV_3227

Alternate gene names: 34498682

Gene position: 3509317-3510633 (Clockwise)

Preceding gene: 34498681

Following gene: 34498683

Centisome position: 73.86

GC content: 69.78

Gene sequence:

>1317_bases
ATGCGTGATGCCGCGCGCCGCCTTCGCCTCCTTGCTGGCCTTGCTGACGGGTTGTGCCGGACCCTCGGTGGCCGATTACG
CCGCCAATCGCCCGCTGCTGGACCCTGGCCGTTTTTTCCTCGGCAAGACCGAGGCCTGGGGCATGTTCCAGGACCGGCAA
GGCCGCGTGGCCAAGCGCTTCACCGTGGACATGGACGGCGAACGCCAGGGCGAGGAGCTGGTGCTGACCGAGCGCTTCCA
TTACAGCGACGGCAGCCGCCAGCAGCGCGTATGGCGGCTCAAGCCCACCGGCGACGGCCGCTGGCGCGGCCTGGCCGACG
ATGTGGTCGGCGAGGCCGTCGGCGAGACGGCCGGCAACGCGCTGCGCTGGCGCTACACGCTGAAGCTGCCGGTGGACGGC
AAACAGTACCTGGTGCAGTTCGACGACTGGATGTTCCTGCAGGACGAGCGCAGCCTGCTCAACCGGACGACGATGAGCAA
GTTCGGCTTCCGCCTGGGCGAAGTCACGCTGTTCTTCCGCAAGCCGGAGGCCAAGCCATGACGCTGCGCCTCAATCCCGC
CATAGCGGACTGGCGCGCGCGCCGGGTGTGGGTGATAGGCGCGTCCAGCGGCATCGGCGCGGCCTTGGCCGACGAACTGC
TGCAGGCCGGCGCCGAAGTCATCCTGTCGGCGCGCCGCGCCGAGCCGATGCGCATGCTGGCGGCGGGCTGCCCGGGCGCG
CGGGTGGAAACGCTGGACGTGACCGATCCCGCCGCCTGGCAGGCCGCCTGGTCGCATCTGGAGGCCGCCGGCGCGCTGCC
CGATTTCGTGGTGTTCTGCGCGGCCGATTACCGGCCGCAAACCTGCCTGGACCTGTACGCAGAGGAAACCCGCCGCCTGC
TCGACACCAATCTGCTGGGCGTCTACCACGGGCTGGAAGTGGTGTTGCCGACGCTGGCGCGGCAAGGCCGCGGCGGCGTG
GCGCTGGTCGCCAGCGTGGCCGGTTACGCCGGCCTGCCCGGCGCCGTGGTCTACGGCCCCGGTAAGGCGGCGCTGATCAA
TCTGGCGGAAATCCTCTACACCGAGCTCAGGCCGCGCGGGGTGGCGGTTTACCTGATCAATCCCGGCTTCGTCGCCACGC
CGCTCACCGCCAAGAACCACTTCACCATGCCGGCGCTGCTGACGCCGCGCCAGGCTGCGCGGCACATCATGCGCGGGCTA
GAGCGCGGCGCGTTCGAAATCCACTTCCCGCTGCGCTTCACCGTATGGCTCAAACTGTTGCGGCTGCTGCCCTACCGGCT
GCGGCTGCCCTTGCTCGCGAGGTTGGCACGACCATGA

Upstream 100 bases:

>100_bases
GACGAGGCCTTCATCCGGCTGTGGCGGCTGTACCTGTGCTACTGCGAAGCCGGTTTCGACGAAGGCCGCATCGGCGTTTC
GCAATTTCTGCTGGAAAGGA

Downstream 100 bases:

>100_bases
AACGCATTCCTACCCAAACCGAATGGCAGGCCCTGCTCGACTGGTACCAGACGCTGACGCCGGACACGCTGCCGGACATC
GGCCGCTATTACGCCGAAGA

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRDAARRLRLLAGLADGLCRTLGGRLRRQSPAAGPWPFFPRQDRGLGHVPGPARPRGQALHRGHGRRTPGRGAGADRALP
LQRRQPPAARMAAQAHRRRPLARPGRRCGRRGRRRDGRQRAALALHAEAAGGRQTVPGAVRRLDVPAGRAQPAQPDDDEQ
VRLPPGRSHAVLPQAGGQAMTLRLNPAIADWRARRVWVIGASSGIGAALADELLQAGAEVILSARRAEPMRMLAAGCPGA
RVETLDVTDPAAWQAAWSHLEAAGALPDFVVFCAADYRPQTCLDLYAEETRRLLDTNLLGVYHGLEVVLPTLARQGRGGV
ALVASVAGYAGLPGAVVYGPGKAALINLAEILYTELRPRGVAVYLINPGFVATPLTAKNHFTMPALLTPRQAARHIMRGL
ERGAFEIHFPLRFTVWLKLLRLLPYRLRLPLLARLARP

Sequences:

>Translated_438_residues
MRDAARRLRLLAGLADGLCRTLGGRLRRQSPAAGPWPFFPRQDRGLGHVPGPARPRGQALHRGHGRRTPGRGAGADRALP
LQRRQPPAARMAAQAHRRRPLARPGRRCGRRGRRRDGRQRAALALHAEAAGGRQTVPGAVRRLDVPAGRAQPAQPDDDEQ
VRLPPGRSHAVLPQAGGQAMTLRLNPAIADWRARRVWVIGASSGIGAALADELLQAGAEVILSARRAEPMRMLAAGCPGA
RVETLDVTDPAAWQAAWSHLEAAGALPDFVVFCAADYRPQTCLDLYAEETRRLLDTNLLGVYHGLEVVLPTLARQGRGGV
ALVASVAGYAGLPGAVVYGPGKAALINLAEILYTELRPRGVAVYLINPGFVATPLTAKNHFTMPALLTPRQAARHIMRGL
ERGAFEIHFPLRFTVWLKLLRLLPYRLRLPLLARLARP
>Mature_438_residues
MRDAARRLRLLAGLADGLCRTLGGRLRRQSPAAGPWPFFPRQDRGLGHVPGPARPRGQALHRGHGRRTPGRGAGADRALP
LQRRQPPAARMAAQAHRRRPLARPGRRCGRRGRRRDGRQRAALALHAEAAGGRQTVPGAVRRLDVPAGRAQPAQPDDDEQ
VRLPPGRSHAVLPQAGGQAMTLRLNPAIADWRARRVWVIGASSGIGAALADELLQAGAEVILSARRAEPMRMLAAGCPGA
RVETLDVTDPAAWQAAWSHLEAAGALPDFVVFCAADYRPQTCLDLYAEETRRLLDTNLLGVYHGLEVVLPTLARQGRGGV
ALVASVAGYAGLPGAVVYGPGKAALINLAEILYTELRPRGVAVYLINPGFVATPLTAKNHFTMPALLTPRQAARHIMRGL
ERGAFEIHFPLRFTVWLKLLRLLPYRLRLPLLARLARP

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7706318, Length=209, Percent_Identity=29.6650717703349, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI32483357, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=189, Percent_Identity=29.6296296296296, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082100, Length=186, Percent_Identity=29.5698924731183, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI23397609, Length=184, Percent_Identity=36.9565217391304, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644339, Length=195, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI116007236, Length=225, Percent_Identity=28.4444444444444, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24584752, Length=212, Percent_Identity=30.6603773584906, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28571526, Length=193, Percent_Identity=27.979274611399, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357041, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=191, Percent_Identity=31.9371727748691, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640442, Length=226, Percent_Identity=26.9911504424779, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24580925, Length=205, Percent_Identity=28.2926829268293, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571387, Length=200, Percent_Identity=29.5, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 47450; Mature: 47450

Theoretical pI: Translated: 12.13; Mature: 12.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDAARRLRLLAGLADGLCRTLGGRLRRQSPAAGPWPFFPRQDRGLGHVPGPARPRGQAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
HRGHGRRTPGRGAGADRALPLQRRQPPAARMAAQAHRRRPLARPGRRCGRRGRRRDGRQR
HCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHH
AALALHAEAAGGRQTVPGAVRRLDVPAGRAQPAQPDDDEQVRLPPGRSHAVLPQAGGQAM
HHEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCEECCCCCCCEE
TLRLNPAIADWRARRVWVIGASSGIGAALADELLQAGAEVILSARRAEPMRMLAAGCPGA
EEEECCCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
RVETLDVTDPAAWQAAWSHLEAAGALPDFVVFCAADYRPQTCLDLYAEETRRLLDTNLLG
EEEEEECCCCHHHHHHHHHHHHHCCCHHEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHH
VYHGLEVVLPTLARQGRGGVALVASVAGYAGLPGAVVYGPGKAALINLAEILYTELRPRG
HHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCC
VAVYLINPGFVATPLTAKNHFTMPALLTPRQAARHIMRGLERGAFEIHFPLRFTVWLKLL
EEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHH
RLLPYRLRLPLLARLARP
HHCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRDAARRLRLLAGLADGLCRTLGGRLRRQSPAAGPWPFFPRQDRGLGHVPGPARPRGQAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHH
HRGHGRRTPGRGAGADRALPLQRRQPPAARMAAQAHRRRPLARPGRRCGRRGRRRDGRQR
HCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHH
AALALHAEAAGGRQTVPGAVRRLDVPAGRAQPAQPDDDEQVRLPPGRSHAVLPQAGGQAM
HHEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCEECCCCCCCEE
TLRLNPAIADWRARRVWVIGASSGIGAALADELLQAGAEVILSARRAEPMRMLAAGCPGA
EEEECCCHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
RVETLDVTDPAAWQAAWSHLEAAGALPDFVVFCAADYRPQTCLDLYAEETRRLLDTNLLG
EEEEEECCCCHHHHHHHHHHHHHCCCHHEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHH
VYHGLEVVLPTLARQGRGGVALVASVAGYAGLPGAVVYGPGKAALINLAEILYTELRPRG
HHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCC
VAVYLINPGFVATPLTAKNHFTMPALLTPRQAARHIMRGLERGAFEIHFPLRFTVWLKLL
EEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHH
RLLPYRLRLPLLARLARP
HHCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1730672 [H]